ENSG00000140464

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000268058 ENSG00000140464 HEK293_OSMI2_2hA HEK293_TMG_2hB PML protein_coding protein_coding 14.89873 24.02226 9.043014 0.8568537 0.3869673 -1.408502 1.0399579 0.0000000 0.81813967 0.0000000 0.41061917 6.3718022 0.07800833 0.00000000 0.088600000 0.08860000 9.564995e-02 4.207118e-21 FALSE TRUE
ENST00000268059 ENSG00000140464 HEK293_OSMI2_2hA HEK293_TMG_2hB PML protein_coding protein_coding 14.89873 24.02226 9.043014 0.8568537 0.3869673 -1.408502 2.9529672 6.9308878 0.70823493 1.0299062 0.38592364 -3.2725925 0.18573333 0.28646667 0.078833333 -0.20763333 2.915977e-01 4.207118e-21 FALSE TRUE
ENST00000354026 ENSG00000140464 HEK293_OSMI2_2hA HEK293_TMG_2hB PML protein_coding protein_coding 14.89873 24.02226 9.043014 0.8568537 0.3869673 -1.408502 1.6242263 0.0000000 2.36701093 0.0000000 0.44700510 7.8930047 0.11798750 0.00000000 0.261500000 0.26150000 4.207118e-21 4.207118e-21 FALSE TRUE
ENST00000395135 ENSG00000140464 HEK293_OSMI2_2hA HEK293_TMG_2hB PML protein_coding protein_coding 14.89873 24.02226 9.043014 0.8568537 0.3869673 -1.408502 2.7202586 4.5497705 1.92566049 0.5924490 0.16652129 -1.2361353 0.17508333 0.19050000 0.212300000 0.02180000 8.245373e-01 4.207118e-21 FALSE TRUE
ENST00000435786 ENSG00000140464 HEK293_OSMI2_2hA HEK293_TMG_2hB PML protein_coding protein_coding 14.89873 24.02226 9.043014 0.8568537 0.3869673 -1.408502 0.9537541 0.9565669 0.87193038 0.2387048 0.12099465 -0.1322048 0.07670833 0.03920000 0.097133333 0.05793333 4.831714e-02 4.207118e-21 FALSE TRUE
ENST00000562086 ENSG00000140464 HEK293_OSMI2_2hA HEK293_TMG_2hB PML protein_coding protein_coding 14.89873 24.02226 9.043014 0.8568537 0.3869673 -1.408502 1.2944547 1.5513645 0.80785531 0.2729739 0.09565516 -0.9328898 0.09136667 0.06533333 0.089566667 0.02423333 5.636611e-01 4.207118e-21 FALSE TRUE
ENST00000564725 ENSG00000140464 HEK293_OSMI2_2hA HEK293_TMG_2hB PML protein_coding retained_intron 14.89873 24.02226 9.043014 0.8568537 0.3869673 -1.408502 0.8072912 1.3711646 0.54604155 0.1155711 0.03703862 -1.3126206 0.05806667 0.05690000 0.060300000 0.00340000 9.323033e-01 4.207118e-21 FALSE TRUE
ENST00000567606 ENSG00000140464 HEK293_OSMI2_2hA HEK293_TMG_2hB PML protein_coding protein_coding 14.89873 24.02226 9.043014 0.8568537 0.3869673 -1.408502 1.4669244 4.4146626 0.06418021 0.6376301 0.06418021 -5.8983892 0.07295833 0.18620000 0.006533333 -0.17966667 3.019729e-04 4.207118e-21 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000140464 E001 3.718153 0.0044167698 9.992634e-01 1.000000e+00 15 73994673 73994715 43 + 0.619 0.625 0.024
ENSG00000140464 E002 3.718153 0.0044167698 9.992634e-01 1.000000e+00 15 73994716 73994716 1 + 0.619 0.625 0.024
ENSG00000140464 E003 8.611784 0.0047638633 4.825691e-02 1.060891e-01 15 73994717 73994728 12 + 1.082 0.859 -0.830
ENSG00000140464 E004 9.284553 0.0246451747 6.196422e-02 1.299217e-01 15 73994729 73994730 2 + 1.118 0.882 -0.875
ENSG00000140464 E005 10.572355 0.0053729637 7.005245e-03 2.123736e-02 15 73994731 73994732 2 + 1.198 0.916 -1.029
ENSG00000140464 E006 14.934808 0.0014429156 1.086256e-01 2.035066e-01 15 73994733 73994743 11 + 1.239 1.096 -0.511
ENSG00000140464 E007 39.981039 0.0006032530 5.998839e-01 7.212106e-01 15 73994744 73994802 59 + 1.513 1.554 0.137
ENSG00000140464 E008 61.939315 0.0008291986 2.437035e-01 3.785328e-01 15 73994803 73994941 139 + 1.676 1.744 0.233
ENSG00000140464 E009 36.391691 0.0006356635 3.928130e-02 8.968418e-02 15 73998004 73998023 20 + 1.384 1.534 0.517
ENSG00000140464 E010 194.096114 0.0005338872 5.532292e-04 2.358673e-03 15 73998024 73998476 453 + 2.285 2.193 -0.307
ENSG00000140464 E011 108.757621 0.0002943511 4.504619e-07 4.020477e-06 15 74022828 74022904 77 + 2.094 1.919 -0.588
ENSG00000140464 E012 67.879959 0.0004178186 3.435042e-07 3.140422e-06 15 74022905 74022911 7 + 1.926 1.703 -0.751
ENSG00000140464 E013 85.317037 0.0015482002 3.716614e-07 3.373425e-06 15 74022912 74022980 69 + 2.016 1.803 -0.718
ENSG00000140464 E014 138.350265 0.0081363098 3.046922e-01 4.467242e-01 15 74022981 74023294 314 + 2.104 2.063 -0.137
ENSG00000140464 E015 85.096279 0.0020604554 6.113463e-01 7.304531e-01 15 74023295 74023365 71 + 1.835 1.868 0.109
ENSG00000140464 E016 81.373727 0.0004402128 8.110525e-01 8.801564e-01 15 74023366 74023408 43 + 1.829 1.846 0.060
ENSG00000140464 E017 76.778407 0.0017863829 3.033733e-01 4.452764e-01 15 74024857 74024879 23 + 1.771 1.830 0.200
ENSG00000140464 E018 91.061866 0.0012000904 1.222758e-01 2.231911e-01 15 74024880 74024927 48 + 1.829 1.907 0.263
ENSG00000140464 E019 102.053197 0.0002949445 1.282052e-01 2.316508e-01 15 74024928 74028442 3515 + 1.889 1.957 0.231
ENSG00000140464 E020 0.776011 0.0159215614 1.307749e-01 2.352346e-01 15 74032395 74032571 177 + 0.412 0.147 -1.977
ENSG00000140464 E021 82.003886 0.0004185730 1.070080e-02 3.045635e-02 15 74032572 74032698 127 + 1.747 1.873 0.426
ENSG00000140464 E022 42.286839 0.0131102199 7.563571e-02 1.525235e-01 15 74032699 74032715 17 + 1.445 1.605 0.545
ENSG00000140464 E023 208.504052 0.0003026102 6.606987e-02 1.368293e-01 15 74033156 74033414 259 + 2.206 2.265 0.198
ENSG00000140464 E024 8.095242 0.0020713486 5.476184e-01 6.776445e-01 15 74033415 74033422 8 + 0.832 0.916 0.320
ENSG00000140464 E025 1.134210 0.0190029395 1.050230e-01 1.981209e-01 15 74033423 74034477 1055 + 0.492 0.205 -1.804
ENSG00000140464 E026 104.766014 0.0073575276 8.519607e-01 9.082249e-01 15 74034478 74034530 53 + 1.959 1.956 -0.012
ENSG00000140464 E027 39.914134 0.0005788900 2.015904e-04 9.706126e-04 15 74034531 74035131 601 + 1.694 1.485 -0.714
ENSG00000140464 E028 5.892618 0.0219888027 8.644064e-01 9.165866e-01 15 74035132 74035142 11 + 0.797 0.779 -0.072
ENSG00000140464 E029 12.185338 0.0014607356 9.209373e-01 9.541154e-01 15 74035143 74035171 29 + 1.042 1.059 0.062
ENSG00000140464 E030 294.561803 0.0006141814 5.259475e-07 4.632010e-06 15 74035172 74036006 835 + 2.292 2.430 0.459
ENSG00000140464 E031 74.740330 0.0033058677 1.530628e-05 9.748796e-05 15 74036007 74036034 28 + 1.602 1.862 0.879
ENSG00000140464 E032 164.783660 0.0097361777 1.264678e-03 4.859040e-03 15 74036035 74036394 360 + 1.996 2.191 0.655
ENSG00000140464 E033 2.107718 0.0074661630 1.525742e-01 2.651737e-01 15 74041329 74041570 242 + 0.619 0.381 -1.169
ENSG00000140464 E034 66.696961 0.0074142122 2.397526e-01 3.738305e-01 15 74042989 74043139 151 + 1.699 1.782 0.283
ENSG00000140464 E035 29.962615 0.0069002325 3.123078e-04 1.429850e-03 15 74043140 74043342 203 + 1.151 1.489 1.179
ENSG00000140464 E036 162.697521 0.0003555329 3.834784e-10 6.136918e-09 15 74044221 74047827 3607 + 2.272 2.093 -0.598