ENSG00000140521

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000268124 ENSG00000140521 HEK293_OSMI2_2hA HEK293_TMG_2hB POLG protein_coding protein_coding 74.9305 96.37881 53.50219 5.687316 3.070702 -0.848998 5.089888 6.366428 0.8821538 1.068448 0.8821538 -2.8373842 0.06302917 0.0652000 0.01583333 -0.04936667 1.124691e-01 6.465934e-07 FALSE TRUE
ENST00000442287 ENSG00000140521 HEK293_OSMI2_2hA HEK293_TMG_2hB POLG protein_coding protein_coding 74.9305 96.37881 53.50219 5.687316 3.070702 -0.848998 22.893218 30.607349 14.9156670 2.359376 0.1924064 -1.0365540 0.30559583 0.3169667 0.28086667 -0.03610000 4.813064e-01 6.465934e-07 FALSE TRUE
ENST00000636937 ENSG00000140521 HEK293_OSMI2_2hA HEK293_TMG_2hB POLG protein_coding processed_transcript 74.9305 96.37881 53.50219 5.687316 3.070702 -0.848998 8.778320 5.700229 9.8281862 2.433616 2.4221154 0.7848437 0.11799167 0.0573000 0.18156667 0.12426667 3.501234e-02 6.465934e-07   FALSE
ENST00000637264 ENSG00000140521 HEK293_OSMI2_2hA HEK293_TMG_2hB POLG protein_coding protein_coding 74.9305 96.37881 53.50219 5.687316 3.070702 -0.848998 6.544124 15.925339 1.5617436 0.554932 0.3420099 -3.3417919 0.07934167 0.1671333 0.02963333 -0.13750000 6.465934e-07 6.465934e-07 FALSE TRUE
MSTRG.11506.16 ENSG00000140521 HEK293_OSMI2_2hA HEK293_TMG_2hB POLG protein_coding   74.9305 96.37881 53.50219 5.687316 3.070702 -0.848998 6.809929 13.649374 3.0275377 1.824721 0.6194060 -2.1689171 0.08277500 0.1426667 0.05813333 -0.08453333 4.174865e-02 6.465934e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000140521 E001 0.5901394 0.2956445844 8.044549e-01 8.756094e-01 15 89305198 89305224 27 - 0.186 0.150 -0.374
ENSG00000140521 E002 7.6266288 0.0084772818 5.864078e-01 7.099741e-01 15 89316305 89316319 15 - 0.802 0.879 0.300
ENSG00000140521 E003 10.9204506 0.0209104369 2.225827e-01 3.534789e-01 15 89316320 89316327 8 - 0.870 1.041 0.640
ENSG00000140521 E004 17.4086999 0.0068877482 3.692051e-01 5.136391e-01 15 89316328 89316329 2 - 1.257 1.174 -0.296
ENSG00000140521 E005 53.0571894 0.0005667509 2.497852e-04 1.174401e-03 15 89316330 89316338 9 - 1.482 1.708 0.768
ENSG00000140521 E006 54.0932525 0.0008914161 1.471887e-04 7.350200e-04 15 89316339 89316340 2 - 1.482 1.717 0.802
ENSG00000140521 E007 61.2556709 0.0004545852 6.454326e-05 3.536420e-04 15 89316341 89316349 9 - 1.539 1.769 0.780
ENSG00000140521 E008 66.3270959 0.0005400928 5.986701e-06 4.189121e-05 15 89316350 89316354 5 - 1.553 1.807 0.863
ENSG00000140521 E009 74.9541604 0.0005108779 4.145328e-06 3.003595e-05 15 89316355 89316356 2 - 1.613 1.856 0.823
ENSG00000140521 E010 431.5777850 0.0054579232 5.608403e-07 4.915318e-06 15 89316357 89316516 160 - 2.390 2.608 0.726
ENSG00000140521 E011 756.9238683 0.0021044037 2.238772e-10 3.716514e-09 15 89316517 89316683 167 - 2.666 2.844 0.594
ENSG00000140521 E012 397.8081228 0.0001429923 2.782966e-12 6.352869e-11 15 89316684 89316705 22 - 2.401 2.559 0.527
ENSG00000140521 E013 648.5164513 0.0003703595 3.010077e-17 1.380751e-15 15 89316706 89316827 122 - 2.606 2.773 0.554
ENSG00000140521 E014 527.8300138 0.0012946226 2.411243e-03 8.495446e-03 15 89317376 89317442 67 - 2.587 2.668 0.271
ENSG00000140521 E015 402.3551036 0.0021000441 2.918246e-02 7.035533e-02 15 89317443 89317471 29 - 2.478 2.550 0.240
ENSG00000140521 E016 300.3276492 0.0024006303 1.275705e-01 2.307637e-01 15 89317472 89317476 5 - 2.363 2.420 0.189
ENSG00000140521 E017 459.1046374 0.0027917294 8.745262e-03 2.564848e-02 15 89317477 89317536 60 - 2.520 2.610 0.301
ENSG00000140521 E018 56.5249376 0.0087914937 6.950730e-11 1.259609e-09 15 89317537 89317938 402 - 1.968 1.543 -1.437
ENSG00000140521 E019 43.0505000 0.0008882744 9.690716e-04 3.852676e-03 15 89317939 89317975 37 - 1.709 1.520 -0.642
ENSG00000140521 E020 37.2554576 0.0015872900 2.283320e-02 5.739792e-02 15 89317976 89318037 62 - 1.619 1.476 -0.486
ENSG00000140521 E021 60.0124512 0.0085260757 5.818081e-09 7.508298e-08 15 89318038 89318540 503 - 1.960 1.593 -1.241
ENSG00000140521 E022 740.2693789 0.0011374814 1.310730e-06 1.061307e-05 15 89318541 89318749 209 - 2.708 2.821 0.377
ENSG00000140521 E023 538.9100336 0.0003018612 9.788291e-05 5.121013e-04 15 89318931 89319063 133 - 2.595 2.675 0.266
ENSG00000140521 E024 366.3708141 0.0001511343 2.872855e-02 6.946177e-02 15 89319064 89319099 36 - 2.451 2.502 0.170
ENSG00000140521 E025 354.2134823 0.0001644731 1.290309e-01 2.328270e-01 15 89319228 89319262 35 - 2.447 2.483 0.123
ENSG00000140521 E026 270.9269654 0.0001849440 3.676088e-02 8.501580e-02 15 89319263 89319267 5 - 2.315 2.371 0.189
ENSG00000140521 E027 376.3889889 0.0001677544 5.376564e-01 6.691780e-01 15 89319268 89319291 24 - 2.489 2.505 0.053
ENSG00000140521 E028 431.8782856 0.0001398673 8.112038e-01 8.802056e-01 15 89319292 89319337 46 - 2.555 2.563 0.025
ENSG00000140521 E029 332.3420724 0.0001497483 8.444824e-01 9.031960e-01 15 89319338 89319350 13 - 2.443 2.450 0.023
ENSG00000140521 E030 27.9181505 0.0007203163 1.231814e-13 3.454678e-12 15 89319351 89319401 51 - 1.704 1.217 -1.681
ENSG00000140521 E031 17.1264469 0.0010832418 4.220896e-08 4.621105e-07 15 89319402 89319408 7 - 1.482 1.030 -1.594
ENSG00000140521 E032 401.8748803 0.0001352494 4.113279e-02 9.313191e-02 15 89320766 89320819 54 - 2.495 2.541 0.152
ENSG00000140521 E033 374.3442783 0.0001386274 2.148390e-01 3.442581e-01 15 89320820 89320869 50 - 2.477 2.506 0.098
ENSG00000140521 E034 535.9211249 0.0005045232 4.621652e-01 6.020436e-01 15 89320870 89321012 143 - 2.641 2.659 0.062
ENSG00000140521 E035 18.8308917 0.0036207128 2.574033e-13 6.904187e-12 15 89321013 89321124 112 - 1.590 0.989 -2.113
ENSG00000140521 E036 462.4377424 0.0001589975 3.963109e-01 5.400928e-01 15 89321125 89321260 136 - 2.575 2.595 0.065
ENSG00000140521 E037 296.9480727 0.0001777220 5.648892e-01 6.921124e-01 15 89321736 89321774 39 - 2.388 2.405 0.055
ENSG00000140521 E038 380.7938136 0.0002584343 9.788941e-01 9.908456e-01 15 89321775 89321853 79 - 2.504 2.506 0.007
ENSG00000140521 E039 13.6733456 0.0157182474 1.121993e-07 1.129608e-06 15 89321854 89321961 108 - 1.451 0.889 -2.013
ENSG00000140521 E040 290.9314861 0.0012021784 8.914778e-01 9.346981e-01 15 89321962 89322015 54 - 2.383 2.391 0.026
ENSG00000140521 E041 290.6261235 0.0009761905 5.104522e-01 6.456508e-01 15 89322742 89322804 63 - 2.372 2.394 0.074
ENSG00000140521 E042 390.4409556 0.0006919174 1.901065e-01 3.139146e-01 15 89322805 89322902 98 - 2.491 2.526 0.117
ENSG00000140521 E043 430.8484047 0.0009750026 4.345623e-01 5.769039e-01 15 89323404 89323511 108 - 2.543 2.566 0.077
ENSG00000140521 E044 9.6537103 0.0017840942 1.303197e-01 2.346030e-01 15 89323512 89323513 2 - 1.087 0.921 -0.611
ENSG00000140521 E045 8.7388719 0.0018786240 4.940818e-02 1.081070e-01 15 89323514 89323519 6 - 1.087 0.866 -0.820
ENSG00000140521 E046 9.8901223 0.0016760390 3.251444e-03 1.100528e-02 15 89323520 89323552 33 - 1.188 0.878 -1.138
ENSG00000140521 E047 9.7718273 0.0075496443 1.292983e-12 3.113661e-11 15 89323553 89323814 262 - 1.398 0.622 -2.916
ENSG00000140521 E048 385.1967268 0.0005830528 5.295290e-01 6.622984e-01 15 89323815 89323901 87 - 2.521 2.509 -0.039
ENSG00000140521 E049 315.1408158 0.0001518207 4.829214e-01 6.210250e-01 15 89324107 89324187 81 - 2.436 2.423 -0.046
ENSG00000140521 E050 242.2004305 0.0001816473 9.439291e-02 1.819764e-01 15 89324188 89324227 40 - 2.344 2.303 -0.138
ENSG00000140521 E051 0.7727888 0.0603886443 5.453330e-01 6.757124e-01 15 89324228 89324291 64 - 0.315 0.202 -0.851
ENSG00000140521 E052 236.6931116 0.0002433539 1.583793e-01 2.729640e-01 15 89325450 89325489 40 - 2.329 2.294 -0.118
ENSG00000140521 E053 547.9253422 0.0002386049 4.150022e-02 9.381076e-02 15 89325490 89325686 197 - 2.691 2.656 -0.115
ENSG00000140521 E054 421.5640110 0.0001374370 1.120716e-01 2.085826e-01 15 89326612 89326738 127 - 2.574 2.544 -0.098
ENSG00000140521 E055 343.1355822 0.0001501305 8.121717e-01 8.808710e-01 15 89326912 89327012 101 - 2.457 2.465 0.026
ENSG00000140521 E056 293.9084906 0.0007628693 3.154481e-01 4.582243e-01 15 89327013 89327063 51 - 2.415 2.391 -0.078
ENSG00000140521 E057 14.7875289 0.0973649492 1.486619e-02 4.018829e-02 15 89327064 89327079 16 - 1.409 0.987 -1.499
ENSG00000140521 E058 19.5655844 0.0558258613 1.935596e-03 7.026518e-03 15 89327080 89327166 87 - 1.526 1.101 -1.490
ENSG00000140521 E059 447.5429617 0.0001610970 1.719110e-02 4.536442e-02 15 89327167 89327349 183 - 2.610 2.566 -0.146
ENSG00000140521 E060 42.4708028 0.0033545700 2.743165e-17 1.264746e-15 15 89327350 89328455 1106 - 1.885 1.379 -1.725
ENSG00000140521 E061 278.0840423 0.0004051064 6.460821e-04 2.702069e-03 15 89328456 89328535 80 - 2.433 2.350 -0.278
ENSG00000140521 E062 395.1669859 0.0012916096 2.804590e-04 1.300218e-03 15 89328685 89328831 147 - 2.593 2.502 -0.304
ENSG00000140521 E063 419.0995418 0.0006806423 5.939074e-04 2.511321e-03 15 89328943 89329110 168 - 2.607 2.532 -0.249
ENSG00000140521 E064 338.9423878 0.0027875949 5.115702e-03 1.624517e-02 15 89330081 89330207 127 - 2.526 2.437 -0.295
ENSG00000140521 E065 154.0615048 0.0030312460 2.871317e-02 6.942848e-02 15 89330208 89330210 3 - 2.184 2.097 -0.289
ENSG00000140521 E066 204.3015478 0.0014215542 4.385975e-02 9.812583e-02 15 89330211 89330261 51 - 2.287 2.224 -0.211
ENSG00000140521 E067 139.2973498 0.0017687597 4.021749e-01 5.458891e-01 15 89330262 89330276 15 - 2.096 2.067 -0.099
ENSG00000140521 E068 13.4288649 0.0054029533 1.417546e-04 7.110887e-04 15 89332218 89332374 157 - 1.339 0.971 -1.319
ENSG00000140521 E069 605.0904354 0.0047541676 3.013701e-04 1.385231e-03 15 89333096 89333792 697 - 2.801 2.677 -0.411
ENSG00000140521 E070 163.4854001 0.0008674207 7.113172e-14 2.063343e-12 15 89333793 89333827 35 - 2.310 2.072 -0.798
ENSG00000140521 E071 135.6680981 0.0015087134 1.233894e-10 2.145549e-09 15 89333828 89333849 22 - 2.230 1.995 -0.784
ENSG00000140521 E072 197.8473968 0.0006155883 1.354047e-17 6.538879e-16 15 89333850 89333913 64 - 2.397 2.153 -0.814
ENSG00000140521 E073 21.3485101 0.0008943529 4.992917e-16 1.962841e-14 15 89333949 89334013 65 - 1.646 1.046 -2.094
ENSG00000140521 E074 16.5291928 0.0010649803 3.028101e-18 1.570393e-16 15 89334367 89334672 306 - 1.590 0.866 -2.576
ENSG00000140521 E075 33.3819734 0.0009049342 1.818722e-07 1.756840e-06 15 89334673 89334684 12 - 1.686 1.359 -1.121
ENSG00000140521 E076 159.2633173 0.0005159202 4.589726e-16 1.811102e-14 15 89334685 89334861 177 - 2.307 2.056 -0.840