ENSG00000140598

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000268206 ENSG00000140598 HEK293_OSMI2_2hA HEK293_TMG_2hB EFL1 protein_coding protein_coding 8.652057 5.809086 10.13246 0.4352312 0.284927 0.801543 5.6849657 2.2697361 8.010826 0.4541091 0.2091686 1.814884 0.61625417 0.3970333 0.7922333 0.39520000 2.877376e-03 1.789328e-12 FALSE TRUE
ENST00000561340 ENSG00000140598 HEK293_OSMI2_2hA HEK293_TMG_2hB EFL1 protein_coding protein_coding 8.652057 5.809086 10.13246 0.4352312 0.284927 0.801543 0.2154751 0.6698839 0.256165 0.1810934 0.1573826 -1.352968 0.02760833 0.1211667 0.0248000 -0.09636667 2.066122e-01 1.789328e-12 FALSE TRUE
ENST00000696327 ENSG00000140598 HEK293_OSMI2_2hA HEK293_TMG_2hB EFL1 protein_coding protein_coding 8.652057 5.809086 10.13246 0.4352312 0.284927 0.801543 1.3393412 2.1883235 0.000000 0.6734519 0.0000000 -7.780260 0.20591250 0.3637667 0.0000000 -0.36376667 1.789328e-12 1.789328e-12 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000140598 E001 0.0000000       15 82130206 82130217 12 -      
ENSG00000140598 E002 0.2955422 0.0285312299 6.089756e-01   15 82130218 82130232 15 - 0.090 0.165 1.005
ENSG00000140598 E003 0.8469850 0.0143962574 3.347398e-02 7.872203e-02 15 82130233 82130233 1 - 0.090 0.454 3.007
ENSG00000140598 E004 0.8469850 0.0143962574 3.347398e-02 7.872203e-02 15 82130234 82130240 7 - 0.090 0.454 3.007
ENSG00000140598 E005 0.8469850 0.0143962574 3.347398e-02 7.872203e-02 15 82130241 82130241 1 - 0.090 0.454 3.007
ENSG00000140598 E006 1.8422631 0.0082802335 1.057252e-03 4.157531e-03 15 82130242 82130259 18 - 0.164 0.712 3.176
ENSG00000140598 E007 16.6267752 0.0336434488 3.834022e-03 1.267616e-02 15 82130260 82130372 113 - 1.072 1.432 1.270
ENSG00000140598 E008 75.6079125 0.0004898026 2.695217e-11 5.228886e-10 15 82130373 82130561 189 - 1.754 2.020 0.896
ENSG00000140598 E009 97.1339958 0.0007222994 1.538886e-11 3.108406e-10 15 82138658 82138842 185 - 1.873 2.116 0.815
ENSG00000140598 E010 1.2491791 0.4490350803 7.836362e-01 8.611725e-01 15 82151451 82151464 14 - 0.282 0.395 0.700
ENSG00000140598 E011 228.4710682 0.0002388906 1.314746e-11 2.686309e-10 15 82151465 82152423 959 - 2.288 2.436 0.491
ENSG00000140598 E012 2.1434106 0.0068472645 1.112546e-01 2.073943e-01 15 82157268 82157712 445 - 0.574 0.284 -1.577
ENSG00000140598 E013 57.3286760 0.0004218490 7.989463e-01 8.717170e-01 15 82157713 82157860 148 - 1.758 1.744 -0.046
ENSG00000140598 E014 1.0309706 0.0136232163 3.603451e-02 8.364942e-02 15 82159932 82160096 165 - 0.416 0.000 -13.035
ENSG00000140598 E015 49.4346934 0.0005321572 2.592972e-02 6.380365e-02 15 82163853 82163984 132 - 1.732 1.614 -0.401
ENSG00000140598 E016 0.1472490 0.0429835462 1.000000e+00   15 82165838 82165927 90 - 0.090 0.000 -10.138
ENSG00000140598 E017 28.0165681 0.0007493605 6.958194e-02 1.426633e-01 15 82214717 82214782 66 - 1.492 1.365 -0.441
ENSG00000140598 E018 21.4916846 0.0011199398 7.691912e-01 8.508856e-01 15 82214783 82214855 73 - 1.326 1.347 0.073
ENSG00000140598 E019 0.1482932 0.0407613592 2.428943e-01   15 82214856 82215582 727 - 0.000 0.164 10.450
ENSG00000140598 E020 1.7736722 0.0078964710 3.828009e-03 1.265915e-02 15 82215583 82216050 468 - 0.574 0.000 -13.752
ENSG00000140598 E021 38.5744385 0.0144837781 4.568194e-01 5.971879e-01 15 82219652 82219818 167 - 1.607 1.537 -0.238
ENSG00000140598 E022 40.6865344 0.0005289165 1.371483e-01 2.441185e-01 15 82220078 82220229 152 - 1.638 1.552 -0.295
ENSG00000140598 E023 34.2168384 0.0104473787 9.477962e-02 1.825454e-01 15 82225165 82225264 100 - 1.582 1.448 -0.459
ENSG00000140598 E024 41.1123303 0.0009731429 4.228547e-02 9.524489e-02 15 82227450 82227572 123 - 1.654 1.534 -0.408
ENSG00000140598 E025 1.1135859 0.0118060634 2.624785e-01 4.002589e-01 15 82227573 82227579 7 - 0.376 0.165 -1.576
ENSG00000140598 E026 43.8793054 0.0005553857 1.585639e-02 4.241542e-02 15 82228191 82228327 137 - 1.688 1.551 -0.464
ENSG00000140598 E027 25.2138347 0.0212467266 7.386327e-01 8.284652e-01 15 82229034 82229110 77 - 1.399 1.431 0.111
ENSG00000140598 E028 33.8149375 0.0006730172 2.936909e-01 4.347397e-01 15 82230848 82230971 124 - 1.558 1.491 -0.228
ENSG00000140598 E029 0.2944980 0.3513807923 5.799958e-01   15 82233663 82233774 112 - 0.164 0.000 -10.264
ENSG00000140598 E030 47.6934589 0.0307409641 9.335968e-02 1.803736e-01 15 82238307 82238484 178 - 1.730 1.562 -0.570
ENSG00000140598 E031 25.8148235 0.0008778716 3.572688e-03 1.193544e-02 15 82238485 82238521 37 - 1.486 1.268 -0.755
ENSG00000140598 E032 49.2634396 0.0007328550 5.922820e-04 2.505382e-03 15 82240418 82240555 138 - 1.751 1.563 -0.638
ENSG00000140598 E033 44.9068630 0.0005101574 9.871512e-07 8.199440e-06 15 82241270 82241403 134 - 1.736 1.451 -0.974
ENSG00000140598 E034 1.9314286 0.0077183337 1.494741e-01 2.609516e-01 15 82252132 82252457 326 - 0.547 0.284 -1.453
ENSG00000140598 E035 1.4853014 0.0231717432 3.632651e-01 5.076928e-01 15 82252458 82252548 91 - 0.453 0.283 -0.997
ENSG00000140598 E036 0.2955422 0.0285312299 6.089756e-01   15 82252549 82252690 142 - 0.090 0.165 1.005
ENSG00000140598 E037 41.1358029 0.0005286753 4.814307e-03 1.541416e-02 15 82252691 82252775 85 - 1.669 1.504 -0.563
ENSG00000140598 E038 38.2197162 0.0007427443 1.438287e-02 3.909425e-02 15 82259088 82259155 68 - 1.633 1.485 -0.508
ENSG00000140598 E039 25.6730723 0.0009301147 9.542387e-02 1.835232e-01 15 82261688 82261728 41 - 1.459 1.338 -0.420
ENSG00000140598 E040 28.9892611 0.0006632611 6.610906e-02 1.368971e-01 15 82261729 82261791 63 - 1.508 1.381 -0.436
ENSG00000140598 E041 20.2394908 0.0009442001 2.041309e-01 3.313426e-01 15 82261792 82261797 6 - 1.349 1.246 -0.361
ENSG00000140598 E042 1.4059059 0.0095836979 9.928358e-01 9.996191e-01 15 82261986 82262136 151 - 0.376 0.377 0.007
ENSG00000140598 E043 2.1400997 0.0069136910 8.449544e-01 9.035413e-01 15 82262137 82262348 212 - 0.486 0.519 0.158
ENSG00000140598 E044 1.1813402 0.0107226790 1.829210e-01 3.048532e-01 15 82262349 82262613 265 - 0.416 0.165 -1.800
ENSG00000140598 E045 19.1041230 0.0010124687 1.011473e-01 1.922241e-01 15 82262614 82262773 160 - 1.336 1.198 -0.484