ENSG00000140382

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000336216 ENSG00000140382 HEK293_OSMI2_2hA HEK293_TMG_2hB HMG20A protein_coding protein_coding 29.62031 22.89148 34.93194 2.265022 0.1334505 0.6095188 17.4530361 14.753598 19.9725412 1.4188860 0.79669874 0.43669572 0.60827500 0.64503333 0.57173333 -0.073300000 2.468995e-01 9.16364e-19 FALSE TRUE
ENST00000558845 ENSG00000140382 HEK293_OSMI2_2hA HEK293_TMG_2hB HMG20A protein_coding protein_coding 29.62031 22.89148 34.93194 2.265022 0.1334505 0.6095188 2.2220478 1.759759 1.8373740 0.2611250 0.11357483 0.06192283 0.07707917 0.07983333 0.05260000 -0.027233333 4.771601e-01 9.16364e-19 FALSE TRUE
ENST00000559728 ENSG00000140382 HEK293_OSMI2_2hA HEK293_TMG_2hB HMG20A protein_coding retained_intron 29.62031 22.89148 34.93194 2.265022 0.1334505 0.6095188 0.7790061 2.569064 0.2723449 0.8810799 0.05376271 -3.19131739 0.03128333 0.11296667 0.00780000 -0.105166667 1.756495e-04 9.16364e-19 FALSE TRUE
ENST00000560867 ENSG00000140382 HEK293_OSMI2_2hA HEK293_TMG_2hB HMG20A protein_coding protein_coding 29.62031 22.89148 34.93194 2.265022 0.1334505 0.6095188 2.7525865 0.000000 4.3152907 0.0000000 0.69683097 8.75665328 0.07235417 0.00000000 0.12360000 0.123600000 9.163640e-19 9.16364e-19 FALSE FALSE
MSTRG.11285.2 ENSG00000140382 HEK293_OSMI2_2hA HEK293_TMG_2hB HMG20A protein_coding   29.62031 22.89148 34.93194 2.265022 0.1334505 0.6095188 3.3382490 2.091880 3.4557641 0.4109010 0.16573867 0.72149282 0.11179583 0.08990000 0.09893333 0.009033333 8.446968e-01 9.16364e-19 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000140382 E001 8.8381304 0.0019584477 6.603107e-01 7.689992e-01 15 77420412 77420673 262 + 0.961 1.030 0.255
ENSG00000140382 E002 9.7968794 0.0020816084 3.611739e-01 5.055586e-01 15 77420674 77420721 48 + 1.025 1.048 0.084
ENSG00000140382 E003 12.7067372 0.0023754210 5.657599e-02 1.207176e-01 15 77420722 77420737 16 + 1.159 1.096 -0.224
ENSG00000140382 E004 39.4367257 0.0010206424 1.325401e-03 5.060629e-03 15 77420738 77420834 97 + 1.628 1.570 -0.195
ENSG00000140382 E005 38.7787953 0.0006123086 1.676901e-04 8.252813e-04 15 77420835 77420887 53 + 1.633 1.544 -0.302
ENSG00000140382 E006 37.6770426 0.0008148643 1.187490e-05 7.756125e-05 15 77420888 77420901 14 + 1.635 1.504 -0.448
ENSG00000140382 E007 51.5903224 0.0004644302 8.569533e-06 5.782832e-05 15 77420902 77420920 19 + 1.754 1.659 -0.323
ENSG00000140382 E008 51.1217751 0.0004386329 4.286961e-08 4.687870e-07 15 77420921 77420934 14 + 1.767 1.615 -0.516
ENSG00000140382 E009 101.1429739 0.0003197260 4.111005e-09 5.437911e-08 15 77420935 77421004 70 + 2.036 1.951 -0.284
ENSG00000140382 E010 0.0000000       15 77421011 77421094 84 +      
ENSG00000140382 E011 7.1769328 0.0049780522 8.653465e-02 1.698568e-01 15 77447719 77447811 93 + 0.950 0.856 -0.356
ENSG00000140382 E012 0.1482932 0.0411597534 3.592996e-01   15 77458217 77458284 68 + 0.000 0.159 15.155
ENSG00000140382 E013 112.4956526 0.0054581012 3.386276e-05 1.987868e-04 15 77458404 77458453 50 + 2.078 1.995 -0.279
ENSG00000140382 E014 118.0225870 0.0030669515 3.354495e-08 3.743471e-07 15 77458454 77458496 43 + 2.109 1.997 -0.375
ENSG00000140382 E015 0.6299079 0.0240106850 4.881959e-01 6.257934e-01 15 77458497 77458558 62 + 0.235 0.159 -0.701
ENSG00000140382 E016 141.4452223 0.0002174973 3.542074e-12 7.942187e-11 15 77464240 77464322 83 + 2.180 2.097 -0.277
ENSG00000140382 E017 141.9679745 0.0002770875 2.136990e-09 2.977468e-08 15 77464323 77464387 65 + 2.170 2.115 -0.182
ENSG00000140382 E018 1.5521107 0.0090634778 1.418513e-01 2.505698e-01 15 77464388 77464823 436 + 0.465 0.275 -1.116
ENSG00000140382 E019 160.0235110 0.0002671758 1.695967e-11 3.401036e-10 15 77467095 77467182 88 + 2.226 2.160 -0.220
ENSG00000140382 E020 198.3887424 0.0013504588 2.469227e-04 1.162494e-03 15 77467183 77467307 125 + 2.288 2.304 0.053
ENSG00000140382 E021 192.4875525 0.0061584449 2.113232e-02 5.387650e-02 15 77470910 77471042 133 + 2.272 2.292 0.065
ENSG00000140382 E022 102.2802252 0.0003580356 3.842843e-02 8.815556e-02 15 77471783 77471814 32 + 1.988 2.043 0.186
ENSG00000140382 E023 118.4317272 0.0002588737 4.772339e-03 1.529634e-02 15 77477555 77477630 76 + 2.058 2.094 0.121
ENSG00000140382 E024 2.4723771 0.0126713930 5.320157e-02 1.148538e-01 15 77478123 77478292 170 + 0.614 0.367 -1.231
ENSG00000140382 E025 1.1071294 0.0913176199 1.536055e-01 2.665674e-01 15 77478293 77478294 2 + 0.387 0.160 -1.691
ENSG00000140382 E026 182.2877607 0.0033507312 5.384484e-01 6.698808e-01 15 77478295 77478510 216 + 2.214 2.311 0.324
ENSG00000140382 E027 182.4765847 0.0076364875 7.471542e-01 8.347356e-01 15 77479179 77479321 143 + 2.213 2.314 0.337
ENSG00000140382 E028 17.1289967 0.0134832220 4.561167e-02 1.013202e-01 15 77479322 77479604 283 + 1.097 1.405 1.086
ENSG00000140382 E029 13.0261703 0.0013605941 2.757034e-05 1.654231e-04 15 77482050 77482969 920 + 1.232 0.930 -1.094
ENSG00000140382 E030 1714.5775715 0.0061168961 8.108884e-14 2.336432e-12 15 77482970 77485607 2638 + 3.090 3.374 0.944