ENSG00000141076

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000314423 ENSG00000141076 HEK293_OSMI2_2hA HEK293_TMG_2hB UTP4 protein_coding protein_coding 56.95554 60.7418 55.34796 8.443881 1.427539 -0.1341365 42.853129 50.129877 39.420919 6.8996015 0.2712056 -0.3466311 0.75075000 0.82570000 0.71326667 -0.11243333 0.0001844139 0.0001844139 FALSE TRUE
ENST00000564408 ENSG00000141076 HEK293_OSMI2_2hA HEK293_TMG_2hB UTP4 protein_coding retained_intron 56.95554 60.7418 55.34796 8.443881 1.427539 -0.1341365 2.963759 1.387786 2.344709 0.1519282 0.8095768 0.7524050 0.05315000 0.02336667 0.04166667 0.01830000 0.6635020680 0.0001844139 FALSE FALSE
ENST00000569800 ENSG00000141076 HEK293_OSMI2_2hA HEK293_TMG_2hB UTP4 protein_coding retained_intron 56.95554 60.7418 55.34796 8.443881 1.427539 -0.1341365 2.981162 1.732015 2.672839 0.1321619 0.4665569 0.6230030 0.05292083 0.02913333 0.04813333 0.01900000 0.1641879365 0.0001844139 FALSE FALSE
MSTRG.12904.2 ENSG00000141076 HEK293_OSMI2_2hA HEK293_TMG_2hB UTP4 protein_coding   56.95554 60.7418 55.34796 8.443881 1.427539 -0.1341365 3.294869 2.435030 4.679839 0.4587400 0.3567836 0.9396864 0.05879583 0.03970000 0.08476667 0.04506667 0.0004119859 0.0001844139 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000141076 E001 0.147249 0.0446908488 3.737367e-01   16 69131291 69131408 118 + 0.139 0.000 -9.922
ENSG00000141076 E002 1.622066 0.0085645101 6.245054e-01 7.408123e-01 16 69132596 69132612 17 + 0.460 0.382 -0.419
ENSG00000141076 E003 13.588854 0.0014564702 1.817667e-03 6.656193e-03 16 69132613 69132645 33 + 1.297 1.024 -0.975
ENSG00000141076 E004 20.583496 0.0016134384 8.723349e-04 3.517469e-03 16 69132646 69132648 3 + 1.454 1.210 -0.853
ENSG00000141076 E005 21.501556 0.0031340062 3.149616e-03 1.070614e-02 16 69132649 69132649 1 + 1.460 1.239 -0.769
ENSG00000141076 E006 36.301083 0.0008145283 2.341094e-05 1.428706e-04 16 69132650 69132657 8 + 1.692 1.456 -0.804
ENSG00000141076 E007 48.780419 0.0007484629 1.546837e-07 1.514907e-06 16 69132658 69132662 5 + 1.827 1.572 -0.867
ENSG00000141076 E008 107.450515 0.0023406591 5.356425e-03 1.690053e-02 16 69132663 69132689 27 + 2.089 1.981 -0.365
ENSG00000141076 E009 1.284579 0.0103652444 6.610175e-01 7.695622e-01 16 69132873 69132883 11 + 0.399 0.327 -0.419
ENSG00000141076 E010 2.198388 0.0627569588 6.143328e-01 7.328336e-01 16 69132884 69133012 129 + 0.560 0.471 -0.427
ENSG00000141076 E011 184.809482 0.0013404963 9.163427e-02 1.776869e-01 16 69133458 69133510 53 + 2.289 2.243 -0.153
ENSG00000141076 E012 143.614605 0.0021643586 9.699849e-01 9.852118e-01 16 69133511 69133511 1 + 2.149 2.153 0.013
ENSG00000141076 E013 320.460314 0.0011086423 5.014742e-04 2.165355e-03 16 69133512 69133618 107 + 2.547 2.465 -0.272
ENSG00000141076 E014 2.645447 0.0428695851 9.329458e-02 1.802717e-01 16 69136679 69136695 17 + 0.711 0.429 -1.296
ENSG00000141076 E015 485.368246 0.0015771256 2.110199e-05 1.301507e-04 16 69136696 69136887 192 + 2.736 2.637 -0.332
ENSG00000141076 E016 309.984385 0.0002214053 3.312755e-08 3.698895e-07 16 69137801 69137885 85 + 2.548 2.444 -0.348
ENSG00000141076 E017 10.987586 0.0018094893 4.260564e-01 5.689291e-01 16 69137886 69137977 92 + 1.115 1.046 -0.250
ENSG00000141076 E018 5.956652 0.0730984481 3.771683e-01 5.215082e-01 16 69137978 69138026 49 + 0.911 0.793 -0.456
ENSG00000141076 E019 1.920830 0.0074404092 2.686788e-01 4.071576e-01 16 69139012 69139111 100 + 0.560 0.382 -0.904
ENSG00000141076 E020 12.101390 0.0026522817 7.838341e-03 2.337675e-02 16 69139672 69139824 153 + 1.244 1.000 -0.879
ENSG00000141076 E021 324.219992 0.0001697258 2.816782e-04 1.305264e-03 16 69139825 69139914 90 + 2.544 2.482 -0.209
ENSG00000141076 E022 0.000000       16 69142116 69142299 184 +      
ENSG00000141076 E023 483.555251 0.0004403688 7.960873e-04 3.245456e-03 16 69143178 69143389 212 + 2.711 2.657 -0.178
ENSG00000141076 E024 433.795486 0.0001207716 3.945702e-04 1.753833e-03 16 69150537 69150708 172 + 2.664 2.613 -0.168
ENSG00000141076 E025 372.663868 0.0001548254 1.195936e-04 6.120108e-04 16 69150813 69150904 92 + 2.605 2.543 -0.205
ENSG00000141076 E026 409.646674 0.0008322499 9.507586e-04 3.790529e-03 16 69153584 69153680 97 + 2.645 2.581 -0.213
ENSG00000141076 E027 294.573562 0.0013094522 1.099960e-02 3.116119e-02 16 69154393 69154421 29 + 2.500 2.440 -0.199
ENSG00000141076 E028 287.450595 0.0018622768 1.151459e-01 2.130610e-01 16 69154422 69154457 36 + 2.476 2.436 -0.135
ENSG00000141076 E029 460.993266 0.0002328359 8.829705e-01 9.291053e-01 16 69155871 69155993 123 + 2.651 2.663 0.040
ENSG00000141076 E030 483.432044 0.0001467254 1.234243e-06 1.005217e-05 16 69157084 69157240 157 + 2.620 2.712 0.306
ENSG00000141076 E031 202.425274 0.0002007374 5.563367e-05 3.098343e-04 16 69160356 69160361 6 + 2.228 2.344 0.385
ENSG00000141076 E032 430.758319 0.0001474045 2.792112e-06 2.104800e-05 16 69160362 69160462 101 + 2.570 2.665 0.313
ENSG00000141076 E033 435.328055 0.0005009852 3.464253e-03 1.162305e-02 16 69163083 69163178 96 + 2.591 2.657 0.219
ENSG00000141076 E034 669.950381 0.0020367171 1.040854e-03 4.100367e-03 16 69165341 69165526 186 + 2.762 2.850 0.292
ENSG00000141076 E035 9.719963 0.0017931601 3.650915e-02 8.454923e-02 16 69165527 69167074 1548 + 1.140 0.934 -0.752
ENSG00000141076 E036 366.446010 0.0038369983 2.163603e-03 7.731258e-03 16 69167075 69167103 29 + 2.482 2.598 0.385
ENSG00000141076 E037 437.286081 0.0019409302 1.419533e-09 2.045690e-08 16 69167104 69167185 82 + 2.520 2.693 0.574
ENSG00000141076 E038 10.008885 0.0657259505 3.401308e-01 4.840833e-01 16 69167186 69167842 657 + 1.103 1.006 -0.353
ENSG00000141076 E039 345.700015 0.0013612208 9.050377e-19 5.026581e-17 16 69168821 69169038 218 + 2.367 2.614 0.822
ENSG00000141076 E040 0.000000       16 69230383 69230462 80 +      
ENSG00000141076 E041 0.000000       16 69230927 69231130 204 +