ENSG00000140470

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000268070 ENSG00000140470 HEK293_OSMI2_2hA HEK293_TMG_2hB ADAMTS17 protein_coding protein_coding 5.089865 8.003876 4.251187 0.7684568 0.1589602 -0.9112448 2.1913601 3.2440776 2.2247818 0.2641049 0.08872489 -0.5421147 0.4330125 0.40663333 0.5261667 0.11953333 0.14522584 0.01506506 FALSE TRUE
ENST00000558960 ENSG00000140470 HEK293_OSMI2_2hA HEK293_TMG_2hB ADAMTS17 protein_coding nonsense_mediated_decay 5.089865 8.003876 4.251187 0.7684568 0.1589602 -0.9112448 0.2267533 0.5634874 0.0000000 0.2840541 0.00000000 -5.8416898 0.0289875 0.06446667 0.0000000 -0.06446667 0.23736466 0.01506506 FALSE FALSE
ENST00000560486 ENSG00000140470 HEK293_OSMI2_2hA HEK293_TMG_2hB ADAMTS17 protein_coding processed_transcript 5.089865 8.003876 4.251187 0.7684568 0.1589602 -0.9112448 1.6111965 3.4753002 0.7084561 0.1952901 0.28499375 -2.2783110 0.2957583 0.43806667 0.1622000 -0.27586667 0.01506506 0.01506506 FALSE FALSE
MSTRG.11651.2 ENSG00000140470 HEK293_OSMI2_2hA HEK293_TMG_2hB ADAMTS17 protein_coding   5.089865 8.003876 4.251187 0.7684568 0.1589602 -0.9112448 0.3559760 0.1689203 0.6114287 0.1689203 0.13646084 1.7962719 0.0827875 0.02576667 0.1465333 0.12076667 0.11721596 0.01506506 TRUE TRUE
MSTRG.11651.5 ENSG00000140470 HEK293_OSMI2_2hA HEK293_TMG_2hB ADAMTS17 protein_coding   5.089865 8.003876 4.251187 0.7684568 0.1589602 -0.9112448 0.4114344 0.1571961 0.5495362 0.1571961 0.11405241 1.7426905 0.0978500 0.01713333 0.1277000 0.11056667 0.06397078 0.01506506 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000140470 E001 171.9425602 0.0007336201 2.902790e-07 2.694521e-06 15 99971437 99972758 1322 - 2.118 2.274 0.523
ENSG00000140470 E002 53.2102620 0.0044905918 5.429924e-01 6.736847e-01 15 99972759 99972955 197 - 1.683 1.730 0.160
ENSG00000140470 E003 40.0873782 0.0005778021 1.601913e-01 2.753806e-01 15 99972956 99973095 140 - 1.544 1.632 0.301
ENSG00000140470 E004 39.9982443 0.0059780080 4.733684e-01 6.123002e-01 15 99973096 99973243 148 - 1.562 1.620 0.200
ENSG00000140470 E005 55.2300351 0.0065504016 3.069784e-01 4.491480e-01 15 99973244 99973475 232 - 1.683 1.759 0.257
ENSG00000140470 E006 31.3975438 0.0119278272 5.074994e-01 6.429935e-01 15 99973476 99973572 97 - 1.444 1.514 0.240
ENSG00000140470 E007 97.0186564 0.0003711419 7.220799e-01 8.162831e-01 15 99973573 99974401 829 - 1.977 1.974 -0.011
ENSG00000140470 E008 30.2919043 0.0078184844 2.640554e-01 4.020027e-01 15 99974402 99974562 161 - 1.529 1.455 -0.255
ENSG00000140470 E009 25.1444005 0.0008470028 3.701465e-01 5.145785e-01 15 99976045 99976222 178 - 1.438 1.386 -0.181
ENSG00000140470 E010 0.6685028 0.0164833100 7.535636e-01 8.394607e-01 15 99976223 99976279 57 - 0.244 0.194 -0.427
ENSG00000140470 E011 23.5989123 0.0008756802 8.876781e-02 1.732333e-01 15 99993048 99993200 153 - 1.438 1.327 -0.385
ENSG00000140470 E012 27.7497119 0.0181825053 4.795568e-01 6.179345e-01 15 99997385 99997589 205 - 1.473 1.420 -0.184
ENSG00000140470 E013 23.6543377 0.0022525744 7.929183e-01 8.675834e-01 15 100048857 100048992 136 - 1.352 1.381 0.100
ENSG00000140470 E014 28.1797200 0.0012308873 1.155346e-01 2.136133e-01 15 100051572 100051731 160 - 1.504 1.410 -0.324
ENSG00000140470 E015 27.2522161 0.0084365420 1.489583e-04 7.425179e-04 15 100053897 100054054 158 - 1.588 1.304 -0.978
ENSG00000140470 E016 0.7300267 0.0264769053 4.822582e-01 6.204111e-01 15 100063614 100063678 65 - 0.139 0.266 1.162
ENSG00000140470 E017 17.3582436 0.0107569056 1.268784e-04 6.450733e-04 15 100063679 100063759 81 - 1.432 1.087 -1.214
ENSG00000140470 E018 19.8868140 0.0011782813 2.359178e-02 5.897074e-02 15 100096356 100096476 121 - 1.401 1.238 -0.569
ENSG00000140470 E019 22.6365668 0.0035316955 2.655804e-01 4.036536e-01 15 100108989 100109116 128 - 1.407 1.332 -0.260
ENSG00000140470 E020 23.2595574 0.0136020461 7.505586e-01 8.371987e-01 15 100116847 100117013 167 - 1.345 1.387 0.145
ENSG00000140470 E021 19.3527319 0.0227232512 8.264285e-01 8.907641e-01 15 100132007 100132152 146 - 1.307 1.295 -0.041
ENSG00000140470 E022 15.7766166 0.0179095545 4.349476e-01 5.771931e-01 15 100133214 100133315 102 - 1.255 1.185 -0.247
ENSG00000140470 E023 28.2913669 0.0015714773 2.686002e-01 4.070808e-01 15 100152612 100152762 151 - 1.489 1.424 -0.221
ENSG00000140470 E024 28.7698390 0.0008055653 2.149827e-02 5.463997e-02 15 100155180 100155320 141 - 1.539 1.401 -0.476
ENSG00000140470 E025 0.6558305 0.0694636827 7.589430e-01 8.434170e-01 15 100155321 100155412 92 - 0.244 0.194 -0.423
ENSG00000140470 E026 1.3953073 0.0098028937 3.168016e-01 4.596019e-01 15 100168388 100168706 319 - 0.244 0.429 1.159
ENSG00000140470 E027 22.4864648 0.0008959052 1.179239e-02 3.303611e-02 15 100199318 100199423 106 - 1.455 1.284 -0.594
ENSG00000140470 E028 13.7359479 0.0629394735 2.725037e-01 4.114137e-01 15 100254136 100254179 44 - 1.254 1.080 -0.620
ENSG00000140470 E029 42.3328824 0.0480132867 2.197429e-06 1.693707e-05 15 100256422 100257074 653 - 1.175 1.768 2.046
ENSG00000140470 E030 40.4889358 0.0097922925 9.328727e-01 9.617066e-01 15 100261479 100261636 158 - 1.596 1.609 0.045
ENSG00000140470 E031 20.7538464 0.0142131867 3.985362e-01 5.422750e-01 15 100262352 100262388 37 - 1.272 1.359 0.302
ENSG00000140470 E032 22.8858021 0.0200907318 7.689199e-01 8.506749e-01 15 100262389 100262435 47 - 1.344 1.377 0.112
ENSG00000140470 E033 32.9392632 0.0006268708 6.169543e-02 1.294827e-01 15 100281229 100281401 173 - 1.575 1.472 -0.354
ENSG00000140470 E034 1.0361649 0.0138672763 6.623764e-01 7.706956e-01 15 100305888 100306577 690 - 0.244 0.327 0.574
ENSG00000140470 E035 22.8098855 0.0008176422 3.664711e-01 5.108071e-01 15 100330889 100331013 125 - 1.394 1.338 -0.194
ENSG00000140470 E036 13.7055507 0.0132769771 6.548264e-01 7.648969e-01 15 100331014 100331054 41 - 1.164 1.130 -0.122
ENSG00000140470 E037 0.4031496 0.0243625740 2.983821e-01 4.398214e-01 15 100338999 100339129 131 - 0.000 0.194 9.502
ENSG00000140470 E038 0.3332198 0.0292596322 8.178427e-01   15 100341004 100341038 35 - 0.139 0.107 -0.426
ENSG00000140470 E039 10.3799292 0.0239571218 3.843386e-02 8.816375e-02 15 100341039 100341409 371 - 1.164 0.925 -0.873
ENSG00000140470 E040 10.5689266 0.0037810273 8.564856e-01 9.112531e-01 15 100341821 100342005 185 - 1.018 1.047 0.103