ENSG00000141298

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000269033 ENSG00000141298 HEK293_OSMI2_2hA HEK293_TMG_2hB SSH2 protein_coding protein_coding 7.082029 9.098551 6.129018 0.1986234 0.7623941 -0.5692138 2.2913562 1.6976373 2.0572166 0.1807586 0.1750776 0.2756879 0.3408042 0.1861667 0.3394667 0.15330000 0.001523983 0.001523983 FALSE TRUE
ENST00000324677 ENSG00000141298 HEK293_OSMI2_2hA HEK293_TMG_2hB SSH2 protein_coding protein_coding 7.082029 9.098551 6.129018 0.1986234 0.7623941 -0.5692138 0.4289593 0.5461195 0.8212288 0.2682800 0.1480207 0.5798507 0.0614250 0.0594000 0.1337667 0.07436667 0.288078820 0.001523983 FALSE TRUE
ENST00000582084 ENSG00000141298 HEK293_OSMI2_2hA HEK293_TMG_2hB SSH2 protein_coding protein_coding 7.082029 9.098551 6.129018 0.1986234 0.7623941 -0.5692138 1.7599016 2.7675691 1.2504301 0.1372333 0.4211493 -1.1399067 0.2319958 0.3039667 0.1921667 -0.11180000 0.392806927 0.001523983   FALSE
ENST00000590153 ENSG00000141298 HEK293_OSMI2_2hA HEK293_TMG_2hB SSH2 protein_coding protein_coding 7.082029 9.098551 6.129018 0.1986234 0.7623941 -0.5692138 1.8718909 3.3451909 1.4716884 0.2467097 0.3792301 -1.1791528 0.2534833 0.3678667 0.2364667 -0.13140000 0.158031670 0.001523983 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000141298 E001 328.8644766 0.0067204971 5.072762e-09 6.612671e-08 17 29625938 29630601 4664 - 2.394 2.613 0.731
ENSG00000141298 E002 14.9423858 0.0202168472 1.340303e-01 2.397496e-01 17 29630602 29630788 187 - 1.258 1.142 -0.411
ENSG00000141298 E003 7.7845492 0.0021626613 1.823243e-02 4.763853e-02 17 29630789 29630799 11 - 1.044 0.817 -0.858
ENSG00000141298 E004 26.7531811 0.0007151867 3.774654e-03 1.251044e-02 17 29630800 29631178 379 - 1.515 1.372 -0.492
ENSG00000141298 E005 74.9900124 0.0070732522 1.183967e-06 9.680164e-06 17 29631179 29632651 1473 - 1.983 1.765 -0.734
ENSG00000141298 E006 20.0332485 0.0474436612 4.411598e-04 1.932581e-03 17 29632652 29632931 280 - 1.493 1.078 -1.458
ENSG00000141298 E007 34.9082907 0.1338352225 6.761699e-03 2.060486e-02 17 29635968 29636802 835 - 1.719 1.316 -1.383
ENSG00000141298 E008 0.1472490 0.0436189111 5.054628e-01   17 29647694 29648143 450 - 0.116 0.000 -8.858
ENSG00000141298 E009 15.4614491 0.0089232974 3.425516e-08 3.814682e-07 17 29648144 29648344 201 - 1.410 0.900 -1.831
ENSG00000141298 E010 12.3262821 0.0022269433 3.355179e-06 2.485740e-05 17 29650654 29650800 147 - 1.292 0.880 -1.497
ENSG00000141298 E011 7.7814694 0.0091706261 3.535592e-03 1.182820e-02 17 29655561 29655607 47 - 1.079 0.768 -1.177
ENSG00000141298 E012 11.2890585 0.0119831302 4.738830e-06 3.391730e-05 17 29666867 29666995 129 - 1.272 0.793 -1.763
ENSG00000141298 E013 10.4523363 0.0441947466 4.988329e-03 1.589638e-02 17 29667130 29667223 94 - 1.203 0.843 -1.327
ENSG00000141298 E014 13.1262225 0.0379418742 1.358471e-02 3.727021e-02 17 29671935 29672129 195 - 1.265 0.991 -0.985
ENSG00000141298 E015 0.0000000       17 29673840 29673900 61 -      
ENSG00000141298 E016 9.5486601 0.0440281962 3.144396e-01 4.571571e-01 17 29673901 29674159 259 - 0.921 1.112 0.704
ENSG00000141298 E017 0.3289534 0.0294560963 1.000000e+00   17 29675830 29676819 990 - 0.116 0.129 0.187
ENSG00000141298 E018 17.5635642 0.0011171007 9.139454e-01 9.495041e-01 17 29676820 29676885 66 - 1.257 1.295 0.133
ENSG00000141298 E019 16.7563070 0.0012254741 6.871578e-01 7.895581e-01 17 29677673 29677718 46 - 1.250 1.263 0.048
ENSG00000141298 E020 16.2329794 0.0011986857 2.330799e-01 3.660746e-01 17 29677719 29677738 20 - 1.272 1.220 -0.181
ENSG00000141298 E021 12.4730053 0.0014188765 1.674817e-01 2.849225e-01 17 29677739 29677741 3 - 1.177 1.095 -0.294
ENSG00000141298 E022 23.4211296 0.0008155345 8.727467e-02 1.710040e-01 17 29684563 29684684 122 - 1.425 1.353 -0.252
ENSG00000141298 E023 15.3518298 0.0011413228 8.003325e-03 2.378735e-02 17 29695459 29695523 65 - 1.299 1.119 -0.639
ENSG00000141298 E024 15.5294818 0.0012167707 8.215493e-03 2.433054e-02 17 29702959 29703062 104 - 1.299 1.119 -0.638
ENSG00000141298 E025 3.2764997 0.0063506373 2.992127e-01 4.407096e-01 17 29761150 29761417 268 - 0.696 0.577 -0.515
ENSG00000141298 E026 0.2934659 0.0289934709 1.000000e+00   17 29793616 29793893 278 - 0.116 0.129 0.184
ENSG00000141298 E027 6.3861268 0.0181008281 8.481900e-01 9.057435e-01 17 29793894 29793937 44 - 0.851 0.862 0.042
ENSG00000141298 E028 0.0000000       17 29838927 29839142 216 -      
ENSG00000141298 E029 1.3973861 0.0428805666 3.539332e-01 4.982099e-01 17 29848849 29848929 81 - 0.452 0.310 -0.815
ENSG00000141298 E030 8.5037039 0.0024973488 1.608886e-04 7.959226e-04 17 29925217 29925276 60 - 0.668 1.152 1.849
ENSG00000141298 E031 43.0535063 0.0040797414 1.292490e-12 3.112871e-11 17 29925277 29925555 279 - 1.325 1.818 1.687
ENSG00000141298 E032 1.9960558 0.0526248540 1.399480e-01 2.479540e-01 17 29928282 29928584 303 - 0.282 0.580 1.614
ENSG00000141298 E033 33.9008912 0.0357202838 8.665415e-04 3.496564e-03 17 29929938 29930040 103 - 1.286 1.689 1.386
ENSG00000141298 E034 20.0658022 0.0325625430 4.261893e-04 1.874891e-03 17 29930041 29930158 118 - 1.032 1.481 1.584
ENSG00000141298 E035 8.0965630 0.0998366697 2.016981e-02 5.183977e-02 17 29930159 29930276 118 - 0.668 1.115 1.721