ENSG00000141380

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000269137 ENSG00000141380 HEK293_OSMI2_2hA HEK293_TMG_2hB SS18 protein_coding protein_coding 25.43415 12.54083 39.67485 1.248354 0.7311592 1.660806 4.832038 0.6058528 8.195757 0.30414415 0.3122410 3.735979 0.15530833 0.04866667 0.20700000 0.15833333 1.961667e-01 8.625136e-30 FALSE TRUE
ENST00000415083 ENSG00000141380 HEK293_OSMI2_2hA HEK293_TMG_2hB SS18 protein_coding protein_coding 25.43415 12.54083 39.67485 1.248354 0.7311592 1.660806 14.396551 10.3437859 21.500490 1.00367279 0.2629975 1.054882 0.63101250 0.82523333 0.54203333 -0.28320000 8.625136e-30 8.625136e-30 FALSE TRUE
ENST00000542420 ENSG00000141380 HEK293_OSMI2_2hA HEK293_TMG_2hB SS18 protein_coding protein_coding 25.43415 12.54083 39.67485 1.248354 0.7311592 1.660806 1.700812 0.2208346 2.608706 0.08875357 0.5959071 3.503923 0.05140833 0.01923333 0.06526667 0.04603333 1.460056e-01 8.625136e-30 FALSE TRUE
ENST00000580958 ENSG00000141380 HEK293_OSMI2_2hA HEK293_TMG_2hB SS18 protein_coding retained_intron 25.43415 12.54083 39.67485 1.248354 0.7311592 1.660806 2.054775 0.4032170 3.398937 0.09663393 0.1697027 3.044350 0.07836667 0.03146667 0.08570000 0.05423333 9.730786e-05 8.625136e-30   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000141380 E001 611.1915181 0.0085904177 1.173255e-13 3.302178e-12 18 26016253 26017342 1090 - 2.603 2.973 1.232
ENSG00000141380 E002 388.9972778 0.0013489910 7.997213e-11 1.434840e-09 18 26017343 26017884 542 - 2.474 2.687 0.710
ENSG00000141380 E003 182.8952680 0.0002603306 2.967129e-06 2.222496e-05 18 26017885 26018006 122 - 2.157 2.345 0.627
ENSG00000141380 E004 100.2975721 0.0002956751 2.095452e-02 5.349518e-02 18 26018007 26018013 7 - 1.915 2.059 0.484
ENSG00000141380 E005 176.5624821 0.0018011992 2.694556e-01 4.079659e-01 18 26018014 26018119 106 - 2.176 2.269 0.309
ENSG00000141380 E006 235.6000244 0.0001770677 3.642464e-01 5.086155e-01 18 26018120 26018349 230 - 2.305 2.385 0.267
ENSG00000141380 E007 102.9485970 0.0011182591 9.580451e-01 9.777026e-01 18 26018350 26018380 31 - 1.956 2.015 0.199
ENSG00000141380 E008 0.0000000       18 26023613 26023632 20 -      
ENSG00000141380 E009 155.3186774 0.0005278146 3.359507e-01 4.797664e-01 18 26032399 26032532 134 - 2.123 2.210 0.294
ENSG00000141380 E010 127.0209723 0.0002555147 6.637387e-01 7.717343e-01 18 26035005 26035090 86 - 2.043 2.115 0.243
ENSG00000141380 E011 97.5146603 0.0005185669 4.779424e-01 6.164035e-01 18 26035091 26035127 37 - 1.943 1.973 0.099
ENSG00000141380 E012 24.6592425 0.0007737826 1.795297e-06 1.410908e-05 18 26035128 26035614 487 - 1.443 1.073 -1.303
ENSG00000141380 E013 11.3667093 0.0015588084 4.094892e-04 1.810846e-03 18 26035745 26035830 86 - 1.134 0.745 -1.469
ENSG00000141380 E014 38.9154036 0.0122943649 2.127873e-01 3.418262e-01 18 26035831 26035923 93 - 1.571 1.524 -0.162
ENSG00000141380 E015 154.4978038 0.0002534362 5.823024e-04 2.468459e-03 18 26038555 26038659 105 - 2.163 2.110 -0.180
ENSG00000141380 E016 168.8661411 0.0003955259 9.392839e-07 7.838620e-06 18 26039289 26039409 121 - 2.212 2.112 -0.336
ENSG00000141380 E017 114.5078736 0.0042508026 2.897331e-02 6.995445e-02 18 26039410 26039456 47 - 2.033 1.982 -0.174
ENSG00000141380 E018 132.1171599 0.0003118017 9.054436e-04 3.633031e-03 18 26052624 26052681 58 - 2.096 2.037 -0.201
ENSG00000141380 E019 107.4684107 0.0002600982 9.611992e-04 3.825633e-03 18 26052682 26052704 23 - 2.011 1.940 -0.238
ENSG00000141380 E020 111.8405093 0.0002470494 3.787692e-06 2.771278e-05 18 26052705 26052742 38 - 2.039 1.917 -0.411
ENSG00000141380 E021 102.3040939 0.0002922250 4.740384e-06 3.392586e-05 18 26052743 26052770 28 - 2.002 1.873 -0.436
ENSG00000141380 E022 120.3857637 0.0002749303 6.117714e-09 7.857508e-08 18 26052771 26052822 52 - 2.079 1.914 -0.555
ENSG00000141380 E023 86.4434241 0.0003306578 1.782087e-07 1.725058e-06 18 26052823 26052845 23 - 1.939 1.759 -0.606
ENSG00000141380 E024 88.5622671 0.0003236391 9.665705e-06 6.448807e-05 18 26057589 26057611 23 - 1.942 1.804 -0.464
ENSG00000141380 E025 118.6868481 0.0003605296 1.821628e-05 1.140569e-04 18 26057612 26057694 83 - 2.060 1.954 -0.355
ENSG00000141380 E026 65.2575652 0.0003741835 5.213593e-03 1.651230e-02 18 26057695 26057698 4 - 1.801 1.719 -0.278
ENSG00000141380 E027 77.7727907 0.0003438369 8.866709e-04 3.567672e-03 18 26057699 26057718 20 - 1.880 1.784 -0.322
ENSG00000141380 E028 76.3976254 0.0004216197 1.436313e-03 5.427557e-03 18 26057719 26057731 13 - 1.871 1.780 -0.307
ENSG00000141380 E029 76.2408656 0.0010750293 1.007040e-04 5.251327e-04 18 26057732 26057742 11 - 1.880 1.746 -0.452
ENSG00000141380 E030 0.1451727 0.0432040404 1.000000e+00   18 26064832 26064871 40 - 0.074 0.000 -9.133
ENSG00000141380 E031 0.5869318 0.2695546848 4.339781e-01 5.763668e-01 18 26068260 26068493 234 - 0.137 0.324 1.584
ENSG00000141380 E032 0.7352249 0.3904078009 3.125705e-01 4.550912e-01 18 26068494 26068557 64 - 0.137 0.420 2.138
ENSG00000141380 E033 82.6062157 0.0005388420 1.745608e-03 6.426106e-03 18 26078076 26078102 27 - 1.901 1.816 -0.285
ENSG00000141380 E034 96.5827342 0.0018623552 2.020783e-04 9.727889e-04 18 26078103 26078160 58 - 1.976 1.859 -0.393
ENSG00000141380 E035 1.3338878 0.0095186418 3.439358e-02 8.051007e-02 18 26078161 26078386 226 - 0.427 0.000 -12.303
ENSG00000141380 E036 1.9209213 0.0072259793 8.337247e-03 2.463605e-02 18 26079011 26079125 115 - 0.533 0.000 -12.834
ENSG00000141380 E037 1.1739533 0.0121145953 5.014981e-02 1.094277e-01 18 26079126 26079146 21 - 0.395 0.000 -12.133
ENSG00000141380 E038 2.7927715 0.0803607204 7.113867e-01 8.083617e-01 18 26080305 26080370 66 - 0.556 0.517 -0.182
ENSG00000141380 E039 2.0606791 0.0105408855 7.738726e-01 8.541440e-01 18 26080371 26080423 53 - 0.427 0.516 0.450
ENSG00000141380 E040 0.8868421 0.0349831185 5.607438e-01 6.886996e-01 18 26081225 26081365 141 - 0.285 0.196 -0.706
ENSG00000141380 E041 5.1744655 0.0170862879 4.672034e-01 6.067169e-01 18 26082363 26082382 20 - 0.765 0.699 -0.271
ENSG00000141380 E042 9.8093821 0.0018496720 1.406464e-01 2.489027e-01 18 26082383 26082528 146 - 1.020 0.895 -0.468
ENSG00000141380 E043 4.1028512 0.0039460962 3.021588e-01 4.440201e-01 18 26084052 26084175 124 - 0.706 0.586 -0.519
ENSG00000141380 E044 0.4804688 0.0222367481 8.029786e-01 8.745502e-01 18 26085923 26086027 105 - 0.137 0.196 0.619
ENSG00000141380 E045 103.6106630 0.0003152622 5.823871e-10 9.025070e-09 18 26087501 26087577 77 - 2.025 1.823 -0.678
ENSG00000141380 E046 0.1515154 0.0425534558 1.000000e+00   18 26089758 26089824 67 - 0.074 0.000 -9.134
ENSG00000141380 E047 0.3332198 0.0285306218 4.657670e-01   18 26089825 26090135 311 - 0.074 0.196 1.619
ENSG00000141380 E048 69.2998747 0.0056871449 1.340137e-11 2.734062e-10 18 26090501 26090901 401 - 1.886 1.485 -1.362
ENSG00000141380 E049 1.5082172 0.0093115254 6.057503e-01 7.260794e-01 18 26091004 26091095 92 - 0.395 0.330 -0.381
ENSG00000141380 E050 7.0491744 0.1166910977 7.878808e-01 8.641277e-01 18 26091096 26091217 122 - 0.851 0.898 0.178