ENSG00000140443

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000649865 ENSG00000140443 HEK293_OSMI2_2hA HEK293_TMG_2hB IGF1R protein_coding protein_coding 8.843503 7.855246 8.005603 0.6876717 0.2352123 0.02731925 1.3057585 1.943297561 0.6320550 0.361816514 0.4479317 -1.6051429 0.15238750 0.2427667 0.07960000 -0.16316667 3.023690e-01 3.258945e-19 FALSE TRUE
ENST00000650285 ENSG00000140443 HEK293_OSMI2_2hA HEK293_TMG_2hB IGF1R protein_coding protein_coding 8.843503 7.855246 8.005603 0.6876717 0.2352123 0.02731925 2.7487653 1.803598808 3.2263836 0.094282059 0.5877253 0.8355273 0.30819167 0.2311667 0.40236667 0.17120000 1.446715e-01 3.258945e-19 FALSE TRUE
MSTRG.11627.5 ENSG00000140443 HEK293_OSMI2_2hA HEK293_TMG_2hB IGF1R protein_coding   8.843503 7.855246 8.005603 0.6876717 0.2352123 0.02731925 1.5361013 1.231352199 0.7018887 0.503816479 0.3977364 -0.8021888 0.17223333 0.1501000 0.08743333 -0.06266667 7.269605e-01 3.258945e-19 FALSE TRUE
MSTRG.11627.6 ENSG00000140443 HEK293_OSMI2_2hA HEK293_TMG_2hB IGF1R protein_coding   8.843503 7.855246 8.005603 0.6876717 0.2352123 0.02731925 1.5061147 2.120391480 1.5778575 0.203664609 0.2102380 -0.4240371 0.17447917 0.2719000 0.19880000 -0.07310000 3.988472e-01 3.258945e-19 FALSE TRUE
MSTRG.11627.7 ENSG00000140443 HEK293_OSMI2_2hA HEK293_TMG_2hB IGF1R protein_coding   8.843503 7.855246 8.005603 0.6876717 0.2352123 0.02731925 1.2257419 0.006392632 1.6356898 0.006392632 0.1701546 6.6495011 0.13190000 0.0010000 0.20406667 0.20306667 3.258945e-19 3.258945e-19 FALSE TRUE
MSTRG.11627.8 ENSG00000140443 HEK293_OSMI2_2hA HEK293_TMG_2hB IGF1R protein_coding   8.843503 7.855246 8.005603 0.6876717 0.2352123 0.02731925 0.2609715 0.711795120 0.0000000 0.374156484 0.0000000 -6.1735175 0.03382917 0.0985000 0.00000000 -0.09850000 1.617366e-01 3.258945e-19 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000140443 E001 2.5486391 0.0057730077 1.967836e-05 1.222778e-04 15 98648539 98648630 92 + 0.799 0.121 -4.049
ENSG00000140443 E002 6.0497030 0.0027424883 5.292655e-03 1.672830e-02 15 98648631 98648971 341 + 0.983 0.685 -1.164
ENSG00000140443 E003 21.0571880 0.0232962895 2.570834e-04 1.204791e-03 15 98648972 98649451 480 + 1.479 1.167 -1.091
ENSG00000140443 E004 16.5043295 0.0301779198 1.291511e-01 2.329930e-01 15 98649452 98649581 130 + 1.290 1.185 -0.372
ENSG00000140443 E005 22.1421572 0.0154333175 9.391165e-02 1.812450e-01 15 98649582 98649675 94 + 1.406 1.315 -0.315
ENSG00000140443 E006 65.4468766 0.0059505998 6.274887e-07 5.443303e-06 15 98707562 98707830 269 + 1.923 1.703 -0.743
ENSG00000140443 E007 75.5237940 0.0034908535 1.736509e-04 8.511457e-04 15 98707831 98708107 277 + 1.940 1.819 -0.406
ENSG00000140443 E008 0.0000000       15 98734712 98734753 42 +      
ENSG00000140443 E009 0.0000000       15 98820866 98820883 18 +      
ENSG00000140443 E010 0.0000000       15 98820884 98820940 57 +      
ENSG00000140443 E011 0.0000000       15 98824180 98824242 63 +      
ENSG00000140443 E012 0.0000000       15 98873719 98873855 137 +      
ENSG00000140443 E013 0.0000000       15 98890341 98890468 128 +      
ENSG00000140443 E014 0.1482932 0.0426325006 5.701481e-01   15 98890542 98890755 214 + 0.000 0.120 11.496
ENSG00000140443 E015 63.4241711 0.0060123656 9.361141e-05 4.919800e-04 15 98891325 98891637 313 + 1.885 1.723 -0.550
ENSG00000140443 E016 47.9130090 0.0045636533 4.083350e-07 3.675656e-06 15 98896757 98896905 149 + 1.798 1.557 -0.819
ENSG00000140443 E017 0.1515154 0.0429510083 4.152739e-01   15 98896906 98896919 14 + 0.124 0.000 -12.252
ENSG00000140443 E018 0.0000000       15 98897286 98897488 203 +      
ENSG00000140443 E019 52.3009417 0.0098004563 4.489529e-03 1.451289e-02 15 98899477 98899621 145 + 1.782 1.658 -0.420
ENSG00000140443 E020 0.1817044 0.0395309923 5.697534e-01   15 98900610 98900763 154 + 0.000 0.121 11.532
ENSG00000140443 E021 73.1650803 0.0194028631 7.060134e-03 2.138187e-02 15 98908685 98908899 215 + 1.933 1.800 -0.449
ENSG00000140443 E022 50.6378383 0.0120010062 2.381415e-04 1.125573e-03 15 98911315 98911441 127 + 1.805 1.610 -0.662
ENSG00000140443 E023 58.9001052 0.0004575647 3.022428e-05 1.797093e-04 15 98913044 98913175 132 + 1.840 1.710 -0.440
ENSG00000140443 E024 58.3830659 0.0088746172 7.569874e-03 2.269453e-02 15 98913176 98913282 107 + 1.826 1.719 -0.359
ENSG00000140443 E025 38.4030239 0.0008290144 4.527551e-03 1.462058e-02 15 98915964 98915993 30 + 1.644 1.543 -0.343
ENSG00000140443 E026 32.6623968 0.0006993039 9.543190e-04 3.802643e-03 15 98915994 98916013 20 + 1.592 1.450 -0.484
ENSG00000140443 E027 61.9932090 0.0004388679 5.083106e-05 2.859542e-04 15 98916014 98916131 118 + 1.854 1.734 -0.407
ENSG00000140443 E028 0.8157519 0.0163167434 5.257456e-01 6.590807e-01 15 98916485 98916671 187 + 0.299 0.215 -0.633
ENSG00000140443 E029 87.6969440 0.0012637037 2.205984e-03 7.861051e-03 15 98916672 98916876 205 + 1.976 1.914 -0.209
ENSG00000140443 E030 0.0000000       15 98916877 98916955 79 +      
ENSG00000140443 E031 101.0516794 0.0007357284 1.784747e-02 4.680676e-02 15 98922148 98922431 284 + 2.017 1.991 -0.085
ENSG00000140443 E032 0.0000000       15 98923782 98923875 94 +      
ENSG00000140443 E033 70.4650978 0.0004662357 6.216135e-01 7.385609e-01 15 98923876 98924012 137 + 1.827 1.867 0.134
ENSG00000140443 E034 54.7156648 0.0006398991 2.008040e-01 3.271992e-01 15 98924525 98924599 75 + 1.666 1.789 0.417
ENSG00000140443 E035 56.2470455 0.0069513816 7.426878e-01 8.315307e-01 15 98924600 98924684 85 + 1.707 1.789 0.277
ENSG00000140443 E036 21.0278521 0.0011138328 9.155377e-01 9.505394e-01 15 98929558 98929560 3 + 1.312 1.363 0.177
ENSG00000140443 E037 60.4738760 0.0014158281 5.763141e-01 7.017865e-01 15 98929561 98929660 100 + 1.768 1.802 0.115
ENSG00000140443 E038 50.9771727 0.0004834323 2.451117e-02 6.087449e-02 15 98930235 98930305 71 + 1.740 1.690 -0.169
ENSG00000140443 E039 97.7866258 0.0035541731 6.261024e-01 7.421026e-01 15 98934824 98935053 230 + 1.968 2.009 0.135
ENSG00000140443 E040 79.9165369 0.0016348886 2.899571e-01 4.307138e-01 15 98935316 98935426 111 + 1.889 1.905 0.054
ENSG00000140443 E041 90.3349809 0.0003183741 1.032929e-01 1.954879e-01 15 98939201 98939360 160 + 1.951 1.951 0.000
ENSG00000140443 E042 77.1585866 0.0013905768 8.131763e-01 8.815416e-01 15 98942923 98943052 130 + 1.858 1.909 0.171
ENSG00000140443 E043 68.1847529 0.0003818209 8.043122e-01 8.755094e-01 15 98948574 98948708 135 + 1.794 1.865 0.241
ENSG00000140443 E044 0.7675920 0.0163486502 5.246258e-01 6.581077e-01 15 98952795 98953110 316 + 0.299 0.215 -0.634
ENSG00000140443 E045 132.3180431 0.0027392432 6.460057e-02 1.343755e-01 15 98957061 98957469 409 + 2.042 2.177 0.452
ENSG00000140443 E046 24.3166566 0.0008542714 2.713360e-02 6.627018e-02 15 98957470 98957474 5 + 1.260 1.479 0.759
ENSG00000140443 E047 23.9813736 0.0008365721 2.499928e-02 6.187179e-02 15 98957475 98957476 2 + 1.252 1.474 0.771
ENSG00000140443 E048 129.9241522 0.0002754671 8.383231e-02 1.655508e-01 15 98957477 98957962 486 + 2.041 2.157 0.388
ENSG00000140443 E049 1384.7186522 0.0054662252 5.579278e-09 7.220285e-08 15 98957963 98964530 6568 + 3.013 3.218 0.681