ENSG00000141219

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000268942 ENSG00000141219 HEK293_OSMI2_2hA HEK293_TMG_2hB C17orf80 protein_coding protein_coding 15.1558 6.543702 24.77849 0.2416377 0.9114491 1.919289 4.3009376 1.0539305 8.3841487 0.7268477 0.81708831 2.979980 0.23729167 0.1612000 0.337933333 0.1767333 4.814853e-01 7.297453e-07 FALSE TRUE
ENST00000426147 ENSG00000141219 HEK293_OSMI2_2hA HEK293_TMG_2hB C17orf80 protein_coding protein_coding 15.1558 6.543702 24.77849 0.2416377 0.9114491 1.919289 0.9064494 0.0000000 1.2309437 0.0000000 0.66515630 6.955294 0.05586667 0.0000000 0.048200000 0.0482000 3.552432e-01 7.297453e-07 FALSE TRUE
ENST00000535032 ENSG00000141219 HEK293_OSMI2_2hA HEK293_TMG_2hB C17orf80 protein_coding protein_coding 15.1558 6.543702 24.77849 0.2416377 0.9114491 1.919289 7.3111519 1.8507741 12.2651450 0.1684568 0.48883051 2.721765 0.42016250 0.2846000 0.495066667 0.2104667 7.303154e-05 7.297453e-07 FALSE TRUE
ENST00000577615 ENSG00000141219 HEK293_OSMI2_2hA HEK293_TMG_2hB C17orf80 protein_coding protein_coding 15.1558 6.543702 24.77849 0.2416377 0.9114491 1.919289 0.4465748 0.8833388 0.0000000 0.4529101 0.00000000 -6.481136 0.05937083 0.1352000 0.000000000 -0.1352000 5.259451e-02 7.297453e-07 FALSE TRUE
ENST00000582793 ENSG00000141219 HEK293_OSMI2_2hA HEK293_TMG_2hB C17orf80 protein_coding protein_coding 15.1558 6.543702 24.77849 0.2416377 0.9114491 1.919289 1.0186756 2.1338670 0.1336581 0.5758703 0.07604285 -3.899504 0.14910000 0.3206667 0.005566667 -0.3151000 7.297453e-07 7.297453e-07   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000141219 E001 2.3186585 0.0077556124 9.682983e-01 9.842006e-01 17 73232233 73232432 200 + 0.444 0.498 0.273
ENSG00000141219 E002 10.4138104 0.0016857598 2.274985e-02 5.723248e-02 17 73232433 73232464 32 + 1.008 0.779 -0.875
ENSG00000141219 E003 20.9670662 0.0008791041 2.675058e-02 6.547313e-02 17 73232465 73232489 25 + 1.270 1.142 -0.453
ENSG00000141219 E004 0.5954526 0.0183836964 3.991405e-01 5.428757e-01 17 73232529 73232621 93 + 0.202 0.000 -10.475
ENSG00000141219 E005 0.2987644 0.0273460967 1.000000e+00   17 73232622 73232629 8 + 0.113 0.000 -9.441
ENSG00000141219 E006 0.0000000       17 73232630 73232636 7 +      
ENSG00000141219 E007 0.1451727 0.0430590237 1.000000e+00   17 73232637 73232661 25 + 0.060 0.000 -8.359
ENSG00000141219 E008 21.5836242 0.0797744693 1.581755e-02 4.232828e-02 17 73232662 73232717 56 + 1.303 0.997 -1.098
ENSG00000141219 E009 6.3008662 0.0034776151 1.702799e-01 2.885422e-01 17 73232729 73233219 491 + 0.802 0.661 -0.576
ENSG00000141219 E010 48.5359541 0.0006340984 9.674884e-06 6.454704e-05 17 73233220 73233225 6 + 1.631 1.416 -0.737
ENSG00000141219 E011 81.2859400 0.0011351384 2.418240e-06 1.847515e-05 17 73233226 73233325 100 + 1.845 1.684 -0.546
ENSG00000141219 E012 263.4527778 0.0035984776 7.051518e-07 6.050769e-06 17 73235476 73236022 547 + 2.342 2.251 -0.302
ENSG00000141219 E013 381.5556420 0.0004622394 3.956358e-05 2.282895e-04 17 73236023 73236995 973 + 2.484 2.490 0.017
ENSG00000141219 E014 55.6453168 0.0004697034 6.445515e-01 7.568245e-01 17 73242244 73242351 108 + 1.643 1.708 0.222
ENSG00000141219 E015 94.2272980 0.0009385600 9.935204e-01 1.000000e+00 17 73242896 73243003 108 + 1.861 1.953 0.309
ENSG00000141219 E016 2.9622194 0.0946853368 3.780257e-02 8.696941e-02 17 73245168 73245344 177 + 0.395 0.865 2.090
ENSG00000141219 E017 577.8915318 0.0119388042 1.745048e-07 1.692057e-06 17 73247241 73248959 1719 + 2.595 2.872 0.922