ENSG00000140157

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000337451 ENSG00000140157 HEK293_OSMI2_2hA HEK293_TMG_2hB NIPA2 protein_coding protein_coding 25.80892 16.30019 38.87024 1.740812 1.197608 1.253264 2.6109139 1.7327182 4.0061637 0.8711353 0.3069918 1.2044788 0.11900417 0.11906667 0.1028333 -0.01623333 9.312270e-01 3.106054e-31 FALSE TRUE
ENST00000398013 ENSG00000140157 HEK293_OSMI2_2hA HEK293_TMG_2hB NIPA2 protein_coding protein_coding 25.80892 16.30019 38.87024 1.740812 1.197608 1.253264 6.7165283 5.3684118 8.9263588 0.7199445 0.7456479 0.7325069 0.27198333 0.32796667 0.2289333 -0.09903333 1.180137e-02 3.106054e-31 FALSE TRUE
ENST00000559571 ENSG00000140157 HEK293_OSMI2_2hA HEK293_TMG_2hB NIPA2 protein_coding processed_transcript 25.80892 16.30019 38.87024 1.740812 1.197608 1.253264 1.3128567 0.0000000 4.9656293 0.0000000 0.5405902 8.9587352 0.03337500 0.00000000 0.1279333 0.12793333 1.837315e-22 3.106054e-31   FALSE
ENST00000560205 ENSG00000140157 HEK293_OSMI2_2hA HEK293_TMG_2hB NIPA2 protein_coding processed_transcript 25.80892 16.30019 38.87024 1.740812 1.197608 1.253264 2.1526944 0.0000000 4.7376106 0.0000000 0.3512894 8.8910578 0.05996250 0.00000000 0.1216000 0.12160000 3.106054e-31 3.106054e-31   FALSE
ENST00000674173 ENSG00000140157 HEK293_OSMI2_2hA HEK293_TMG_2hB NIPA2 protein_coding protein_coding 25.80892 16.30019 38.87024 1.740812 1.197608 1.253264 2.6788432 1.7046969 2.7882453 0.6402393 0.6693049 0.7065689 0.10614583 0.09920000 0.0729000 -0.02630000 7.681845e-01 3.106054e-31 FALSE TRUE
ENST00000674477 ENSG00000140157 HEK293_OSMI2_2hA HEK293_TMG_2hB NIPA2 protein_coding protein_coding 25.80892 16.30019 38.87024 1.740812 1.197608 1.253264 2.7392133 1.5102298 5.4280014 0.7662198 0.3831319 1.8387871 0.08775833 0.09093333 0.1403000 0.04936667 7.207755e-01 3.106054e-31 FALSE TRUE
MSTRG.10319.1 ENSG00000140157 HEK293_OSMI2_2hA HEK293_TMG_2hB NIPA2 protein_coding   25.80892 16.30019 38.87024 1.740812 1.197608 1.253264 0.2656943 0.9336144 0.0000000 0.4677559 0.0000000 -6.5601255 0.01490000 0.05510000 0.0000000 -0.05510000 6.438940e-02 3.106054e-31 FALSE TRUE
MSTRG.10319.11 ENSG00000140157 HEK293_OSMI2_2hA HEK293_TMG_2hB NIPA2 protein_coding   25.80892 16.30019 38.87024 1.740812 1.197608 1.253264 0.8512086 1.0190280 0.0000000 0.1824126 0.0000000 -6.6851384 0.05037500 0.06166667 0.0000000 -0.06166667 9.381609e-26 3.106054e-31 FALSE TRUE
MSTRG.10319.9 ENSG00000140157 HEK293_OSMI2_2hA HEK293_TMG_2hB NIPA2 protein_coding   25.80892 16.30019 38.87024 1.740812 1.197608 1.253264 1.4508831 1.6306322 0.3656571 0.8790799 0.1872311 -2.1267634 0.06834167 0.10123333 0.0093000 -0.09193333 6.217713e-01 3.106054e-31 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000140157 E001 0.147249 0.0440039716 7.585350e-01   15 22838644 22838644 1 + 0.094 0.000 -8.484
ENSG00000140157 E002 4.076827 0.0043412719 6.711764e-02 1.385656e-01 15 22838645 22838657 13 + 0.785 0.558 -0.964
ENSG00000140157 E003 4.440236 0.0054687875 2.076993e-01 3.357138e-01 15 22838658 22838658 1 + 0.785 0.652 -0.550
ENSG00000140157 E004 4.739000 0.0094017595 1.372285e-01 2.442207e-01 15 22838659 22838659 1 + 0.819 0.652 -0.682
ENSG00000140157 E005 7.957096 0.0030826433 2.244053e-01 3.556941e-01 15 22838660 22838665 6 + 0.989 0.901 -0.328
ENSG00000140157 E006 14.284347 0.0012637687 4.786990e-02 1.053937e-01 15 22838666 22838674 9 + 1.231 1.106 -0.446
ENSG00000140157 E007 16.762010 0.0010688899 7.391736e-03 2.223648e-02 15 22838675 22838675 1 + 1.310 1.135 -0.620
ENSG00000140157 E008 26.104498 0.0016771792 2.067748e-02 5.290741e-02 15 22838676 22838678 3 + 1.472 1.366 -0.368
ENSG00000140157 E009 42.135545 0.0005358075 2.118648e-03 7.592131e-03 15 22838679 22838685 7 + 1.673 1.560 -0.386
ENSG00000140157 E010 43.697131 0.0005919109 4.067480e-03 1.333100e-02 15 22838686 22838686 1 + 1.684 1.585 -0.338
ENSG00000140157 E011 45.428768 0.0005222356 6.209889e-03 1.916721e-02 15 22838687 22838688 2 + 1.697 1.609 -0.300
ENSG00000140157 E012 45.573941 0.0005104494 5.433456e-03 1.710796e-02 15 22838689 22838689 1 + 1.699 1.609 -0.307
ENSG00000140157 E013 54.814953 0.0004386921 9.496231e-05 4.983469e-04 15 22838690 22838697 8 + 1.792 1.658 -0.456
ENSG00000140157 E014 217.614983 0.0058437930 1.582249e-05 1.004330e-04 15 22838698 22838873 176 + 2.382 2.241 -0.470
ENSG00000140157 E015 117.459672 0.0090944673 7.543680e-04 3.095225e-03 15 22838874 22838921 48 + 2.117 1.971 -0.491
ENSG00000140157 E016 21.015209 0.0015452277 1.252828e-01 2.275354e-01 15 22838922 22838947 26 + 1.359 1.296 -0.221
ENSG00000140157 E017 24.881081 0.0007831234 1.848104e-06 1.448503e-05 15 22838948 22839061 114 + 1.503 1.199 -1.057
ENSG00000140157 E018 26.868158 0.0006962802 2.627763e-07 2.461175e-06 15 22839062 22839174 113 + 1.541 1.223 -1.105
ENSG00000140157 E019 111.116091 0.0005016068 3.881185e-06 2.831917e-05 15 22839655 22839790 136 + 2.082 1.975 -0.360
ENSG00000140157 E020 7.579802 0.0628039868 4.332161e-01 5.756331e-01 15 22843102 22843228 127 + 0.955 0.877 -0.295
ENSG00000140157 E021 76.158700 0.0044744124 7.040884e-03 2.133079e-02 15 22845146 22845267 122 + 1.913 1.823 -0.305
ENSG00000140157 E022 7.717843 0.0021239725 5.660104e-02 1.207601e-01 15 22851042 22851638 597 + 0.999 0.824 -0.665
ENSG00000140157 E023 200.912330 0.0005470485 8.192533e-04 3.328224e-03 15 22851639 22851708 70 + 2.311 2.277 -0.112
ENSG00000140157 E024 332.572237 0.0003583902 4.728070e-02 1.043377e-01 15 22851709 22851870 162 + 2.510 2.527 0.055
ENSG00000140157 E025 181.916439 0.0037038141 4.128700e-01 5.564431e-01 15 22853212 22853268 57 + 2.220 2.302 0.276
ENSG00000140157 E026 2.510984 0.0060810988 9.046167e-01 9.432744e-01 15 22858286 22858539 254 + 0.535 0.558 0.107
ENSG00000140157 E027 208.036474 0.0002052687 4.713975e-01 6.105103e-01 15 22858540 22858630 91 + 2.283 2.360 0.256
ENSG00000140157 E028 318.052011 0.0001560301 7.067516e-01 8.048569e-01 15 22860629 22860789 161 + 2.472 2.539 0.222
ENSG00000140157 E029 1543.040992 0.0031244676 4.981487e-11 9.263130e-10 15 22866213 22869362 3150 + 3.105 3.275 0.567