ENSG00000140534

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000268138 ENSG00000140534 HEK293_OSMI2_2hA HEK293_TMG_2hB TICRR protein_coding protein_coding 23.06752 26.3053 19.82092 1.854428 0.3302379 -0.4081503 12.618220 9.8552945 12.823966 1.8232196 0.6431507 0.379533 0.54898750 0.37063333 0.64833333 0.27770000 0.0033254795 0.0005197319 FALSE TRUE
ENST00000560985 ENSG00000140534 HEK293_OSMI2_2hA HEK293_TMG_2hB TICRR protein_coding protein_coding 23.06752 26.3053 19.82092 1.854428 0.3302379 -0.4081503 5.251596 11.0755202 1.883712 1.2155878 1.2172019 -2.549387 0.21986667 0.42546667 0.09326667 -0.33220000 0.2490941075 0.0005197319 FALSE TRUE
ENST00000561095 ENSG00000140534 HEK293_OSMI2_2hA HEK293_TMG_2hB TICRR protein_coding nonsense_mediated_decay 23.06752 26.3053 19.82092 1.854428 0.3302379 -0.4081503 3.205455 4.6563346 2.315071 0.2930193 0.3670100 -1.005015 0.13697083 0.17726667 0.11636667 -0.06090000 0.1079985018 0.0005197319 TRUE TRUE
MSTRG.11502.5 ENSG00000140534 HEK293_OSMI2_2hA HEK293_TMG_2hB TICRR protein_coding   23.06752 26.3053 19.82092 1.854428 0.3302379 -0.4081503 1.855413 0.7086474 2.458429 0.2681945 0.3703507 1.780237 0.08735417 0.02616667 0.12463333 0.09846667 0.0005197319 0.0005197319 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000140534 E001 26.15423 0.0424481067 2.134566e-03 7.641335e-03 15 89575469 89575586 118 + 1.582 1.277 -1.054
ENSG00000140534 E002 76.11682 0.0307875282 1.808531e-04 8.816342e-04 15 89575587 89575868 282 + 2.027 1.735 -0.986
ENSG00000140534 E003 53.96865 0.0153509280 1.832743e-05 1.146846e-04 15 89575869 89575966 98 + 1.870 1.592 -0.941
ENSG00000140534 E004 118.40137 0.0057966207 4.490462e-11 8.398451e-10 15 89575967 89576240 274 + 2.208 1.933 -0.923
ENSG00000140534 E005 164.33650 0.0112017507 1.857890e-09 2.618642e-08 15 89582686 89582965 280 + 2.361 2.064 -0.990
ENSG00000140534 E006 43.68862 0.0117354962 2.120746e-10 3.535454e-09 15 89584286 89584288 3 + 1.846 1.415 -1.468
ENSG00000140534 E007 146.16538 0.0160908129 6.196880e-06 4.320393e-05 15 89584289 89584527 239 + 2.289 2.039 -0.835
ENSG00000140534 E008 127.42727 0.0040722902 7.979394e-10 1.205288e-08 15 89585708 89585942 235 + 2.216 1.995 -0.741
ENSG00000140534 E009 37.98234 0.0181338465 1.192041e-04 6.102322e-04 15 89592047 89592061 15 + 1.731 1.449 -0.959
ENSG00000140534 E010 83.38168 0.0051782465 7.427634e-11 1.338046e-09 15 89592062 89592176 115 + 2.067 1.776 -0.979
ENSG00000140534 E011 115.45653 0.0014056928 7.505743e-13 1.879382e-11 15 89594415 89594554 140 + 2.173 1.952 -0.739
ENSG00000140534 E012 180.47412 0.0003785208 8.972671e-16 3.413345e-14 15 89595393 89595611 219 + 2.342 2.166 -0.588
ENSG00000140534 E013 142.09636 0.0032195553 1.867344e-05 1.166488e-04 15 89599324 89599475 152 + 2.216 2.089 -0.423
ENSG00000140534 E014 100.84685 0.0003151573 1.003529e-07 1.018403e-06 15 89600585 89600685 101 + 2.077 1.931 -0.488
ENSG00000140534 E015 111.22739 0.0003032544 6.392847e-04 2.677423e-03 15 89601298 89601391 94 + 2.078 2.005 -0.244
ENSG00000140534 E016 112.80036 0.0026108861 2.645237e-02 6.485469e-02 15 89601489 89601568 80 + 2.071 2.025 -0.154
ENSG00000140534 E017 213.11251 0.0031487912 3.994859e-04 1.772398e-03 15 89601737 89601976 240 + 2.365 2.285 -0.268
ENSG00000140534 E018 141.28625 0.0022333553 8.424422e-03 2.484946e-02 15 89602796 89602892 97 + 2.171 2.118 -0.177
ENSG00000140534 E019 110.52388 0.0003097391 1.930208e-02 4.999003e-02 15 89606768 89606825 58 + 2.056 2.020 -0.123
ENSG00000140534 E020 155.92550 0.0029611326 2.559889e-02 6.311915e-02 15 89608803 89608949 147 + 2.207 2.168 -0.130
ENSG00000140534 E021 107.42275 0.0069004862 6.162933e-01 7.343769e-01 15 89616405 89616495 91 + 2.013 2.032 0.064
ENSG00000140534 E022 93.06107 0.0003352082 1.551202e-01 2.685607e-01 15 89618152 89618210 59 + 1.968 1.959 -0.032
ENSG00000140534 E023 170.50364 0.0034344248 4.010394e-02 9.122596e-02 15 89619708 89619842 135 + 2.243 2.211 -0.108
ENSG00000140534 E024 184.21780 0.0041698816 7.557244e-02 1.524298e-01 15 89621393 89621550 158 + 2.272 2.248 -0.081
ENSG00000140534 E025 1116.65074 0.0012520924 2.054049e-01 3.329227e-01 15 89623623 89625399 1777 + 2.995 3.064 0.229
ENSG00000140534 E026 418.10828 0.0007304227 1.272878e-15 4.752523e-14 15 89625400 89625786 387 + 2.468 2.687 0.730
ENSG00000140534 E027 269.36612 0.0023464887 2.894318e-11 5.590406e-10 15 89625936 89626061 126 + 2.248 2.509 0.872
ENSG00000140534 E028 366.18586 0.0084901713 2.928462e-08 3.302312e-07 15 89626956 89627182 227 + 2.344 2.656 1.039
ENSG00000140534 E029 812.82663 0.0110461428 1.899284e-14 6.002897e-13 15 89627183 89628023 841 + 2.604 3.026 1.404
ENSG00000140534 E030 57.73801 0.0011297477 1.906409e-01 3.145584e-01 15 89628052 89628385 334 + 1.773 1.753 -0.067
ENSG00000140534 E031 375.07026 0.0012616905 3.284952e-08 3.670663e-07 15 89629430 89633093 3664 + 2.445 2.629 0.611