ENSG00000140750

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000289968 ENSG00000140750 HEK293_OSMI2_2hA HEK293_TMG_2hB ARHGAP17 protein_coding protein_coding 31.47973 42.47233 23.89307 0.5755823 1.523754 -0.8296671 14.2700333 20.7513466 10.622221 1.91255588 0.8838273 -0.9654570 0.44251250 0.489733333 0.44910000 -0.04063333 0.848343290 1.487989e-06 FALSE TRUE
ENST00000303665 ENSG00000140750 HEK293_OSMI2_2hA HEK293_TMG_2hB ARHGAP17 protein_coding protein_coding 31.47973 42.47233 23.89307 0.5755823 1.523754 -0.8296671 4.6527674 3.7002638 3.273175 0.07186296 0.4151365 -0.1764302 0.15577500 0.087200000 0.13746667 0.05026667 0.067257593 1.487989e-06 FALSE TRUE
ENST00000571843 ENSG00000140750 HEK293_OSMI2_2hA HEK293_TMG_2hB ARHGAP17 protein_coding protein_coding 31.47973 42.47233 23.89307 0.5755823 1.523754 -0.8296671 5.8581388 15.4414823 1.122615 2.07965245 1.1226148 -3.7700160 0.15082083 0.362466667 0.04283333 -0.31963333 0.043280996 1.487989e-06 FALSE FALSE
ENST00000575975 ENSG00000140750 HEK293_OSMI2_2hA HEK293_TMG_2hB ARHGAP17 protein_coding processed_transcript 31.47973 42.47233 23.89307 0.5755823 1.523754 -0.8296671 0.7873786 0.0000000 1.675012 0.00000000 0.8381774 7.3966148 0.03126667 0.000000000 0.06626667 0.06626667 0.123469345 1.487989e-06 FALSE TRUE
MSTRG.12303.5 ENSG00000140750 HEK293_OSMI2_2hA HEK293_TMG_2hB ARHGAP17 protein_coding   31.47973 42.47233 23.89307 0.5755823 1.523754 -0.8296671 2.5830558 0.1789324 4.194582 0.17893242 1.0581497 4.4760202 0.10571250 0.004133333 0.18046667 0.17633333 0.003724724 1.487989e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000140750 E001 3.4319722 0.0054205960 5.155114e-03 1.635114e-02 16 24919389 24919392 4 - 0.257 0.758 2.549
ENSG00000140750 E002 3.7651920 0.0083825277 1.350904e-02 3.709754e-02 16 24919393 24919394 2 - 0.344 0.777 2.042
ENSG00000140750 E003 3.9866372 0.0049938356 8.722709e-03 2.559281e-02 16 24919395 24919396 2 - 0.344 0.796 2.117
ENSG00000140750 E004 4.7261140 0.0064385739 2.107111e-03 7.555901e-03 16 24919397 24919397 1 - 0.344 0.863 2.380
ENSG00000140750 E005 16.4284231 0.0116725106 5.354033e-09 6.947774e-08 16 24919398 24919413 16 - 0.626 1.375 2.815
ENSG00000140750 E006 438.1340810 0.0071503184 5.352535e-10 8.343797e-09 16 24919414 24919841 428 - 2.403 2.706 1.010
ENSG00000140750 E007 228.1697416 0.0017868385 8.599291e-08 8.839446e-07 16 24919842 24919891 50 - 2.199 2.401 0.671
ENSG00000140750 E008 549.0380455 0.0036023683 1.619546e-05 1.025805e-04 16 24919892 24920247 356 - 2.606 2.771 0.547
ENSG00000140750 E009 125.5771962 0.0056556886 7.502052e-03 2.251792e-02 16 24920248 24920260 13 - 1.972 2.134 0.544
ENSG00000140750 E010 6.0104052 0.0633066680 7.465718e-02 1.509889e-01 16 24920261 24921004 744 - 0.582 0.937 1.439
ENSG00000140750 E011 48.3740766 0.0021254804 3.695715e-03 1.228348e-02 16 24927684 24927732 49 - 1.532 1.729 0.669
ENSG00000140750 E012 1.2512805 0.0103707048 6.035423e-01 7.243284e-01 16 24929613 24929660 48 - 0.257 0.364 0.705
ENSG00000140750 E013 351.0528661 0.0089180163 5.687797e-02 1.212513e-01 16 24930784 24931160 377 - 2.443 2.566 0.410
ENSG00000140750 E014 195.1356616 0.0002261252 4.004757e-07 3.610571e-06 16 24931161 24931404 244 - 2.156 2.323 0.558
ENSG00000140750 E015 177.7659801 0.0002670887 5.597737e-04 2.384053e-03 16 24935470 24935639 170 - 2.143 2.269 0.422
ENSG00000140750 E016 5.3736152 0.0031109651 3.020556e-01 4.438891e-01 16 24935640 24936827 1188 - 0.666 0.831 0.671
ENSG00000140750 E017 203.3310269 0.0019317319 4.862309e-01 6.240388e-01 16 24939364 24939597 234 - 2.254 2.305 0.169
ENSG00000140750 E018 3.8998243 0.0236407158 1.611779e-02 4.299628e-02 16 24939598 24939921 324 - 0.872 0.526 -1.452
ENSG00000140750 E019 3.9909749 0.0040517458 3.486453e-04 1.574714e-03 16 24941696 24941986 291 - 0.938 0.453 -2.060
ENSG00000140750 E020 235.2212464 0.0002925015 5.971257e-02 1.261358e-01 16 24941987 24942143 157 - 2.364 2.345 -0.063
ENSG00000140750 E021 172.4854598 0.0019012106 2.903603e-01 4.311571e-01 16 24943771 24943834 64 - 2.223 2.214 -0.030
ENSG00000140750 E022 134.9001772 0.0008528308 8.686968e-02 1.703820e-01 16 24943835 24943862 28 - 2.130 2.099 -0.104
ENSG00000140750 E023 222.7241038 0.0047617029 2.103546e-01 3.389701e-01 16 24947482 24947595 114 - 2.343 2.320 -0.076
ENSG00000140750 E024 1.8842983 0.0074621017 4.754509e-02 1.048089e-01 16 24948982 24949127 146 - 0.626 0.312 -1.619
ENSG00000140750 E025 4.8305970 0.0186164949 7.753676e-02 1.555077e-01 16 24949128 24949403 276 - 0.895 0.668 -0.907
ENSG00000140750 E026 181.6006082 0.0025510031 2.924352e-01 4.333991e-01 16 24949404 24949484 81 - 2.246 2.235 -0.036
ENSG00000140750 E027 186.2142998 0.0024704537 6.225553e-02 1.304311e-01 16 24952289 24952370 82 - 2.273 2.234 -0.129
ENSG00000140750 E028 179.5367193 0.0016000216 1.051189e-02 3.000657e-02 16 24952931 24953042 112 - 2.268 2.212 -0.188
ENSG00000140750 E029 153.2596360 0.0032280964 2.662344e-02 6.520997e-02 16 24954603 24954691 89 - 2.202 2.142 -0.201
ENSG00000140750 E030 116.1250418 0.0065851546 1.071153e-01 2.012802e-01 16 24954692 24954730 39 - 2.080 2.024 -0.188
ENSG00000140750 E031 12.4477492 0.0014727243 5.734583e-05 3.183335e-04 16 24954731 24957536 2806 - 1.309 0.961 -1.250
ENSG00000140750 E032 169.0481158 0.0032338290 2.987082e-02 7.171280e-02 16 24959671 24959752 82 - 2.243 2.186 -0.188
ENSG00000140750 E033 99.4446496 0.0028896122 8.371356e-02 1.653593e-01 16 24959911 24959916 6 - 2.008 1.958 -0.166
ENSG00000140750 E034 155.2793556 0.0048893698 3.633580e-02 8.421909e-02 16 24959917 24959979 63 - 2.210 2.147 -0.213
ENSG00000140750 E035 0.2214452 0.0400798148 7.544331e-01   16 24959980 24959981 2 - 0.000 0.102 8.144
ENSG00000140750 E036 144.4903040 0.0054513762 2.252619e-01 3.567403e-01 16 24964197 24964244 48 - 2.156 2.130 -0.089
ENSG00000140750 E037 123.5291302 0.0017053887 4.835021e-03 1.547264e-02 16 24964245 24964283 39 - 2.122 2.043 -0.266
ENSG00000140750 E038 111.3908932 0.0017301751 7.009101e-03 2.124769e-02 16 24964284 24964308 25 - 2.079 2.000 -0.263
ENSG00000140750 E039 176.6058197 0.0008644449 3.481043e-07 3.178031e-06 16 24968351 24968427 77 - 2.305 2.180 -0.417
ENSG00000140750 E040 1.0277339 0.1727213640 2.298653e-01 3.622933e-01 16 24968562 24968660 99 - 0.417 0.187 -1.583
ENSG00000140750 E041 190.1843680 0.0002389665 3.373980e-10 5.439455e-09 16 24968661 24968768 108 - 2.345 2.207 -0.461
ENSG00000140750 E042 81.0150238 0.0004788912 3.542408e-06 2.609636e-05 16 24968769 24968772 4 - 1.992 1.834 -0.532
ENSG00000140750 E043 144.3215775 0.0002692769 3.165974e-11 6.071306e-10 16 24970507 24970580 74 - 2.247 2.075 -0.573
ENSG00000140750 E044 0.2998086 0.0290674516 7.189888e-01   16 24972596 24972633 38 - 0.147 0.101 -0.622
ENSG00000140750 E045 155.5183284 0.0003559069 3.117724e-06 2.323355e-05 16 24977215 24977319 105 - 2.242 2.131 -0.369
ENSG00000140750 E046 0.2934659 0.0293638510 7.197919e-01   16 24977320 24977456 137 - 0.147 0.101 -0.621
ENSG00000140750 E047 85.4553429 0.0029324394 1.649914e-03 6.120688e-03 16 24978966 24979005 40 - 1.988 1.871 -0.394
ENSG00000140750 E048 3.7160410 0.0611769228 2.579153e-01 3.950992e-01 16 25013863 25013956 94 - 0.766 0.589 -0.746
ENSG00000140750 E049 87.6935222 0.0115803472 1.989097e-02 5.125524e-02 16 25015209 25015388 180 - 2.001 1.881 -0.402
ENSG00000140750 E050 0.7813216 0.0790464708 9.221972e-01 9.549206e-01 16 25015501 25015666 166 - 0.257 0.251 -0.047