ENSG00000141040

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000395824 ENSG00000141040 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF287 protein_coding protein_coding 3.992439 3.2393 4.344472 0.02012606 0.2254272 0.4223689 0.3687508 0.1599974 0.4646342 0.08677807 0.18999785 1.4813033 0.09013333 0.04970000 0.11200000 0.06230000 0.6926692 0.0343361 FALSE TRUE
ENST00000395825 ENSG00000141040 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF287 protein_coding protein_coding 3.992439 3.2393 4.344472 0.02012606 0.2254272 0.4223689 0.2363928 0.1327034 0.3019290 0.05209997 0.04321234 1.1281980 0.05642500 0.04080000 0.06893333 0.02813333 0.5575068 0.0343361 FALSE TRUE
ENST00000448349 ENSG00000141040 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF287 protein_coding protein_coding 3.992439 3.2393 4.344472 0.02012606 0.2254272 0.4223689 0.5167418 0.3451431 0.2215568 0.21468285 0.15714846 -0.6170344 0.12611250 0.10633333 0.05216667 -0.05416667 0.8698400 0.0343361 FALSE FALSE
ENST00000461555 ENSG00000141040 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF287 protein_coding processed_transcript 3.992439 3.2393 4.344472 0.02012606 0.2254272 0.4223689 0.1550678 0.0000000 0.3114879 0.00000000 0.16488184 5.0066924 0.03638750 0.00000000 0.07083333 0.07083333 0.2276874 0.0343361   FALSE
MSTRG.13743.3 ENSG00000141040 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF287 protein_coding   3.992439 3.2393 4.344472 0.02012606 0.2254272 0.4223689 0.3567077 0.1052923 0.7495107 0.10529228 0.38081241 2.7197744 0.10343333 0.03223333 0.18033333 0.14810000 0.5365867 0.0343361 FALSE FALSE
MSTRG.13743.4 ENSG00000141040 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF287 protein_coding   3.992439 3.2393 4.344472 0.02012606 0.2254272 0.4223689 0.6350180 0.3802768 1.0470133 0.26300885 0.56257507 1.4374240 0.15115000 0.11830000 0.23000000 0.11170000 0.6528198 0.0343361 FALSE FALSE
MSTRG.13743.5 ENSG00000141040 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF287 protein_coding   3.992439 3.2393 4.344472 0.02012606 0.2254272 0.4223689 1.4816265 1.7246483 1.2483407 0.24020237 0.15303891 -0.4631207 0.37416667 0.53253333 0.28563333 -0.24690000 0.0343361 0.0343361 FALSE TRUE
MSTRG.13743.6 ENSG00000141040 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF287 protein_coding   3.992439 3.2393 4.344472 0.02012606 0.2254272 0.4223689 0.1169367 0.3912390 0.0000000 0.22915862 0.00000000 -5.3263900 0.03697500 0.12013333 0.00000000 -0.12013333 0.1221581 0.0343361 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000141040 E001 18.828685 0.0747261323 1.508223e-01 0.262794297 17 16546954 16551386 4433 - 1.388 1.168 -0.770
ENSG00000141040 E002 23.639328 0.0045278590 2.599106e-05 0.000156978 17 16551387 16553109 1723 - 1.525 1.190 -1.166
ENSG00000141040 E003 36.792486 0.0044640473 3.223886e-01 0.465678181 17 16553110 16553426 317 - 1.558 1.608 0.172
ENSG00000141040 E004 27.755673 0.0009052032 1.162605e-01 0.214626704 17 16563146 16563232 87 - 1.418 1.506 0.303
ENSG00000141040 E005 0.000000       17 16563233 16563264 32 -      
ENSG00000141040 E006 33.582557 0.0007895996 2.399718e-01 0.374107695 17 16563699 16563825 127 - 1.517 1.574 0.193
ENSG00000141040 E007 28.852174 0.0008021709 9.492568e-01 0.972216802 17 16566525 16566622 98 - 1.490 1.476 -0.047
ENSG00000141040 E008 15.208992 0.0016597998 7.436228e-01 0.832223386 17 16567329 16567361 33 - 1.210 1.228 0.062
ENSG00000141040 E009 31.267446 0.0008021709 6.124465e-01 0.731374496 17 16567362 16567559 198 - 1.502 1.521 0.066
ENSG00000141040 E010 12.884089 0.0014915628 1.644222e-01 0.280933096 17 16567560 16567581 22 - 1.084 1.199 0.414
ENSG00000141040 E011 19.637187 0.0062922869 3.219145e-01 0.465189158 17 16567582 16567675 94 - 1.282 1.349 0.233
ENSG00000141040 E012 17.185097 0.0012542432 4.442229e-02 0.099151358 17 16567676 16567806 131 - 1.178 1.327 0.527
ENSG00000141040 E013 7.258947 0.0023200279 1.677850e-01 0.285317500 17 16567807 16567823 17 - 0.836 0.986 0.567
ENSG00000141040 E014 11.812151 0.0017030132 6.011121e-01 0.722252042 17 16567824 16567929 106 - 1.133 1.074 -0.215
ENSG00000141040 E015 2.762692 0.0909577329 9.941718e-01 1.000000000 17 16568043 16568117 75 - 0.560 0.556 -0.022
ENSG00000141040 E016 1.187683 0.0108647759 5.494248e-02 0.117892717 17 16568701 16568749 49 - 0.484 0.134 -2.498
ENSG00000141040 E017 2.702129 0.0079235493 1.445705e-02 0.039261534 17 16568750 16568951 202 - 0.732 0.319 -2.019
ENSG00000141040 E018 18.291407 0.0112494222 2.687821e-01 0.407261951 17 16568952 16569204 253 - 1.333 1.220 -0.394