ENSG00000141295

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000290216 ENSG00000141295 HEK293_OSMI2_2hA HEK293_TMG_2hB SCRN2 protein_coding protein_coding 24.36724 40.30463 15.76575 1.68729 0.08707402 -1.353595 8.808425 20.0903766 6.5147965 0.6449966 0.2013420 -1.6232177 0.3368583 0.499133333 0.41316667 -0.085966667 0.02769741 0.02769741 FALSE  
ENST00000407215 ENSG00000141295 HEK293_OSMI2_2hA HEK293_TMG_2hB SCRN2 protein_coding protein_coding 24.36724 40.30463 15.76575 1.68729 0.08707402 -1.353595 6.719877 8.9050102 3.7255995 0.6881589 0.4012428 -1.2548967 0.2847833 0.221400000 0.23623333 0.014833333 0.89799322 0.02769741 FALSE  
ENST00000582656 ENSG00000141295 HEK293_OSMI2_2hA HEK293_TMG_2hB SCRN2 protein_coding retained_intron 24.36724 40.30463 15.76575 1.68729 0.08707402 -1.353595 1.131706 0.3172829 0.5600776 0.3172829 0.1021425 0.8006203 0.0565250 0.008566667 0.03546667 0.026900000 0.15022141 0.02769741    
ENST00000584123 ENSG00000141295 HEK293_OSMI2_2hA HEK293_TMG_2hB SCRN2 protein_coding protein_coding 24.36724 40.30463 15.76575 1.68729 0.08707402 -1.353595 2.773678 5.4188164 2.1924882 0.3451465 0.3113148 -1.3015034 0.1046375 0.134233333 0.13886667 0.004633333 0.97455995 0.02769741 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000141295 E001 16.667178 0.0011542263 7.228382e-01 8.168569e-01 17 47837692 47837706 15 - 1.137 1.169 0.114
ENSG00000141295 E002 16.997176 0.0011432987 6.417990e-01 7.547575e-01 17 47837707 47837707 1 - 1.137 1.179 0.152
ENSG00000141295 E003 26.083451 0.0008313200 4.273576e-02 9.606019e-02 17 47837708 47837719 12 - 1.205 1.375 0.599
ENSG00000141295 E004 34.207586 0.0043478105 6.859915e-03 2.086060e-02 17 47837720 47837731 12 - 1.277 1.499 0.771
ENSG00000141295 E005 258.880129 0.0004923849 7.945679e-02 1.586699e-01 17 47837732 47838002 271 - 2.288 2.333 0.150
ENSG00000141295 E006 92.103620 0.0029385942 1.540382e-01 2.671617e-01 17 47838003 47838269 267 - 1.934 1.862 -0.242
ENSG00000141295 E007 172.589861 0.0002660621 7.418958e-01 8.309308e-01 17 47838270 47838312 43 - 2.157 2.144 -0.046
ENSG00000141295 E008 147.874076 0.0003282624 7.017674e-01 8.007879e-01 17 47838313 47838335 23 - 2.091 2.075 -0.055
ENSG00000141295 E009 254.475762 0.0001869161 1.623876e-02 4.325078e-02 17 47838336 47838450 115 - 2.265 2.326 0.204
ENSG00000141295 E010 223.665573 0.0005669109 2.753686e-02 6.708557e-02 17 47838531 47838648 118 - 2.207 2.270 0.210
ENSG00000141295 E011 142.724957 0.0006337851 2.716093e-01 4.103839e-01 17 47838649 47838696 48 - 2.035 2.073 0.126
ENSG00000141295 E012 4.801319 0.0364415622 8.990258e-01 9.395804e-01 17 47838697 47838719 23 - 0.703 0.685 -0.072
ENSG00000141295 E013 243.317512 0.0002240863 5.395933e-03 1.700338e-02 17 47838791 47838958 168 - 2.238 2.312 0.246
ENSG00000141295 E014 116.986212 0.0014359137 2.404735e-02 5.991265e-02 17 47838959 47838960 2 - 1.907 2.003 0.322
ENSG00000141295 E015 169.223290 0.0004168360 4.498295e-01 5.910298e-01 17 47838961 47839006 46 - 2.125 2.147 0.073
ENSG00000141295 E016 137.255198 0.0002442386 9.637440e-01 9.811085e-01 17 47839444 47839458 15 - 2.053 2.048 -0.016
ENSG00000141295 E017 289.477201 0.0002302709 8.038912e-01 8.752217e-01 17 47839459 47839643 185 - 2.370 2.373 0.010
ENSG00000141295 E018 5.746264 0.0500108869 9.620065e-02 1.846778e-01 17 47839644 47839660 17 - 0.958 0.696 -1.027
ENSG00000141295 E019 5.452900 0.0059559351 1.346181e-02 3.699265e-02 17 47839661 47839673 13 - 0.985 0.651 -1.316
ENSG00000141295 E020 13.377809 0.0019985463 1.403274e-05 9.009288e-05 17 47839674 47839858 185 - 1.361 0.949 -1.477
ENSG00000141295 E021 5.906049 0.1824749053 1.869346e-01 3.098815e-01 17 47839859 47839901 43 - 1.013 0.656 -1.397
ENSG00000141295 E022 17.135632 0.0541330009 3.574263e-04 1.608890e-03 17 47839902 47840190 289 - 1.501 1.009 -1.738
ENSG00000141295 E023 318.323194 0.0004095171 2.731324e-03 9.467235e-03 17 47840191 47840372 182 - 2.467 2.394 -0.244
ENSG00000141295 E024 10.713156 0.0231277363 5.762733e-03 1.798867e-02 17 47840373 47840669 297 - 1.220 0.876 -1.258
ENSG00000141295 E025 274.287676 0.0001861619 1.572558e-02 4.211725e-02 17 47840670 47840843 174 - 2.395 2.333 -0.207
ENSG00000141295 E026 46.110164 0.0035723006 1.330617e-01 2.383907e-01 17 47840844 47841173 330 - 1.658 1.558 -0.340
ENSG00000141295 E027 6.235376 0.0028322886 2.658666e-01 4.039687e-01 17 47841185 47841207 23 - 0.899 0.747 -0.596
ENSG00000141295 E028 102.555628 0.0014155771 2.013196e-01 3.278332e-01 17 47841208 47841362 155 - 1.968 1.910 -0.194