ENSG00000140553

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000418476 ENSG00000140553 HEK293_OSMI2_2hA HEK293_TMG_2hB UNC45A protein_coding protein_coding 89.04836 156.5671 41.02344 6.768624 1.341144 -1.932002 64.418899 118.437448 26.118018 6.174240 0.7345890 -2.180578 0.69504167 0.75603333 0.63683333 -0.11920000 2.350724e-05 2.350724e-05 FALSE TRUE
ENST00000553671 ENSG00000140553 HEK293_OSMI2_2hA HEK293_TMG_2hB UNC45A protein_coding processed_transcript 89.04836 156.5671 41.02344 6.768624 1.341144 -1.932002 4.253691 2.234029 5.648499 1.097091 0.7241786 1.334328 0.06924167 0.01383333 0.13710000 0.12326667 1.298343e-02 2.350724e-05 FALSE TRUE
MSTRG.11567.7 ENSG00000140553 HEK293_OSMI2_2hA HEK293_TMG_2hB UNC45A protein_coding   89.04836 156.5671 41.02344 6.768624 1.341144 -1.932002 7.228476 17.753759 1.592124 2.621369 0.8661750 -3.470880 0.07057500 0.11343333 0.04006667 -0.07336667 5.222352e-01 2.350724e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000140553 E001 1.550987 0.0086230130 6.528084e-01 7.634552e-01 15 90930180 90930217 38 + 0.237 0.335 0.681
ENSG00000140553 E002 2.249679 0.0067632221 9.123009e-01 9.484211e-01 15 90930218 90930255 38 + 0.390 0.415 0.140
ENSG00000140553 E003 2.312436 0.2312827820 9.421302e-01 9.676748e-01 15 90930953 90931052 100 + 0.390 0.405 0.084
ENSG00000140553 E004 2.974509 0.0056821212 4.644446e-01 6.041613e-01 15 90931053 90931579 527 + 0.592 0.462 -0.617
ENSG00000140553 E005 2.915075 0.0059275154 1.919994e-01 3.162661e-01 15 90933977 90934040 64 + 0.666 0.439 -1.055
ENSG00000140553 E006 2.621596 0.0057697234 3.272651e-01 4.707050e-01 15 90934041 90934118 78 + 0.592 0.416 -0.858
ENSG00000140553 E007 1.442435 0.0098629622 7.589296e-01 8.434170e-01 15 90934119 90934143 25 + 0.237 0.305 0.489
ENSG00000140553 E008 1.875774 0.0081333665 1.149821e-01 2.128100e-01 15 90934339 90934434 96 + 0.000 0.391 10.922
ENSG00000140553 E009 2.873230 0.0054460241 8.166955e-01 8.840326e-01 15 90934435 90934549 115 + 0.502 0.462 -0.202
ENSG00000140553 E010 1.069474 0.0121989077 3.057372e-01 4.478785e-01 15 90934550 90934943 394 + 0.000 0.273 10.173
ENSG00000140553 E011 4.752100 0.0579305581 5.069907e-01 6.426025e-01 15 90934944 90935100 157 + 0.729 0.611 -0.500
ENSG00000140553 E012 4.528592 0.0037294660 3.953836e-01 5.391898e-01 15 90935101 90935218 118 + 0.729 0.593 -0.581
ENSG00000140553 E013 10.190385 0.0017098829 6.277225e-01 7.434740e-01 15 90935219 90935284 66 + 0.954 0.895 -0.223
ENSG00000140553 E014 82.884044 0.0028890981 1.024801e-04 5.335135e-04 15 90935285 90935305 21 + 1.931 1.728 -0.686
ENSG00000140553 E015 106.011691 0.0006390867 8.605351e-07 7.248490e-06 15 90935306 90935309 4 + 2.041 1.832 -0.705
ENSG00000140553 E016 214.124110 0.0037808125 3.039577e-05 1.806043e-04 15 90935310 90935330 21 + 2.314 2.145 -0.562
ENSG00000140553 E017 130.967912 0.0047847157 6.849938e-02 1.408905e-01 15 90935331 90935375 45 + 2.036 1.948 -0.293
ENSG00000140553 E018 0.816796 0.0151560067 2.148947e-01 3.443124e-01 15 90935424 90935543 120 + 0.390 0.157 -1.735
ENSG00000140553 E019 593.074978 0.0019153602 1.154167e-06 9.458151e-06 15 90935544 90935705 162 + 2.722 2.595 -0.423
ENSG00000140553 E020 454.051701 0.0016609641 1.799129e-05 1.127637e-04 15 90935946 90935982 37 + 2.597 2.481 -0.387
ENSG00000140553 E021 3.191024 0.0848916512 7.573470e-02 1.526780e-01 15 90935983 90936136 154 + 0.785 0.438 -1.548
ENSG00000140553 E022 13.701349 0.0043279035 3.426962e-08 3.815844e-07 15 90936137 90936284 148 + 1.434 0.895 -1.935
ENSG00000140553 E023 764.139807 0.0024415660 2.774960e-03 9.598637e-03 15 90936285 90936460 176 + 2.793 2.715 -0.261
ENSG00000140553 E024 0.554665 0.0203027793 4.521957e-01 5.930778e-01 15 90936900 90936957 58 + 0.237 0.111 -1.316
ENSG00000140553 E025 643.116673 0.0012634908 1.901067e-02 4.935678e-02 15 90939731 90939823 93 + 2.695 2.644 -0.171
ENSG00000140553 E026 752.698940 0.0013518882 5.724207e-04 2.430649e-03 15 90940306 90940473 168 + 2.784 2.709 -0.252
ENSG00000140553 E027 11.926598 0.0015288506 1.195189e-07 1.196939e-06 15 90940474 90940976 503 + 1.372 0.835 -1.950
ENSG00000140553 E028 358.816746 0.0001612443 1.474545e-07 1.449503e-06 15 90942437 90942442 6 + 2.500 2.377 -0.412
ENSG00000140553 E029 741.427216 0.0002267966 3.846095e-05 2.226255e-04 15 90942443 90942605 163 + 2.771 2.702 -0.231
ENSG00000140553 E030 27.758451 0.0007180867 4.645231e-13 1.203042e-11 15 90942606 90942911 306 + 1.696 1.184 -1.769
ENSG00000140553 E031 764.654334 0.0016617002 1.327663e-01 2.379536e-01 15 90942912 90943082 171 + 2.752 2.722 -0.102
ENSG00000140553 E032 2.899177 0.0055928842 3.142716e-02 7.474273e-02 15 90943083 90943089 7 + 0.000 0.523 11.590
ENSG00000140553 E033 739.332253 0.0029103423 8.627812e-01 9.155090e-01 15 90944892 90945035 144 + 2.708 2.713 0.014
ENSG00000140553 E034 426.123702 0.0031024555 2.359279e-01 3.694511e-01 15 90945036 90945063 28 + 2.502 2.469 -0.111
ENSG00000140553 E035 616.550340 0.0013458721 8.113750e-01 8.803143e-01 15 90946614 90946683 70 + 2.633 2.634 0.004
ENSG00000140553 E036 653.672156 0.0021221130 9.483939e-01 9.716219e-01 15 90946684 90946764 81 + 2.651 2.661 0.032
ENSG00000140553 E037 795.942501 0.0002855397 4.868123e-02 1.068261e-01 15 90946765 90946914 150 + 2.706 2.750 0.147
ENSG00000140553 E038 9.543755 0.0298655649 7.109493e-01 8.080102e-01 15 90946915 90947138 224 + 0.834 0.899 0.252
ENSG00000140553 E039 7.624512 0.0096944123 6.834265e-01 7.866210e-01 15 90947237 90947795 559 + 0.833 0.777 -0.223
ENSG00000140553 E040 653.507469 0.0001213452 1.914960e-01 3.156048e-01 15 90947796 90947890 95 + 2.629 2.661 0.105
ENSG00000140553 E041 898.125370 0.0001014334 2.275883e-02 5.724670e-02 15 90948142 90948283 142 + 2.756 2.801 0.148
ENSG00000140553 E042 28.606007 0.0007095008 4.853201e-08 5.248455e-07 15 90948284 90948653 370 + 1.628 1.231 -1.369
ENSG00000140553 E043 923.615809 0.0002447855 5.253734e-02 1.136799e-01 15 90948654 90948794 141 + 2.772 2.813 0.136
ENSG00000140553 E044 633.885400 0.0001164210 4.692857e-02 1.036935e-01 15 90949316 90949352 37 + 2.604 2.650 0.153
ENSG00000140553 E045 656.015420 0.0001053927 2.884112e-02 6.968598e-02 15 90949353 90949443 91 + 2.616 2.665 0.164
ENSG00000140553 E046 565.078366 0.0006156144 8.612665e-03 2.531839e-02 15 90949654 90949720 67 + 2.534 2.605 0.236
ENSG00000140553 E047 28.475798 0.0011083902 6.036021e-06 4.218957e-05 15 90949721 90950153 433 + 1.589 1.253 -1.161
ENSG00000140553 E048 804.355371 0.0001942653 4.880525e-03 1.559758e-02 15 90950154 90950267 114 + 2.697 2.756 0.195
ENSG00000140553 E049 930.339838 0.0003561658 2.695537e-03 9.360660e-03 15 90950500 90950615 116 + 2.758 2.820 0.207
ENSG00000140553 E050 1012.835062 0.0007438636 3.552770e-04 1.600508e-03 15 90952929 90953046 118 + 2.780 2.860 0.268
ENSG00000140553 E051 1126.941588 0.0024908361 8.838084e-04 3.557448e-03 15 90953155 90953310 156 + 2.808 2.909 0.338
ENSG00000140553 E052 2182.583251 0.0031688618 5.343279e-05 2.989128e-04 15 90953459 90954093 635 + 3.078 3.199 0.402