ENSG00000140691

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000268314 ENSG00000140691 HEK293_OSMI2_2hA HEK293_TMG_2hB ARMC5 protein_coding protein_coding 14.72923 24.63178 9.404598 1.369253 0.4581205 -1.388135 6.3864110 9.7810095 4.8933556 2.3690265 0.29521684 -0.9976882 0.44900000 0.39863333 0.52186667 0.12323333 0.602801034 0.001358678 FALSE  
ENST00000457010 ENSG00000140691 HEK293_OSMI2_2hA HEK293_TMG_2hB ARMC5 protein_coding protein_coding 14.72923 24.63178 9.404598 1.369253 0.4581205 -1.388135 0.9138071 0.9763886 0.8689428 0.0915895 0.07158529 -0.1663868 0.07392500 0.03976667 0.09260000 0.05283333 0.001358678 0.001358678 FALSE  
ENST00000564900 ENSG00000140691 HEK293_OSMI2_2hA HEK293_TMG_2hB ARMC5 protein_coding protein_coding 14.72923 24.63178 9.404598 1.369253 0.4581205 -1.388135 1.0900940 1.9444495 0.0000000 1.1839096 0.00000000 -7.6106185 0.04661250 0.08263333 0.00000000 -0.08263333 0.261598541 0.001358678 FALSE  
ENST00000570119 ENSG00000140691 HEK293_OSMI2_2hA HEK293_TMG_2hB ARMC5 protein_coding retained_intron 14.72923 24.63178 9.404598 1.369253 0.4581205 -1.388135 0.9246366 1.7854521 0.1778774 0.9140319 0.17787740 -3.2564837 0.06787917 0.07066667 0.01733333 -0.05333333 0.592141856 0.001358678 FALSE  
MSTRG.12526.6 ENSG00000140691 HEK293_OSMI2_2hA HEK293_TMG_2hB ARMC5 protein_coding   14.72923 24.63178 9.404598 1.369253 0.4581205 -1.388135 4.6629963 8.6154139 2.6981832 1.5442593 0.52501594 -1.6712684 0.31036667 0.34673333 0.28526667 -0.06146667 0.750851447 0.001358678 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000140691 E001 0.000000       16 31457553 31458079 527 +      
ENSG00000140691 E002 11.753385 0.0017339084 0.0363287934 0.0842066867 16 31458080 31458501 422 + 1.168 0.980 -0.681
ENSG00000140691 E003 2.320768 0.0088528860 0.2963739149 0.4375712936 16 31458824 31458851 28 + 0.305 0.518 1.175
ENSG00000140691 E004 1.621032 0.0868123223 0.7237895093 0.8175223350 16 31458852 31458853 2 + 0.305 0.393 0.534
ENSG00000140691 E005 13.152806 0.0040257953 0.6435826167 0.7560861832 16 31458854 31458976 123 + 1.103 1.082 -0.079
ENSG00000140691 E006 25.585804 0.0105332269 0.3720067357 0.5164823058 16 31458977 31459340 364 + 1.396 1.347 -0.171
ENSG00000140691 E007 16.420674 0.0013225023 0.0201170974 0.0517330730 16 31459341 31459467 127 + 1.308 1.131 -0.627
ENSG00000140691 E008 17.418028 0.0011628116 0.0333532716 0.0784880100 16 31459468 31459500 33 + 1.318 1.163 -0.549
ENSG00000140691 E009 104.278092 0.0192934719 0.0450973577 0.1003766566 16 31459501 31459960 460 + 2.037 1.929 -0.363
ENSG00000140691 E010 56.272461 0.0188509341 0.2262787906 0.3579311110 16 31459961 31459993 33 + 1.744 1.675 -0.232
ENSG00000140691 E011 49.013175 0.0064426671 0.2663846819 0.4045647509 16 31459994 31459999 6 + 1.665 1.621 -0.149
ENSG00000140691 E012 1.035121 0.0128706085 0.2550196860 0.3918115457 16 31460000 31460278 279 + 0.402 0.211 -1.284
ENSG00000140691 E013 105.131188 0.0006065236 0.0282511918 0.0685051714 16 31461922 31462029 108 + 2.000 1.945 -0.187
ENSG00000140691 E014 95.852880 0.0002958289 0.0346274463 0.0809501512 16 31462131 31462195 65 + 1.961 1.907 -0.183
ENSG00000140691 E015 318.933528 0.0015822025 0.1930172157 0.3175584023 16 31462196 31462771 576 + 2.443 2.440 -0.011
ENSG00000140691 E016 130.480952 0.0002930441 0.4015868231 0.5452873983 16 31462772 31462917 146 + 2.007 2.065 0.195
ENSG00000140691 E017 215.318591 0.0002196783 0.9769026566 0.9895854303 16 31464394 31464887 494 + 2.248 2.275 0.093
ENSG00000140691 E018 10.042431 0.0449102678 0.0001114177 0.0005742354 16 31464888 31465332 445 + 1.296 0.785 -1.881
ENSG00000140691 E019 12.246186 0.0295205525 0.0320292981 0.0759127063 16 31465333 31465849 517 + 1.224 0.991 -0.841
ENSG00000140691 E020 121.231458 0.0002830283 0.2294351729 0.3617568180 16 31465850 31465982 133 + 1.968 2.041 0.243
ENSG00000140691 E021 10.941582 0.0068024296 0.5519609855 0.6813534960 16 31465983 31466060 78 + 1.048 1.008 -0.147
ENSG00000140691 E022 16.014773 0.0447912671 0.3524839597 0.4967343351 16 31466061 31466078 18 + 1.224 1.149 -0.267
ENSG00000140691 E023 711.815732 0.0079719766 0.0009318869 0.0037261116 16 31466079 31467166 1088 + 2.681 2.824 0.476