ENSG00000140987

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000571285 ENSG00000140987 HEK293_OSMI2_2hA HEK293_TMG_2hB ZSCAN32 protein_coding retained_intron 9.595768 6.821377 11.18021 1.165282 0.4016568 0.7119885 1.9422978 2.1961036 1.652034 0.4745937 0.2544562 -0.4085509 0.21940833 0.3211667 0.1478667 -0.17330000 0.005198889 0.005198889 FALSE TRUE
ENST00000574940 ENSG00000140987 HEK293_OSMI2_2hA HEK293_TMG_2hB ZSCAN32 protein_coding protein_coding 9.595768 6.821377 11.18021 1.165282 0.4016568 0.7119885 1.4901014 0.7978642 1.881625 0.2453549 0.1675092 1.2274416 0.15350000 0.1127667 0.1695000 0.05673333 0.423561988 0.005198889 FALSE TRUE
ENST00000618425 ENSG00000140987 HEK293_OSMI2_2hA HEK293_TMG_2hB ZSCAN32 protein_coding protein_coding 9.595768 6.821377 11.18021 1.165282 0.4016568 0.7119885 3.6872983 2.2031106 4.844545 0.3650709 0.1631680 1.1332606 0.37452083 0.3237333 0.4344333 0.11070000 0.054732142 0.005198889 FALSE TRUE
MSTRG.11937.2 ENSG00000140987 HEK293_OSMI2_2hA HEK293_TMG_2hB ZSCAN32 protein_coding   9.595768 6.821377 11.18021 1.165282 0.4016568 0.7119885 0.9374634 0.7708012 1.105656 0.2195832 0.1662621 0.5148655 0.09689167 0.1278000 0.0984000 -0.02940000 0.938205658 0.005198889 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000140987 E001 0.000000       16 3382081 3382084 4 -      
ENSG00000140987 E002 64.228173 0.0004629242 0.0008036605 0.0032721760 16 3382085 3382357 273 - 1.747 1.897 0.508
ENSG00000140987 E003 83.423970 0.0003937266 0.0000301978 0.0001795801 16 3382358 3382498 141 - 1.851 2.014 0.548
ENSG00000140987 E004 297.197400 0.0018443911 0.0012140833 0.0046884187 16 3382499 3383700 1202 - 2.443 2.519 0.253
ENSG00000140987 E005 29.264450 0.0007445582 0.5335386930 0.6657180619 16 3383701 3383711 11 - 1.468 1.515 0.162
ENSG00000140987 E006 24.519908 0.0009058106 0.6381670634 0.7518724582 16 3383712 3384083 372 - 1.421 1.396 -0.086
ENSG00000140987 E007 21.727495 0.0062974734 0.3163652663 0.4591196269 16 3384084 3384301 218 - 1.394 1.320 -0.256
ENSG00000140987 E008 9.049271 0.0019540095 0.9924419804 0.9993576767 16 3384302 3384318 17 - 1.008 1.017 0.034
ENSG00000140987 E009 15.301943 0.0315902411 0.8065918085 0.8770987978 16 3384319 3384458 140 - 1.200 1.244 0.153
ENSG00000140987 E010 36.321767 0.0007285293 0.9677507368 0.9838498813 16 3384459 3384497 39 - 1.577 1.582 0.019
ENSG00000140987 E011 87.423327 0.0003361945 0.0016281524 0.0060512151 16 3384498 3384820 323 - 1.997 1.889 -0.363
ENSG00000140987 E012 24.477802 0.0007695809 0.0003923522 0.0017453671 16 3384821 3384839 19 - 1.506 1.261 -0.849
ENSG00000140987 E013 39.258534 0.0006398346 0.1198844284 0.2198130648 16 3384840 3384941 102 - 1.643 1.564 -0.268
ENSG00000140987 E014 18.675886 0.0104552099 0.9019750086 0.9415455334 16 3390010 3390133 124 - 1.305 1.302 -0.009
ENSG00000140987 E015 2.607534 0.2919844520 0.2654391852 0.4034972944 16 3390134 3390183 50 - 0.681 0.335 -1.706
ENSG00000140987 E016 14.335069 0.0013015422 0.5313833160 0.6638463192 16 3390423 3390517 95 - 1.215 1.168 -0.166
ENSG00000140987 E017 24.440203 0.0011862466 0.3836243057 0.5278191459 16 3393649 3393814 166 - 1.435 1.382 -0.181
ENSG00000140987 E018 103.571425 0.0020112009 0.0001130094 0.0005816795 16 3397192 3397744 553 - 2.082 1.936 -0.490
ENSG00000140987 E019 1.106097 0.0116701384 0.4931439897 0.6301831326 16 3397745 3397787 43 - 0.371 0.251 -0.783
ENSG00000140987 E020 20.229648 0.0009286952 0.0282209559 0.0684520054 16 3400945 3400973 29 - 1.394 1.232 -0.564
ENSG00000140987 E021 9.656289 0.0019301172 0.1835478167 0.3056581070 16 3400974 3401065 92 - 1.082 0.947 -0.497