ENSG00000140332

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000440567 ENSG00000140332 HEK293_OSMI2_2hA HEK293_TMG_2hB TLE3 protein_coding protein_coding 35.8068 45.17837 21.77789 3.5329 0.1802378 -1.052425 2.462317 0.1525147 3.0754226 0.0810841 0.6940770 4.2468261 0.09275833 0.003466667 0.1412667 0.13780000 2.441046e-06 2.441046e-06 FALSE TRUE
ENST00000451782 ENSG00000140332 HEK293_OSMI2_2hA HEK293_TMG_2hB TLE3 protein_coding protein_coding 35.8068 45.17837 21.77789 3.5329 0.1802378 -1.052425 14.021092 20.3663110 7.3156391 2.1096232 0.2688398 -1.4758663 0.37312500 0.448933333 0.3360333 -0.11290000 2.824029e-03 2.441046e-06 FALSE TRUE
ENST00000557919 ENSG00000140332 HEK293_OSMI2_2hA HEK293_TMG_2hB TLE3 protein_coding nonsense_mediated_decay 35.8068 45.17837 21.77789 3.5329 0.1802378 -1.052425 1.809968 1.3033862 2.6977978 0.4076671 0.4962974 1.0438288 0.06003333 0.027666667 0.1238333 0.09616667 1.652819e-03 2.441046e-06 FALSE TRUE
ENST00000558939 ENSG00000140332 HEK293_OSMI2_2hA HEK293_TMG_2hB TLE3 protein_coding protein_coding 35.8068 45.17837 21.77789 3.5329 0.1802378 -1.052425 2.298433 3.6292188 1.1595413 1.0636347 0.5967372 -1.6376860 0.06963750 0.085433333 0.0535000 -0.03193333 7.780654e-01 2.441046e-06 FALSE TRUE
ENST00000559608 ENSG00000140332 HEK293_OSMI2_2hA HEK293_TMG_2hB TLE3 protein_coding retained_intron 35.8068 45.17837 21.77789 3.5329 0.1802378 -1.052425 6.642928 12.7113359 0.5170829 0.9757873 0.3393854 -4.5930765 0.15401250 0.282733333 0.0235000 -0.25923333 1.994790e-02 2.441046e-06   FALSE
ENST00000654081 ENSG00000140332 HEK293_OSMI2_2hA HEK293_TMG_2hB TLE3 protein_coding processed_transcript 35.8068 45.17837 21.77789 3.5329 0.1802378 -1.052425 3.591612 3.9004066 2.4730675 0.7714912 0.1952429 -0.6551952 0.09935000 0.084566667 0.1136667 0.02910000 4.112648e-01 2.441046e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000140332 E001 261.6487169 0.0087018097 4.931355e-12 1.079661e-10 15 70047790 70048274 485 - 2.078 2.469 1.306
ENSG00000140332 E002 557.4941159 0.0053544137 1.080070e-20 7.530952e-19 15 70048275 70048868 594 - 2.406 2.796 1.298
ENSG00000140332 E003 220.4864645 0.0050535971 1.103963e-17 5.393052e-16 15 70048869 70048975 107 - 1.981 2.398 1.393
ENSG00000140332 E004 98.9176720 0.0060462834 3.244893e-16 1.309898e-14 15 70048976 70048976 1 - 1.546 2.066 1.756
ENSG00000140332 E005 262.2260673 0.0028770514 7.802271e-07 6.633681e-06 15 70048977 70049090 114 - 2.236 2.433 0.656
ENSG00000140332 E006 742.5680627 0.0007942639 1.241025e-09 1.805888e-08 15 70049091 70049798 708 - 2.734 2.868 0.446
ENSG00000140332 E007 106.9124778 0.0003264315 1.019413e-02 2.924360e-02 15 70049799 70049800 2 - 1.908 2.023 0.386
ENSG00000140332 E008 105.3300790 0.0003151268 5.746429e-03 1.794546e-02 15 70049801 70049801 1 - 1.896 2.019 0.413
ENSG00000140332 E009 140.8613202 0.0002896798 2.597256e-03 9.057383e-03 15 70049802 70049835 34 - 2.028 2.145 0.393
ENSG00000140332 E010 408.8226163 0.0001503001 2.109581e-07 2.013572e-06 15 70049836 70050096 261 - 2.486 2.605 0.397
ENSG00000140332 E011 281.6255739 0.0001877254 2.145807e-01 3.439518e-01 15 70050097 70050204 108 - 2.378 2.423 0.151
ENSG00000140332 E012 37.7941849 0.0005919048 8.020564e-01 8.738924e-01 15 70050205 70051390 1186 - 1.546 1.546 0.002
ENSG00000140332 E013 259.2467409 0.0002039697 9.188935e-01 9.527651e-01 15 70051391 70051467 77 - 2.361 2.380 0.063
ENSG00000140332 E014 4.8804740 0.0035987970 3.306728e-01 4.742777e-01 15 70051468 70051505 38 - 0.618 0.775 0.655
ENSG00000140332 E015 253.8374955 0.0005458817 5.928828e-01 7.153448e-01 15 70052374 70052524 151 - 2.345 2.376 0.103
ENSG00000140332 E016 19.1474418 0.0078736795 4.408655e-02 9.854246e-02 15 70052525 70053173 649 - 1.371 1.208 -0.570
ENSG00000140332 E017 5.0115730 0.0316579625 2.347480e-03 8.299239e-03 15 70053174 70053226 53 - 0.999 0.557 -1.786
ENSG00000140332 E018 259.0938168 0.0001820033 5.246918e-01 6.581596e-01 15 70053227 70053374 148 - 2.352 2.384 0.106
ENSG00000140332 E019 5.6199574 0.0087257211 8.042883e-02 1.602326e-01 15 70053375 70054437 1063 - 0.936 0.719 -0.850
ENSG00000140332 E020 324.1727683 0.0002521899 3.281073e-02 7.743155e-02 15 70054438 70054680 243 - 2.491 2.461 -0.099
ENSG00000140332 E021 108.3358754 0.0003595357 1.909396e-02 4.954381e-02 15 70054681 70054685 5 - 2.046 1.977 -0.230
ENSG00000140332 E022 2.3865225 0.0067809288 2.135944e-01 3.427712e-01 15 70054686 70055048 363 - 0.618 0.424 -0.929
ENSG00000140332 E023 315.3367179 0.0010928378 2.235735e-03 7.953454e-03 15 70055049 70055296 248 - 2.501 2.440 -0.203
ENSG00000140332 E024 84.4243197 0.0009306930 3.097292e-02 7.386362e-02 15 70055297 70055298 2 - 1.941 1.866 -0.251
ENSG00000140332 E025 4.5429798 0.0950211606 2.315305e-01 3.642875e-01 15 70055299 70056297 999 - 0.861 0.633 -0.926
ENSG00000140332 E026 157.1499691 0.0002585239 1.857445e-03 6.781060e-03 15 70056298 70056374 77 - 2.209 2.132 -0.258
ENSG00000140332 E027 36.1358228 0.0005896120 8.762593e-02 1.715297e-01 15 70057459 70057473 15 - 1.588 1.500 -0.300
ENSG00000140332 E028 136.2261450 0.0002421316 1.184073e-02 3.315190e-02 15 70057474 70057519 46 - 2.140 2.075 -0.217
ENSG00000140332 E029 214.1621082 0.0002949124 2.076176e-02 5.308463e-02 15 70057520 70057658 139 - 2.321 2.277 -0.148
ENSG00000140332 E030 9.5349308 0.0021562389 1.599677e-03 5.960233e-03 15 70057659 70058090 432 - 1.174 0.853 -1.183
ENSG00000140332 E031 2.9173282 0.0095529647 1.107890e-01 2.067004e-01 15 70058091 70058149 59 - 0.703 0.461 -1.097
ENSG00000140332 E032 19.4722245 0.0296552204 6.799055e-01 7.839734e-01 15 70058150 70058158 9 - 1.298 1.275 -0.080
ENSG00000140332 E033 105.6113216 0.0002773668 1.988052e-01 3.247038e-01 15 70058159 70058185 27 - 2.009 1.978 -0.104
ENSG00000140332 E034 216.1010815 0.0002444954 9.554122e-05 5.010796e-04 15 70058186 70058291 106 - 2.354 2.270 -0.280
ENSG00000140332 E035 3.0538966 0.0055585224 1.090503e-03 4.271795e-03 15 70058292 70058662 371 - 0.863 0.383 -2.154
ENSG00000140332 E036 225.3850178 0.0011039999 7.271671e-06 4.986413e-05 15 70058663 70058815 153 - 2.391 2.280 -0.373
ENSG00000140332 E037 153.3393132 0.0013750680 2.486773e-05 1.509393e-04 15 70059410 70059460 51 - 2.234 2.107 -0.424
ENSG00000140332 E038 209.8635708 0.0005219228 3.885761e-11 7.346030e-10 15 70060530 70060649 120 - 2.389 2.228 -0.539
ENSG00000140332 E039 109.0903168 0.0004406754 1.363102e-09 1.970663e-08 15 70064454 70064470 17 - 2.130 1.932 -0.665
ENSG00000140332 E040 170.3795988 0.0065274668 9.591916e-04 3.818926e-03 15 70066014 70066122 109 - 2.291 2.148 -0.476
ENSG00000140332 E041 91.1228788 0.0054024541 2.892207e-02 6.984944e-02 15 70066123 70066143 21 - 1.993 1.896 -0.327
ENSG00000140332 E042 122.6106322 0.0016224941 5.282752e-02 1.141803e-01 15 70066144 70066215 72 - 2.092 2.035 -0.193
ENSG00000140332 E043 53.3298934 0.0070401205 2.737460e-01 4.128352e-01 15 70066216 70066218 3 - 1.729 1.676 -0.178
ENSG00000140332 E044 3.7652687 0.0041103033 8.632553e-01 9.158214e-01 15 70066618 70066939 322 - 0.618 0.657 0.169
ENSG00000140332 E045 8.0526506 0.0024086948 2.156766e-02 5.478363e-02 15 70074503 70074532 30 - 1.071 0.824 -0.929
ENSG00000140332 E046 138.2561964 0.0014218091 2.621988e-05 1.581749e-04 15 70074533 70074607 75 - 2.191 2.058 -0.443
ENSG00000140332 E047 153.7696804 0.0019588698 3.684435e-07 3.346623e-06 15 70076096 70076158 63 - 2.257 2.093 -0.550
ENSG00000140332 E048 122.0744373 0.0002923006 6.277859e-09 8.045585e-08 15 70094532 70094576 45 - 2.165 1.988 -0.593
ENSG00000140332 E049 0.1515154 0.0429251870 2.494447e-01   15 70094726 70094785 60 - 0.161 0.000 -10.336
ENSG00000140332 E050 0.1472490 0.0430801136 2.497456e-01   15 70095390 70095577 188 - 0.161 0.000 -10.332
ENSG00000140332 E051 142.1787012 0.0037070913 1.315354e-08 1.586186e-07 15 70095578 70095641 64 - 2.256 2.038 -0.730
ENSG00000140332 E052 1.1050531 0.0114087575 4.775821e-03 1.530542e-02 15 70095642 70095950 309 - 0.568 0.092 -3.515
ENSG00000140332 E053 136.3283952 0.0096714591 2.729766e-05 1.639911e-04 15 70096161 70096261 101 - 2.235 2.022 -0.711
ENSG00000140332 E054 2.3197001 0.0065721107 2.128085e-01 3.418459e-01 15 70096262 70096676 415 - 0.618 0.423 -0.930
ENSG00000140332 E055 1.0298222 0.0976768692 9.837516e-01 9.939307e-01 15 70096677 70096752 76 - 0.278 0.289 0.074
ENSG00000140332 E056 156.2634481 0.0232713713 8.383513e-04 3.395979e-03 15 70096775 70097404 630 - 2.306 2.074 -0.778
ENSG00000140332 E057 49.8676150 0.0092852282 6.689639e-04 2.784794e-03 15 70097405 70097439 35 - 1.803 1.591 -0.716
ENSG00000140332 E058 91.8491442 0.0122164662 5.672115e-02 1.209837e-01 15 70097440 70097558 119 - 1.996 1.895 -0.339
ENSG00000140332 E059 99.0796292 0.0207437860 5.540818e-01 6.831251e-01 15 70097559 70097657 99 - 1.971 1.957 -0.049
ENSG00000140332 E060 152.1661004 0.0080295060 2.576644e-02 6.345795e-02 15 70097658 70098176 519 - 2.208 2.115 -0.311