ENSG00000140943

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000343411 ENSG00000140943 HEK293_OSMI2_2hA HEK293_TMG_2hB MBTPS1 protein_coding protein_coding 49.92372 40.15436 53.15547 2.125847 0.6002296 0.4045736 38.669323 31.702283 42.0198834 1.2745605 0.55920748 0.4063737 0.77452500 0.79160000 0.790866667 -0.0007333333 1.000000e+00 6.399816e-05 FALSE  
ENST00000570064 ENSG00000140943 HEK293_OSMI2_2hA HEK293_TMG_2hB MBTPS1 protein_coding retained_intron 49.92372 40.15436 53.15547 2.125847 0.6002296 0.4045736 0.889562 2.203591 0.1039928 1.2794356 0.04171577 -4.2793740 0.02024167 0.05270000 0.001966667 -0.0507333333 8.310529e-03 6.399816e-05 FALSE  
MSTRG.13143.10 ENSG00000140943 HEK293_OSMI2_2hA HEK293_TMG_2hB MBTPS1 protein_coding   49.92372 40.15436 53.15547 2.125847 0.6002296 0.4045736 2.677448 1.214078 3.5521583 0.1248866 0.26455192 1.5410560 0.05124583 0.03013333 0.066766667 0.0366333333 6.399816e-05 6.399816e-05 TRUE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000140943 E001 0.5149111 0.0203681635 4.839014e-01 6.219211e-01 16 84053761 84053762 2 - 0.114 0.232 1.235
ENSG00000140943 E002 3.6447974 0.0085674658 1.572132e-05 9.986112e-05 16 84053763 84053765 3 - 0.204 0.905 3.551
ENSG00000140943 E003 14.6975635 0.0406013236 1.550765e-04 7.696420e-04 16 84053766 84053773 8 - 0.863 1.392 1.910
ENSG00000140943 E004 1122.1586105 0.0021643831 3.601898e-16 1.442031e-14 16 84053774 84054645 872 - 2.941 3.137 0.651
ENSG00000140943 E005 480.4656538 0.0005231882 1.490277e-03 5.604870e-03 16 84056005 84056135 131 - 2.651 2.718 0.222
ENSG00000140943 E006 28.9548890 0.0014661158 6.042219e-02 1.273353e-01 16 84056136 84058044 1909 - 1.408 1.538 0.445
ENSG00000140943 E007 241.4430046 0.0002119537 9.095463e-02 1.766464e-01 16 84059302 84059302 1 - 2.365 2.411 0.152
ENSG00000140943 E008 490.3929577 0.0005203611 1.417457e-04 7.110630e-04 16 84059303 84059428 126 - 2.653 2.731 0.259
ENSG00000140943 E009 9.3461656 0.0079744371 1.265297e-01 2.293142e-01 16 84059429 84059474 46 - 0.914 1.090 0.649
ENSG00000140943 E010 42.0696089 0.0007410455 6.650021e-02 1.375567e-01 16 84059475 84060681 1207 - 1.685 1.592 -0.316
ENSG00000140943 E011 437.5038208 0.0001456156 1.269767e-08 1.535220e-07 16 84060682 84060813 132 - 2.589 2.695 0.350
ENSG00000140943 E012 82.5012737 0.0147627986 8.605108e-01 9.140367e-01 16 84060814 84061631 818 - 1.929 1.912 -0.055
ENSG00000140943 E013 15.3443037 0.0045347796 3.414459e-01 4.853385e-01 16 84063165 84063173 9 - 1.258 1.179 -0.280
ENSG00000140943 E014 41.3916813 0.0015761696 8.950140e-01 9.369124e-01 16 84063174 84063304 131 - 1.634 1.633 -0.003
ENSG00000140943 E015 463.4303399 0.0001662444 8.324389e-08 8.588234e-07 16 84063305 84063445 141 - 2.618 2.716 0.325
ENSG00000140943 E016 327.7367552 0.0004927030 1.871726e-05 1.168676e-04 16 84065690 84065767 78 - 2.465 2.564 0.330
ENSG00000140943 E017 398.7474592 0.0001814976 1.089488e-04 5.632427e-04 16 84066489 84066609 121 - 2.563 2.640 0.257
ENSG00000140943 E018 178.4247334 0.0002078100 2.374639e-01 3.712243e-01 16 84066610 84066613 4 - 2.237 2.275 0.126
ENSG00000140943 E019 392.2221932 0.0001870388 3.087954e-03 1.052449e-02 16 84067667 84067823 157 - 2.567 2.628 0.203
ENSG00000140943 E020 331.6920671 0.0005397022 4.046865e-01 5.483866e-01 16 84068339 84068454 116 - 2.514 2.539 0.083
ENSG00000140943 E021 420.9683608 0.0003516361 5.183423e-01 6.525913e-01 16 84069866 84070018 153 - 2.620 2.639 0.062
ENSG00000140943 E022 217.1457007 0.0018127252 2.619167e-01 3.996425e-01 16 84070019 84070038 20 - 2.320 2.358 0.129
ENSG00000140943 E023 196.7071223 0.0033774649 7.100431e-01 8.072708e-01 16 84070588 84070597 10 - 2.289 2.304 0.051
ENSG00000140943 E024 346.3863343 0.0005775109 3.413872e-01 4.852805e-01 16 84070598 84070714 117 - 2.528 2.554 0.084
ENSG00000140943 E025 223.3208742 0.0028127134 3.146100e-01 4.573400e-01 16 84070715 84070763 49 - 2.332 2.369 0.125
ENSG00000140943 E026 166.7192281 0.0031450812 4.764694e-01 6.150858e-01 16 84070764 84070776 13 - 2.209 2.239 0.100
ENSG00000140943 E027 0.5138669 0.0199037640 6.617727e-01 7.701717e-01 16 84071804 84072137 334 - 0.204 0.131 -0.764
ENSG00000140943 E028 348.4907675 0.0021113303 5.391248e-01 6.704130e-01 16 84074597 84074741 145 - 2.533 2.552 0.064
ENSG00000140943 E029 4.4297352 0.0077580485 5.751294e-01 7.008362e-01 16 84074742 84075433 692 - 0.690 0.774 0.341
ENSG00000140943 E030 0.6997360 0.0166222233 2.610710e-02 6.416428e-02 16 84075523 84075656 134 - 0.000 0.382 11.498
ENSG00000140943 E031 2.4388496 0.0091965118 6.329401e-01 7.477324e-01 16 84081522 84081746 225 - 0.568 0.494 -0.350
ENSG00000140943 E032 333.5374593 0.0002115711 9.638415e-01 9.811709e-01 16 84081747 84081903 157 - 2.524 2.529 0.016
ENSG00000140943 E033 121.2839974 0.0009359900 6.121993e-01 7.311864e-01 16 84081904 84081908 5 - 2.081 2.105 0.081
ENSG00000140943 E034 1.1749974 0.0125719817 4.309552e-02 9.673017e-02 16 84081909 84082169 261 - 0.491 0.131 -2.574
ENSG00000140943 E035 205.4693609 0.0038447836 2.555389e-01 3.924373e-01 16 84084983 84085053 71 - 2.337 2.299 -0.128
ENSG00000140943 E036 242.3584916 0.0001773869 3.452561e-04 1.561008e-03 16 84085054 84085134 81 - 2.427 2.351 -0.255
ENSG00000140943 E037 299.9403995 0.0001812229 9.174715e-08 9.377514e-07 16 84087358 84087460 103 - 2.530 2.424 -0.356
ENSG00000140943 E038 274.3767490 0.0009046304 1.443700e-03 5.451994e-03 16 84090875 84090942 68 - 2.479 2.402 -0.256
ENSG00000140943 E039 258.6020785 0.0019870664 2.907369e-02 7.014853e-02 16 84091732 84091797 66 - 2.447 2.384 -0.210
ENSG00000140943 E040 218.6702520 0.0001863419 4.463190e-05 2.544885e-04 16 84091798 84091848 51 - 2.390 2.296 -0.312
ENSG00000140943 E041 258.9029170 0.0001807126 2.361073e-04 1.117101e-03 16 84093188 84093297 110 - 2.455 2.378 -0.256
ENSG00000140943 E042 258.2143393 0.0001799017 1.098548e-09 1.616439e-08 16 84093711 84093821 111 - 2.478 2.347 -0.439
ENSG00000140943 E043 353.7415509 0.0008677368 4.039940e-08 4.438897e-07 16 84095602 84095805 204 - 2.610 2.486 -0.412
ENSG00000140943 E044 404.3988413 0.0018790922 2.645158e-08 3.011341e-07 16 84099053 84099310 258 - 2.678 2.529 -0.495
ENSG00000140943 E045 245.3788601 0.0002710979 1.105654e-06 9.094423e-06 16 84101621 84101734 114 - 2.444 2.335 -0.365
ENSG00000140943 E046 161.9060604 0.0002460986 7.967751e-06 5.413379e-05 16 84101735 84101800 66 - 2.271 2.150 -0.404
ENSG00000140943 E047 191.0443317 0.0044158118 3.132936e-05 1.855346e-04 16 84101801 84101897 97 - 2.363 2.192 -0.569
ENSG00000140943 E048 178.8511617 0.0061438458 2.349072e-06 1.799242e-05 16 84101898 84101969 72 - 2.353 2.132 -0.739
ENSG00000140943 E049 201.3382325 0.0074275853 7.723920e-06 5.265468e-05 16 84101970 84102065 96 - 2.404 2.184 -0.736
ENSG00000140943 E050 135.0387234 0.0047013584 3.464214e-07 3.164344e-06 16 84102066 84102107 42 - 2.235 2.003 -0.777
ENSG00000140943 E051 1.9111764 0.0118979859 1.679458e-01 2.855250e-01 16 84109456 84109583 128 - 0.342 0.582 1.231
ENSG00000140943 E052 2.2369857 0.2202137639 4.656998e-01 6.053494e-01 16 84110713 84110825 113 - 0.601 0.432 -0.811
ENSG00000140943 E053 0.8428203 0.0160190237 7.832959e-01 8.609176e-01 16 84110826 84110853 28 - 0.279 0.232 -0.349
ENSG00000140943 E054 153.2998926 0.0044385911 1.043287e-05 6.907371e-05 16 84116735 84117019 285 - 2.275 2.084 -0.639
ENSG00000140943 E055 1.3493254 0.2210459501 8.295093e-01 8.929475e-01 16 84117020 84118209 1190 - 0.342 0.387 0.266