ENSG00000140416

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000358278 ENSG00000140416 HEK293_OSMI2_2hA HEK293_TMG_2hB TPM1 protein_coding protein_coding 24.69114 27.17269 30.88843 2.221414 0.7219745 0.184845 11.492230 10.425579 17.1150778 0.7576472 0.3753718 0.7145999 0.45450417 0.3850333 0.5552333 0.1702 0.0009072691 0.0009072691 FALSE TRUE
ENST00000404484 ENSG00000140416 HEK293_OSMI2_2hA HEK293_TMG_2hB TPM1 protein_coding protein_coding 24.69114 27.17269 30.88843 2.221414 0.7219745 0.184845 7.467942 9.866997 8.3693019 0.8938263 0.3760587 -0.2372425 0.29783333 0.3638000 0.2707000 -0.0931 0.0118390504 0.0009072691 FALSE TRUE
MSTRG.10980.5 ENSG00000140416 HEK293_OSMI2_2hA HEK293_TMG_2hB TPM1 protein_coding   24.69114 27.17269 30.88843 2.221414 0.7219745 0.184845 1.687821 3.407833 0.5750055 0.4136135 0.5750055 -2.5465597 0.07078333 0.1247000 0.0178000 -0.1069 0.0656383479 0.0009072691 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000140416 E001 0.5117906 0.1765594676 6.872890e-01 7.896611e-01 15 63042632 63042647 16 + 0.207 0.131 -0.795
ENSG00000140416 E002 1.6963530 0.0084615769 6.076388e-03 1.881216e-02 15 63042648 63042683 36 + 0.608 0.129 -3.136
ENSG00000140416 E003 1.6963530 0.0084615769 6.076388e-03 1.881216e-02 15 63042684 63042684 1 + 0.608 0.129 -3.136
ENSG00000140416 E004 1.9930411 0.0092054149 1.900525e-03 6.916432e-03 15 63042685 63042686 2 + 0.669 0.129 -3.399
ENSG00000140416 E005 10.0240276 0.0018606780 2.328795e-03 8.239793e-03 15 63042687 63042746 60 + 1.168 0.860 -1.136
ENSG00000140416 E006 9.8015357 0.0027373418 1.062804e-02 3.028052e-02 15 63042747 63042750 4 + 1.140 0.881 -0.958
ENSG00000140416 E007 10.1003001 0.0020000302 5.459715e-03 1.718094e-02 15 63042751 63042754 4 + 1.159 0.881 -1.026
ENSG00000140416 E008 12.9662619 0.0028694717 3.043501e-03 1.039355e-02 15 63042755 63042757 3 + 1.257 0.986 -0.977
ENSG00000140416 E009 27.4473257 0.0485592287 1.548900e-01 2.682682e-01 15 63042758 63042769 12 + 1.526 1.363 -0.561
ENSG00000140416 E010 32.8891692 0.0155204687 3.353600e-02 7.884652e-02 15 63042770 63042776 7 + 1.606 1.436 -0.583
ENSG00000140416 E011 50.1035273 0.0162932464 2.039011e-01 3.310746e-01 15 63042777 63042829 53 + 1.748 1.660 -0.299
ENSG00000140416 E012 92.0891541 0.0052065409 7.717005e-02 1.549576e-01 15 63042830 63042943 114 + 2.005 1.930 -0.252
ENSG00000140416 E013 0.4815130 0.0218364320 5.179086e-01 6.522342e-01 15 63042944 63043468 525 + 0.116 0.229 1.183
ENSG00000140416 E014 0.2998086 0.0287787611 9.543914e-01   15 63043469 63043705 237 + 0.116 0.129 0.182
ENSG00000140416 E015 1.1145414 0.2946809626 6.626466e-01 7.709188e-01 15 63043706 63043831 126 + 0.283 0.373 0.563
ENSG00000140416 E016 0.3332198 0.0284474653 9.487684e-01   15 63043832 63043966 135 + 0.116 0.129 0.185
ENSG00000140416 E017 0.6287620 0.0180918005 9.311479e-01 9.606447e-01 15 63043967 63044026 60 + 0.207 0.229 0.183
ENSG00000140416 E018 116.9669547 0.0003015990 1.964175e-01 3.217510e-01 15 63044027 63044140 114 + 2.086 2.060 -0.087
ENSG00000140416 E019 69.6619494 0.0008379880 4.550258e-01 5.955897e-01 15 63044141 63044152 12 + 1.858 1.841 -0.057
ENSG00000140416 E020 9.0236715 0.0846324509 3.197379e-03 1.084864e-02 15 63044153 63047726 3574 + 0.669 1.175 1.931
ENSG00000140416 E021 0.4428904 0.5675700699 2.988370e-01 4.403205e-01 15 63048169 63048264 96 + 0.000 0.240 11.554
ENSG00000140416 E022 1.2920811 0.2400260189 6.039534e-01 7.246225e-01 15 63048432 63048438 7 + 0.403 0.311 -0.546
ENSG00000140416 E023 2.6540815 0.1338928761 1.004933e-01 1.912019e-01 15 63048439 63048470 32 + 0.696 0.379 -1.508
ENSG00000140416 E024 5.2037607 0.1648995996 2.279139e-01 3.599423e-01 15 63048471 63048486 16 + 0.888 0.661 -0.910
ENSG00000140416 E025 5.3552762 0.1749954384 2.093328e-01 3.377404e-01 15 63048487 63048488 2 + 0.905 0.661 -0.973
ENSG00000140416 E026 6.3129916 0.1507576099 2.621744e-01 3.999239e-01 15 63048489 63048492 4 + 0.952 0.750 -0.785
ENSG00000140416 E027 8.2713724 0.0848025146 2.671129e-01 4.053878e-01 15 63048493 63048499 7 + 1.045 0.867 -0.668
ENSG00000140416 E028 17.9294043 0.0625520332 4.319544e-01 5.744444e-01 15 63048500 63048536 37 + 1.326 1.218 -0.377
ENSG00000140416 E029 20.6918971 0.0205004954 2.174816e-01 3.473513e-01 15 63048537 63048561 25 + 1.389 1.274 -0.403
ENSG00000140416 E030 20.6595275 0.0131686968 4.546262e-01 5.952352e-01 15 63048562 63048575 14 + 1.361 1.304 -0.200
ENSG00000140416 E031 53.4162403 0.0044657878 2.089225e-01 3.372388e-01 15 63048576 63048707 132 + 1.762 1.703 -0.199
ENSG00000140416 E032 0.0000000       15 63048813 63048825 13 +      
ENSG00000140416 E033 1.1426289 0.0113060015 7.988595e-01 8.716669e-01 15 63048826 63048920 95 + 0.347 0.310 -0.230
ENSG00000140416 E034 0.3697384 0.0248781476 1.756839e-01 2.955763e-01 15 63048921 63049517 597 + 0.000 0.229 12.742
ENSG00000140416 E035 0.1451727 0.0427261309 5.373555e-01   15 63050047 63050141 95 + 0.116 0.000 -12.245
ENSG00000140416 E036 0.0000000       15 63054449 63054578 130 +      
ENSG00000140416 E037 0.5546650 0.0214783393 5.135706e-01 6.483744e-01 15 63055729 63056860 1132 + 0.116 0.229 1.187
ENSG00000140416 E038 0.1482932 0.0410386627 4.470615e-01   15 63056861 63056984 124 + 0.000 0.129 11.619
ENSG00000140416 E039 108.4730291 0.0026091912 2.385765e-01 3.724811e-01 15 63056985 63057005 21 + 2.056 2.021 -0.120
ENSG00000140416 E040 197.5924111 0.0001940457 2.013154e-01 3.278317e-01 15 63057006 63057118 113 + 2.309 2.294 -0.051
ENSG00000140416 E041 193.7179242 0.0002010580 6.027200e-01 7.236559e-01 15 63059563 63059638 76 + 2.290 2.293 0.011
ENSG00000140416 E042 145.2835235 0.0002255764 6.659642e-02 1.377211e-01 15 63059639 63059680 42 + 2.131 2.201 0.233
ENSG00000140416 E043 0.8136755 0.0145999513 7.309260e-01 8.226930e-01 15 63059681 63059962 282 + 0.282 0.229 -0.400
ENSG00000140416 E044 180.8632065 0.0002236204 4.143559e-02 9.369150e-02 15 63060869 63060939 71 + 2.224 2.294 0.231
ENSG00000140416 E045 2.4973562 0.0124316880 1.934542e-02 5.008175e-02 15 63060940 63061197 258 + 0.696 0.310 -1.928
ENSG00000140416 E046 142.9475224 0.0003160267 7.714221e-01 8.524498e-01 15 63061198 63061233 36 + 2.149 2.173 0.083
ENSG00000140416 E047 138.8008730 0.0014825934 4.074003e-01 5.509763e-01 15 63061234 63061273 40 + 2.156 2.143 -0.043
ENSG00000140416 E048 5.4043956 0.1009704207 5.812152e-02 1.234107e-01 15 63061274 63061712 439 + 0.952 0.612 -1.362
ENSG00000140416 E049 8.8475009 0.0019582794 3.887910e-01 5.328767e-01 15 63061713 63061788 76 + 0.936 1.044 0.399
ENSG00000140416 E050 2.5258370 0.0064463619 1.607215e-04 7.951790e-04 15 63061789 63062056 268 + 0.770 0.129 -3.816
ENSG00000140416 E051 1.1792638 0.0120084854 3.584303e-02 8.328046e-02 15 63062057 63062107 51 + 0.496 0.129 -2.623
ENSG00000140416 E052 2.8880973 0.0055002581 4.557272e-01 5.962276e-01 15 63062108 63062214 107 + 0.639 0.535 -0.467
ENSG00000140416 E053 146.9349896 0.0032997345 8.253449e-01 8.900071e-01 15 63062215 63062243 29 + 2.170 2.175 0.017
ENSG00000140416 E054 146.8057896 0.0031195116 4.623262e-01 6.021829e-01 15 63062244 63062277 34 + 2.150 2.192 0.140
ENSG00000140416 E055 1.0339774 0.0530931810 7.507661e-02 1.516558e-01 15 63062278 63062332 55 + 0.452 0.129 -2.404
ENSG00000140416 E056 181.9304879 0.0032560898 5.212570e-01 6.551299e-01 15 63062576 63062645 70 + 2.245 2.282 0.124
ENSG00000140416 E057 1.6931308 0.0086842184 4.341849e-02 9.733056e-02 15 63062646 63062892 247 + 0.574 0.229 -1.985
ENSG00000140416 E058 2.1423665 0.0066911821 9.914492e-04 3.928944e-03 15 63063804 63064063 260 + 0.696 0.129 -3.515
ENSG00000140416 E059 20.9722763 0.0027058751 3.841352e-03 1.269618e-02 15 63064064 63064142 79 + 1.211 1.452 0.841
ENSG00000140416 E060 5.6163765 0.0029058619 3.877733e-02 8.877239e-02 15 63064143 63064190 48 + 0.936 0.683 -1.000
ENSG00000140416 E061 12.4561363 0.0260158884 1.710953e-02 4.518434e-02 15 63064191 63064982 792 + 1.250 0.970 -1.012
ENSG00000140416 E062 4.3349150 0.0360170538 5.344596e-01 6.665095e-01 15 63064983 63065278 296 + 0.770 0.682 -0.359
ENSG00000140416 E063 29.5451858 0.0074802147 2.788283e-08 3.158903e-07 15 63065896 63066085 190 + 1.203 1.659 1.578
ENSG00000140416 E064 1.1394067 0.0117678425 6.235841e-01 7.401364e-01 15 63066086 63066178 93 + 0.282 0.378 0.599
ENSG00000140416 E065 10.5569988 0.0227774433 4.161521e-02 9.403030e-02 15 63069870 63071089 1220 + 1.169 0.935 -0.854
ENSG00000140416 E066 551.5278240 0.0088254569 2.601056e-02 6.396602e-02 15 63071090 63071915 826 + 2.684 2.793 0.362