ENSG00000140854

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000379661 ENSG00000140854 HEK293_OSMI2_2hA HEK293_TMG_2hB KATNB1 protein_coding protein_coding 57.11388 96.02767 32.93805 5.124294 0.4941835 -1.543407 35.486154 61.789130 21.269623 3.3069577 0.4726312 -1.5381140 0.61817917 0.64353333 0.64563333 0.0021000 1.000000e+00 7.260874e-39 FALSE TRUE
ENST00000563462 ENSG00000140854 HEK293_OSMI2_2hA HEK293_TMG_2hB KATNB1 protein_coding protein_coding 57.11388 96.02767 32.93805 5.124294 0.4941835 -1.543407 6.053695 16.934832 0.000000 1.3542272 0.0000000 -10.7266296 0.07315833 0.17756667 0.00000000 -0.1775667 7.260874e-39 7.260874e-39 FALSE TRUE
MSTRG.12723.3 ENSG00000140854 HEK293_OSMI2_2hA HEK293_TMG_2hB KATNB1 protein_coding   57.11388 96.02767 32.93805 5.124294 0.4941835 -1.543407 5.654816 3.523587 5.010298 0.7203589 0.3532765 0.5066395 0.12701667 0.03613333 0.15250000 0.1163667 3.141920e-08 7.260874e-39 FALSE TRUE
MSTRG.12723.7 ENSG00000140854 HEK293_OSMI2_2hA HEK293_TMG_2hB KATNB1 protein_coding   57.11388 96.02767 32.93805 5.124294 0.4941835 -1.543407 4.715651 8.597377 2.138601 0.9818519 0.9387582 -2.0021761 0.07263750 0.08896667 0.06456667 -0.0244000 5.827481e-01 7.260874e-39 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000140854 E001 1.5039468 0.2615539900 9.711449e-01 9.859777e-01 16 57735739 57735753 15 + 0.326 0.339 0.080
ENSG00000140854 E002 3.9656210 0.0272136888 7.990794e-01 8.718221e-01 16 57735754 57735769 16 + 0.580 0.627 0.208
ENSG00000140854 E003 10.9244899 0.0016710570 2.569073e-01 3.939257e-01 16 57735770 57735790 21 + 0.888 1.027 0.518
ENSG00000140854 E004 126.4913445 0.0014776529 8.683605e-01 9.193644e-01 16 57735791 57735855 65 + 2.011 2.020 0.031
ENSG00000140854 E005 1.8758924 0.0402023267 4.821824e-03 1.543458e-02 16 57735856 57735863 8 + 0.739 0.244 -2.571
ENSG00000140854 E006 17.8833798 0.0075964472 2.109681e-03 7.564544e-03 16 57735864 57735930 67 + 1.390 1.107 -0.999
ENSG00000140854 E007 58.3345635 0.0004951074 5.318430e-02 1.148191e-01 16 57735931 57736116 186 + 1.761 1.661 -0.338
ENSG00000140854 E008 3.4750094 0.0504323991 3.792085e-01 5.234848e-01 16 57736763 57736878 116 + 0.429 0.608 0.859
ENSG00000140854 E009 0.5117019 0.0257343198 4.258946e-01 5.687667e-01 16 57736973 57736977 5 + 0.001 0.195 8.937
ENSG00000140854 E010 275.1965182 0.0005776385 5.269271e-01 6.601032e-01 16 57736978 57737063 86 + 2.367 2.352 -0.050
ENSG00000140854 E011 176.9449856 0.0002125183 1.305265e-01 2.348881e-01 16 57737064 57737067 4 + 2.199 2.153 -0.152
ENSG00000140854 E012 430.7508177 0.0003506275 1.698766e-01 2.880495e-01 16 57737068 57737191 124 + 2.568 2.541 -0.090
ENSG00000140854 E013 310.4659773 0.0002792437 5.726920e-02 1.219275e-01 16 57737192 57737225 34 + 2.439 2.395 -0.147
ENSG00000140854 E014 306.1111764 0.0003939175 3.352598e-01 4.790325e-01 16 57737226 57737283 58 + 2.416 2.394 -0.073
ENSG00000140854 E015 479.0583615 0.0010037647 1.783315e-01 2.990455e-01 16 57741687 57741817 131 + 2.617 2.589 -0.095
ENSG00000140854 E016 501.8216713 0.0001392475 3.660119e-03 1.218348e-02 16 57744394 57744511 118 + 2.654 2.602 -0.174
ENSG00000140854 E017 509.0398018 0.0002342936 6.639875e-03 2.028875e-02 16 57750827 57750927 101 + 2.658 2.608 -0.165
ENSG00000140854 E018 307.9361273 0.0004971367 1.038347e-01 1.963547e-01 16 57751261 57751302 42 + 2.433 2.394 -0.130
ENSG00000140854 E019 452.7390723 0.0001248819 1.953322e-03 7.081773e-03 16 57751641 57751724 84 + 2.615 2.557 -0.194
ENSG00000140854 E020 593.5873629 0.0001015821 9.496080e-06 6.345469e-05 16 57751940 57752055 116 + 2.743 2.670 -0.241
ENSG00000140854 E021 19.0927651 0.0009678394 1.553540e-08 1.847659e-07 16 57752056 57752529 474 + 1.525 1.078 -1.570
ENSG00000140854 E022 414.3322162 0.0001678341 5.449908e-03 1.715435e-02 16 57752530 57752601 72 + 2.573 2.518 -0.184
ENSG00000140854 E023 22.3328901 0.0076337287 1.701661e-05 1.072330e-04 16 57752602 57752777 176 + 1.540 1.181 -1.249
ENSG00000140854 E024 528.8777249 0.0001375304 3.465419e-02 8.098802e-02 16 57752778 57752928 151 + 2.665 2.628 -0.122
ENSG00000140854 E025 12.8321915 0.0020669934 1.363746e-06 1.100096e-05 16 57752929 57753076 148 + 1.370 0.913 -1.643
ENSG00000140854 E026 510.4005319 0.0001099137 2.721989e-01 4.110551e-01 16 57753077 57753267 191 + 2.604 2.626 0.075
ENSG00000140854 E027 325.3185212 0.0001446608 2.827400e-02 6.855082e-02 16 57753389 57753456 68 + 2.383 2.437 0.181
ENSG00000140854 E028 315.1534289 0.0001462476 7.578143e-01 8.425116e-01 16 57753457 57753519 63 + 2.417 2.411 -0.019
ENSG00000140854 E029 329.2177911 0.0001847690 1.521024e-01 2.645455e-01 16 57753945 57753995 51 + 2.405 2.441 0.120
ENSG00000140854 E030 377.2825852 0.0001494329 2.038710e-02 5.230105e-02 16 57754930 57754997 68 + 2.449 2.503 0.179
ENSG00000140854 E031 310.1425809 0.0001707464 1.310901e-03 5.013451e-03 16 57755119 57755145 27 + 2.341 2.423 0.273
ENSG00000140854 E032 517.3913610 0.0001926723 4.302691e-01 5.729028e-01 16 57755146 57755238 93 + 2.613 2.631 0.058
ENSG00000140854 E033 614.8923745 0.0003000874 7.498823e-01 8.367078e-01 16 57755345 57755447 103 + 2.696 2.705 0.028
ENSG00000140854 E034 494.5085513 0.0001329571 5.654641e-01 6.925575e-01 16 57755448 57755494 47 + 2.599 2.612 0.043
ENSG00000140854 E035 95.7191856 0.0035482613 7.543186e-01 8.399906e-01 16 57755790 57755840 51 + 1.885 1.904 0.066
ENSG00000140854 E036 547.2172025 0.0001320035 1.012164e-01 1.923324e-01 16 57755841 57755917 77 + 2.627 2.659 0.107
ENSG00000140854 E037 18.2354639 0.0012045647 1.081756e-02 3.072726e-02 16 57755918 57755991 74 + 1.359 1.141 -0.767
ENSG00000140854 E038 573.3724519 0.0009741796 2.927059e-02 7.052483e-02 16 57755992 57756066 75 + 2.631 2.685 0.180
ENSG00000140854 E039 10.9036533 0.0039498452 9.337135e-01 9.622382e-01 16 57756067 57756355 289 + 0.999 1.010 0.042
ENSG00000140854 E040 600.4760282 0.0001467908 1.841458e-06 1.443772e-05 16 57756356 57756472 117 + 2.622 2.711 0.295
ENSG00000140854 E041 20.3323906 0.0042982222 6.311626e-05 3.467258e-04 16 57756473 57756813 341 + 1.487 1.158 -1.151
ENSG00000140854 E042 755.5196524 0.0006559822 6.704848e-18 3.354142e-16 16 57756814 57757246 433 + 2.650 2.827 0.589