ENSG00000141084

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000317506 ENSG00000141084 HEK293_OSMI2_2hA HEK293_TMG_2hB RANBP10 protein_coding protein_coding 14.2356 15.92815 10.61644 0.8342638 0.5337317 -0.5848268 11.3559265 14.2772589 7.9255912 0.56124466 0.1233409 -0.8483195 0.78947083 0.89780000 0.74963333 -0.14816667 0.005295058 0.005295058 FALSE TRUE
ENST00000448631 ENSG00000141084 HEK293_OSMI2_2hA HEK293_TMG_2hB RANBP10 protein_coding protein_coding 14.2356 15.92815 10.61644 0.8342638 0.5337317 -0.5848268 0.7684416 0.7745195 0.4252829 0.07371112 0.1483381 -0.8498562 0.05260000 0.04843333 0.04143333 -0.00700000 0.796351033 0.005295058 FALSE TRUE
ENST00000602525 ENSG00000141084 HEK293_OSMI2_2hA HEK293_TMG_2hB RANBP10 protein_coding retained_intron 14.2356 15.92815 10.61644 0.8342638 0.5337317 -0.5848268 0.9769189 0.3492772 0.8292907 0.21438899 0.1522342 1.2240731 0.06995833 0.02070000 0.07736667 0.05666667 0.236155567 0.005295058 FALSE TRUE
ENST00000602677 ENSG00000141084 HEK293_OSMI2_2hA HEK293_TMG_2hB RANBP10 protein_coding protein_coding 14.2356 15.92815 10.61644 0.8342638 0.5337317 -0.5848268 0.2674604 0.0000000 0.5602746 0.00000000 0.2819186 5.8335850 0.02359583 0.00000000 0.05043333 0.05043333 0.129514208 0.005295058 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000141084 E001 1154.9582610 0.0070714609 3.496942e-08 3.885728e-07 16 67723070 67726004 2935 - 2.891 3.113 0.739
ENSG00000141084 E002 13.0288310 0.0243952637 7.316753e-01 8.232977e-01 16 67726005 67726008 4 - 1.108 1.143 0.126
ENSG00000141084 E003 15.0529003 0.0056625987 7.490199e-01 8.360858e-01 16 67726009 67726030 22 - 1.158 1.206 0.170
ENSG00000141084 E004 134.7437601 0.0013984283 4.536885e-01 5.944348e-01 16 67726031 67726558 528 - 2.077 2.134 0.190
ENSG00000141084 E005 75.2154919 0.0003872981 5.188397e-01 6.529831e-01 16 67727327 67727438 112 - 1.790 1.899 0.369
ENSG00000141084 E006 99.8852702 0.0002777749 8.827351e-01 9.289607e-01 16 67727751 67727896 146 - 1.933 2.009 0.257
ENSG00000141084 E007 98.1234983 0.0004943944 9.696481e-03 2.801360e-02 16 67728390 67728511 122 - 1.982 1.968 -0.047
ENSG00000141084 E008 18.7259804 0.0009572802 1.159147e-01 2.141176e-01 16 67728512 67728601 90 - 1.307 1.260 -0.164
ENSG00000141084 E009 123.5228014 0.0028162512 5.428584e-04 2.320358e-03 16 67729280 67729484 205 - 2.109 2.055 -0.182
ENSG00000141084 E010 91.0547211 0.0069838896 5.685429e-03 1.778076e-02 16 67729680 67729828 149 - 1.983 1.918 -0.219
ENSG00000141084 E011 71.7464554 0.0008248683 2.121804e-03 7.601539e-03 16 67729938 67730046 109 - 1.873 1.821 -0.176
ENSG00000141084 E012 5.7244454 0.0545125912 8.012421e-02 1.597433e-01 16 67731029 67731083 55 - 0.928 0.727 -0.786
ENSG00000141084 E013 12.5165301 0.0053877378 1.963178e-03 7.110838e-03 16 67731084 67731471 388 - 1.244 1.018 -0.812
ENSG00000141084 E014 69.2459802 0.0004405772 5.871615e-03 1.827465e-02 16 67731472 67731584 113 - 1.849 1.811 -0.128
ENSG00000141084 E015 69.7281466 0.0003764109 1.065586e-02 3.034712e-02 16 67734858 67734968 111 - 1.847 1.819 -0.096
ENSG00000141084 E016 67.6963288 0.0005218943 1.223343e-03 4.719558e-03 16 67734969 67735042 74 - 1.852 1.791 -0.204
ENSG00000141084 E017 2.5401394 0.0083745428 7.586042e-01 8.431571e-01 16 67735645 67735754 110 - 0.527 0.534 0.036
ENSG00000141084 E018 51.7220563 0.0004913821 2.604309e-03 9.077468e-03 16 67738013 67738035 23 - 1.743 1.675 -0.231
ENSG00000141084 E019 7.4692342 0.0022396707 1.304271e-02 3.601110e-02 16 67744145 67744287 143 - 1.035 0.823 -0.801
ENSG00000141084 E020 91.5841291 0.0004110027 1.605231e-07 1.567639e-06 16 67744288 67744455 168 - 2.013 1.898 -0.385
ENSG00000141084 E021 0.6213751 0.0209803595 1.185633e-01 2.178883e-01 16 67759573 67759732 160 - 0.339 0.103 -2.134
ENSG00000141084 E022 0.1451727 0.0436432836 2.808560e-01   16 67762439 67762584 146 - 0.144 0.000 -15.058
ENSG00000141084 E023 0.0000000       16 67763353 67763499 147 -      
ENSG00000141084 E024 49.3931455 0.0014479799 3.090610e-03 1.053259e-02 16 67772034 67772086 53 - 1.727 1.652 -0.254
ENSG00000141084 E025 55.4645547 0.0199821613 1.243710e-01 2.262122e-01 16 67805428 67805539 112 - 1.755 1.715 -0.136
ENSG00000141084 E026 47.4279581 0.0237890521 1.656292e-02 4.397935e-02 16 67806302 67806560 259 - 1.743 1.613 -0.439