ENSG00000140320

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000416165 ENSG00000140320 HEK293_OSMI2_2hA HEK293_TMG_2hB BAHD1 protein_coding protein_coding 16.59008 24.06502 13.06099 1.617236 0.256069 -0.8811683 3.043235 4.9652877 2.118187 1.0136681 1.06243708 -1.225155 0.17449583 0.20303333 0.1638000 -0.03923333 8.423369e-01 4.365318e-16 FALSE TRUE
ENST00000560846 ENSG00000140320 HEK293_OSMI2_2hA HEK293_TMG_2hB BAHD1 protein_coding protein_coding 16.59008 24.06502 13.06099 1.617236 0.256069 -0.8811683 2.610984 4.7675681 1.831974 0.4697979 1.04224609 -1.375024 0.15317917 0.19746667 0.1376000 -0.05986667 7.579802e-01 4.365318e-16 FALSE TRUE
ENST00000561234 ENSG00000140320 HEK293_OSMI2_2hA HEK293_TMG_2hB BAHD1 protein_coding protein_coding 16.59008 24.06502 13.06099 1.617236 0.256069 -0.8811683 1.247922 0.7012769 2.275487 0.7012769 0.61013860 1.684018 0.08944583 0.02856667 0.1738000 0.14523333 8.679767e-02 4.365318e-16 FALSE TRUE
ENST00000561464 ENSG00000140320 HEK293_OSMI2_2hA HEK293_TMG_2hB BAHD1 protein_coding retained_intron 16.59008 24.06502 13.06099 1.617236 0.256069 -0.8811683 3.421914 6.7108202 1.236937 0.7687691 0.07943154 -2.430248 0.19180417 0.28256667 0.0946000 -0.18796667 9.532125e-05 4.365318e-16   FALSE
MSTRG.10556.1 ENSG00000140320 HEK293_OSMI2_2hA HEK293_TMG_2hB BAHD1 protein_coding   16.59008 24.06502 13.06099 1.617236 0.256069 -0.8811683 1.914318 3.2610404 0.000000 0.4322484 0.00000000 -8.353606 0.10320833 0.13796667 0.0000000 -0.13796667 4.365318e-16 4.365318e-16 FALSE TRUE
MSTRG.10556.5 ENSG00000140320 HEK293_OSMI2_2hA HEK293_TMG_2hB BAHD1 protein_coding   16.59008 24.06502 13.06099 1.617236 0.256069 -0.8811683 4.351711 3.6590295 5.598409 0.8149121 1.02932180 0.612193 0.28783750 0.15030000 0.4302333 0.27993333 1.185782e-02 4.365318e-16 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000140320 E001 1.1435713 0.0357383488 2.227184e-01 3.536178e-01 15 40437514 40437584 71 + 0.150 0.404 1.903
ENSG00000140320 E002 1.5081035 0.0461059680 7.444268e-03 2.237177e-02 15 40439721 40439965 245 + 0.632 0.180 -2.677
ENSG00000140320 E003 0.8814403 0.0141155197 7.156628e-02 1.459405e-01 15 40440953 40440968 16 + 0.000 0.359 10.804
ENSG00000140320 E004 1.0631447 0.0119602040 4.249109e-02 9.561139e-02 15 40440969 40441097 129 + 0.000 0.406 11.086
ENSG00000140320 E005 39.1292644 0.0126204567 4.034648e-02 9.165991e-02 15 40441098 40441268 171 + 1.641 1.536 -0.356
ENSG00000140320 E006 38.7580777 0.0039838231 4.057418e-02 9.207783e-02 15 40458451 40458464 14 + 1.620 1.543 -0.264
ENSG00000140320 E007 528.2030232 0.0014945257 5.423532e-07 4.765197e-06 15 40458465 40459896 1432 + 2.727 2.680 -0.155
ENSG00000140320 E008 29.2248039 0.0014980030 5.775153e-03 1.802121e-02 15 40461912 40461914 3 + 1.530 1.398 -0.455
ENSG00000140320 E009 201.8349114 0.0001939078 3.533784e-03 1.182341e-02 15 40461915 40462294 380 + 2.292 2.271 -0.070
ENSG00000140320 E010 181.8174670 0.0002720793 1.218735e-04 6.224173e-04 15 40463861 40464020 160 + 2.265 2.214 -0.169
ENSG00000140320 E011 126.5737401 0.0003080528 1.742542e-02 4.588050e-02 15 40464471 40464547 77 + 2.092 2.067 -0.082
ENSG00000140320 E012 13.5629210 0.0194332530 2.213136e-01 3.520010e-01 15 40464910 40465334 425 + 1.188 1.103 -0.302
ENSG00000140320 E013 43.4064803 0.0047668054 1.261923e-02 3.501229e-02 15 40465335 40465343 9 + 1.680 1.578 -0.347
ENSG00000140320 E014 135.5062000 0.0002641638 1.054634e-01 1.988033e-01 15 40465344 40465435 92 + 2.105 2.107 0.007
ENSG00000140320 E015 1372.2686413 0.0030442687 8.339488e-11 1.491982e-09 15 40465941 40468236 2296 + 3.000 3.163 0.542