ENSG00000140694

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000341484 ENSG00000140694 HEK293_OSMI2_2hA HEK293_TMG_2hB PARN protein_coding protein_coding 18.02799 12.45109 25.38492 1.043087 0.7753188 1.027109 2.8761664 0.05688346 4.962395 0.05688346 0.4110854 6.2161475 0.1257833 0.005233333 0.19520000 0.1899667 7.713580e-05 1.331076e-09 FALSE TRUE
ENST00000437198 ENSG00000140694 HEK293_OSMI2_2hA HEK293_TMG_2hB PARN protein_coding protein_coding 18.02799 12.45109 25.38492 1.043087 0.7753188 1.027109 12.5764312 10.76433613 16.844718 0.81954603 0.1046726 0.6455536 0.7284667 0.865566667 0.66463333 -0.2009333 1.331076e-09 1.331076e-09 FALSE TRUE
ENST00000652727 ENSG00000140694 HEK293_OSMI2_2hA HEK293_TMG_2hB PARN protein_coding protein_coding 18.02799 12.45109 25.38492 1.043087 0.7753188 1.027109 0.9978145 0.48258491 1.553561 0.04800649 0.3678612 1.6663913 0.0501625 0.038833333 0.06073333 0.0219000 4.645259e-01 1.331076e-09 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000140694 E001 0.0000000       16 14435700 14435700 1 -      
ENSG00000140694 E002 24.8783446 0.0104230803 8.677381e-05 4.599619e-04 16 14435701 14435908 208 - 1.247 1.573 1.128
ENSG00000140694 E003 10.1740982 0.0316763774 1.486860e-03 5.593684e-03 16 14435909 14435910 2 - 0.827 1.249 1.551
ENSG00000140694 E004 10.1740982 0.0316763774 1.486860e-03 5.593684e-03 16 14435911 14435912 2 - 0.827 1.249 1.551
ENSG00000140694 E005 12.7591766 0.0254943827 7.451731e-04 3.061477e-03 16 14435913 14435918 6 - 0.927 1.334 1.463
ENSG00000140694 E006 48.8564437 0.0088850643 7.430532e-04 3.054224e-03 16 14435919 14435972 54 - 1.588 1.814 0.765
ENSG00000140694 E007 93.8868279 0.0009065342 1.180762e-06 9.658544e-06 16 14435973 14436045 73 - 1.891 2.074 0.614
ENSG00000140694 E008 204.1916908 0.0015531963 9.427884e-09 1.168597e-07 16 14436046 14436272 227 - 2.231 2.402 0.571
ENSG00000140694 E009 94.6099627 0.0013373843 8.584429e-06 5.792059e-05 16 14436273 14436311 39 - 1.899 2.072 0.580
ENSG00000140694 E010 229.1006785 0.0002844011 1.475732e-08 1.763311e-07 16 14436312 14436604 293 - 2.301 2.433 0.439
ENSG00000140694 E011 97.9453858 0.0024781696 2.038510e-03 7.346058e-03 16 14436605 14436667 63 - 1.937 2.066 0.433
ENSG00000140694 E012 124.1881835 0.0020865363 2.603944e-05 1.572251e-04 16 14436668 14436772 105 - 2.024 2.182 0.527
ENSG00000140694 E013 109.8264487 0.0039380046 1.890058e-03 6.883896e-03 16 14446888 14446956 69 - 1.980 2.120 0.467
ENSG00000140694 E014 147.7499343 0.0007053118 3.752980e-06 2.749172e-05 16 14446957 14447081 125 - 2.108 2.247 0.467
ENSG00000140694 E015 0.0000000       16 14460709 14460722 14 -      
ENSG00000140694 E016 0.2214452 0.0454871816 2.819253e-01   16 14460723 14460743 21 - 0.000 0.155 13.111
ENSG00000140694 E017 5.7497399 0.1382249503 9.415159e-01 9.672221e-01 16 14460744 14461270 527 - 0.826 0.799 -0.108
ENSG00000140694 E018 4.0779583 0.0054779766 1.474643e-01 2.582425e-01 16 14461271 14461834 564 - 0.776 0.551 -0.956
ENSG00000140694 E019 0.0000000       16 14470089 14470422 334 -      
ENSG00000140694 E020 0.1515154 0.0432030072 8.373564e-01   16 14482270 14482388 119 - 0.096 0.000 -11.821
ENSG00000140694 E021 207.7940142 0.0002126096 2.778942e-04 1.289653e-03 16 14482638 14482827 190 - 2.279 2.365 0.288
ENSG00000140694 E022 0.0000000       16 14501553 14501689 137 -      
ENSG00000140694 E023 0.1817044 0.0410956549 2.824752e-01   16 14531054 14531174 121 - 0.000 0.154 13.107
ENSG00000140694 E024 0.4428904 0.6226666478 1.968419e-01 3.222938e-01 16 14540352 14540947 596 - 0.000 0.281 14.201
ENSG00000140694 E025 0.3697384 0.0248933867 8.865118e-02 1.730693e-01 16 14550397 14550596 200 - 0.000 0.268 14.107
ENSG00000140694 E026 0.0000000       16 14551608 14551709 102 -      
ENSG00000140694 E027 0.4782907 0.0208409442 2.829017e-02 6.858301e-02 16 14551710 14551745 36 - 0.000 0.357 14.688
ENSG00000140694 E028 136.6026243 0.0002279699 5.924157e-02 1.253380e-01 16 14552021 14552095 75 - 2.112 2.165 0.179
ENSG00000140694 E029 107.3042404 0.0002834027 5.120599e-01 6.469967e-01 16 14554065 14554107 43 - 2.023 2.042 0.062
ENSG00000140694 E030 103.3281280 0.0003154311 4.260993e-01 5.689594e-01 16 14554108 14554151 44 - 2.006 2.030 0.081
ENSG00000140694 E031 91.8747235 0.0003215058 7.230374e-01 8.169651e-01 16 14555654 14555685 32 - 1.963 1.973 0.032
ENSG00000140694 E032 74.0702795 0.0003663102 9.271663e-01 9.581806e-01 16 14555686 14555709 24 - 1.876 1.869 -0.027
ENSG00000140694 E033 0.1451727 0.0433390938 8.375634e-01   16 14558373 14558489 117 - 0.096 0.000 -11.820
ENSG00000140694 E034 0.0000000       16 14565016 14565075 60 -      
ENSG00000140694 E035 3.1457835 0.1100527959 3.659517e-02 8.470494e-02 16 14576072 14576276 205 - 0.397 0.830 1.950
ENSG00000140694 E036 0.2924217 0.0274356476 4.037773e-01   16 14578531 14578628 98 - 0.175 0.000 -12.820
ENSG00000140694 E037 112.3246021 0.0002809319 5.875201e-01 7.107893e-01 16 14580874 14580943 70 - 2.044 2.058 0.047
ENSG00000140694 E038 136.0810611 0.0002701109 2.231845e-01 3.541947e-01 16 14582181 14582291 111 - 2.119 2.153 0.112
ENSG00000140694 E039 112.4977968 0.0002818929 1.586738e-01 2.733630e-01 16 14584347 14584422 76 - 2.071 2.018 -0.177
ENSG00000140694 E040 93.6848163 0.0003693686 2.542216e-01 3.908675e-01 16 14584749 14584791 43 - 1.992 1.944 -0.159
ENSG00000140694 E041 91.0154079 0.0003191314 2.659671e-01 4.040890e-01 16 14586318 14586361 44 - 1.978 1.932 -0.157
ENSG00000140694 E042 0.1482932 0.0408248064 2.850020e-01   16 14588098 14588172 75 - 0.000 0.154 13.103
ENSG00000140694 E043 1.5844897 0.0085959286 6.668241e-01 7.742242e-01 16 14591913 14592033 121 - 0.437 0.358 -0.442
ENSG00000140694 E044 5.7165043 0.0588725126 1.940315e-01 3.188479e-01 16 14592034 14593300 1267 - 0.718 0.922 0.798
ENSG00000140694 E045 105.5219899 0.0002675420 2.059779e-01 3.336545e-01 16 14593301 14593378 78 - 2.041 1.992 -0.165
ENSG00000140694 E046 69.7989131 0.0003364757 7.190858e-01 8.140246e-01 16 14599904 14599934 31 - 1.854 1.835 -0.066
ENSG00000140694 E047 68.5396254 0.0003967195 2.809529e-02 6.819958e-02 16 14599935 14599960 26 - 1.878 1.777 -0.340
ENSG00000140694 E048 107.6079350 0.0002879410 2.334540e-02 5.846828e-02 16 14604146 14604223 78 - 2.063 1.979 -0.284
ENSG00000140694 E049 62.9172798 0.0005098974 2.002063e-01 3.264909e-01 16 14604224 14604226 3 - 1.825 1.761 -0.214
ENSG00000140694 E050 96.3759863 0.0003006759 7.467102e-02 1.510120e-01 16 14606484 14606526 43 - 2.011 1.940 -0.237
ENSG00000140694 E051 0.0000000       16 14608107 14608280 174 -      
ENSG00000140694 E052 84.9705263 0.0045271954 2.868194e-02 6.937108e-02 16 14608281 14608319 39 - 1.974 1.854 -0.404
ENSG00000140694 E053 108.0610115 0.0046494871 6.135328e-05 3.381588e-04 16 14609058 14609123 66 - 2.105 1.902 -0.682
ENSG00000140694 E054 75.3612643 0.0028593957 1.362722e-06 1.099317e-05 16 14610644 14610664 21 - 1.966 1.716 -0.840
ENSG00000140694 E055 134.8416770 0.0002791420 4.754398e-09 6.231107e-08 16 14610665 14610809 145 - 2.198 2.003 -0.653
ENSG00000140694 E056 100.0501538 0.0035194024 1.409340e-05 9.043021e-05 16 14617590 14617650 61 - 2.073 1.859 -0.720
ENSG00000140694 E057 0.1451727 0.0433390938 8.375634e-01   16 14623924 14623953 30 - 0.096 0.000 -11.820
ENSG00000140694 E058 87.1040082 0.0117661326 1.080346e-04 5.590657e-04 16 14627106 14627136 31 - 2.030 1.759 -0.912
ENSG00000140694 E059 90.7377505 0.0082073161 3.115829e-05 1.846890e-04 16 14627137 14627174 38 - 2.044 1.782 -0.882
ENSG00000140694 E060 56.8150723 0.0093180348 2.621635e-04 1.225416e-03 16 14627175 14627175 1 - 1.844 1.579 -0.899
ENSG00000140694 E061 60.0223131 0.0137583887 3.119015e-04 1.428094e-03 16 14627176 14627187 12 - 1.874 1.585 -0.980
ENSG00000140694 E062 0.5202097 0.0210972744 9.422139e-01 9.677301e-01 16 14627188 14627268 81 - 0.175 0.154 -0.218
ENSG00000140694 E063 90.8345246 0.0059807752 9.924806e-04 3.932579e-03 16 14627269 14627336 68 - 2.024 1.834 -0.638
ENSG00000140694 E064 0.1817044 0.0410956549 2.824752e-01   16 14627337 14627727 391 - 0.000 0.154 13.107
ENSG00000140694 E065 0.0000000       16 14627728 14627819 92 -      
ENSG00000140694 E066 0.0000000       16 14627820 14628171 352 -      
ENSG00000140694 E067 58.5140875 0.0004306169 2.036974e-02 5.226146e-02 16 14628172 14628190 19 - 1.812 1.696 -0.392
ENSG00000140694 E068 73.2879129 0.0029887065 9.039870e-03 2.637823e-02 16 14628191 14628251 61 - 1.916 1.777 -0.467
ENSG00000140694 E069 68.7074994 0.0039207525 3.421713e-02 8.017728e-02 16 14629597 14629674 78 - 1.881 1.759 -0.410
ENSG00000140694 E070 51.4639509 0.0080539422 9.899476e-02 1.889370e-01 16 14630107 14630189 83 - 1.757 1.637 -0.404
ENSG00000140694 E071 35.5108474 0.0007582209 4.396107e-03 1.425345e-02 16 14630190 14630299 110 - 1.620 1.439 -0.623
ENSG00000140694 E072 0.1817044 0.0410956549 2.824752e-01   16 14632390 14632728 339 - 0.000 0.154 13.107