ENSG00000140471

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000314742 ENSG00000140471 HEK293_OSMI2_2hA HEK293_TMG_2hB LINS1 protein_coding protein_coding 9.154898 3.316984 13.04085 0.6166946 0.4357407 1.971856 0.5563410 0.23098414 0.7627946 0.03561088 0.06342553 1.681147 0.07301250 0.07376667 0.05833333 -0.015433333 8.730593e-01 1.873417e-05 FALSE TRUE
ENST00000559169 ENSG00000140471 HEK293_OSMI2_2hA HEK293_TMG_2hB LINS1 protein_coding retained_intron 9.154898 3.316984 13.04085 0.6166946 0.4357407 1.971856 1.7364627 0.98779493 2.1151260 0.22596539 0.13724301 1.090733 0.22554583 0.29366667 0.16186667 -0.131800000 1.437224e-03 1.873417e-05 FALSE TRUE
ENST00000559736 ENSG00000140471 HEK293_OSMI2_2hA HEK293_TMG_2hB LINS1 protein_coding protein_coding 9.154898 3.316984 13.04085 0.6166946 0.4357407 1.971856 0.3837115 0.02698752 0.8735149 0.02698752 0.15696289 4.578144 0.03253333 0.01006667 0.06786667 0.057800000 3.221274e-02 1.873417e-05 FALSE FALSE
ENST00000560272 ENSG00000140471 HEK293_OSMI2_2hA HEK293_TMG_2hB LINS1 protein_coding protein_coding 9.154898 3.316984 13.04085 0.6166946 0.4357407 1.971856 0.7359741 0.00000000 1.0037322 0.00000000 0.54449798 6.663533 0.05031667 0.00000000 0.07433333 0.074333333 3.782527e-01 1.873417e-05 FALSE FALSE
ENST00000561233 ENSG00000140471 HEK293_OSMI2_2hA HEK293_TMG_2hB LINS1 protein_coding processed_transcript 9.154898 3.316984 13.04085 0.6166946 0.4357407 1.971856 0.6136369 0.40223035 0.7779602 0.13206278 0.17479052 0.934672 0.07250833 0.11553333 0.05920000 -0.056333333 1.551168e-01 1.873417e-05   FALSE
ENST00000561308 ENSG00000140471 HEK293_OSMI2_2hA HEK293_TMG_2hB LINS1 protein_coding protein_coding 9.154898 3.316984 13.04085 0.6166946 0.4357407 1.971856 1.4182957 0.12799222 2.7577423 0.06605776 0.15799712 4.326051 0.11355000 0.03896667 0.21223333 0.173266667 1.873417e-05 1.873417e-05 FALSE TRUE
MSTRG.11663.3 ENSG00000140471 HEK293_OSMI2_2hA HEK293_TMG_2hB LINS1 protein_coding   9.154898 3.316984 13.04085 0.6166946 0.4357407 1.971856 1.7841426 0.92904465 2.5477413 0.18330364 0.05349926 1.445605 0.20731667 0.28083333 0.19570000 -0.085133333 1.089138e-01 1.873417e-05 TRUE TRUE
MSTRG.11663.5 ENSG00000140471 HEK293_OSMI2_2hA HEK293_TMG_2hB LINS1 protein_coding   9.154898 3.316984 13.04085 0.6166946 0.4357407 1.971856 0.8859113 0.36566022 1.3328061 0.11728092 0.24467583 1.837751 0.09670833 0.10533333 0.10320000 -0.002133333 9.492527e-01 1.873417e-05 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000140471 E001 1.7693146 0.0081203991 1.638114e-01 2.801015e-01 15 100559369 100559523 155 - 0.333 0.575 1.257
ENSG00000140471 E002 1.2932139 0.1002856555 9.754411e-01 9.886706e-01 15 100564692 100564785 94 - 0.333 0.325 -0.054
ENSG00000140471 E003 0.8899506 0.0131750964 1.269967e-01 2.299612e-01 15 100565195 100565265 71 - 0.333 0.000 -10.839
ENSG00000140471 E004 25.0382379 0.0327263987 6.264892e-01 7.424310e-01 15 100566924 100569234 2311 - 1.364 1.397 0.115
ENSG00000140471 E005 65.2032382 0.0003844549 9.797715e-04 3.890724e-03 15 100569235 100569688 454 - 1.742 1.886 0.488
ENSG00000140471 E006 45.1766885 0.0005508839 1.111381e-02 3.143819e-02 15 100569689 100569813 125 - 1.587 1.722 0.459
ENSG00000140471 E007 32.7875679 0.0014577471 2.182708e-04 1.042158e-03 15 100569814 100569897 84 - 1.411 1.643 0.793
ENSG00000140471 E008 45.8070614 0.0006954266 1.425386e-04 7.144921e-04 15 100569898 100570117 220 - 1.565 1.766 0.680
ENSG00000140471 E009 5.6472672 0.0064831494 4.554654e-02 1.011981e-01 15 100570361 100570631 271 - 0.702 0.966 1.032
ENSG00000140471 E010 41.0294723 0.0005830354 3.319996e-01 4.756261e-01 15 100571894 100572009 116 - 1.572 1.626 0.186
ENSG00000140471 E011 19.6480322 0.0009674857 6.926214e-01 7.938091e-01 15 100572010 100572021 12 - 1.276 1.307 0.109
ENSG00000140471 E012 22.7649656 0.0008498468 7.761566e-01 8.558672e-01 15 100572022 100572065 44 - 1.341 1.362 0.072
ENSG00000140471 E013 20.9018804 0.0012261963 1.722070e-01 2.910760e-01 15 100572066 100572202 137 - 1.276 1.382 0.372
ENSG00000140471 E014 69.9242692 0.0004391130 7.317919e-03 2.204417e-02 15 100572203 100573300 1098 - 1.781 1.896 0.387
ENSG00000140471 E015 6.8400717 0.0356524122 5.153811e-02 1.118874e-01 15 100573301 100573414 114 - 0.764 1.070 1.163
ENSG00000140471 E016 6.0390540 0.0903464793 7.671203e-02 1.542315e-01 15 100573415 100573476 62 - 0.686 1.045 1.391
ENSG00000140471 E017 13.4010944 0.0014998325 7.646660e-01 8.476815e-01 15 100573477 100573650 174 - 1.124 1.153 0.103
ENSG00000140471 E018 95.4512595 0.0059861664 1.475453e-01 2.583556e-01 15 100573651 100574232 582 - 1.972 1.891 -0.270
ENSG00000140471 E019 15.0761792 0.0055741774 4.912510e-01 6.285484e-01 15 100574233 100574241 9 - 1.193 1.118 -0.269
ENSG00000140471 E020 19.6239998 0.0040084183 1.790476e-01 2.999448e-01 15 100574987 100575021 35 - 1.314 1.185 -0.453
ENSG00000140471 E021 20.2708134 0.0009559445 1.133030e-03 4.414650e-03 15 100575022 100575043 22 - 1.364 1.060 -1.078
ENSG00000140471 E022 22.4809421 0.0009112975 2.028633e-02 5.208273e-02 15 100575044 100575128 85 - 1.385 1.185 -0.699
ENSG00000140471 E023 1.7609868 0.0601353637 2.283349e-02 5.739792e-02 15 100576575 100576702 128 - 0.519 0.000 -11.800
ENSG00000140471 E024 16.8590715 0.0011451000 6.485921e-01 7.600663e-01 15 100580263 100580319 57 - 1.229 1.185 -0.155
ENSG00000140471 E025 14.6863930 0.0094415119 2.219163e-01 3.526842e-01 15 100580320 100580352 33 - 1.198 1.059 -0.501
ENSG00000140471 E026 12.1001911 0.0163618061 3.436541e-01 4.877160e-01 15 100580444 100580455 12 - 1.117 0.991 -0.460
ENSG00000140471 E027 60.4220950 0.0004473472 1.187875e-06 9.708345e-06 15 100580456 100580736 281 - 1.815 1.553 -0.891
ENSG00000140471 E028 33.4380442 0.0006215302 1.778521e-04 8.689503e-04 15 100580737 100580800 64 - 1.567 1.295 -0.940
ENSG00000140471 E029 27.7115763 0.0007711697 5.570070e-03 1.747537e-02 15 100580801 100580898 98 - 1.475 1.257 -0.755
ENSG00000140471 E030 17.3402404 0.0010144488 2.027625e-02 5.206601e-02 15 100580899 100580945 47 - 1.285 1.059 -0.802
ENSG00000140471 E031 2.6885132 0.0055744483 1.247064e-01 2.267169e-01 15 100586224 100586332 109 - 0.610 0.323 -1.480
ENSG00000140471 E032 0.1472490 0.0441307227 1.000000e+00   15 100596910 100596936 27 - 0.076 0.000 -8.343
ENSG00000140471 E033 1.1854928 0.0127884630 3.655372e-01 5.098492e-01 15 100602117 100602120 4 - 0.370 0.191 -1.289
ENSG00000140471 E034 13.7886321 0.0012727453 6.388815e-02 1.331714e-01 15 100602121 100602203 83 - 1.188 0.992 -0.710
ENSG00000140471 E035 0.5159433 0.2532315436 7.128149e-01 8.094244e-01 15 100602519 100603009 491 - 0.141 0.193 0.546
ENSG00000140471 E036 0.0000000       15 100603197 100603230 34 -