ENSG00000140326

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000356231 ENSG00000140326 HEK293_OSMI2_2hA HEK293_TMG_2hB CDAN1 protein_coding protein_coding 9.734219 10.96943 6.29057 0.7068001 0.3664987 -0.8012492 4.2132131 4.7316094 2.5470915 0.6554182 0.28919013 -0.8908730 0.43045000 0.43160000 0.4100333 -0.02156667 9.528162e-01 6.586909e-05 FALSE TRUE
ENST00000562465 ENSG00000140326 HEK293_OSMI2_2hA HEK293_TMG_2hB CDAN1 protein_coding nonsense_mediated_decay 9.734219 10.96943 6.29057 0.7068001 0.3664987 -0.8012492 2.1237355 3.4962640 0.6961508 0.5976031 0.39920817 -2.3118865 0.20468333 0.31790000 0.1052667 -0.21263333 3.706677e-01 6.586909e-05 TRUE TRUE
ENST00000563604 ENSG00000140326 HEK293_OSMI2_2hA HEK293_TMG_2hB CDAN1 protein_coding retained_intron 9.734219 10.96943 6.29057 0.7068001 0.3664987 -0.8012492 0.7048225 0.3912500 0.8362172 0.0727610 0.04617181 1.0765269 0.07970000 0.03646667 0.1336333 0.09716667 6.586909e-05 6.586909e-05 FALSE FALSE
ENST00000643434 ENSG00000140326 HEK293_OSMI2_2hA HEK293_TMG_2hB CDAN1 protein_coding nonsense_mediated_decay 9.734219 10.96943 6.29057 0.7068001 0.3664987 -0.8012492 0.6215748 0.6882760 0.6118889 0.2051443 0.31731556 -0.1671405 0.06890417 0.06476667 0.1032667 0.03850000 1.000000e+00 6.586909e-05 TRUE TRUE
MSTRG.10628.6 ENSG00000140326 HEK293_OSMI2_2hA HEK293_TMG_2hB CDAN1 protein_coding   9.734219 10.96943 6.29057 0.7068001 0.3664987 -0.8012492 1.1751930 0.7471427 1.1106489 0.1856254 0.24572079 0.5656972 0.12557917 0.06806667 0.1734000 0.10533333 4.651720e-02 6.586909e-05 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000140326 E001 7.1452781 0.0828875346 3.752663e-02 8.645636e-02 15 42719325 42720630 1306 - 1.093 0.759 -1.264
ENSG00000140326 E002 0.4470576 0.0228888546 2.551648e-01 3.919963e-01 15 42723544 42723558 15 - 0.281 0.091 -1.966
ENSG00000140326 E003 1.5174769 0.2866953502 9.871146e-01 9.959996e-01 15 42723559 42723561 3 - 0.374 0.405 0.173
ENSG00000140326 E004 8.9505486 0.0042391706 5.072101e-01 6.428022e-01 15 42723562 42723582 21 - 0.918 0.993 0.282
ENSG00000140326 E005 175.1206101 0.0002795924 5.108376e-06 3.628262e-05 15 42723583 42724208 626 - 2.110 2.241 0.440
ENSG00000140326 E006 78.3752389 0.0003456132 3.745477e-02 8.631707e-02 15 42724209 42724263 55 - 1.795 1.882 0.296
ENSG00000140326 E007 76.1248049 0.0018048029 2.152139e-01 3.446802e-01 15 42724264 42724312 49 - 1.804 1.861 0.193
ENSG00000140326 E008 59.2802663 0.0004496478 6.153739e-01 7.336644e-01 15 42724313 42724325 13 - 1.723 1.745 0.074
ENSG00000140326 E009 126.6686815 0.0003296721 4.914736e-01 6.287398e-01 15 42724326 42724616 291 - 2.051 2.071 0.069
ENSG00000140326 E010 7.6727136 0.0023766669 1.165097e-05 7.625638e-05 15 42724617 42724894 278 - 1.192 0.695 -1.877
ENSG00000140326 E011 5.9162868 0.0037764367 1.041451e-06 8.607065e-06 15 42724895 42725143 249 - 1.138 0.522 -2.449
ENSG00000140326 E012 67.6779524 0.0005684430 7.401165e-02 1.499362e-01 15 42725144 42725251 108 - 1.734 1.815 0.276
ENSG00000140326 E013 3.2775042 0.0054951748 1.999640e-02 5.148000e-02 15 42725252 42725488 237 - 0.810 0.457 -1.547
ENSG00000140326 E014 83.0256324 0.0003222999 2.996413e-01 4.411899e-01 15 42725489 42725670 182 - 1.854 1.894 0.136
ENSG00000140326 E015 40.7107510 0.0008770830 2.856456e-02 6.913940e-02 15 42726097 42726160 64 - 1.485 1.616 0.449
ENSG00000140326 E016 61.5095123 0.0036597309 6.384678e-01 7.521098e-01 15 42726310 42726417 108 - 1.741 1.766 0.083
ENSG00000140326 E017 37.8102623 0.0006012500 1.892212e-01 3.127581e-01 15 42727621 42727667 47 - 1.491 1.570 0.269
ENSG00000140326 E018 63.5410854 0.0120914022 4.196229e-01 5.628809e-01 15 42727668 42727769 102 - 1.730 1.784 0.182
ENSG00000140326 E019 62.4845935 0.0020410832 7.820128e-01 8.600220e-01 15 42727955 42728033 79 - 1.752 1.763 0.040
ENSG00000140326 E020 47.7606971 0.0006412731 2.080989e-01 3.361904e-01 15 42728204 42728267 64 - 1.598 1.665 0.228
ENSG00000140326 E021 75.7261513 0.0003631158 3.055341e-01 4.476468e-01 15 42728652 42728810 159 - 1.810 1.852 0.142
ENSG00000140326 E022 54.6804945 0.0004381256 3.079426e-01 4.501763e-01 15 42729023 42729126 104 - 1.667 1.717 0.168
ENSG00000140326 E023 63.0775967 0.0004472936 2.491862e-01 3.849531e-01 15 42729229 42729362 134 - 1.801 1.745 -0.190
ENSG00000140326 E024 43.8825163 0.0005358543 6.815352e-01 7.851899e-01 15 42729568 42729622 55 - 1.627 1.601 -0.087
ENSG00000140326 E025 38.8612588 0.0006614946 9.684298e-01 9.842761e-01 15 42729796 42729885 90 - 1.556 1.556 -0.001
ENSG00000140326 E026 37.4707536 0.0006301849 5.788177e-01 7.038031e-01 15 42730128 42730215 88 - 1.516 1.548 0.108
ENSG00000140326 E027 55.6022500 0.0004360441 9.082315e-01 9.457120e-01 15 42730598 42730764 167 - 1.715 1.707 -0.029
ENSG00000140326 E028 63.7066226 0.0004527814 6.696838e-01 7.763834e-01 15 42730925 42731071 147 - 1.785 1.763 -0.077
ENSG00000140326 E029 66.0505248 0.0030007041 3.043719e-01 4.463755e-01 15 42731211 42731331 121 - 1.825 1.770 -0.187
ENSG00000140326 E030 64.1540113 0.0004199571 5.601441e-01 6.881662e-01 15 42731620 42731825 206 - 1.755 1.780 0.083
ENSG00000140326 E031 40.2888444 0.0005859231 7.830187e-01 8.606936e-01 15 42732333 42732408 76 - 1.562 1.575 0.047
ENSG00000140326 E032 50.1347271 0.0023742844 6.696060e-01 7.763834e-01 15 42733097 42733186 90 - 1.680 1.653 -0.089
ENSG00000140326 E033 50.1088747 0.0006513420 2.520470e-01 3.883687e-01 15 42733938 42734047 110 - 1.707 1.645 -0.212
ENSG00000140326 E034 39.7172668 0.0005915670 7.829120e-01 8.606063e-01 15 42734226 42734346 121 - 1.556 1.570 0.047
ENSG00000140326 E035 38.7969220 0.0144788988 4.691489e-01 6.084426e-01 15 42735100 42735178 79 - 1.607 1.544 -0.218
ENSG00000140326 E036 44.2990874 0.0008997312 9.558679e-04 3.807771e-03 15 42735261 42735374 114 - 1.737 1.556 -0.617
ENSG00000140326 E037 47.8143141 0.0004900501 1.470740e-02 3.983006e-02 15 42735510 42735679 170 - 1.734 1.604 -0.441
ENSG00000140326 E038 43.5925676 0.0005355225 5.189167e-04 2.230807e-03 15 42735875 42736044 170 - 1.734 1.544 -0.644
ENSG00000140326 E039 24.0556949 0.0095027015 2.340435e-02 5.858750e-02 15 42736045 42736078 34 - 1.485 1.293 -0.664
ENSG00000140326 E040 10.2550335 0.0370837992 1.577146e-02 4.221745e-02 15 42736079 42736081 3 - 1.217 0.899 -1.160
ENSG00000140326 E041 33.0749680 0.0101031659 7.010137e-03 2.125015e-02 15 42736302 42736561 260 - 1.623 1.414 -0.714
ENSG00000140326 E042 22.9066908 0.0008355269 1.740172e-01 2.934054e-01 15 42736562 42736780 219 - 1.407 1.304 -0.360
ENSG00000140326 E043 1.5092443 0.0164614047 1.692416e-01 2.871990e-01 15 42736989 42737012 24 - 0.163 0.421 1.848
ENSG00000140326 E044 17.6329167 0.0011622677 5.575641e-01 6.859639e-01 15 42737013 42737128 116 - 1.272 1.220 -0.183