ENSG00000140740

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000268379 ENSG00000140740 HEK293_OSMI2_2hA HEK293_TMG_2hB UQCRC2 protein_coding protein_coding 126.0401 94.55673 145.9545 12.97511 0.664782 0.6262133 30.89810 33.03966 34.66247 6.380762 2.2867110 0.06915518 0.2465917 0.3440000 0.2374333 -0.10656667 0.01063663 4.896104e-05 FALSE TRUE
ENST00000630839 ENSG00000140740 HEK293_OSMI2_2hA HEK293_TMG_2hB UQCRC2 protein_coding protein_coding 126.0401 94.55673 145.9545 12.97511 0.664782 0.6262133 13.47193 9.39427 17.14057 1.147902 0.9021578 0.86686869 0.1057250 0.1009000 0.1174333 0.01653333 0.62592658 4.896104e-05 FALSE TRUE
MSTRG.12250.11 ENSG00000140740 HEK293_OSMI2_2hA HEK293_TMG_2hB UQCRC2 protein_coding   126.0401 94.55673 145.9545 12.97511 0.664782 0.6262133 64.84673 41.84876 73.40745 5.890223 1.3432797 0.81059343 0.5058625 0.4422667 0.5030333 0.06076667 0.02835284 4.896104e-05 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000140740 E001 4.7174922 0.6579381450 1.514795e-01 2.636847e-01 16 21950302 21953009 2708 + 0.965 0.255 -3.367
ENSG00000140740 E002 0.5922303 0.0178864205 4.401709e-01 5.818580e-01 16 21953288 21953297 10 + 0.268 0.137 -1.200
ENSG00000140740 E003 1.0392880 0.0117437747 4.009607e-01 5.446273e-01 16 21953298 21953306 9 + 0.384 0.241 -0.938
ENSG00000140740 E004 69.2583920 0.0004216630 1.025257e-01 1.943582e-01 16 21953307 21953360 54 + 1.878 1.820 -0.197
ENSG00000140740 E005 106.3592021 0.0010823238 4.285139e-01 5.712564e-01 16 21953361 21953370 10 + 2.045 2.024 -0.069
ENSG00000140740 E006 187.3260057 0.0042497297 5.760250e-02 1.225119e-01 16 21953371 21953386 16 + 2.313 2.234 -0.262
ENSG00000140740 E007 252.2232261 0.0025481064 4.088672e-03 1.339073e-02 16 21953387 21953395 9 + 2.449 2.356 -0.310
ENSG00000140740 E008 293.0548214 0.0043905674 1.040273e-03 4.098419e-03 16 21953396 21953402 7 + 2.527 2.399 -0.425
ENSG00000140740 E009 421.3283446 0.0028065826 8.250221e-03 2.441850e-02 16 21953403 21953456 54 + 2.665 2.584 -0.270
ENSG00000140740 E010 358.9153499 0.0021937876 1.181286e-02 3.308709e-02 16 21957235 21957236 2 + 2.592 2.520 -0.239
ENSG00000140740 E011 553.9002632 0.0015249331 3.691411e-04 1.654702e-03 16 21957237 21957318 82 + 2.785 2.701 -0.278
ENSG00000140740 E012 425.4346558 0.0006981943 8.473643e-02 1.669815e-01 16 21957417 21957487 71 + 2.648 2.618 -0.099
ENSG00000140740 E013 587.8661384 0.0002959850 4.412158e-03 1.429791e-02 16 21957488 21957566 79 + 2.792 2.755 -0.123
ENSG00000140740 E014 601.7870566 0.0001099887 2.764290e-03 9.565651e-03 16 21958535 21958599 65 + 2.802 2.770 -0.108
ENSG00000140740 E015 43.9554028 0.0047067814 4.813164e-12 1.055590e-10 16 21959339 21959555 217 + 1.386 1.831 1.518
ENSG00000140740 E016 26.9762387 0.0519665278 6.518512e-04 2.722410e-03 16 21959556 21959780 225 + 1.190 1.615 1.473
ENSG00000140740 E017 12.1956030 0.0048058010 1.579823e-03 5.893393e-03 16 21961328 21961461 134 + 1.243 0.926 -1.149
ENSG00000140740 E018 4.3795636 0.0453360668 2.383539e-01 3.722348e-01 16 21961462 21961465 4 + 0.806 0.603 -0.844
ENSG00000140740 E019 3.8523484 0.0071540520 7.163090e-04 2.957321e-03 16 21962192 21962459 268 + 0.861 0.326 -2.487
ENSG00000140740 E020 538.3793761 0.0002192996 1.336716e-02 3.677401e-02 16 21962460 21962516 57 + 2.753 2.725 -0.094
ENSG00000140740 E021 0.7469680 0.0181053412 3.389876e-02 7.954836e-02 16 21962517 21962760 244 + 0.384 0.000 -12.378
ENSG00000140740 E022 694.1859872 0.0002454196 6.218203e-01 7.387418e-01 16 21962761 21962885 125 + 2.840 2.860 0.064
ENSG00000140740 E023 0.2998086 0.0278586977 8.670479e-01   16 21962886 21963212 327 + 0.109 0.137 0.384
ENSG00000140740 E024 662.5529469 0.0004310425 7.704260e-01 8.517392e-01 16 21965408 21965505 98 + 2.821 2.837 0.053
ENSG00000140740 E025 0.8909948 0.0136062844 1.593927e-01 2.743039e-01 16 21965506 21965533 28 + 0.384 0.137 -1.937
ENSG00000140740 E026 7.4940926 0.0196888645 3.775841e-02 8.688433e-02 16 21967122 21967230 109 + 1.040 0.766 -1.043
ENSG00000140740 E027 2.8595954 0.1113195489 4.759099e-02 1.048978e-01 16 21968462 21968627 166 + 0.743 0.324 -2.030
ENSG00000140740 E028 580.2025188 0.0013680009 1.141340e-02 3.214644e-02 16 21968628 21968685 58 + 2.792 2.743 -0.164
ENSG00000140740 E029 725.0541468 0.0001605782 1.981061e-04 9.557554e-04 16 21971525 21971620 96 + 2.887 2.845 -0.137
ENSG00000140740 E030 1022.1640373 0.0001791335 6.751040e-01 7.804701e-01 16 21971923 21972122 200 + 3.014 3.019 0.018
ENSG00000140740 E031 580.9892345 0.0001061684 1.215015e-04 6.207180e-04 16 21973896 21973976 81 + 2.738 2.807 0.230
ENSG00000140740 E032 697.9615125 0.0017380895 7.635869e-05 4.107770e-04 16 21976167 21976243 77 + 2.796 2.899 0.341
ENSG00000140740 E033 66.0050965 0.0866112868 5.016102e-05 2.826296e-04 16 21976244 21976947 704 + 2.023 1.392 -2.142
ENSG00000140740 E034 114.0094089 0.0130708895 2.194062e-08 2.539148e-07 16 21978883 21979251 369 + 2.204 1.819 -1.291
ENSG00000140740 E035 66.1533071 0.0387941596 4.001666e-02 9.106897e-02 16 21980262 21980546 285 + 1.921 1.693 -0.770
ENSG00000140740 E036 1077.8207458 0.0016159233 1.178552e-09 1.722733e-08 16 21980547 21980700 154 + 2.966 3.100 0.446
ENSG00000140740 E037 991.1268873 0.0018957757 3.249699e-10 5.257885e-09 16 21983088 21983301 214 + 2.922 3.071 0.495
ENSG00000140740 E038 282.3279901 0.0036674308 1.889533e-05 1.178607e-04 16 21983302 21983660 359 + 2.370 2.536 0.555
ENSG00000140740 E039 0.6631923 0.5549212519 7.447906e-01 8.329796e-01 16 21990148 21990179 32 + 0.268 0.142 -1.146
ENSG00000140740 E040 0.6653823 0.0170908724 4.449910e-01 5.865591e-01 16 21991072 21991137 66 + 0.268 0.138 -1.197
ENSG00000140740 E041 0.2987644 0.0290785164 2.866404e-01   16 21993300 21993347 48 + 0.196 0.000 -11.056