ENSG00000140263

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000267814 ENSG00000140263 HEK293_OSMI2_2hA HEK293_TMG_2hB SORD protein_coding protein_coding 22.31068 22.22224 22.35206 3.249324 0.6010644 0.008399699 16.755457 18.5060464 15.799169 3.0264895 0.2353533 -0.2280145 0.74890000 0.8283 0.7083333 -0.11996667 2.231794e-02 1.905687e-05 FALSE TRUE
ENST00000558789 ENSG00000140263 HEK293_OSMI2_2hA HEK293_TMG_2hB SORD protein_coding nonsense_mediated_decay 22.31068 22.22224 22.35206 3.249324 0.6010644 0.008399699 2.231936 0.9484862 2.950587 0.1068006 0.3635853 1.6270539 0.09979583 0.0437 0.1315667 0.08786667 1.905687e-05 1.905687e-05 TRUE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000140263 E001 6.2656330 0.0027170721 2.465462e-01 3.819025e-01 15 45023147 45023167 21 + 0.925 0.806 -0.460
ENSG00000140263 E002 8.5048062 0.0050858593 3.635098e-01 5.079127e-01 15 45023168 45023180 13 + 1.023 0.944 -0.293
ENSG00000140263 E003 21.1256176 0.0067004264 6.504007e-01 7.614503e-01 15 45023181 45023194 14 + 1.353 1.335 -0.062
ENSG00000140263 E004 22.0229551 0.0011515110 3.500673e-01 4.942483e-01 15 45023195 45023199 5 + 1.386 1.342 -0.153
ENSG00000140263 E005 98.0561519 0.0013569821 6.678611e-03 2.038807e-02 15 45023200 45023227 28 + 2.039 1.955 -0.282
ENSG00000140263 E006 222.3191440 0.0023948578 1.491243e-02 4.028915e-02 15 45023228 45023349 122 + 2.380 2.318 -0.207
ENSG00000140263 E007 6.1411461 0.0325169174 2.109619e-01 3.396715e-01 15 45035750 45036235 486 + 0.719 0.928 0.815
ENSG00000140263 E008 2.2833084 0.1769899726 5.366104e-01 6.683446e-01 15 45036236 45036344 109 + 0.583 0.449 -0.642
ENSG00000140263 E009 0.1817044 0.0412465498 5.802226e-01   15 45036345 45036363 19 + 0.000 0.114 8.493
ENSG00000140263 E010 168.2072349 0.0025888452 7.986773e-02 1.593544e-01 15 45040408 45040441 34 + 2.250 2.204 -0.153
ENSG00000140263 E011 0.9964241 0.0127194658 5.849276e-01 7.087300e-01 15 45040442 45043256 2815 + 0.232 0.342 0.762
ENSG00000140263 E012 287.2132670 0.0002405378 3.363113e-01 4.801330e-01 15 45043257 45043421 165 + 2.457 2.461 0.015
ENSG00000140263 E013 1.5091596 0.0126204045 7.185176e-01 8.135905e-01 15 45060982 45061066 85 + 0.442 0.397 -0.241
ENSG00000140263 E014 338.5342746 0.0001782174 6.192682e-01 7.367356e-01 15 45061067 45061226 160 + 2.522 2.537 0.052
ENSG00000140263 E015 324.1130791 0.0001502308 5.630825e-01 6.905921e-01 15 45065271 45065389 119 + 2.491 2.527 0.121
ENSG00000140263 E016 235.1522001 0.0007936798 7.137674e-01 8.101535e-01 15 45068181 45068246 66 + 2.354 2.388 0.113
ENSG00000140263 E017 261.8990500 0.0007912915 2.784321e-01 4.181182e-01 15 45068877 45068978 102 + 2.390 2.440 0.168
ENSG00000140263 E018 218.0357089 0.0002558341 4.571161e-01 5.974768e-01 15 45068979 45069052 74 + 2.317 2.360 0.145
ENSG00000140263 E019 18.4480657 0.0014177327 1.049213e-09 1.550107e-08 15 45069195 45069858 664 + 1.497 1.025 -1.663
ENSG00000140263 E020 25.0244948 0.0008646740 5.214197e-09 6.780245e-08 15 45069859 45070300 442 + 1.597 1.220 -1.306
ENSG00000140263 E021 11.2256891 0.0017880731 1.967824e-04 9.500468e-04 15 45070301 45070453 153 + 1.254 0.913 -1.238
ENSG00000140263 E022 13.8213381 0.0020245422 1.244603e-04 6.342262e-04 15 45070454 45070654 201 + 1.325 1.000 -1.163
ENSG00000140263 E023 6.5783201 0.0025529203 5.014422e-04 2.165266e-03 15 45070655 45070753 99 + 1.064 0.662 -1.559
ENSG00000140263 E024 36.3104359 0.0007315156 1.284635e-09 1.866479e-08 15 45070754 45071626 873 + 1.732 1.408 -1.110
ENSG00000140263 E025 7.6435542 0.0022672274 1.353801e-02 3.716899e-02 15 45071627 45071788 162 + 1.064 0.806 -0.974
ENSG00000140263 E026 1.1436611 0.0168843914 1.595190e-01 2.744839e-01 15 45071789 45072316 528 + 0.442 0.204 -1.557
ENSG00000140263 E027 149.9360496 0.0018701107 1.691226e-01 2.870433e-01 15 45072317 45072438 122 + 2.136 2.209 0.246
ENSG00000140263 E028 3.2568046 0.0703713981 2.793537e-01 4.190936e-01 15 45072439 45073364 926 + 0.720 0.533 -0.818
ENSG00000140263 E029 760.1009745 0.0063395083 2.758769e-03 9.548562e-03 15 45073365 45077185 3821 + 2.802 2.922 0.398