ENSG00000140262

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000267811 ENSG00000140262 HEK293_OSMI2_2hA HEK293_TMG_2hB TCF12 protein_coding protein_coding 6.849407 2.272951 11.41209 0.2458183 0.7472623 2.322854 3.43307869 1.26331170 5.4053374 0.14533368 0.14274169 2.088466 0.51437083 0.56013333 0.47623333 -0.08390000 0.550560150 0.001032233 FALSE TRUE
ENST00000343827 ENSG00000140262 HEK293_OSMI2_2hA HEK293_TMG_2hB TCF12 protein_coding protein_coding 6.849407 2.272951 11.41209 0.2458183 0.7472623 2.322854 0.02550069 0.20400549 0.0000000 0.20400549 0.00000000 -4.419576 0.01029167 0.08233333 0.00000000 -0.08233333 0.517347672 0.001032233 FALSE TRUE
ENST00000557843 ENSG00000140262 HEK293_OSMI2_2hA HEK293_TMG_2hB TCF12 protein_coding protein_coding 6.849407 2.272951 11.41209 0.2458183 0.7472623 2.322854 0.05906620 0.15775032 0.0000000 0.15775032 0.00000000 -4.068244 0.02543750 0.08843333 0.00000000 -0.08843333 0.554612858 0.001032233 FALSE TRUE
ENST00000557947 ENSG00000140262 HEK293_OSMI2_2hA HEK293_TMG_2hB TCF12 protein_coding protein_coding 6.849407 2.272951 11.41209 0.2458183 0.7472623 2.322854 0.27622784 0.03003925 0.7276717 0.03003925 0.41278912 4.203492 0.02476250 0.01173333 0.06693333 0.05520000 0.739798059 0.001032233 FALSE FALSE
ENST00000559609 ENSG00000140262 HEK293_OSMI2_2hA HEK293_TMG_2hB TCF12 protein_coding protein_coding 6.849407 2.272951 11.41209 0.2458183 0.7472623 2.322854 0.35976676 0.00000000 0.8749657 0.00000000 0.20326311 6.467550 0.03675833 0.00000000 0.07886667 0.07886667 0.001032233 0.001032233 FALSE TRUE
ENST00000560506 ENSG00000140262 HEK293_OSMI2_2hA HEK293_TMG_2hB TCF12 protein_coding processed_transcript 6.849407 2.272951 11.41209 0.2458183 0.7472623 2.322854 0.44395181 0.00000000 1.1890948 0.00000000 0.59468395 6.905802 0.03468333 0.00000000 0.09890000 0.09890000 0.389471093 0.001032233 FALSE FALSE
ENST00000560948 ENSG00000140262 HEK293_OSMI2_2hA HEK293_TMG_2hB TCF12 protein_coding protein_coding 6.849407 2.272951 11.41209 0.2458183 0.7472623 2.322854 0.22705114 0.15675576 0.4671513 0.08911517 0.08786643 1.516710 0.05859583 0.06196667 0.04173333 -0.02023333 0.796949333 0.001032233   FALSE
ENST00000561346 ENSG00000140262 HEK293_OSMI2_2hA HEK293_TMG_2hB TCF12 protein_coding processed_transcript 6.849407 2.272951 11.41209 0.2458183 0.7472623 2.322854 0.82080499 0.00000000 1.2961217 0.00000000 0.67706099 7.029146 0.06892083 0.00000000 0.10673333 0.10673333 0.385655449 0.001032233 FALSE FALSE
ENST00000561454 ENSG00000140262 HEK293_OSMI2_2hA HEK293_TMG_2hB TCF12 protein_coding processed_transcript 6.849407 2.272951 11.41209 0.2458183 0.7472623 2.322854 0.02608885 0.20871083 0.0000000 0.20871083 0.00000000 -4.450953 0.01020000 0.08160000 0.00000000 -0.08160000 0.467933098 0.001032233   FALSE
MSTRG.10887.4 ENSG00000140262 HEK293_OSMI2_2hA HEK293_TMG_2hB TCF12 protein_coding   6.849407 2.272951 11.41209 0.2458183 0.7472623 2.322854 0.43068621 0.09712610 0.6445891 0.09712610 0.27503574 2.611280 0.06724167 0.03796667 0.06013333 0.02216667 0.712930055 0.001032233 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000140262 E001 1.0748892 0.0135292983 6.321179e-01 7.470219e-01 15 56918623 56918624 2 + 0.256 0.365 0.714
ENSG00000140262 E002 1.6703418 0.0146562340 8.285052e-01 8.922165e-01 15 56918625 56918643 19 + 0.389 0.365 -0.135
ENSG00000140262 E003 2.4787068 0.0059052088 8.356807e-01 8.972406e-01 15 56918644 56918674 31 + 0.490 0.474 -0.079
ENSG00000140262 E004 18.9772436 0.0009595388 2.927291e-01 4.337192e-01 15 56918675 56918831 157 + 1.240 1.172 -0.243
ENSG00000140262 E005 18.9657318 0.0009607751 1.175860e-01 2.164999e-01 15 56918832 56918906 75 + 1.252 1.131 -0.430
ENSG00000140262 E006 0.2934659 0.0299730295 3.318871e-01   15 56919148 56919228 81 + 0.065 0.220 2.034
ENSG00000140262 E007 1.7694033 0.0085139340 6.155588e-01 7.338110e-01 15 56919517 56919891 375 + 0.359 0.474 0.623
ENSG00000140262 E008 14.8272912 0.0012084518 2.795315e-01 4.193005e-01 15 56919892 56919901 10 + 1.147 1.062 -0.303
ENSG00000140262 E009 29.1025545 0.0007325229 4.241112e-01 5.670990e-01 15 56919902 56919988 87 + 1.411 1.382 -0.101
ENSG00000140262 E010 28.3258635 0.0007019899 3.404694e-01 4.844156e-01 15 56921026 56921098 73 + 1.400 1.357 -0.147
ENSG00000140262 E011 0.4439371 0.0215619510 5.708141e-01 6.972527e-01 15 57001349 57001384 36 + 0.171 0.000 -12.588
ENSG00000140262 E012 0.4417591 0.0898136455 1.031656e-01 1.952957e-01 15 57063748 57063749 2 + 0.065 0.363 3.023
ENSG00000140262 E013 30.5062758 0.0008051899 6.356874e-02 1.326370e-01 15 57063750 57063823 74 + 1.445 1.331 -0.392
ENSG00000140262 E014 1.6671076 0.0082411136 2.975502e-01 4.389126e-01 15 57072653 57072714 62 + 0.416 0.220 -1.285
ENSG00000140262 E015 34.4462095 0.0008678127 1.545276e-01 2.677903e-01 15 57091789 57091891 103 + 1.487 1.416 -0.246
ENSG00000140262 E016 0.0000000       15 57091892 57092023 132 +      
ENSG00000140262 E017 0.0000000       15 57109258 57109317 60 +      
ENSG00000140262 E018 0.0000000       15 57118350 57118433 84 +      
ENSG00000140262 E019 1.2607332 0.0107409573 2.876584e-01 4.281720e-01 15 57129783 57129972 190 + 0.256 0.474 1.299
ENSG00000140262 E020 0.1482932 0.0411588029 1.150505e-01   15 57134316 57134500 185 + 0.000 0.219 12.551
ENSG00000140262 E021 23.5149268 0.0222618118 4.829704e-02 1.061552e-01 15 57166402 57166466 65 + 1.353 1.153 -0.703
ENSG00000140262 E022 30.2797577 0.0007847587 1.378628e-01 2.450984e-01 15 57192158 57192293 136 + 1.439 1.357 -0.285
ENSG00000140262 E023 27.2554523 0.0007680651 7.020626e-01 8.009567e-01 15 57197773 57197825 53 + 1.365 1.427 0.213
ENSG00000140262 E024 0.0000000       15 57214079 57214396 318 +      
ENSG00000140262 E025 0.0000000       15 57219037 57219429 393 +      
ENSG00000140262 E026 0.0000000       15 57219430 57219434 5 +      
ENSG00000140262 E027 0.0000000       15 57219435 57219465 31 +      
ENSG00000140262 E028 0.0000000       15 57219466 57219590 125 +      
ENSG00000140262 E029 40.3508460 0.0005493405 3.767273e-02 8.671914e-02 15 57231152 57231257 106 + 1.566 1.458 -0.372
ENSG00000140262 E030 49.4303372 0.0018988786 7.179851e-03 2.169103e-02 15 57232291 57232430 140 + 1.656 1.514 -0.486
ENSG00000140262 E031 50.4892416 0.0004793970 1.119274e-01 2.083941e-01 15 57232712 57232856 145 + 1.649 1.586 -0.212
ENSG00000140262 E032 35.8155592 0.0006252346 5.000655e-02 1.091880e-01 15 57234043 57234107 65 + 1.514 1.405 -0.376
ENSG00000140262 E033 37.6771421 0.0025071865 4.152428e-02 9.385842e-02 15 57243472 57243550 79 + 1.535 1.416 -0.408
ENSG00000140262 E034 0.2987644 0.0290785164 1.000000e+00   15 57243551 57243553 3 + 0.121 0.000 -11.965
ENSG00000140262 E035 0.0000000       15 57248016 57248040 25 +      
ENSG00000140262 E036 0.0000000       15 57248041 57248041 1 +      
ENSG00000140262 E037 0.0000000       15 57248042 57248081 40 +      
ENSG00000140262 E038 0.4439371 0.0215619510 5.708141e-01 6.972527e-01 15 57251169 57251349 181 + 0.171 0.000 -12.588
ENSG00000140262 E039 36.7223673 0.0035185905 3.159174e-01 4.586950e-01 15 57251350 57251423 74 + 1.510 1.468 -0.143
ENSG00000140262 E040 0.0000000       15 57252199 57252420 222 +      
ENSG00000140262 E041 0.7448917 0.0552825706 2.859342e-01 4.262955e-01 15 57252421 57252492 72 + 0.256 0.000 -13.036
ENSG00000140262 E042 55.3407072 0.0053433517 3.210815e-02 7.606629e-02 15 57253262 57253468 207 + 1.699 1.587 -0.381
ENSG00000140262 E043 46.8626395 0.0004906828 1.712918e-03 6.322716e-03 15 57262094 57262208 115 + 1.639 1.468 -0.587
ENSG00000140262 E044 54.4720450 0.0005155884 1.454809e-02 3.947190e-02 15 57263112 57263274 163 + 1.691 1.579 -0.380
ENSG00000140262 E045 23.8613564 0.0009753026 8.324778e-02 1.646521e-01 15 57273030 57273032 3 + 1.346 1.226 -0.423
ENSG00000140262 E046 60.0675405 0.0004001042 8.236989e-02 1.632499e-01 15 57273033 57273262 230 + 1.723 1.661 -0.211
ENSG00000140262 E047 0.0000000       15 57281647 57281792 146 +      
ENSG00000140262 E048 0.0000000       15 57282183 57282442 260 +      
ENSG00000140262 E049 0.0000000       15 57282443 57282444 2 +      
ENSG00000140262 E050 21.9022245 0.0010115302 8.997293e-01 9.400256e-01 15 57282445 57282454 10 + 1.282 1.304 0.075
ENSG00000140262 E051 43.2811161 0.0005254524 5.524888e-01 6.817698e-01 15 57282455 57282598 144 + 1.553 1.622 0.236
ENSG00000140262 E052 360.6179558 0.0022725321 4.559413e-20 2.918132e-18 15 57286157 57289853 3697 + 2.412 2.658 0.819
ENSG00000140262 E053 2.3668435 0.0064958926 2.671823e-01 4.054736e-01 15 57290829 57291124 296 + 0.416 0.633 1.036
ENSG00000140262 E054 0.2214452 0.0378882252 1.139424e-01   15 57299226 57299281 56 + 0.000 0.220 12.585