ENSG00000140988

Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000343262 ENSG00000140988 HEK293_OSMI2_2hA HEK293_TMG_2hB RPS2 protein_coding protein_coding 19010.09 38269.13 10615.67 975.3776 44.38327 -1.849985 638.9114 709.7489 745.55780 96.29278 45.95108 0.07101059 0.04253750 0.01850000 0.070166667 0.05166667 1.424932e-11 3.284469e-48 FALSE TRUE
ENST00000527302 ENSG00000140988 HEK293_OSMI2_2hA HEK293_TMG_2hB RPS2 protein_coding protein_coding 19010.09 38269.13 10615.67 975.3776 44.38327 -1.849985 6675.5788 13275.9119 3722.31800 1273.18389 69.68754 -1.83453495 0.33674167 0.34613333 0.350633333 0.00450000 9.761249e-01 3.284469e-48 FALSE FALSE
ENST00000533186 ENSG00000140988 HEK293_OSMI2_2hA HEK293_TMG_2hB RPS2 protein_coding protein_coding 19010.09 38269.13 10615.67 975.3776 44.38327 -1.849985 9932.9412 19590.5543 5660.18590 423.61430 48.96922 -1.79123506 0.53390833 0.51250000 0.533233333 0.02073333 6.998178e-01 3.284469e-48 FALSE TRUE
MSTRG.11818.17 ENSG00000140988 HEK293_OSMI2_2hA HEK293_TMG_2hB RPS2 protein_coding   19010.09 38269.13 10615.67 975.3776 44.38327 -1.849985 1134.2634 3690.3800 62.41035 577.92708 25.71747 -5.88561314 0.04855417 0.09676667 0.005866667 -0.09090000 7.409009e-09 3.284469e-48 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.