ENSG00000140995

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000418391 ENSG00000140995 HEK293_OSMI2_2hA HEK293_TMG_2hB DEF8 protein_coding protein_coding 171.6745 310.0632 76.98007 8.333017 2.389228 -2.009865 29.06227 56.69556 11.998223 0.5871177 2.209250 -2.239467 0.16387917 0.18300000 0.1550000 -0.0280 0.68785283 0.0001264001 FALSE TRUE
ENST00000562986 ENSG00000140995 HEK293_OSMI2_2hA HEK293_TMG_2hB DEF8 protein_coding protein_coding 171.6745 310.0632 76.98007 8.333017 2.389228 -2.009865 14.16584 21.11930 8.406036 0.4853845 1.090831 -1.328032 0.09345417 0.06816667 0.1088667 0.0407 0.03275581 0.0001264001 FALSE FALSE
ENST00000610455 ENSG00000140995 HEK293_OSMI2_2hA HEK293_TMG_2hB DEF8 protein_coding protein_coding 171.6745 310.0632 76.98007 8.333017 2.389228 -2.009865 96.29720 182.10968 36.180055 4.0056301 1.761029 -2.331222 0.53894583 0.58750000 0.4710000 -0.1165 0.01786995 0.0001264001 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000140995 E001 11.430087 3.550110e-02 3.302406e-01 4.738300e-01 16 89948697 89948730 34 + 1.085 0.926 -0.587
ENSG00000140995 E002 14.477597 5.618849e-03 8.375342e-01 8.984211e-01 16 89948731 89948754 24 + 1.085 1.043 -0.154
ENSG00000140995 E003 54.325850 4.417087e-04 9.869568e-02 1.885010e-01 16 89948755 89948774 20 + 1.520 1.610 0.308
ENSG00000140995 E004 60.244273 4.251111e-04 4.105120e-02 9.297769e-02 16 89948775 89948778 4 + 1.547 1.658 0.378
ENSG00000140995 E005 132.371778 2.629524e-04 2.217981e-01 3.525349e-01 16 89948779 89948790 12 + 1.953 1.984 0.106
ENSG00000140995 E006 200.048098 2.016559e-04 1.583507e-01 2.729322e-01 16 89948791 89948794 4 + 2.135 2.164 0.096
ENSG00000140995 E007 281.688076 1.968220e-04 4.066941e-03 1.332947e-02 16 89948795 89948802 8 + 2.250 2.315 0.217
ENSG00000140995 E008 467.885784 1.204803e-03 3.102406e-02 7.396323e-02 16 89948803 89948814 12 + 2.491 2.531 0.135
ENSG00000140995 E009 63.539932 5.070869e-04 1.489717e-01 2.602832e-01 16 89949417 89949419 3 + 1.603 1.672 0.235
ENSG00000140995 E010 216.396952 3.947463e-04 5.472914e-01 6.773549e-01 16 89949420 89949513 94 + 2.189 2.190 0.001
ENSG00000140995 E011 26.894548 1.560292e-02 1.191128e-01 2.186691e-01 16 89949514 89949564 51 + 1.440 1.268 -0.597
ENSG00000140995 E012 43.139850 5.208914e-04 8.839525e-02 1.726645e-01 16 89949565 89949638 74 + 1.611 1.479 -0.450
ENSG00000140995 E013 7.419559 8.024313e-03 1.023121e-03 4.038487e-03 16 89950067 89950306 240 + 1.132 0.695 -1.669
ENSG00000140995 E014 1.574948 1.317721e-01 7.755789e-01 8.554292e-01 16 89950307 89950328 22 + 0.380 0.316 -0.385
ENSG00000140995 E015 4.399418 4.109705e-03 1.538115e-03 5.760088e-03 16 89952558 89952561 4 + 0.972 0.495 -1.979
ENSG00000140995 E016 10.440317 1.701657e-03 3.321307e-04 1.509079e-03 16 89952562 89952682 121 + 1.249 0.840 -1.503
ENSG00000140995 E017 15.154010 1.540740e-03 2.725275e-04 1.267947e-03 16 89954172 89954242 71 + 1.355 0.985 -1.323
ENSG00000140995 E018 729.367930 1.284736e-04 7.040276e-13 1.770555e-11 16 89954243 89954288 46 + 2.617 2.733 0.386
ENSG00000140995 E019 1086.939592 1.068628e-04 5.811665e-14 1.708040e-12 16 89954289 89954376 88 + 2.810 2.905 0.315
ENSG00000140995 E020 1387.708441 1.382850e-04 2.926540e-13 7.790140e-12 16 89955169 89955266 98 + 2.929 3.009 0.267
ENSG00000140995 E021 2.931648 8.379806e-02 3.664308e-01 5.107734e-01 16 89956530 89956648 119 + 0.652 0.452 -0.927
ENSG00000140995 E022 3.525841 8.658521e-03 4.087993e-02 9.266955e-02 16 89956694 89956887 194 + 0.819 0.473 -1.501
ENSG00000140995 E023 3.016343 6.256663e-03 1.017048e-03 4.017864e-03 16 89957253 89957472 220 + 0.902 0.374 -2.356
ENSG00000140995 E024 20.860804 1.318047e-02 3.030635e-01 4.449737e-01 16 89957473 89957510 38 + 1.313 1.189 -0.436
ENSG00000140995 E025 872.816343 1.578853e-04 9.063020e-07 7.594489e-06 16 89957511 89957537 27 + 2.741 2.805 0.213
ENSG00000140995 E026 715.143280 1.636863e-04 1.676214e-05 1.057895e-04 16 89957538 89957540 3 + 2.657 2.718 0.203
ENSG00000140995 E027 1622.289748 7.389056e-05 1.800377e-10 3.040435e-09 16 89957541 89957660 120 + 3.017 3.073 0.188
ENSG00000140995 E028 2.392676 7.802274e-03 1.766114e-01 2.968442e-01 16 89958002 89958041 40 + 0.652 0.400 -1.205
ENSG00000140995 E029 6.409670 2.601923e-03 3.844240e-04 1.714447e-03 16 89958351 89958431 81 + 1.110 0.637 -1.831
ENSG00000140995 E030 6.253685 8.887211e-02 1.804829e-01 3.017850e-01 16 89958432 89958533 102 + 0.971 0.689 -1.106
ENSG00000140995 E031 1658.677010 1.853806e-03 6.840002e-02 1.407243e-01 16 89959014 89959155 142 + 3.057 3.080 0.076
ENSG00000140995 E032 998.821287 3.220938e-03 4.311451e-02 9.676134e-02 16 89959156 89959366 211 + 2.818 2.863 0.148
ENSG00000140995 E033 116.154244 4.907167e-03 3.054949e-15 1.085633e-13 16 89960931 89961095 165 + 2.236 1.831 -1.359
ENSG00000140995 E034 95.146738 6.790709e-03 1.350199e-12 3.238683e-11 16 89961737 89961864 128 + 2.155 1.742 -1.388
ENSG00000140995 E035 45.903089 2.078548e-02 5.141496e-06 3.649050e-05 16 89962012 89962052 41 + 1.850 1.431 -1.425
ENSG00000140995 E036 56.719671 1.209855e-02 6.221819e-07 5.401452e-06 16 89962053 89962125 73 + 1.914 1.531 -1.297
ENSG00000140995 E037 66.607893 6.450268e-03 3.991575e-08 4.391103e-07 16 89963363 89963443 81 + 1.962 1.606 -1.203
ENSG00000140995 E038 15.958310 1.160579e-03 3.098942e-16 1.254992e-14 16 89963798 89963839 42 + 1.595 0.876 -2.557
ENSG00000140995 E039 12.281809 1.427398e-03 3.352266e-13 8.846312e-12 16 89963840 89963886 47 + 1.492 0.779 -2.584
ENSG00000140995 E040 15.802385 1.471913e-03 1.713542e-08 2.022840e-07 16 89963887 89964169 283 + 1.482 0.956 -1.867
ENSG00000140995 E041 43.912515 1.827886e-03 1.215468e-17 5.896718e-16 16 89964170 89964220 51 + 1.899 1.374 -1.787
ENSG00000140995 E042 73.226917 4.233059e-04 3.149676e-23 2.865979e-21 16 89964221 89964310 90 + 2.081 1.612 -1.581
ENSG00000140995 E043 5.373577 1.721114e-02 3.750004e-02 8.640457e-02 16 89964311 89964465 155 + 0.938 0.607 -1.333
ENSG00000140995 E044 96.322718 4.702769e-03 7.487105e-16 2.876515e-14 16 89964466 89964575 110 + 2.171 1.742 -1.443
ENSG00000140995 E045 947.823032 1.484279e-03 1.151076e-46 5.862040e-44 16 89965861 89968060 2200 + 3.087 2.764 -1.074