ENSG00000140829

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000268482 ENSG00000140829 HEK293_OSMI2_2hA HEK293_TMG_2hB DHX38 protein_coding protein_coding 45.81116 51.58493 39.43566 2.596078 1.349187 -0.3873629 33.343939 43.535356 24.916973 1.8136480 0.5265531 -0.8048111 0.71690833 0.84533333 0.6324333 -0.21290000 1.503584e-06 5.747957e-38 FALSE TRUE
ENST00000566329 ENSG00000140829 HEK293_OSMI2_2hA HEK293_TMG_2hB DHX38 protein_coding retained_intron 45.81116 51.58493 39.43566 2.596078 1.349187 -0.3873629 2.512819 1.019052 2.620094 0.2340432 0.3692510 1.3537988 0.05804583 0.01953333 0.0660000 0.04646667 4.874923e-05 5.747957e-38 FALSE TRUE
ENST00000569935 ENSG00000140829 HEK293_OSMI2_2hA HEK293_TMG_2hB DHX38 protein_coding retained_intron 45.81116 51.58493 39.43566 2.596078 1.349187 -0.3873629 2.513843 0.000000 4.165244 0.0000000 0.3786906 8.7057167 0.05955417 0.00000000 0.1058333 0.10583333 5.747957e-38 5.747957e-38 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000140829 E001 7.1964940 0.0023167235 5.958921e-03 1.850005e-02 16 72093613 72093813 201 + 1.078 0.751 -1.239
ENSG00000140829 E002 10.8760164 0.0015369786 4.588708e-04 2.002066e-03 16 72093814 72093846 33 + 1.253 0.901 -1.279
ENSG00000140829 E003 38.6531613 0.0005337100 2.109636e-05 1.301287e-04 16 72093847 72093889 43 + 1.717 1.470 -0.841
ENSG00000140829 E004 50.5381345 0.0006904775 3.417269e-07 3.125532e-06 16 72093890 72093923 34 + 1.839 1.576 -0.891
ENSG00000140829 E005 193.2711831 0.0025701989 1.542657e-11 3.115026e-10 16 72093924 72094051 128 + 2.402 2.159 -0.811
ENSG00000140829 E006 0.0000000       16 72094397 72094454 58 +      
ENSG00000140829 E007 492.0666794 0.0017055748 8.628045e-21 6.077313e-19 16 72096139 72096480 342 + 2.805 2.566 -0.797
ENSG00000140829 E008 272.4183893 0.0010937693 8.733142e-17 3.789435e-15 16 72096822 72096926 105 + 2.541 2.315 -0.756
ENSG00000140829 E009 263.3860470 0.0007453754 2.926024e-16 1.189032e-14 16 72096927 72097009 83 + 2.518 2.304 -0.712
ENSG00000140829 E010 14.8711338 0.0276904729 1.498594e-05 9.567112e-05 16 72097160 72097676 517 + 1.453 0.956 -1.768
ENSG00000140829 E011 283.0931276 0.0015182381 9.012919e-08 9.225580e-07 16 72097677 72097781 105 + 2.516 2.359 -0.524
ENSG00000140829 E012 314.2906488 0.0004426034 1.052284e-10 1.849791e-09 16 72098645 72098792 148 + 2.557 2.407 -0.502
ENSG00000140829 E013 294.9240214 0.0009563132 3.756564e-08 4.150646e-07 16 72098927 72099045 119 + 2.528 2.382 -0.485
ENSG00000140829 E014 4.0621498 0.0038378676 6.436462e-04 2.693189e-03 16 72099046 72099203 158 + 0.943 0.456 -2.063
ENSG00000140829 E015 256.9401938 0.0025553803 2.675319e-04 1.247405e-03 16 72099204 72099280 77 + 2.455 2.330 -0.416
ENSG00000140829 E016 312.7583029 0.0049367351 4.455546e-02 9.938186e-02 16 72099732 72099887 156 + 2.512 2.430 -0.273
ENSG00000140829 E017 0.4470576 0.0214742429 2.535258e-01 3.900509e-01 16 72099888 72099888 1 + 0.282 0.091 -1.978
ENSG00000140829 E018 302.1115689 0.0022981465 3.836272e-02 8.803432e-02 16 72100436 72100597 162 + 2.488 2.419 -0.229
ENSG00000140829 E019 0.5911836 0.0374180471 2.459669e-01 3.812233e-01 16 72101082 72101085 4 + 0.000 0.230 9.813
ENSG00000140829 E020 291.4560396 0.0002307452 1.960446e-06 1.527958e-05 16 72101086 72101193 108 + 2.499 2.388 -0.371
ENSG00000140829 E021 368.4901686 0.0001622133 5.351430e-03 1.688702e-02 16 72101500 72101612 113 + 2.569 2.508 -0.201
ENSG00000140829 E022 232.2526506 0.0028613787 1.395210e-01 2.473687e-01 16 72103074 72103100 27 + 2.369 2.312 -0.189
ENSG00000140829 E023 337.2411498 0.0001615699 5.955409e-01 7.176071e-01 16 72103101 72103211 111 + 2.500 2.484 -0.053
ENSG00000140829 E024 401.5466267 0.0001212900 7.378173e-01 8.278852e-01 16 72103602 72103788 187 + 2.572 2.561 -0.037
ENSG00000140829 E025 10.9025264 0.0038102789 7.171402e-09 9.074882e-08 16 72103789 72103921 133 + 1.360 0.769 -2.169
ENSG00000140829 E026 413.0140345 0.0001446771 1.418746e-01 2.505987e-01 16 72103946 72104131 186 + 2.598 2.565 -0.109
ENSG00000140829 E027 57.0119798 0.0329603191 1.772577e-07 1.716290e-06 16 72104132 72104485 354 + 2.015 1.492 -1.769
ENSG00000140829 E028 382.5424038 0.0001761773 9.120695e-01 9.482430e-01 16 72104486 72104626 141 + 2.544 2.542 -0.009
ENSG00000140829 E029 313.3476879 0.0001506822 7.783050e-01 8.573487e-01 16 72105027 72105137 111 + 2.465 2.454 -0.036
ENSG00000140829 E030 241.7468290 0.0001664316 3.149723e-02 7.487554e-02 16 72105232 72105291 60 + 2.310 2.359 0.164
ENSG00000140829 E031 271.3928034 0.0001993176 1.070701e-01 2.012133e-01 16 72105292 72105348 57 + 2.369 2.403 0.112
ENSG00000140829 E032 310.9072086 0.0001502400 1.434888e-01 2.527611e-01 16 72105517 72105624 108 + 2.434 2.462 0.092
ENSG00000140829 E033 297.9734711 0.0001552133 1.212969e-02 3.384591e-02 16 72106005 72106117 113 + 2.397 2.449 0.174
ENSG00000140829 E034 393.8166534 0.0001558005 3.031388e-07 2.802757e-06 16 72107340 72107548 209 + 2.482 2.581 0.330
ENSG00000140829 E035 380.5025437 0.0001293267 1.026222e-06 8.490469e-06 16 72107645 72107799 155 + 2.472 2.567 0.316
ENSG00000140829 E036 302.6147216 0.0002925760 2.891424e-06 2.171113e-05 16 72108227 72108295 69 + 2.366 2.472 0.354
ENSG00000140829 E037 169.8310561 0.0007057242 1.591359e-02 4.254020e-02 16 72108296 72108296 1 + 2.143 2.215 0.244
ENSG00000140829 E038 264.6344837 0.0006540416 5.153874e-05 2.894453e-04 16 72108297 72108353 57 + 2.310 2.414 0.348
ENSG00000140829 E039 195.6123412 0.0002378487 3.687693e-08 4.078832e-07 16 72108354 72108371 18 + 2.140 2.295 0.519
ENSG00000140829 E040 190.7699415 0.0002010559 8.264888e-08 8.530883e-07 16 72108372 72108382 11 + 2.130 2.282 0.509
ENSG00000140829 E041 8.7117562 0.0754308123 4.281599e-02 9.620534e-02 16 72108383 72108472 90 + 1.153 0.839 -1.162
ENSG00000140829 E042 400.0399233 0.0017239059 2.941981e-05 1.754216e-04 16 72108473 72108607 135 + 2.481 2.595 0.379
ENSG00000140829 E043 2.3023235 0.1415163103 2.132713e-01 3.423918e-01 16 72108608 72108629 22 + 0.669 0.380 -1.388
ENSG00000140829 E044 4.4175433 0.1413778029 1.983444e-01 3.241441e-01 16 72108630 72108799 170 + 0.897 0.579 -1.301
ENSG00000140829 E045 418.9238472 0.0019483037 9.581490e-04 3.815337e-03 16 72108800 72108925 126 + 2.519 2.609 0.302
ENSG00000140829 E046 392.2469793 0.0037172348 8.138450e-03 2.413584e-02 16 72109415 72109510 96 + 2.489 2.580 0.304
ENSG00000140829 E047 2.9934274 0.0054122442 9.982871e-02 1.902211e-01 16 72109511 72109756 246 + 0.745 0.489 -1.130
ENSG00000140829 E048 338.4584139 0.0014889314 1.802533e-07 1.742979e-06 16 72110956 72111042 87 + 2.384 2.529 0.484
ENSG00000140829 E049 225.3851464 0.0009728787 2.815051e-11 5.447426e-10 16 72111043 72111077 35 + 2.165 2.366 0.672
ENSG00000140829 E050 335.5874646 0.0016983275 3.043169e-13 8.071108e-12 16 72112413 72112529 117 + 2.324 2.539 0.717
ENSG00000140829 E051 322.5532321 0.0009758233 3.151998e-17 1.442010e-15 16 72112530 72112624 95 + 2.298 2.525 0.756
ENSG00000140829 E052 332.4600948 0.0026031643 5.402055e-10 8.417529e-09 16 72112625 72112720 96 + 2.331 2.534 0.679
ENSG00000140829 E053 250.3908634 0.0020397742 2.951735e-09 4.010308e-08 16 72112721 72113018 298 + 2.215 2.411 0.657