ENSG00000141385

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000269143 ENSG00000141385 HEK293_OSMI2_2hA HEK293_TMG_2hB AFG3L2 protein_coding protein_coding 40.30488 42.18227 38.02976 2.723205 0.7813575 -0.1494706 23.38571 19.44779 28.022950 1.182655 1.0072649 0.526776 0.5816208 0.4636 0.7369 0.2733 3.872378e-06 3.872378e-06 FALSE TRUE
ENST00000692988 ENSG00000141385 HEK293_OSMI2_2hA HEK293_TMG_2hB AFG3L2 protein_coding retained_intron 40.30488 42.18227 38.02976 2.723205 0.7813575 -0.1494706 13.92789 19.51502 8.002902 2.304028 0.8332016 -1.284927 0.3437000 0.4602 0.2105 -0.2497 4.318226e-06 3.872378e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000141385 E001 8.2022796 0.0020476345 9.486810e-01 9.718288e-01 18 12328944 12328956 13 - 0.954 0.965 0.041
ENSG00000141385 E002 9.3803062 0.0017963721 4.384269e-01 5.803069e-01 18 12328957 12328959 3 - 0.954 1.055 0.373
ENSG00000141385 E003 15.6801025 0.0013357734 1.775141e-01 2.980178e-01 18 12328960 12328966 7 - 1.142 1.278 0.482
ENSG00000141385 E004 1008.0134546 0.0045469343 1.623793e-08 1.925049e-07 18 12328967 12329783 817 - 2.878 3.070 0.638
ENSG00000141385 E005 455.3208489 0.0001497257 2.205746e-09 3.065825e-08 18 12337341 12337535 195 - 2.582 2.705 0.408
ENSG00000141385 E006 424.9292805 0.0001553377 1.219488e-06 9.941408e-06 18 12340201 12340401 201 - 2.563 2.669 0.353
ENSG00000141385 E007 3.1355814 0.0049474195 2.978216e-02 7.153540e-02 18 12340402 12340716 315 - 0.768 0.451 -1.413
ENSG00000141385 E008 0.9222279 0.0132204591 8.254283e-01 8.900514e-01 18 12340915 12340936 22 - 0.310 0.282 -0.192
ENSG00000141385 E009 35.0514746 0.0060009458 2.252681e-07 2.138416e-06 18 12340937 12344131 3195 - 1.714 1.368 -1.185
ENSG00000141385 E010 304.6987285 0.0001593317 1.407572e-04 7.067966e-04 18 12344132 12344247 116 - 2.424 2.523 0.331
ENSG00000141385 E011 0.8179419 0.0158726120 5.233832e-01 6.570931e-01 18 12346779 12346900 122 - 0.310 0.207 -0.775
ENSG00000141385 E012 0.1482932 0.0410566198 5.673301e-01   18 12346901 12346927 27 - 0.000 0.115 9.080
ENSG00000141385 E013 297.0965535 0.0001928154 2.443590e-03 8.593003e-03 18 12348273 12348383 111 - 2.421 2.505 0.280
ENSG00000141385 E014 330.5733645 0.0011152670 7.186909e-01 8.136947e-01 18 12351085 12351210 126 - 2.501 2.526 0.086
ENSG00000141385 E015 274.4399361 0.0008264604 5.382162e-01 6.696623e-01 18 12351306 12351413 108 - 2.416 2.449 0.111
ENSG00000141385 E016 334.5631464 0.0001642993 3.072631e-01 4.494743e-01 18 12353005 12353158 154 - 2.524 2.524 0.001
ENSG00000141385 E017 314.9316359 0.0003668223 5.418476e-02 1.165744e-01 18 12356694 12356831 138 - 2.510 2.489 -0.070
ENSG00000141385 E018 179.2936712 0.0002203167 2.229505e-02 5.628790e-02 18 12358670 12358703 34 - 2.277 2.237 -0.136
ENSG00000141385 E019 263.5419876 0.0002246561 5.099339e-03 1.620136e-02 18 12358704 12358804 101 - 2.444 2.402 -0.142
ENSG00000141385 E020 318.6997276 0.0007737530 1.270468e-02 3.521844e-02 18 12358805 12358943 139 - 2.523 2.484 -0.132
ENSG00000141385 E021 369.4763662 0.0019256340 1.080047e-04 5.589412e-04 18 12359927 12360051 125 - 2.614 2.525 -0.295
ENSG00000141385 E022 1.3953073 0.0096765512 2.344458e-01 3.676926e-01 18 12360052 12360233 182 - 0.229 0.452 1.396
ENSG00000141385 E023 273.8964699 0.0021407213 1.405874e-02 3.835852e-02 18 12363782 12363856 75 - 2.467 2.409 -0.194
ENSG00000141385 E024 338.9117959 0.0005661434 3.150522e-15 1.117082e-13 18 12366965 12367117 153 - 2.609 2.457 -0.506
ENSG00000141385 E025 240.1536829 0.0001822001 1.105630e-14 3.613219e-13 18 12367276 12367382 107 - 2.463 2.306 -0.525
ENSG00000141385 E026 1.9648373 0.0079204214 3.836825e-01 5.278800e-01 18 12367383 12367492 110 - 0.536 0.402 -0.675
ENSG00000141385 E027 156.4737177 0.0030696466 1.114319e-03 4.351771e-03 18 12370849 12370926 78 - 2.253 2.143 -0.368
ENSG00000141385 E028 135.1606389 0.0004263777 6.687953e-06 4.627511e-05 18 12371592 12371691 100 - 2.196 2.075 -0.405
ENSG00000141385 E029 74.8616880 0.0063156922 2.974449e-06 2.227539e-05 18 12376969 12377227 259 - 1.999 1.753 -0.828