ENSG00000140632

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000321919 ENSG00000140632 HEK293_OSMI2_2hA HEK293_TMG_2hB GLYR1 protein_coding protein_coding 55.9151 49.65358 58.5934 1.057051 1.130062 0.2387962 29.779622 30.3666609 28.713205 0.8397216 1.29134373 -0.08074654 0.53647083 0.611900000 0.49033333 -0.12156667 2.029529e-02 8.912337e-33 FALSE TRUE
ENST00000436648 ENSG00000140632 HEK293_OSMI2_2hA HEK293_TMG_2hB GLYR1 protein_coding protein_coding 55.9151 49.65358 58.5934 1.057051 1.130062 0.2387962 2.656313 4.2476090 2.001487 0.4368095 0.08066162 -1.08178130 0.04967500 0.085266667 0.03413333 -0.05113333 1.565814e-07 8.912337e-33 FALSE TRUE
ENST00000589389 ENSG00000140632 HEK293_OSMI2_2hA HEK293_TMG_2hB GLYR1 protein_coding protein_coding 55.9151 49.65358 58.5934 1.057051 1.130062 0.2387962 4.917194 7.4058778 0.000000 1.1378323 0.00000000 -9.53447367 0.09145833 0.148700000 0.00000000 -0.14870000 8.912337e-33 8.912337e-33 FALSE TRUE
ENST00000591451 ENSG00000140632 HEK293_OSMI2_2hA HEK293_TMG_2hB GLYR1 protein_coding protein_coding 55.9151 49.65358 58.5934 1.057051 1.130062 0.2387962 2.478003 0.0000000 3.147840 0.0000000 1.58963384 8.30279435 0.04074167 0.000000000 0.05316667 0.05316667 1.944650e-01 8.912337e-33 FALSE TRUE
MSTRG.11991.10 ENSG00000140632 HEK293_OSMI2_2hA HEK293_TMG_2hB GLYR1 protein_coding   55.9151 49.65358 58.5934 1.057051 1.130062 0.2387962 1.807003 0.4033821 4.032981 0.2136230 0.22351152 3.28987167 0.03119167 0.008066667 0.06903333 0.06096667 3.010117e-02 8.912337e-33 TRUE TRUE
MSTRG.11991.14 ENSG00000140632 HEK293_OSMI2_2hA HEK293_TMG_2hB GLYR1 protein_coding   55.9151 49.65358 58.5934 1.057051 1.130062 0.2387962 2.895818 2.1014330 4.482647 0.7353289 1.06145854 1.08934320 0.05170833 0.042866667 0.07626667 0.03340000 4.867880e-01 8.912337e-33 TRUE TRUE
MSTRG.11991.3 ENSG00000140632 HEK293_OSMI2_2hA HEK293_TMG_2hB GLYR1 protein_coding   55.9151 49.65358 58.5934 1.057051 1.130062 0.2387962 1.134422 0.0000000 5.816008 0.0000000 0.92915401 9.18636376 0.01952083 0.000000000 0.09936667 0.09936667 5.704674e-26 8.912337e-33 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000140632 E001 0.3299976 0.0274424043 2.199967e-01   16 4803131 4803202 72 - 0.000 0.215 11.499
ENSG00000140632 E002 83.3214582 0.0093466998 5.836135e-11 1.070985e-09 16 4803203 4803253 51 - 1.633 2.073 1.482
ENSG00000140632 E003 423.8541734 0.0035671858 2.589499e-27 3.447454e-25 16 4803254 4803565 312 - 2.370 2.761 1.301
ENSG00000140632 E004 195.9062197 0.0039921261 3.803829e-04 1.698864e-03 16 4803566 4803682 117 - 2.197 2.361 0.546
ENSG00000140632 E005 130.2481275 0.0054719634 1.973202e-02 5.092114e-02 16 4803683 4803702 20 - 2.042 2.172 0.432
ENSG00000140632 E006 120.5088747 0.0029494994 2.563731e-03 8.953491e-03 16 4803703 4803707 5 - 2.000 2.144 0.483
ENSG00000140632 E007 236.9563101 0.0020758401 1.302976e-05 8.424737e-05 16 4803708 4803755 48 - 2.282 2.440 0.529
ENSG00000140632 E008 247.1157397 0.0012652188 5.243208e-06 3.713169e-05 16 4803756 4803789 34 - 2.307 2.455 0.492
ENSG00000140632 E009 875.2019283 0.0017044264 1.055721e-04 5.476541e-04 16 4803790 4804148 359 - 2.881 2.984 0.344
ENSG00000140632 E010 699.9714682 0.0003304526 2.298877e-09 3.188253e-08 16 4804149 4804521 373 - 2.781 2.891 0.365
ENSG00000140632 E011 945.2838770 0.0010993220 3.345172e-03 1.127678e-02 16 4804522 4805048 527 - 2.933 3.004 0.237
ENSG00000140632 E012 447.4196562 0.0015160202 1.585470e-03 5.911834e-03 16 4805049 4805310 262 - 2.594 2.688 0.314
ENSG00000140632 E013 330.0829204 0.0004008677 5.609772e-01 6.888836e-01 16 4811170 4811294 125 - 2.515 2.519 0.013
ENSG00000140632 E014 431.3562776 0.0004914393 1.644888e-01 2.810164e-01 16 4811623 4811802 180 - 2.640 2.628 -0.038
ENSG00000140632 E015 10.7640409 0.0016484883 3.706890e-01 5.150987e-01 16 4811889 4811975 87 - 1.111 1.038 -0.264
ENSG00000140632 E016 11.2307816 0.0042412883 1.217910e-01 2.224799e-01 16 4811976 4812085 110 - 1.163 1.025 -0.501
ENSG00000140632 E017 408.6470275 0.0001439756 1.229883e-03 4.742087e-03 16 4812086 4812248 163 - 2.633 2.592 -0.137
ENSG00000140632 E018 297.0933617 0.0002068953 2.097242e-01 3.382249e-01 16 4813737 4813838 102 - 2.479 2.469 -0.033
ENSG00000140632 E019 26.2371331 0.0150602263 1.439411e-02 3.912031e-02 16 4813839 4813955 117 - 1.529 1.323 -0.711
ENSG00000140632 E020 184.5173922 0.0013205757 1.524062e-01 2.649473e-01 16 4814537 4814566 30 - 2.285 2.257 -0.091
ENSG00000140632 E021 218.9179010 0.0017323879 8.711102e-01 9.211378e-01 16 4814567 4814629 63 - 2.336 2.348 0.037
ENSG00000140632 E022 111.3339725 0.0042747524 5.408167e-01 6.719009e-01 16 4814630 4814647 18 - 2.025 2.066 0.140
ENSG00000140632 E023 239.0045290 0.0018328343 4.296692e-02 9.648611e-02 16 4817598 4817652 55 - 2.403 2.355 -0.161
ENSG00000140632 E024 180.0832882 0.0040716558 5.578585e-03 1.749695e-02 16 4817653 4817663 11 - 2.307 2.207 -0.335
ENSG00000140632 E025 230.4634951 0.0037478366 3.362492e-04 1.525395e-03 16 4817664 4817697 34 - 2.424 2.303 -0.406
ENSG00000140632 E026 9.3721460 0.0244679175 1.913965e-02 4.964463e-02 16 4817698 4817923 226 - 1.143 0.853 -1.075
ENSG00000140632 E027 11.3156912 0.0015624600 8.411692e-03 2.481694e-02 16 4821204 4821379 176 - 1.210 0.969 -0.872
ENSG00000140632 E028 303.5758134 0.0023236392 5.882153e-05 3.255876e-04 16 4821380 4821453 74 - 2.538 2.428 -0.367
ENSG00000140632 E029 7.8680869 0.0029527326 5.395572e-05 3.015176e-04 16 4821454 4821546 93 - 1.143 0.685 -1.749
ENSG00000140632 E030 233.8008301 0.0025594951 2.876328e-04 1.329669e-03 16 4821547 4821597 51 - 2.424 2.316 -0.361
ENSG00000140632 E031 6.2254041 0.0566829425 6.998347e-02 1.433438e-01 16 4821598 4821664 67 - 0.983 0.713 -1.048
ENSG00000140632 E032 229.9722837 0.0007475071 1.218488e-05 7.935335e-05 16 4822875 4822899 25 - 2.413 2.314 -0.334
ENSG00000140632 E033 241.9572457 0.0010032181 4.595282e-05 2.612576e-04 16 4822900 4822931 32 - 2.432 2.337 -0.319
ENSG00000140632 E034 302.2440583 0.0019030269 5.672737e-03 1.774722e-02 16 4823821 4823907 87 - 2.514 2.448 -0.223
ENSG00000140632 E035 479.6064147 0.0001916412 1.465400e-13 4.068821e-12 16 4831979 4832221 243 - 2.737 2.629 -0.361
ENSG00000140632 E036 0.1472490 0.0427713492 4.621132e-01   16 4832455 4832773 319 - 0.124 0.000 -10.891
ENSG00000140632 E037 371.6920885 0.0005754841 2.539366e-07 2.385694e-06 16 4832774 4832864 91 - 2.619 2.527 -0.309
ENSG00000140632 E038 302.2167922 0.0010826244 4.095732e-04 1.811087e-03 16 4832865 4832912 48 - 2.520 2.446 -0.247
ENSG00000140632 E039 0.1472490 0.0427713492 4.621132e-01   16 4833120 4833200 81 - 0.124 0.000 -10.891
ENSG00000140632 E040 5.4070184 0.0031032809 7.095182e-01 8.068836e-01 16 4843404 4843602 199 - 0.821 0.787 -0.135
ENSG00000140632 E041 0.1472490 0.0427713492 4.621132e-01   16 4843603 4843912 310 - 0.124 0.000 -10.891
ENSG00000140632 E042 328.6073086 0.0019605696 2.777318e-05 1.664782e-04 16 4845074 4845153 80 - 2.571 2.466 -0.350
ENSG00000140632 E043 251.0860046 0.0003439182 1.003821e-07 1.018645e-06 16 4846174 4846210 37 - 2.457 2.348 -0.363
ENSG00000140632 E044 159.2796549 0.0002088391 8.311962e-14 2.392035e-12 16 4847228 4847362 135 - 2.301 2.107 -0.649