ENSG00000141101

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000268802 ENSG00000141101 HEK293_OSMI2_2hA HEK293_TMG_2hB NOB1 protein_coding protein_coding 93.34458 138.0289 68.37232 4.850151 1.643624 -1.013379 83.22304 128.648 57.72949 4.697397 1.916595 -1.155911 0.8807625 0.9319667 0.8441 -0.08786667 4.737075e-07 4.737075e-07 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000141101 E001 1866.974002 0.0001203057 4.888241e-15 1.683750e-13 16 69741871 69742575 705 - 3.155 3.231 0.255
ENSG00000141101 E002 518.281046 0.0007308426 3.330656e-01 4.767315e-01 16 69742576 69742601 26 - 2.641 2.662 0.072
ENSG00000141101 E003 518.265065 0.0003227464 5.857535e-01 7.093891e-01 16 69744873 69744902 30 - 2.649 2.660 0.038
ENSG00000141101 E004 759.936020 0.0003581698 1.060012e-01 1.996145e-01 16 69744903 69745017 115 - 2.802 2.830 0.092
ENSG00000141101 E005 668.926595 0.0015201210 2.671455e-03 9.286903e-03 16 69748232 69748329 98 - 2.711 2.783 0.237
ENSG00000141101 E006 5.061567 0.0182448398 2.026424e-03 7.308620e-03 16 69748748 69748917 170 - 1.006 0.570 -1.751
ENSG00000141101 E007 467.523473 0.0010727494 5.006836e-03 1.594838e-02 16 69748918 69748950 33 - 2.559 2.626 0.224
ENSG00000141101 E008 772.138921 0.0001168506 1.577830e-01 2.721740e-01 16 69748951 69749052 102 - 2.813 2.835 0.072
ENSG00000141101 E009 805.379048 0.0001066558 5.073493e-01 6.429194e-01 16 69749053 69749118 66 - 2.855 2.846 -0.027
ENSG00000141101 E010 4.249063 0.0036954534 9.352207e-03 2.716279e-02 16 69749119 69749212 94 - 0.909 0.544 -1.506
ENSG00000141101 E011 841.006628 0.0002110951 8.266794e-04 3.354868e-03 16 69749213 69749309 97 - 2.902 2.855 -0.156
ENSG00000141101 E012 564.775357 0.0004547620 1.280946e-02 3.546531e-02 16 69749310 69749338 29 - 2.729 2.683 -0.151
ENSG00000141101 E013 661.261881 0.0001216178 3.688127e-05 2.143791e-04 16 69749559 69749630 72 - 2.809 2.747 -0.207
ENSG00000141101 E014 770.691641 0.0005766430 6.844454e-04 2.842184e-03 16 69752241 69752371 131 - 2.872 2.813 -0.196
ENSG00000141101 E015 735.022747 0.0007671476 3.901643e-04 1.736693e-03 16 69754594 69754726 133 - 2.856 2.788 -0.224
ENSG00000141101 E016 31.096107 0.0133851937 2.465847e-02 6.117697e-02 16 69754727 69754847 121 - 1.586 1.393 -0.662
ENSG00000141101 E017 416.229129 0.0005001516 4.668469e-04 2.033260e-03 16 69754848 69754926 79 - 2.614 2.540 -0.248