ENSG00000140463

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000268057 ENSG00000140463 HEK293_OSMI2_2hA HEK293_TMG_2hB BBS4 protein_coding protein_coding 12.19373 8.071365 13.7409 1.161221 0.6993615 0.7668554 7.6105405 4.9348485 8.9256252 0.22875167 0.07855380 0.8536423 0.62897500 0.636500000 0.65250000 0.016000000 9.990935e-01 3.22683e-07 FALSE  
ENST00000562219 ENSG00000140463 HEK293_OSMI2_2hA HEK293_TMG_2hB BBS4 protein_coding retained_intron 12.19373 8.071365 13.7409 1.161221 0.6993615 0.7668554 0.6884361 0.4875214 0.3593035 0.10852780 0.06403898 -0.4299517 0.06242083 0.064133333 0.02610000 -0.038033333 1.467628e-01 3.22683e-07 FALSE  
ENST00000566197 ENSG00000140463 HEK293_OSMI2_2hA HEK293_TMG_2hB BBS4 protein_coding protein_coding 12.19373 8.071365 13.7409 1.161221 0.6993615 0.7668554 0.2502071 1.0997771 0.0000000 1.09977706 0.00000000 -6.7941261 0.02505417 0.107633333 0.00000000 -0.107633333 7.038469e-01 3.22683e-07 FALSE  
ENST00000568535 ENSG00000140463 HEK293_OSMI2_2hA HEK293_TMG_2hB BBS4 protein_coding retained_intron 12.19373 8.071365 13.7409 1.161221 0.6993615 0.7668554 1.0673133 0.4263000 0.7558930 0.07161440 0.23847112 0.8118223 0.08883333 0.054600000 0.05356667 -0.001033333 9.902544e-01 3.22683e-07 FALSE  
ENST00000569151 ENSG00000140463 HEK293_OSMI2_2hA HEK293_TMG_2hB BBS4 protein_coding retained_intron 12.19373 8.071365 13.7409 1.161221 0.6993615 0.7668554 0.5760247 0.0000000 0.6829186 0.00000000 0.10367059 6.1146140 0.04224583 0.000000000 0.05073333 0.050733333 3.226830e-07 3.22683e-07    
ENST00000569338 ENSG00000140463 HEK293_OSMI2_2hA HEK293_TMG_2hB BBS4 protein_coding protein_coding 12.19373 8.071365 13.7409 1.161221 0.6993615 0.7668554 0.2963236 0.0611512 0.7939478 0.03122898 0.20683360 3.4981417 0.02215417 0.007033333 0.05890000 0.051866667 7.001332e-03 3.22683e-07 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000140463 E001 0.2965864 0.0736800048 0.1234598893   15 72686179 72686185 7 + 0.000 0.257 12.219
ENSG00000140463 E002 0.4417591 0.0484913400 0.3741055389 0.518522216 15 72686186 72686193 8 + 0.100 0.258 1.639
ENSG00000140463 E003 1.3274407 0.0251820546 0.2176149773 0.347521745 15 72686194 72686203 10 + 0.250 0.482 1.382
ENSG00000140463 E004 1.8423649 0.0078287752 0.1201004635 0.220136735 15 72686204 72686206 3 + 0.310 0.585 1.454
ENSG00000140463 E005 8.3328965 0.0021317199 0.8193555707 0.885938820 15 72686207 72686219 13 + 0.970 0.961 -0.032
ENSG00000140463 E006 17.4772942 0.0020846126 0.3400081912 0.483944762 15 72686220 72686236 17 + 1.289 1.227 -0.218
ENSG00000140463 E007 23.0390466 0.0011098713 0.7656440173 0.848349104 15 72686237 72686251 15 + 1.359 1.398 0.137
ENSG00000140463 E008 1.8716129 0.0089039881 0.6365129396 0.750516381 15 72686252 72686389 138 + 0.489 0.420 -0.354
ENSG00000140463 E009 1.9207283 0.0075897238 0.2109708994 0.339683194 15 72686390 72686461 72 + 0.362 0.585 1.130
ENSG00000140463 E010 4.4231795 0.0036786576 0.5048179872 0.640693061 15 72686462 72686564 103 + 0.690 0.799 0.439
ENSG00000140463 E011 0.1472490 0.0429475241 0.7205131980   15 72686750 72686840 91 + 0.100 0.000 -10.230
ENSG00000140463 E012 32.5125641 0.0216077956 0.3820127770 0.526274021 15 72695177 72695228 52 + 1.548 1.479 -0.236
ENSG00000140463 E013 0.2987644 0.0290785164 0.3416765469   15 72697992 72698037 46 + 0.182 0.000 -11.230
ENSG00000140463 E014 0.3332198 0.0284860212 0.7668471440   15 72704424 72704481 58 + 0.100 0.148 0.647
ENSG00000140463 E015 27.2464614 0.0089788683 0.3331470144 0.476826449 15 72709700 72709705 6 + 1.471 1.407 -0.223
ENSG00000140463 E016 44.1799428 0.0380647029 0.1335777252 0.239113872 15 72709706 72709779 74 + 1.707 1.560 -0.500
ENSG00000140463 E017 43.8738425 0.0219299190 0.0734882346 0.149107053 15 72712244 72712307 64 + 1.705 1.556 -0.507
ENSG00000140463 E018 51.7224061 0.0067064357 0.0565620862 0.120696067 15 72715291 72715402 112 + 1.761 1.657 -0.353
ENSG00000140463 E019 32.5942428 0.0091194182 0.6857909233 0.788431101 15 72716778 72716827 50 + 1.504 1.551 0.159
ENSG00000140463 E020 29.9096892 0.0006906879 0.4330763814 0.575528362 15 72716828 72716850 23 + 1.501 1.470 -0.107
ENSG00000140463 E021 0.2965864 0.0736800048 0.1234598893   15 72716851 72716851 1 + 0.000 0.257 12.236
ENSG00000140463 E022 0.7644715 0.0182769216 0.3491702564 0.493389753 15 72717030 72717355 326 + 0.310 0.148 -1.353
ENSG00000140463 E023 1.6532867 0.0167233089 0.5312185303 0.663710484 15 72722789 72722793 5 + 0.362 0.483 0.648
ENSG00000140463 E024 36.0590363 0.0006018166 0.1392501695 0.247024869 15 72722794 72722829 36 + 1.594 1.526 -0.231
ENSG00000140463 E025 37.1646401 0.0005798466 0.0002882801 0.001332272 15 72722830 72722847 18 + 1.653 1.458 -0.667
ENSG00000140463 E026 0.0000000       15 72722848 72722848 1 +      
ENSG00000140463 E027 75.4713109 0.0003657245 0.0002790875 0.001294652 15 72724528 72724655 128 + 1.933 1.804 -0.436
ENSG00000140463 E028 0.7782011 0.0152957004 0.9964552873 1.000000000 15 72724656 72724657 2 + 0.251 0.259 0.060
ENSG00000140463 E029 49.2296896 0.0004799945 0.3179280608 0.460837330 15 72727940 72727994 55 + 1.714 1.683 -0.103
ENSG00000140463 E030 49.2883836 0.0005342985 0.1277912008 0.231096407 15 72729616 72729684 69 + 1.722 1.665 -0.196
ENSG00000140463 E031 63.5247576 0.0004458790 0.9337564873 0.962255618 15 72731305 72731457 153 + 1.802 1.818 0.052
ENSG00000140463 E032 0.0000000       15 72731458 72731458 1 +      
ENSG00000140463 E033 24.4673475 0.0008005348 0.1379202984 0.245186896 15 72731555 72731556 2 + 1.349 1.470 0.418
ENSG00000140463 E034 56.0828119 0.0004146150 0.2826918871 0.422722450 15 72731557 72731681 125 + 1.727 1.795 0.233
ENSG00000140463 E035 41.3697111 0.0005775169 0.5761367801 0.701628180 15 72731682 72731726 45 + 1.635 1.624 -0.036
ENSG00000140463 E036 0.2934659 0.0285809382 0.7708719265   15 72735077 72735112 36 + 0.100 0.148 0.644
ENSG00000140463 E037 57.0117566 0.0094722628 0.9232618810 0.955610398 15 72735113 72735182 70 + 1.757 1.778 0.069
ENSG00000140463 E038 11.3003581 0.0023223616 0.2953865459 0.436519821 15 72735183 72735516 334 + 1.026 1.147 0.437
ENSG00000140463 E039 10.2644702 0.0551204984 0.3863262248 0.530519472 15 72735517 72735824 308 + 0.983 1.120 0.501
ENSG00000140463 E040 84.2105009 0.0079979421 0.6847802987 0.787686316 15 72735825 72735966 142 + 1.910 1.958 0.160
ENSG00000140463 E041 94.1504695 0.0032846005 0.2281765195 0.360254995 15 72736762 72736963 202 + 1.948 2.022 0.248
ENSG00000140463 E042 2.2809915 0.0147967582 0.8298091924 0.893173920 15 72736964 72737092 129 + 0.489 0.537 0.233
ENSG00000140463 E043 216.4022888 0.0082867402 0.0003051286 0.001400298 15 72737478 72738475 998 + 2.250 2.429 0.597