ENSG00000140471

1 Isoform Switch

Summary Plot
Results

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Rows: 1-8 / 8
Columns:
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isoform_id
gene_id
condition_1
condition_2
gene_name
gene_biotype
iso_biotype
gene_overall_mean
gene_value_1
gene_value_2
gene_stderr_1
gene_stderr_2
gene_log2_fold_change
iso_overall_mean
iso_value_1
iso_value_2
iso_stderr_1
iso_stderr_2
iso_log2_fold_change
IF_overall
IF1
IF2
dIF
isoform_switch_q_value
gene_switch_q_value
PTC
codingPotential
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isoform_id	gene_id	condition_1	condition_2	gene_name	gene_biotype	iso_biotype	gene_overall_mean	gene_value_1	gene_value_2	gene_stderr_1	gene_stderr_2	gene_log2_fold_change	iso_overall_mean	iso_value_1	iso_value_2	iso_stderr_1	iso_stderr_2	iso_log2_fold_change	IF_overall	IF1	IF2	dIF	isoform_switch_q_value	gene_switch_q_value	PTC	codingPotential

ENST00000314742	ENSG00000140471	HEK293_OSMI2_2hA	HEK293_TMG_2hB	LINS1	protein_coding	protein_coding	9.154898	3.316984	13.04085	0.6166946	0.4357407	1.971856	0.5563410	0.23098414	0.7627946	0.03561088	0.06342553	1.681147	0.07301250	0.07376667	0.05833333	-0.015433333	8.730593e-01	1.873417e-05	FALSE	TRUE
ENST00000559169	ENSG00000140471	HEK293_OSMI2_2hA	HEK293_TMG_2hB	LINS1	protein_coding	retained_intron	9.154898	3.316984	13.04085	0.6166946	0.4357407	1.971856	1.7364627	0.98779493	2.1151260	0.22596539	0.13724301	1.090733	0.22554583	0.29366667	0.16186667	-0.131800000	1.437224e-03	1.873417e-05	FALSE	TRUE
ENST00000559736	ENSG00000140471	HEK293_OSMI2_2hA	HEK293_TMG_2hB	LINS1	protein_coding	protein_coding	9.154898	3.316984	13.04085	0.6166946	0.4357407	1.971856	0.3837115	0.02698752	0.8735149	0.02698752	0.15696289	4.578144	0.03253333	0.01006667	0.06786667	0.057800000	3.221274e-02	1.873417e-05	FALSE	FALSE
ENST00000560272	ENSG00000140471	HEK293_OSMI2_2hA	HEK293_TMG_2hB	LINS1	protein_coding	protein_coding	9.154898	3.316984	13.04085	0.6166946	0.4357407	1.971856	0.7359741	0.00000000	1.0037322	0.00000000	0.54449798	6.663533	0.05031667	0.00000000	0.07433333	0.074333333	3.782527e-01	1.873417e-05	FALSE	FALSE
ENST00000561233	ENSG00000140471	HEK293_OSMI2_2hA	HEK293_TMG_2hB	LINS1	protein_coding	processed_transcript	9.154898	3.316984	13.04085	0.6166946	0.4357407	1.971856	0.6136369	0.40223035	0.7779602	0.13206278	0.17479052	0.934672	0.07250833	0.11553333	0.05920000	-0.056333333	1.551168e-01	1.873417e-05		FALSE
ENST00000561308	ENSG00000140471	HEK293_OSMI2_2hA	HEK293_TMG_2hB	LINS1	protein_coding	protein_coding	9.154898	3.316984	13.04085	0.6166946	0.4357407	1.971856	1.4182957	0.12799222	2.7577423	0.06605776	0.15799712	4.326051	0.11355000	0.03896667	0.21223333	0.173266667	1.873417e-05	1.873417e-05	FALSE	TRUE
MSTRG.11663.3	ENSG00000140471	HEK293_OSMI2_2hA	HEK293_TMG_2hB	LINS1	protein_coding		9.154898	3.316984	13.04085	0.6166946	0.4357407	1.971856	1.7841426	0.92904465	2.5477413	0.18330364	0.05349926	1.445605	0.20731667	0.28083333	0.19570000	-0.085133333	1.089138e-01	1.873417e-05	TRUE	TRUE
MSTRG.11663.5	ENSG00000140471	HEK293_OSMI2_2hA	HEK293_TMG_2hB	LINS1	protein_coding		9.154898	3.316984	13.04085	0.6166946	0.4357407	1.971856	0.8859113	0.36566022	1.3328061	0.11728092	0.24467583	1.837751	0.09670833	0.10533333	0.10320000	-0.002133333	9.492527e-01	1.873417e-05	TRUE	TRUE

Note:
- The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

All exons whithin this gene region are shown and numbering below.

All isoforms whithin this gene region are shown below.

Rows: 1-10 / 36
Columns:
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groupID
featureID
exonBaseMean
dispersion
pvalue
padj
seqnames
start
end
width
strand
HEK293_TMG_2hB
HEK293_OSMI2_2hA
log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
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groupID	featureID	exonBaseMean	dispersion	pvalue	padj	seqnames	start	end	width	strand	HEK293_TMG_2hB	HEK293_OSMI2_2hA	log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB

ENSG00000140471	E001	1.7693146	0.0081203991	1.638114e-01	2.801015e-01	15	100559369	100559523	155	-	0.333	0.575	1.257
ENSG00000140471	E002	1.2932139	0.1002856555	9.754411e-01	9.886706e-01	15	100564692	100564785	94	-	0.333	0.325	-0.054
ENSG00000140471	E003	0.8899506	0.0131750964	1.269967e-01	2.299612e-01	15	100565195	100565265	71	-	0.333	0.000	-10.839
ENSG00000140471	E004	25.0382379	0.0327263987	6.264892e-01	7.424310e-01	15	100566924	100569234	2311	-	1.364	1.397	0.115
ENSG00000140471	E005	65.2032382	0.0003844549	9.797715e-04	3.890724e-03	15	100569235	100569688	454	-	1.742	1.886	0.488
ENSG00000140471	E006	45.1766885	0.0005508839	1.111381e-02	3.143819e-02	15	100569689	100569813	125	-	1.587	1.722	0.459
ENSG00000140471	E007	32.7875679	0.0014577471	2.182708e-04	1.042158e-03	15	100569814	100569897	84	-	1.411	1.643	0.793
ENSG00000140471	E008	45.8070614	0.0006954266	1.425386e-04	7.144921e-04	15	100569898	100570117	220	-	1.565	1.766	0.680
ENSG00000140471	E009	5.6472672	0.0064831494	4.554654e-02	1.011981e-01	15	100570361	100570631	271	-	0.702	0.966	1.032
ENSG00000140471	E010	41.0294723	0.0005830354	3.319996e-01	4.756261e-01	15	100571894	100572009	116	-	1.572	1.626	0.186
ENSG00000140471	E011	19.6480322	0.0009674857	6.926214e-01	7.938091e-01	15	100572010	100572021	12	-	1.276	1.307	0.109
ENSG00000140471	E012	22.7649656	0.0008498468	7.761566e-01	8.558672e-01	15	100572022	100572065	44	-	1.341	1.362	0.072
ENSG00000140471	E013	20.9018804	0.0012261963	1.722070e-01	2.910760e-01	15	100572066	100572202	137	-	1.276	1.382	0.372
ENSG00000140471	E014	69.9242692	0.0004391130	7.317919e-03	2.204417e-02	15	100572203	100573300	1098	-	1.781	1.896	0.387
ENSG00000140471	E015	6.8400717	0.0356524122	5.153811e-02	1.118874e-01	15	100573301	100573414	114	-	0.764	1.070	1.163
ENSG00000140471	E016	6.0390540	0.0903464793	7.671203e-02	1.542315e-01	15	100573415	100573476	62	-	0.686	1.045	1.391
ENSG00000140471	E017	13.4010944	0.0014998325	7.646660e-01	8.476815e-01	15	100573477	100573650	174	-	1.124	1.153	0.103
ENSG00000140471	E018	95.4512595	0.0059861664	1.475453e-01	2.583556e-01	15	100573651	100574232	582	-	1.972	1.891	-0.270
ENSG00000140471	E019	15.0761792	0.0055741774	4.912510e-01	6.285484e-01	15	100574233	100574241	9	-	1.193	1.118	-0.269
ENSG00000140471	E020	19.6239998	0.0040084183	1.790476e-01	2.999448e-01	15	100574987	100575021	35	-	1.314	1.185	-0.453
ENSG00000140471	E021	20.2708134	0.0009559445	1.133030e-03	4.414650e-03	15	100575022	100575043	22	-	1.364	1.060	-1.078
ENSG00000140471	E022	22.4809421	0.0009112975	2.028633e-02	5.208273e-02	15	100575044	100575128	85	-	1.385	1.185	-0.699
ENSG00000140471	E023	1.7609868	0.0601353637	2.283349e-02	5.739792e-02	15	100576575	100576702	128	-	0.519	0.000	-11.800
ENSG00000140471	E024	16.8590715	0.0011451000	6.485921e-01	7.600663e-01	15	100580263	100580319	57	-	1.229	1.185	-0.155
ENSG00000140471	E025	14.6863930	0.0094415119	2.219163e-01	3.526842e-01	15	100580320	100580352	33	-	1.198	1.059	-0.501
ENSG00000140471	E026	12.1001911	0.0163618061	3.436541e-01	4.877160e-01	15	100580444	100580455	12	-	1.117	0.991	-0.460
ENSG00000140471	E027	60.4220950	0.0004473472	1.187875e-06	9.708345e-06	15	100580456	100580736	281	-	1.815	1.553	-0.891
ENSG00000140471	E028	33.4380442	0.0006215302	1.778521e-04	8.689503e-04	15	100580737	100580800	64	-	1.567	1.295	-0.940
ENSG00000140471	E029	27.7115763	0.0007711697	5.570070e-03	1.747537e-02	15	100580801	100580898	98	-	1.475	1.257	-0.755
ENSG00000140471	E030	17.3402404	0.0010144488	2.027625e-02	5.206601e-02	15	100580899	100580945	47	-	1.285	1.059	-0.802
ENSG00000140471	E031	2.6885132	0.0055744483	1.247064e-01	2.267169e-01	15	100586224	100586332	109	-	0.610	0.323	-1.480
ENSG00000140471	E032	0.1472490	0.0441307227	1.000000e+00		15	100596910	100596936	27	-	0.076	0.000	-8.343
ENSG00000140471	E033	1.1854928	0.0127884630	3.655372e-01	5.098492e-01	15	100602117	100602120	4	-	0.370	0.191	-1.289
ENSG00000140471	E034	13.7886321	0.0012727453	6.388815e-02	1.331714e-01	15	100602121	100602203	83	-	1.188	0.992	-0.710
ENSG00000140471	E035	0.5159433	0.2532315436	7.128149e-01	8.094244e-01	15	100602519	100603009	491	-	0.141	0.193	0.546
ENSG00000140471	E036	0.0000000				15	100603197	100603230	34	-

Isoforom Switch Analysis

WANG Ziyi

Date: 19 5月 2022

ENSG00000140471

1 Isoform Switch

TableFilter v0.7.3

2 Differential Exon Usage

TableFilter v0.7.3