ENSG00000140199

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000290209 ENSG00000140199 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC12A6 protein_coding protein_coding 3.601634 1.855361 3.770515 0.1539854 0.232289 1.019128 2.1491125 1.50932691 1.8547236 0.11210447 0.10342838 0.2955295 0.62900417 0.81466667 0.49786667 -0.31680000 0.0003417587 0.0003417587 FALSE TRUE
ENST00000558950 ENSG00000140199 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC12A6 protein_coding retained_intron 3.601634 1.855361 3.770515 0.1539854 0.232289 1.019128 0.1901954 0.00000000 0.4430602 0.00000000 0.18232891 5.5016310 0.04695417 0.00000000 0.11343333 0.11343333 0.0053384246 0.0003417587 FALSE FALSE
ENST00000559664 ENSG00000140199 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC12A6 protein_coding nonsense_mediated_decay 3.601634 1.855361 3.770515 0.1539854 0.232289 1.019128 0.1561419 0.04454012 0.2505644 0.04454012 0.25056441 2.2562504 0.04032500 0.02063333 0.07110000 0.05046667 0.9595605232 0.0003417587 TRUE TRUE
ENST00000560611 ENSG00000140199 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC12A6 protein_coding protein_coding 3.601634 1.855361 3.770515 0.1539854 0.232289 1.019128 0.3259185 0.00000000 0.5104756 0.00000000 0.31511923 5.7017587 0.06820000 0.00000000 0.12726667 0.12726667 0.2974107234 0.0003417587 FALSE TRUE
ENST00000676379 ENSG00000140199 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC12A6 protein_coding protein_coding 3.601634 1.855361 3.770515 0.1539854 0.232289 1.019128 0.1865033 0.23266918 0.1476877 0.02846400 0.09381328 -0.6219211 0.07153750 0.12863333 0.04076667 -0.08786667 0.1909863792 0.0003417587 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000140199 E001 0.0000000       15 34229784 34229995 212 -      
ENSG00000140199 E002 2.5860063 0.0204409443 2.073279e-04 9.953536e-04 15 34229996 34230035 40 - 0.170 0.829 3.583
ENSG00000140199 E003 148.0701236 0.0169465127 1.638488e-10 2.787665e-09 15 34230036 34232535 2500 - 1.939 2.375 1.456
ENSG00000140199 E004 40.8743850 0.0154822157 6.750070e-02 1.391915e-01 15 34232536 34233155 620 - 1.522 1.720 0.675
ENSG00000140199 E005 10.3967095 0.0282614251 9.047907e-01 9.433817e-01 15 34233156 34233187 32 - 1.024 1.094 0.255
ENSG00000140199 E006 12.4972705 0.0016318184 5.882472e-01 7.114596e-01 15 34233188 34233258 71 - 1.121 1.127 0.020
ENSG00000140199 E007 5.8228575 0.0028096750 9.407825e-01 9.667989e-01 15 34233259 34233261 3 - 0.813 0.857 0.169
ENSG00000140199 E008 5.9711507 0.0027724138 8.976596e-01 9.386652e-01 15 34233262 34233262 1 - 0.813 0.883 0.268
ENSG00000140199 E009 39.6655997 0.0005385849 3.128793e-01 4.553937e-01 15 34233263 34233711 449 - 1.553 1.668 0.392
ENSG00000140199 E010 26.5944499 0.0157990662 8.613168e-01 9.145339e-01 15 34233712 34233880 169 - 1.401 1.475 0.255
ENSG00000140199 E011 13.5020841 0.0626937345 7.007718e-01 8.001685e-01 15 34233881 34233972 92 - 1.111 1.215 0.369
ENSG00000140199 E012 19.7805054 0.0137826842 8.380590e-01 8.987541e-01 15 34235181 34235314 134 - 1.277 1.356 0.273
ENSG00000140199 E013 24.3607178 0.0008357479 6.458495e-01 7.579164e-01 15 34236015 34236199 185 - 1.384 1.411 0.093
ENSG00000140199 E014 20.6320920 0.0030778573 3.932230e-01 5.371171e-01 15 34236708 34236815 108 - 1.329 1.320 -0.032
ENSG00000140199 E015 0.6277178 0.0214963610 5.802095e-01 7.049900e-01 15 34237084 34237389 306 - 0.235 0.159 -0.699
ENSG00000140199 E016 0.6717251 0.0264415163 5.847351e-01 7.085919e-01 15 34237390 34237418 29 - 0.235 0.159 -0.697
ENSG00000140199 E017 13.9246737 0.0228935067 1.318337e-01 2.366748e-01 15 34237419 34237480 62 - 1.206 1.083 -0.442
ENSG00000140199 E018 11.7243574 0.0015826216 1.028523e-01 1.948312e-01 15 34237481 34237550 70 - 1.136 1.031 -0.383
ENSG00000140199 E019 14.0460572 0.0012841363 7.950958e-01 8.691126e-01 15 34238232 34238331 100 - 1.159 1.193 0.122
ENSG00000140199 E020 11.0286062 0.0016212904 9.823728e-01 9.930293e-01 15 34238332 34238401 70 - 1.053 1.112 0.214
ENSG00000140199 E021 0.2903454 0.3571055865 4.653920e-01   15 34238402 34238710 309 - 0.169 0.000 -11.151
ENSG00000140199 E022 22.9143661 0.0010677544 5.048064e-01 6.406827e-01 15 34238965 34239160 196 - 1.362 1.372 0.035
ENSG00000140199 E023 20.0941379 0.0009398654 2.402680e-01 3.744431e-01 15 34240661 34240829 169 - 1.325 1.292 -0.114
ENSG00000140199 E024 1.7672158 0.0107611411 1.390081e-03 5.274002e-03 15 34240830 34241044 215 - 0.588 0.000 -13.993
ENSG00000140199 E025 0.5954526 0.0183546257 1.006561e-01 1.914615e-01 15 34241063 34241232 170 - 0.292 0.000 -12.633
ENSG00000140199 E026 16.1445429 0.0014721946 2.075317e-01 3.355259e-01 15 34241233 34241337 105 - 1.244 1.193 -0.178
ENSG00000140199 E027 0.0000000       15 34241862 34242101 240 -      
ENSG00000140199 E028 18.4973907 0.0545893662 4.260561e-01 5.689291e-01 15 34242102 34242221 120 - 1.289 1.251 -0.133
ENSG00000140199 E029 14.4552661 0.0014541722 1.671626e-02 4.431200e-02 15 34243974 34244072 99 - 1.232 1.065 -0.595
ENSG00000140199 E030 16.3599609 0.0016543485 5.257604e-02 1.137457e-01 15 34245285 34245403 119 - 1.267 1.155 -0.397
ENSG00000140199 E031 21.9018627 0.0013335103 1.366664e-02 3.746622e-02 15 34245693 34245867 175 - 1.393 1.262 -0.457
ENSG00000140199 E032 15.2435056 0.0016022131 2.494244e-01 3.852458e-01 15 34250298 34250355 58 - 1.213 1.168 -0.159
ENSG00000140199 E033 17.7233609 0.0045194257 1.467569e-02 3.976124e-02 15 34250631 34250729 99 - 1.315 1.155 -0.563
ENSG00000140199 E034 17.6240181 0.0025829573 1.478101e-02 4.000083e-02 15 34250899 34251057 159 - 1.310 1.155 -0.546
ENSG00000140199 E035 18.7237324 0.0477304298 4.818834e-01 6.200865e-01 15 34252170 34252384 215 - 1.305 1.251 -0.188
ENSG00000140199 E036 18.5193924 0.0247625511 3.174237e-01 4.603031e-01 15 34254348 34254589 242 - 1.305 1.248 -0.200
ENSG00000140199 E037 11.7526239 0.0033768936 3.037010e-02 7.269323e-02 15 34255262 34255392 131 - 1.159 0.993 -0.601
ENSG00000140199 E038 8.0088053 0.0756663866 1.274603e-01 2.306146e-01 15 34256229 34256283 55 - 1.024 0.821 -0.769
ENSG00000140199 E039 10.5626649 0.1202588231 1.953415e-01 3.203863e-01 15 34257642 34257788 147 - 1.121 0.943 -0.656
ENSG00000140199 E040 9.8436758 0.0071302302 7.181912e-03 2.169657e-02 15 34258813 34258872 60 - 1.113 0.857 -0.953
ENSG00000140199 E041 9.2115898 0.0023826450 2.968722e-02 7.134536e-02 15 34258873 34258944 72 - 1.071 0.883 -0.700
ENSG00000140199 E042 3.7824175 0.0051744991 1.558977e-02 4.182389e-02 15 34260926 34260929 4 - 0.780 0.442 -1.508
ENSG00000140199 E043 6.8051046 0.0027158719 6.234109e-02 1.305904e-01 15 34260930 34260977 48 - 0.949 0.768 -0.700
ENSG00000140199 E044 8.8969016 0.0072498893 3.571734e-01 5.015776e-01 15 34260978 34261020 43 - 1.004 0.953 -0.191
ENSG00000140199 E045 9.6665830 0.0421926445 4.784274e-01 6.168486e-01 15 34275345 34275389 45 - 1.034 0.994 -0.148
ENSG00000140199 E046 0.0000000       15 34299569 34299658 90 -      
ENSG00000140199 E047 7.6051482 0.0243022961 2.915874e-01 4.324606e-01 15 34318561 34318779 219 - 0.950 0.860 -0.339
ENSG00000140199 E048 8.6754448 0.0020283566 1.261373e-01 2.287759e-01 15 34336410 34336601 192 - 1.024 0.907 -0.437
ENSG00000140199 E049 6.3150457 0.0025520907 2.568675e-02 6.329211e-02 15 34336602 34336667 66 - 0.938 0.697 -0.945
ENSG00000140199 E050 3.5199693 0.0119423252 4.385503e-01 5.804210e-01 15 34336668 34336686 19 - 0.684 0.612 -0.311
ENSG00000140199 E051 3.7570452 0.0041975443 6.787063e-02 1.398356e-01 15 34336687 34336752 66 - 0.744 0.507 -1.040
ENSG00000140199 E052 12.9380475 0.0014261949 2.430581e-01 3.777874e-01 15 34336753 34337331 579 - 1.151 1.097 -0.195
ENSG00000140199 E053 3.7539629 0.3171437670 2.689319e-01 4.073993e-01 15 34337332 34337474 143 - 0.725 0.567 -0.682
ENSG00000140199 E054 3.6003329 0.0454056507 5.740092e-02 1.221682e-01 15 34337475 34337960 486 - 0.744 0.444 -1.350
ENSG00000140199 E055 0.4470576 0.0214080134 8.731179e-01 9.224628e-01 15 34337961 34338060 100 - 0.170 0.159 -0.116