ENSG00000140374

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000267950 ENSG00000140374 HEK293_OSMI2_2hA HEK293_TMG_2hB ETFA protein_coding nonsense_mediated_decay 115.0304 75.44729 155.7176 13.07256 2.369985 1.045293 8.370865 7.8607594 11.68361 1.7510479 3.299405 0.5711457 0.08057500 0.10276667 0.07496667 -0.027800000 0.55697165 0.04832072   FALSE
ENST00000433983 ENSG00000140374 HEK293_OSMI2_2hA HEK293_TMG_2hB ETFA protein_coding protein_coding 115.0304 75.44729 155.7176 13.07256 2.369985 1.045293 22.804756 17.6143438 29.31006 2.8761784 1.565820 0.7343184 0.20500833 0.23443333 0.18836667 -0.046066667 0.15610180 0.04832072 FALSE TRUE
ENST00000559973 ENSG00000140374 HEK293_OSMI2_2hA HEK293_TMG_2hB ETFA protein_coding processed_transcript 115.0304 75.44729 155.7176 13.07256 2.369985 1.045293 38.228400 22.5146928 50.64942 4.6575854 4.621839 1.1693231 0.32253333 0.29533333 0.32496667 0.029633333 0.74761490 0.04832072 FALSE FALSE
ENST00000560595 ENSG00000140374 HEK293_OSMI2_2hA HEK293_TMG_2hB ETFA protein_coding protein_coding 115.0304 75.44729 155.7176 13.07256 2.369985 1.045293 12.236201 9.3982355 15.10418 0.2799763 1.894597 0.6839070 0.10908750 0.13200000 0.09706667 -0.034933333 0.57120297 0.04832072 FALSE TRUE
ENST00000685548 ENSG00000140374 HEK293_OSMI2_2hA HEK293_TMG_2hB ETFA protein_coding nonsense_mediated_decay 115.0304 75.44729 155.7176 13.07256 2.369985 1.045293 18.846318 12.3531604 22.93792 4.1003293 4.794352 0.8923160 0.15851250 0.15566667 0.14653333 -0.009133333 0.93410221 0.04832072 TRUE TRUE
ENST00000688637 ENSG00000140374 HEK293_OSMI2_2hA HEK293_TMG_2hB ETFA protein_coding processed_transcript 115.0304 75.44729 155.7176 13.07256 2.369985 1.045293 8.247325 0.7021071 17.70161 0.5250447 4.815695 4.6364574 0.06472083 0.01063333 0.11443333 0.103800000 0.04832072 0.04832072 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000140374 E001 3.6785008 5.680757e-03 2.668263e-02 6.533045e-02 15 76188555 76188598 44 - 0.495 0.819 1.395
ENSG00000140374 E002 4.7197618 6.815999e-03 3.525739e-03 1.180065e-02 15 76205902 76206041 140 - 0.530 0.933 1.665
ENSG00000140374 E003 5.0855286 1.734239e-02 9.656666e-01 9.824323e-01 15 76214525 76214697 173 - 0.781 0.764 -0.069
ENSG00000140374 E004 0.3332198 2.763148e-02 7.560339e-01   15 76215353 76215356 4 - 0.102 0.146 0.588
ENSG00000140374 E005 1.1834270 1.571093e-02 3.586524e-01 5.030401e-01 15 76215357 76215378 22 - 0.254 0.414 1.003
ENSG00000140374 E006 8.1490115 2.315272e-03 2.449857e-01 3.800166e-01 15 76215379 76215573 195 - 0.898 1.024 0.472
ENSG00000140374 E007 18.9034833 3.070458e-02 8.587591e-01 9.128926e-01 15 76215574 76216083 510 - 1.286 1.338 0.184
ENSG00000140374 E008 7.8066429 3.141219e-01 7.154463e-01 8.113562e-01 15 76216084 76216129 46 - 0.850 1.043 0.722
ENSG00000140374 E009 6.4815959 6.316615e-02 7.945816e-01 8.687610e-01 15 76216130 76216249 120 - 0.897 0.879 -0.071
ENSG00000140374 E010 10.8272203 1.691665e-03 9.093085e-01 9.464008e-01 15 76216250 76216286 37 - 1.085 1.071 -0.051
ENSG00000140374 E011 13.5623630 1.519132e-03 6.390510e-02 1.332009e-01 15 76216287 76216294 8 - 1.094 1.258 0.586
ENSG00000140374 E012 19.9361665 4.926420e-03 5.470534e-04 2.336022e-03 15 76216295 76216313 19 - 1.186 1.470 0.991
ENSG00000140374 E013 19.6458211 8.909199e-03 8.579981e-04 3.465929e-03 15 76216314 76216314 1 - 1.170 1.468 1.038
ENSG00000140374 E014 575.9595093 4.595694e-04 2.065140e-04 9.918482e-04 15 76216315 76216467 153 - 2.737 2.799 0.205
ENSG00000140374 E015 517.4059581 5.900234e-04 5.744978e-03 1.794182e-02 15 76216468 76216482 15 - 2.696 2.743 0.157
ENSG00000140374 E016 559.5718718 9.690408e-04 1.704298e-02 4.503001e-02 15 76216483 76216538 56 - 2.732 2.773 0.138
ENSG00000140374 E017 428.8929601 2.254698e-03 5.868347e-03 1.826598e-02 15 76216539 76216558 20 - 2.603 2.673 0.231
ENSG00000140374 E018 503.4552275 1.008119e-03 2.728262e-03 9.457486e-03 15 76216559 76216597 39 - 2.679 2.737 0.194
ENSG00000140374 E019 1.3671074 1.106530e-02 1.144805e-01 2.120868e-01 15 76217586 76217677 92 - 0.254 0.530 1.583
ENSG00000140374 E020 360.9371306 7.131130e-04 2.889784e-06 2.170139e-05 15 76225849 76225856 8 - 2.515 2.615 0.331
ENSG00000140374 E021 631.0080196 2.314122e-04 4.074536e-04 1.803230e-03 15 76225857 76225904 48 - 2.781 2.831 0.166
ENSG00000140374 E022 464.0434249 1.313257e-04 1.000665e-01 1.905850e-01 15 76225905 76225909 5 - 2.660 2.685 0.081
ENSG00000140374 E023 535.9293583 1.282370e-04 6.232765e-03 1.922466e-02 15 76225910 76225929 20 - 2.715 2.755 0.132
ENSG00000140374 E024 13.3073934 1.338710e-03 7.323507e-01 8.238130e-01 15 76225930 76227137 1208 - 1.146 1.175 0.102
ENSG00000140374 E025 3.6985652 4.370898e-03 8.132386e-01 8.815845e-01 15 76227138 76227230 93 - 0.697 0.661 -0.151
ENSG00000140374 E026 5.9684725 3.123068e-02 1.429896e-01 2.521168e-01 15 76227231 76227712 482 - 0.926 0.698 -0.899
ENSG00000140374 E027 3.6276533 6.050570e-02 5.755986e-02 1.224335e-01 15 76227713 76227720 8 - 0.781 0.417 -1.648
ENSG00000140374 E028 8.3549845 1.542476e-02 7.425191e-02 1.503313e-01 15 76227721 76227866 146 - 1.055 0.819 -0.888
ENSG00000140374 E029 3.7685993 4.153429e-03 3.662188e-02 8.475204e-02 15 76227867 76227897 31 - 0.800 0.476 -1.413
ENSG00000140374 E030 3.7781642 4.317137e-03 1.079410e-02 3.067213e-02 15 76227898 76227918 21 - 0.818 0.414 -1.805
ENSG00000140374 E031 8.2098791 5.489203e-03 3.958500e-02 9.026334e-02 15 76227919 76228249 331 - 1.065 0.818 -0.930
ENSG00000140374 E032 0.7416694 1.723733e-02 3.540817e-01 4.983494e-01 15 76230504 76230715 212 - 0.314 0.146 -1.414
ENSG00000140374 E033 0.4482035 2.894289e-02 1.805542e-01 3.018803e-01 15 76230716 76230730 15 - 0.254 0.000 -10.400
ENSG00000140374 E034 15.0349757 1.510698e-02 3.524659e-02 8.211923e-02 15 76230731 76231332 602 - 1.292 1.056 -0.843
ENSG00000140374 E035 714.3346896 9.636478e-05 2.033891e-02 5.219510e-02 15 76231333 76231398 66 - 2.846 2.874 0.094
ENSG00000140374 E036 2.2549922 6.759496e-03 6.992203e-02 1.432472e-01 15 76243170 76243267 98 - 0.367 0.661 1.434
ENSG00000140374 E037 0.4470576 2.278823e-02 8.485795e-01 9.059807e-01 15 76245212 76245248 37 - 0.185 0.146 -0.414
ENSG00000140374 E038 0.0000000       15 76274133 76274175 43 -      
ENSG00000140374 E039 0.9662351 1.371453e-02 6.215562e-01 7.385115e-01 15 76274176 76274411 236 - 0.254 0.342 0.587
ENSG00000140374 E040 404.3428254 1.452138e-04 9.736595e-01 9.875675e-01 15 76274412 76274418 7 - 2.614 2.611 -0.011
ENSG00000140374 E041 640.0430805 7.574309e-04 2.222714e-02 5.614635e-02 15 76274419 76274494 76 - 2.793 2.832 0.130
ENSG00000140374 E042 0.6589510 4.784488e-02 1.637459e-01 2.800124e-01 15 76281936 76283756 1821 - 0.102 0.341 2.171
ENSG00000140374 E043 755.2594298 6.391818e-04 8.649562e-01 9.169745e-01 15 76283757 76283825 69 - 2.885 2.879 -0.022
ENSG00000140374 E044 1.1102750 1.610134e-02 3.653510e-01 5.096621e-01 15 76283826 76283841 16 - 0.254 0.414 1.000
ENSG00000140374 E045 1.9489427 8.424710e-03 4.772347e-01 6.158323e-01 15 76284365 76284460 96 - 0.414 0.531 0.588
ENSG00000140374 E046 7.1857977 2.365771e-03 3.577392e-01 5.021570e-01 15 76284805 76284852 48 - 0.867 0.972 0.395
ENSG00000140374 E047 9.9467209 4.953282e-03 8.192030e-01 8.858367e-01 15 76284853 76284927 75 - 1.034 1.055 0.076
ENSG00000140374 E048 897.9358633 5.725953e-04 3.460072e-01 4.901523e-01 15 76285637 76285738 102 - 2.966 2.945 -0.070
ENSG00000140374 E049 631.4070509 1.297200e-03 2.274808e-01 3.594022e-01 15 76286371 76286405 35 - 2.819 2.782 -0.125
ENSG00000140374 E050 733.1448493 1.385662e-04 4.099832e-02 9.287680e-02 15 76286406 76286463 58 - 2.884 2.852 -0.107
ENSG00000140374 E051 516.0385725 1.274629e-04 1.221863e-03 4.714697e-03 15 76286464 76286481 18 - 2.741 2.686 -0.186
ENSG00000140374 E052 1.0361649 1.394500e-02 1.903147e-01 3.141681e-01 15 76286482 76287016 535 - 0.185 0.414 1.588
ENSG00000140374 E053 2.7652783 1.336264e-01 1.233880e-01 2.247817e-01 15 76287768 76287845 78 - 0.699 0.341 -1.749
ENSG00000140374 E054 953.1111487 9.734552e-04 1.410030e-03 5.340030e-03 15 76287846 76287945 100 - 3.010 2.941 -0.231
ENSG00000140374 E055 818.0231588 8.833798e-04 6.991286e-04 2.896047e-03 15 76292431 76292513 83 - 2.946 2.874 -0.241
ENSG00000140374 E056 1.3222584 3.578567e-01 7.660220e-01 8.486335e-01 15 76292514 76292618 105 - 0.412 0.331 -0.472
ENSG00000140374 E057 741.0746178 7.699880e-04 4.449109e-04 1.947153e-03 15 76292619 76292700 82 - 2.903 2.830 -0.244
ENSG00000140374 E058 0.1451727 4.376388e-02 7.558961e-01   15 76293012 76293133 122 - 0.102 0.000 -8.814
ENSG00000140374 E059 614.6190544 1.321293e-03 9.306627e-06 6.230300e-05 15 76295591 76295737 147 - 2.836 2.724 -0.371
ENSG00000140374 E060 4.5058609 2.941464e-02 1.141209e-01 2.115385e-01 15 76309932 76310062 131 - 0.835 0.579 -1.065
ENSG00000140374 E061 1.6971817 1.291477e-02 8.104680e-01 8.797232e-01 15 76310063 76310064 2 - 0.456 0.414 -0.221
ENSG00000140374 E062 398.9646041 7.635961e-03 7.209798e-02 1.468288e-01 15 76311350 76311730 381 - 2.645 2.536 -0.363