ENSG00000141349

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000269097 ENSG00000141349 HEK293_OSMI2_2hA HEK293_TMG_2hB G6PC3 protein_coding protein_coding 107.8774 172.3955 70.75126 5.275868 0.6600708 -1.284775 90.635110 136.124187 63.35221 8.064046 0.2682761 -1.103335 0.8525917 0.7882 0.8955667 0.1073667 7.020660e-04 4.232547e-11 FALSE TRUE
ENST00000591696 ENSG00000141349 HEK293_OSMI2_2hA HEK293_TMG_2hB G6PC3 protein_coding protein_coding 107.8774 172.3955 70.75126 5.275868 0.6600708 -1.284775 1.743455 8.947265 0.00000 3.362122 0.0000000 -9.806915 0.0118625 0.0532 0.0000000 -0.0532000 4.232547e-11 4.232547e-11 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000141349 E001 6.6925351 0.0025260046 8.016423e-01 8.736071e-01 17 44070620 44070700 81 + 0.789 0.842 0.209
ENSG00000141349 E002 5.6616807 0.0028145729 4.157534e-01 5.591120e-01 17 44070701 44070714 14 + 0.664 0.802 0.566
ENSG00000141349 E003 2.1766157 0.0081146938 7.918411e-01 8.668538e-01 17 44070715 44070729 15 + 0.486 0.455 -0.158
ENSG00000141349 E004 2.0283226 0.0074500886 6.574593e-01 7.668105e-01 17 44070730 44070734 5 + 0.486 0.422 -0.327
ENSG00000141349 E005 2.1766157 0.0081146938 7.918411e-01 8.668538e-01 17 44070735 44070744 10 + 0.486 0.455 -0.158
ENSG00000141349 E006 2.3249089 0.0151772800 9.213343e-01 9.543345e-01 17 44070745 44070787 43 + 0.486 0.484 -0.008
ENSG00000141349 E007 1.8810735 0.0099059650 9.908887e-01 9.984411e-01 17 44070788 44070812 25 + 0.406 0.422 0.088
ENSG00000141349 E008 0.1482932 0.0414025474 1.000000e+00   17 44070813 44070842 30 + 0.001 0.081 7.472
ENSG00000141349 E009 0.6203429 0.0203452133 3.453616e-01 4.894647e-01 17 44070843 44070853 11 + 0.308 0.149 -1.328
ENSG00000141349 E010 0.9869609 0.1267227013 3.186040e-01 4.615673e-01 17 44070854 44070856 3 + 0.405 0.209 -1.320
ENSG00000141349 E011 30.7812969 0.0044925603 4.405086e-03 1.427817e-02 17 44070857 44070877 21 + 1.569 1.385 -0.633
ENSG00000141349 E012 63.5469014 0.0004160934 1.700926e-01 2.883125e-01 17 44070878 44070891 14 + 1.776 1.731 -0.154
ENSG00000141349 E013 68.3251669 0.0012532482 1.550387e-01 2.684644e-01 17 44070892 44070892 1 + 1.809 1.760 -0.164
ENSG00000141349 E014 139.9744654 0.0064561748 5.681357e-01 6.948468e-01 17 44070893 44070912 20 + 2.087 2.082 -0.014
ENSG00000141349 E015 413.6672567 0.0048317142 8.416725e-01 9.012349e-01 17 44070913 44070956 44 + 2.539 2.557 0.062
ENSG00000141349 E016 1064.1994863 0.0032350432 7.071786e-02 1.445355e-01 17 44070957 44071166 210 + 2.981 2.957 -0.079
ENSG00000141349 E017 501.8878042 0.0015798006 8.530721e-02 1.679015e-01 17 44071167 44071183 17 + 2.650 2.631 -0.064
ENSG00000141349 E018 31.6531126 0.0009883286 3.574740e-01 5.018789e-01 17 44071184 44071242 59 + 1.475 1.433 -0.145
ENSG00000141349 E019 4.6363441 0.0864730511 9.012647e-02 1.753195e-01 17 44071243 44071627 385 + 0.887 0.612 -1.115
ENSG00000141349 E020 5.4673807 0.0149746142 4.288505e-01 5.715804e-01 17 44071628 44071811 184 + 0.824 0.726 -0.390
ENSG00000141349 E021 1.2554226 0.0123584029 5.970051e-03 1.852806e-02 17 44071812 44071821 10 + 0.612 0.150 -2.912
ENSG00000141349 E022 14.4938765 0.0033909285 1.704067e-08 2.012784e-07 17 44071822 44073939 2118 + 1.436 0.945 -1.750
ENSG00000141349 E023 790.5628014 0.0021358338 4.088016e-01 5.524101e-01 17 44074160 44074229 70 + 2.831 2.835 0.013
ENSG00000141349 E024 688.1873803 0.0012313099 2.349386e-01 3.682824e-01 17 44074230 44074266 37 + 2.774 2.772 -0.007
ENSG00000141349 E025 899.3307527 0.0001634241 9.473871e-04 3.779480e-03 17 44074680 44074750 71 + 2.906 2.883 -0.076
ENSG00000141349 E026 577.8607630 0.0007457731 2.072142e-02 5.300082e-02 17 44074751 44074770 20 + 2.716 2.692 -0.078
ENSG00000141349 E027 989.4922343 0.0001309096 7.214619e-03 2.178206e-02 17 44074969 44075087 119 + 2.940 2.928 -0.040
ENSG00000141349 E028 17.7922220 0.0010965128 1.142846e-02 3.218312e-02 17 44075088 44075309 222 + 1.345 1.151 -0.684
ENSG00000141349 E029 1259.7450327 0.0008101685 2.478777e-01 3.834289e-01 17 44075310 44075451 142 + 3.031 3.037 0.019
ENSG00000141349 E030 1182.1758261 0.0009139852 3.404320e-03 1.145091e-02 17 44075680 44075818 139 + 2.949 3.026 0.255
ENSG00000141349 E031 2176.3172840 0.0054233893 4.220565e-04 1.858997e-03 17 44075819 44076344 526 + 3.168 3.304 0.453
ENSG00000141349 E032 2.8885959 0.1944972919 2.642640e-01 4.022240e-01 17 44077197 44077331 135 + 0.307 0.607 1.564
ENSG00000141349 E033 6.2205249 0.0159572047 4.577823e-01 5.980968e-01 17 44077332 44078104 773 + 0.710 0.841 0.525
ENSG00000141349 E034 1.3231874 0.0556895571 5.705068e-01 6.969717e-01 17 44080098 44080100 3 + 0.406 0.307 -0.592
ENSG00000141349 E035 11.9568202 0.0080279393 4.945692e-01 6.314945e-01 17 44080101 44082151 2051 + 1.091 1.036 -0.201