ENSG00000140983

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000315082 ENSG00000140983 HEK293_OSMI2_2hA HEK293_TMG_2hB RHOT2 protein_coding protein_coding 123.1078 167.0959 95.44097 14.04342 3.142257 -0.8079309 34.66860 66.710267 17.780708 3.596855 0.6287818 -1.9070012 0.26180833 0.4013667 0.1866 -0.21476667 2.095848e-16 3.012764e-25 FALSE TRUE
ENST00000564659 ENSG00000140983 HEK293_OSMI2_2hA HEK293_TMG_2hB RHOT2 protein_coding retained_intron 123.1078 167.0959 95.44097 14.04342 3.142257 -0.8079309 24.55693 40.212616 16.782969 5.674802 2.1745330 -1.2601496 0.19078750 0.2395667 0.1748 -0.06476667 2.676460e-01 3.012764e-25 FALSE FALSE
MSTRG.11740.6 ENSG00000140983 HEK293_OSMI2_2hA HEK293_TMG_2hB RHOT2 protein_coding   123.1078 167.0959 95.44097 14.04342 3.142257 -0.8079309 10.13160 8.753587 7.818012 1.152257 0.1283140 -0.1628755 0.08731667 0.0524000 0.0822 0.02980000 4.048480e-02 3.012764e-25 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000140983 E001 1.104964 0.0696049942 1.882241e-01 3.115013e-01 16 668105 668105 1 + 0.464 0.221 -1.529
ENSG00000140983 E002 1.547855 0.0126298566 4.056741e-01 5.493283e-01 16 668106 668111 6 + 0.464 0.324 -0.786
ENSG00000140983 E003 6.575655 0.0536226436 2.805509e-01 4.204030e-01 16 668112 668122 11 + 0.937 0.776 -0.619
ENSG00000140983 E004 12.374276 0.0791573184 7.492983e-01 8.362976e-01 16 668123 668123 1 + 1.095 1.065 -0.109
ENSG00000140983 E005 17.956679 0.0410738685 6.863942e-01 7.889153e-01 16 668124 668131 8 + 1.248 1.216 -0.112
ENSG00000140983 E006 20.493670 0.0484349933 6.704474e-01 7.768875e-01 16 668132 668134 3 + 1.303 1.270 -0.114
ENSG00000140983 E007 87.161999 0.0142790168 2.481699e-01 3.837743e-01 16 668135 668150 16 + 1.937 1.875 -0.208
ENSG00000140983 E008 100.222850 0.0078838126 2.617500e-01 3.994341e-01 16 668151 668152 2 + 1.985 1.939 -0.153
ENSG00000140983 E009 103.438764 0.0062368560 2.605855e-01 3.981349e-01 16 668153 668154 2 + 1.995 1.954 -0.141
ENSG00000140983 E010 112.662509 0.0172773417 7.746903e-01 8.547876e-01 16 668155 668161 7 + 2.006 2.004 -0.005
ENSG00000140983 E011 161.545448 0.0197657168 8.878458e-01 9.323038e-01 16 668162 668177 16 + 2.158 2.163 0.016
ENSG00000140983 E012 170.473091 0.0174022887 8.733195e-01 9.226037e-01 16 668178 668179 2 + 2.180 2.186 0.019
ENSG00000140983 E013 181.981190 0.0137257558 9.646126e-01 9.816848e-01 16 668180 668181 2 + 2.198 2.218 0.068
ENSG00000140983 E014 203.852285 0.0149462466 9.657811e-01 9.824749e-01 16 668182 668186 5 + 2.250 2.266 0.054
ENSG00000140983 E015 251.008587 0.0161150068 7.365189e-01 8.269844e-01 16 668187 668208 22 + 2.323 2.363 0.134
ENSG00000140983 E016 287.304247 0.0101523804 7.348868e-01 8.257391e-01 16 668209 668236 28 + 2.383 2.420 0.125
ENSG00000140983 E017 19.469486 0.0017418562 2.222493e-05 1.363424e-04 16 668237 668352 116 + 1.465 1.142 -1.133
ENSG00000140983 E018 224.755269 0.0021976582 7.382748e-01 8.281903e-01 16 668353 668357 5 + 2.298 2.303 0.018
ENSG00000140983 E019 413.094512 0.0027114985 8.889757e-01 9.329886e-01 16 668358 668411 54 + 2.558 2.571 0.043
ENSG00000140983 E020 19.948694 0.0063295143 3.838199e-04 1.712075e-03 16 668412 668487 76 + 1.458 1.169 -1.009
ENSG00000140983 E021 488.279262 0.0024041645 2.719029e-01 4.107095e-01 16 668488 668559 72 + 2.648 2.635 -0.045
ENSG00000140983 E022 374.111185 0.0037061009 1.356723e-01 2.420559e-01 16 668560 668569 10 + 2.547 2.514 -0.110
ENSG00000140983 E023 49.908889 0.0012918265 2.159681e-10 3.594983e-09 16 668570 668655 86 + 1.856 1.535 -1.087
ENSG00000140983 E024 368.291938 0.0031053503 3.136998e-02 7.462359e-02 16 668656 668657 2 + 2.554 2.501 -0.176
ENSG00000140983 E025 365.302413 0.0030585748 4.594111e-02 1.019277e-01 16 668658 668658 1 + 2.547 2.499 -0.159
ENSG00000140983 E026 499.849165 0.0035676607 1.016380e-01 1.929883e-01 16 668659 668699 41 + 2.674 2.639 -0.117
ENSG00000140983 E027 85.122320 0.0003390624 1.547207e-53 1.158552e-50 16 668700 669552 853 + 2.216 1.634 -1.958
ENSG00000140983 E028 472.280546 0.0017086832 1.132069e-01 2.102041e-01 16 669553 669606 54 + 2.642 2.617 -0.082
ENSG00000140983 E029 96.868884 0.0029440948 3.938074e-47 2.049605e-44 16 669607 670122 516 + 2.286 1.659 -2.107
ENSG00000140983 E030 459.086285 0.0021375634 5.974892e-01 7.192316e-01 16 670123 670175 53 + 2.611 2.613 0.009
ENSG00000140983 E031 35.722215 0.0054344549 8.546685e-07 7.203559e-06 16 670176 670248 73 + 1.721 1.401 -1.093
ENSG00000140983 E032 288.401135 0.0018108058 4.947527e-01 6.316566e-01 16 670249 670265 17 + 2.384 2.421 0.124
ENSG00000140983 E033 549.079980 0.0008148954 6.356008e-01 7.498655e-01 16 670266 670357 92 + 2.669 2.696 0.090
ENSG00000140983 E034 2.879676 0.0053373951 3.796293e-01 5.238901e-01 16 670455 670455 1 + 0.638 0.507 -0.595
ENSG00000140983 E035 522.401981 0.0010158640 8.238955e-01 8.890365e-01 16 670456 670527 72 + 2.653 2.674 0.072
ENSG00000140983 E036 421.872490 0.0004963271 5.515216e-01 6.809749e-01 16 670528 670557 30 + 2.554 2.582 0.094
ENSG00000140983 E037 267.861471 0.0032870198 2.051519e-03 7.385913e-03 16 670675 670695 21 + 2.276 2.411 0.450
ENSG00000140983 E038 352.525754 0.0029551289 4.533378e-03 1.463591e-02 16 670696 670773 78 + 2.412 2.527 0.382
ENSG00000140983 E039 35.364416 0.0019447161 9.044829e-08 9.254743e-07 16 670774 670775 2 + 1.709 1.390 -1.092
ENSG00000140983 E040 84.132869 0.0003426896 2.312027e-16 9.521882e-15 16 670776 670888 113 + 2.076 1.765 -1.046
ENSG00000140983 E041 63.266437 0.0006055282 2.513219e-04 1.180799e-03 16 670889 670891 3 + 1.865 1.706 -0.534
ENSG00000140983 E042 481.045871 0.0012404291 7.158849e-01 8.116799e-01 16 670892 671000 109 + 2.615 2.640 0.084
ENSG00000140983 E043 87.278990 0.0004105351 7.092972e-09 8.989445e-08 16 671001 671081 81 + 2.038 1.822 -0.725
ENSG00000140983 E044 52.495230 0.0095070582 4.246407e-03 1.383129e-02 16 671082 671082 1 + 1.801 1.619 -0.617
ENSG00000140983 E045 299.878235 0.0020680142 1.637939e-01 2.800767e-01 16 671083 671114 32 + 2.384 2.445 0.202
ENSG00000140983 E046 456.320516 0.0016289171 8.787216e-01 9.261001e-01 16 671115 671203 89 + 2.594 2.615 0.071
ENSG00000140983 E047 11.486322 0.0014752310 3.972127e-09 5.271507e-08 16 671204 671312 109 + 1.371 0.815 -2.021
ENSG00000140983 E048 436.182076 0.0017660579 7.438445e-01 8.323683e-01 16 671697 671781 85 + 2.570 2.596 0.088
ENSG00000140983 E049 0.669547 0.0185333512 8.047200e-01 8.757520e-01 16 671782 671785 4 + 0.170 0.221 0.473
ENSG00000140983 E050 384.627553 0.0061550936 2.790983e-01 4.187934e-01 16 671860 671916 57 + 2.490 2.553 0.211
ENSG00000140983 E051 513.603019 0.0039776865 3.564098e-01 5.007919e-01 16 671917 672002 86 + 2.625 2.676 0.168
ENSG00000140983 E052 19.800612 0.0080506059 2.715485e-08 3.083437e-07 16 672003 672083 81 + 1.544 1.076 -1.637
ENSG00000140983 E053 686.618643 0.0022345477 2.806526e-01 4.205127e-01 16 672084 672181 98 + 2.753 2.800 0.156
ENSG00000140983 E054 801.370698 0.0026679398 2.160606e-02 5.486058e-02 16 672254 672384 131 + 2.794 2.877 0.277
ENSG00000140983 E055 85.780487 0.0029526402 6.377242e-15 2.163204e-13 16 672385 672488 104 + 2.105 1.760 -1.159
ENSG00000140983 E056 614.590065 0.0036004663 2.969335e-02 7.135648e-02 16 672489 672566 78 + 2.673 2.764 0.303
ENSG00000140983 E057 92.373448 0.0035750940 3.378124e-23 3.065016e-21 16 672567 672667 101 + 2.189 1.742 -1.503
ENSG00000140983 E058 68.748916 0.0051068235 2.049278e-16 8.472926e-15 16 672668 672702 35 + 2.054 1.624 -1.453
ENSG00000140983 E059 540.027633 0.0029988203 3.066953e-01 4.488771e-01 16 672703 672748 46 + 2.647 2.698 0.170
ENSG00000140983 E060 568.899175 0.0025275735 6.022941e-01 7.232775e-01 16 672749 672791 43 + 2.681 2.716 0.117
ENSG00000140983 E061 591.172506 0.0040777295 6.407685e-01 7.539598e-01 16 672792 672825 34 + 2.696 2.734 0.125
ENSG00000140983 E062 17.241117 0.0437389589 1.053142e-04 5.465516e-04 16 672826 672927 102 + 1.487 1.022 -1.639
ENSG00000140983 E063 1217.255099 0.0044597518 1.361066e-01 2.426252e-01 16 672928 673130 203 + 2.984 3.056 0.239
ENSG00000140983 E064 62.301165 0.0003893224 6.857426e-15 2.318199e-13 16 673131 673308 178 + 1.965 1.626 -1.148
ENSG00000140983 E065 495.953525 0.0033448191 2.805497e-02 6.812265e-02 16 673480 673497 18 + 2.578 2.671 0.308
ENSG00000140983 E066 1693.928721 0.0007766594 1.750986e-14 5.568241e-13 16 673498 673933 436 + 3.072 3.214 0.471
ENSG00000140983 E067 698.793921 0.0006023962 5.134789e-06 3.644973e-05 16 673934 674174 241 + 2.716 2.820 0.347