ENSG00000140525

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000310775 ENSG00000140525 HEK293_OSMI2_2hA HEK293_TMG_2hB FANCI protein_coding protein_coding 53.86727 27.20856 84.21034 3.683652 0.6696533 1.629578 12.2373005 5.129824 20.97162611 0.8159004 2.26298881 2.0293356 0.22023750 0.1883333 0.24886667 0.06053333 3.724080e-01 7.246706e-92 FALSE TRUE
ENST00000566615 ENSG00000140525 HEK293_OSMI2_2hA HEK293_TMG_2hB FANCI protein_coding processed_transcript 53.86727 27.20856 84.21034 3.683652 0.6696533 1.629578 0.7235148 3.543763 0.06001527 2.2127039 0.06001527 -5.6655340 0.02417083 0.1162667 0.00070000 -0.11556667 3.131129e-04 7.246706e-92 FALSE TRUE
ENST00000566895 ENSG00000140525 HEK293_OSMI2_2hA HEK293_TMG_2hB FANCI protein_coding retained_intron 53.86727 27.20856 84.21034 3.683652 0.6696533 1.629578 3.6132446 1.217366 5.49577540 0.2627339 0.40785682 2.1653801 0.07040833 0.0488000 0.06520000 0.01640000 6.347135e-01 7.246706e-92 FALSE TRUE
ENST00000567891 ENSG00000140525 HEK293_OSMI2_2hA HEK293_TMG_2hB FANCI protein_coding protein_coding 53.86727 27.20856 84.21034 3.683652 0.6696533 1.629578 9.6483574 0.000000 21.20302644 0.0000000 0.10711289 11.0507347 0.13240417 0.0000000 0.25180000 0.25180000 7.246706e-92 7.246706e-92 FALSE FALSE
MSTRG.11505.8 ENSG00000140525 HEK293_OSMI2_2hA HEK293_TMG_2hB FANCI protein_coding   53.86727 27.20856 84.21034 3.683652 0.6696533 1.629578 5.0975415 5.837527 3.56178279 0.5672952 1.79113409 -0.7111822 0.13098333 0.2238333 0.04226667 -0.18156667 3.527276e-01 7.246706e-92 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000140525 E001 0.4782907 0.0207869977 1.541900e-02 4.144145e-02 15 89243945 89243948 4 + 0.000 0.398 14.031
ENSG00000140525 E002 1.6866994 0.0095577936 6.878565e-01 7.901023e-01 15 89243949 89243965 17 + 0.394 0.478 0.442
ENSG00000140525 E003 2.4606341 0.0067981415 5.637095e-01 6.911457e-01 15 89243966 89243972 7 + 0.493 0.603 0.512
ENSG00000140525 E004 2.6058068 0.0110189871 6.879103e-01 7.901497e-01 15 89243973 89243974 2 + 0.521 0.603 0.374
ENSG00000140525 E005 3.3421656 0.0086999010 7.382300e-01 8.281597e-01 15 89243975 89243978 4 + 0.641 0.603 -0.166
ENSG00000140525 E006 3.0226634 0.0051538534 2.905235e-01 4.313453e-01 15 89243979 89243979 1 + 0.641 0.478 -0.750
ENSG00000140525 E007 8.9288953 0.0621084693 1.952444e-01 3.202937e-01 15 89243980 89243982 3 + 1.037 0.843 -0.730
ENSG00000140525 E008 11.3709541 0.0093612704 1.839979e-01 3.062327e-01 15 89243983 89243989 7 + 1.115 0.979 -0.495
ENSG00000140525 E009 24.8410997 0.0013913754 2.391830e-02 5.963663e-02 15 89243990 89243995 6 + 1.437 1.280 -0.545
ENSG00000140525 E010 34.2477039 0.0007162332 4.768093e-02 1.050484e-01 15 89243996 89244003 8 + 1.559 1.449 -0.378
ENSG00000140525 E011 45.6997636 0.0005030920 1.656990e-02 4.399357e-02 15 89244004 89244007 4 + 1.682 1.564 -0.400
ENSG00000140525 E012 54.4581811 0.0007322772 3.259849e-01 4.694292e-01 15 89244008 89244016 9 + 1.732 1.701 -0.106
ENSG00000140525 E013 80.7466597 0.0054969900 1.962553e-01 3.215371e-01 15 89244017 89244033 17 + 1.907 1.850 -0.191
ENSG00000140525 E014 51.8127765 0.0004600204 1.183619e-01 2.175876e-01 15 89244034 89244038 5 + 1.718 1.655 -0.215
ENSG00000140525 E015 71.1410775 0.0011445751 9.426750e-02 1.817882e-01 15 89244039 89244044 6 + 1.854 1.794 -0.203
ENSG00000140525 E016 64.4580336 0.0076523278 8.703890e-02 1.706539e-01 15 89244045 89244067 23 + 1.822 1.729 -0.315
ENSG00000140525 E017 3.2432033 0.0489616089 8.654338e-01 9.173115e-01 15 89244175 89244249 75 + 0.620 0.602 -0.076
ENSG00000140525 E018 2.7574239 0.0121805665 4.437307e-01 5.853226e-01 15 89244250 89244280 31 + 0.597 0.478 -0.557
ENSG00000140525 E019 18.1260493 0.0022677850 4.418316e-02 9.872811e-02 15 89245195 89245311 117 + 1.310 1.148 -0.573
ENSG00000140525 E020 8.3277830 0.0021131327 6.435762e-03 1.975495e-02 15 89245607 89245708 102 + 1.038 0.700 -1.304
ENSG00000140525 E021 25.0050168 0.0008694288 9.662233e-01 9.828012e-01 15 89245756 89245839 84 + 1.391 1.408 0.057
ENSG00000140525 E022 1.1146300 0.0260911471 9.132351e-01 9.490193e-01 15 89247602 89247628 27 + 0.313 0.302 -0.071
ENSG00000140525 E023 247.1798477 0.0014210359 1.908156e-04 9.247035e-04 15 89247629 89247726 98 + 2.402 2.307 -0.318
ENSG00000140525 E024 122.0324237 0.0013465443 1.460761e-03 5.509611e-03 15 89247727 89247731 5 + 2.100 1.995 -0.353
ENSG00000140525 E025 0.1472490 0.0439822357 1.000000e+00   15 89254551 89254814 264 + 0.083 0.000 -10.316
ENSG00000140525 E026 253.0455117 0.0022016245 7.133127e-04 2.946299e-03 15 89258704 89258776 73 + 2.412 2.316 -0.318
ENSG00000140525 E027 1.1050651 0.0445971156 5.130099e-01 6.478608e-01 15 89258777 89259350 574 + 0.266 0.398 0.833
ENSG00000140525 E028 314.7315904 0.0001748483 3.131291e-07 2.885982e-06 15 89260713 89260843 131 + 2.506 2.411 -0.315
ENSG00000140525 E029 304.2169665 0.0004074392 2.933790e-09 3.989074e-08 15 89261585 89261741 157 + 2.500 2.377 -0.412
ENSG00000140525 E030 152.9358363 0.0002743182 1.252026e-05 8.135015e-05 15 89261821 89261837 17 + 2.201 2.081 -0.404
ENSG00000140525 E031 152.2750395 0.0002190257 1.436152e-02 3.904944e-02 15 89261838 89261878 41 + 2.182 2.125 -0.189
ENSG00000140525 E032 122.9733497 0.0002392060 2.872743e-01 4.277615e-01 15 89263419 89263436 18 + 2.077 2.060 -0.055
ENSG00000140525 E033 139.3951966 0.0002349091 7.302824e-02 1.483740e-01 15 89263437 89263460 24 + 2.138 2.100 -0.128
ENSG00000140525 E034 227.6816910 0.0001873972 2.719849e-03 9.432118e-03 15 89263903 89264026 124 + 2.357 2.300 -0.190
ENSG00000140525 E035 0.2987644 0.0274258503 5.433247e-01   15 89264027 89264037 11 + 0.153 0.000 -11.317
ENSG00000140525 E036 196.5207169 0.0012505081 7.344451e-05 3.967222e-04 15 89264522 89264607 86 + 2.308 2.199 -0.363
ENSG00000140525 E037 3.7922223 0.0110760658 1.385182e-05 8.905810e-05 15 89264608 89264651 44 + 0.313 0.979 3.016
ENSG00000140525 E038 243.8171625 0.0002872615 1.287546e-14 4.170316e-13 15 89268399 89268525 127 + 2.422 2.238 -0.613
ENSG00000140525 E039 8.3162457 0.0031942749 4.588004e-03 1.478631e-02 15 89268526 89268544 19 + 0.812 1.147 1.249
ENSG00000140525 E040 7.5130670 0.0330007328 5.464402e-02 1.173793e-01 15 89268545 89268631 87 + 0.798 1.092 1.106
ENSG00000140525 E041 215.4182002 0.0005262056 6.819170e-14 1.983527e-12 15 89273377 89273469 93 + 2.372 2.173 -0.665
ENSG00000140525 E042 210.4643188 0.0020266832 7.066137e-07 6.061941e-06 15 89274168 89274304 137 + 2.348 2.191 -0.527
ENSG00000140525 E043 283.6374733 0.0055315703 1.589471e-03 5.925004e-03 15 89276711 89276891 181 + 2.468 2.344 -0.413
ENSG00000140525 E044 176.2232092 0.0045816878 4.322884e-05 2.472847e-04 15 89278687 89278774 88 + 2.274 2.104 -0.568
ENSG00000140525 E045 216.9894702 0.0090238218 1.360060e-03 5.176791e-03 15 89281170 89281300 131 + 2.362 2.204 -0.525
ENSG00000140525 E046 188.6667276 0.0113619493 7.889138e-03 2.350106e-02 15 89281765 89281835 71 + 2.297 2.154 -0.479
ENSG00000140525 E047 109.1528456 0.0360106053 6.557494e-04 2.736820e-03 15 89281836 89282992 1157 + 2.104 1.766 -1.136
ENSG00000140525 E048 28.4127218 0.0265199776 9.260876e-03 2.693594e-02 15 89282993 89283135 143 + 1.517 1.237 -0.970
ENSG00000140525 E049 245.0337517 0.0062166655 1.719178e-02 4.536496e-02 15 89283136 89283250 115 + 2.397 2.302 -0.317
ENSG00000140525 E050 242.4097049 0.0003469176 5.937700e-06 4.157290e-05 15 89285096 89285218 123 + 2.394 2.295 -0.331
ENSG00000140525 E051 195.7384852 0.0002071389 6.176374e-07 5.365688e-06 15 89290213 89290281 69 + 2.310 2.189 -0.404
ENSG00000140525 E052 0.4460135 0.0341217363 3.116394e-01 4.541089e-01 15 89290282 89290592 311 + 0.213 0.000 -11.902
ENSG00000140525 E053 259.3897856 0.0017885704 1.849177e-05 1.156328e-04 15 89291613 89291714 102 + 2.429 2.310 -0.396
ENSG00000140525 E054 311.9444952 0.0017309919 8.241486e-03 2.439684e-02 15 89292688 89292864 177 + 2.492 2.431 -0.204
ENSG00000140525 E055 219.7894712 0.0025003677 8.444885e-01 9.031960e-01 15 89292942 89293063 122 + 2.317 2.325 0.027
ENSG00000140525 E056 293.0073174 0.0007934354 3.147788e-01 4.575221e-01 15 89293833 89293997 165 + 2.447 2.439 -0.027
ENSG00000140525 E057 170.3035134 0.0016714437 2.947803e-01 4.358858e-01 15 89294915 89294956 42 + 2.216 2.195 -0.068
ENSG00000140525 E058 309.3970380 0.0003662137 4.136747e-01 5.570979e-01 15 89294957 89295094 138 + 2.470 2.470 0.003
ENSG00000140525 E059 16.3425039 0.0021393015 1.615701e-01 2.771522e-01 15 89299199 89299799 601 + 1.161 1.303 0.498
ENSG00000140525 E060 350.9801080 0.0005840980 5.252037e-02 1.136500e-01 15 89299800 89299966 167 + 2.502 2.565 0.210
ENSG00000140525 E061 279.3580549 0.0023650483 6.677227e-02 1.380230e-01 15 89300300 89300385 86 + 2.399 2.477 0.260
ENSG00000140525 E062 301.7638581 0.0020325381 6.074137e-02 1.278755e-01 15 89301326 89301442 117 + 2.432 2.509 0.256
ENSG00000140525 E063 33.2931206 0.0234246566 6.550573e-01 7.650391e-01 15 89301443 89303863 2421 + 1.488 1.545 0.197
ENSG00000140525 E064 227.2798554 0.0001762907 1.343469e-01 2.402026e-01 15 89303864 89303915 52 + 2.317 2.374 0.193
ENSG00000140525 E065 13.3482915 0.0380784803 1.188005e-01 2.182358e-01 15 89303916 89305114 1199 + 1.047 1.260 0.764
ENSG00000140525 E066 320.9764246 0.0003159576 2.725390e-02 6.650484e-02 15 89305115 89305242 128 + 2.462 2.531 0.230
ENSG00000140525 E067 260.6151230 0.0007945100 2.642808e-04 1.234106e-03 15 89305341 89305409 69 + 2.354 2.469 0.385
ENSG00000140525 E068 328.2390226 0.0007439437 1.602703e-03 5.970037e-03 15 89305605 89305698 94 + 2.461 2.555 0.316
ENSG00000140525 E069 169.2591669 0.0004072484 1.960879e-01 3.213309e-01 15 89306007 89306009 3 + 2.189 2.248 0.196
ENSG00000140525 E070 373.5831286 0.0025332185 8.688213e-05 4.604716e-04 15 89306010 89306194 185 + 2.499 2.638 0.463
ENSG00000140525 E071 6.6588564 0.0055991054 2.638497e-01 4.017613e-01 15 89306859 89307475 617 + 0.798 0.956 0.607
ENSG00000140525 E072 177.0756606 0.0008698191 6.371391e-10 9.806962e-09 15 89307476 89307529 54 + 2.148 2.356 0.693
ENSG00000140525 E073 187.9260483 0.0020967451 5.708713e-07 4.995605e-06 15 89307613 89307672 60 + 2.181 2.374 0.644
ENSG00000140525 E074 4.3500249 0.0038057244 2.547365e-03 8.904708e-03 15 89307673 89307858 186 + 0.521 0.955 1.790
ENSG00000140525 E075 5.7979791 0.0028691535 3.565438e-01 5.009244e-01 15 89307859 89308092 234 + 0.767 0.904 0.533
ENSG00000140525 E076 8.7668893 0.0056743241 4.332376e-03 1.407570e-02 15 89308093 89308729 637 + 0.839 1.176 1.245
ENSG00000140525 E077 5.3465242 0.0106995824 1.145871e-02 3.225489e-02 15 89308923 89309671 749 + 0.620 0.980 1.433
ENSG00000140525 E078 11.8833735 0.0017160192 9.543214e-01 9.753790e-01 15 89309672 89311646 1975 + 1.086 1.098 0.046
ENSG00000140525 E079 1.7005307 0.0105430576 8.132391e-01 8.815845e-01 15 89311647 89311778 132 + 0.429 0.399 -0.165
ENSG00000140525 E080 10.6402541 0.0397093307 8.109713e-02 1.612639e-01 15 89311779 89312903 1125 + 0.945 1.201 0.930
ENSG00000140525 E081 252.7710914 0.0008993197 6.462935e-19 3.637503e-17 15 89312904 89312972 69 + 2.281 2.536 0.853
ENSG00000140525 E082 315.1848045 0.0033731004 1.909191e-11 3.796878e-10 15 89314612 89314707 96 + 2.376 2.628 0.840
ENSG00000140525 E083 321.1880948 0.0027396953 1.703104e-13 4.691697e-12 15 89315282 89315389 108 + 2.382 2.640 0.858
ENSG00000140525 E084 766.0926141 0.0053350090 8.150030e-14 2.347118e-12 15 89316397 89317261 865 + 2.740 3.033 0.974