ENSG00000140092

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000342058 ENSG00000140092 HEK293_OSMI2_2hA HEK293_TMG_2hB FBLN5 protein_coding protein_coding 3.523827 5.267441 3.316545 0.08023619 0.2386735 -0.6658137 2.7361962 2.826443 2.9232329 0.4543168 0.2305607 0.0484086 0.8168500 0.5345000 0.88430000 0.3498000 0.01555062 0.01555062 FALSE TRUE
MSTRG.10090.1 ENSG00000140092 HEK293_OSMI2_2hA HEK293_TMG_2hB FBLN5 protein_coding   3.523827 5.267441 3.316545 0.08023619 0.2386735 -0.6658137 0.5714473 2.253115 0.2143993 0.4386699 0.2143993 -3.3341695 0.1185708 0.4301333 0.05936667 -0.3707667 0.05399338 0.01555062 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000140092 E001 0.6998377 0.0164909175 6.047705e-01 0.7252032125 14 91869411 91869411 1 - 0.267 0.176 -0.764
ENSG00000140092 E002 4.5975195 0.0035707976 8.862348e-01 0.9312418833 14 91869412 91869440 29 - 0.720 0.740 0.081
ENSG00000140092 E003 97.1835129 0.0012225382 1.703974e-05 0.0001073609 14 91869441 91869988 548 - 1.846 2.013 0.561
ENSG00000140092 E004 23.9831704 0.0008893454 8.043551e-02 0.1602425615 14 91869989 91870020 32 - 1.284 1.414 0.451
ENSG00000140092 E005 28.4193315 0.0007412545 5.241314e-02 0.1134529083 14 91870021 91870042 22 - 1.347 1.480 0.461
ENSG00000140092 E006 54.6861628 0.0074792041 3.301595e-04 0.0015014216 14 91870043 91870226 184 - 1.554 1.782 0.775
ENSG00000140092 E007 43.5726970 0.0014119997 5.806315e-04 0.0024623129 14 91870227 91870385 159 - 1.481 1.682 0.686
ENSG00000140092 E008 1.9028591 0.0997701457 4.401243e-01 0.5818217823 14 91873497 91874816 1320 - 0.549 0.396 -0.772
ENSG00000140092 E009 43.1117993 0.0005880063 8.485277e-01 0.9059611131 14 91877487 91877682 196 - 1.625 1.615 -0.035
ENSG00000140092 E010 0.0000000       14 91877928 91878042 115 -      
ENSG00000140092 E011 38.1490258 0.0006363068 2.609701e-01 0.3985659889 14 91881292 91881418 127 - 1.607 1.543 -0.218
ENSG00000140092 E012 38.2636432 0.0042755935 1.989132e-01 0.3248466658 14 91882954 91883076 123 - 1.616 1.535 -0.277
ENSG00000140092 E013 36.9799854 0.0041798957 1.362818e-01 0.2428644028 14 91887193 91887312 120 - 1.612 1.516 -0.328
ENSG00000140092 E014 33.0085940 0.0176081812 4.490433e-01 0.5902523769 14 91891221 91891337 117 - 1.543 1.480 -0.217
ENSG00000140092 E015 24.4084992 0.0008413568 9.632712e-01 0.9808010846 14 91894950 91895007 58 - 1.379 1.375 -0.013
ENSG00000140092 E016 24.6886273 0.0010554274 7.943699e-01 0.8686296279 14 91895008 91895072 65 - 1.394 1.375 -0.065
ENSG00000140092 E017 23.6318162 0.0008210466 1.206657e-01 0.2209142180 14 91936947 91937010 64 - 1.436 1.327 -0.380
ENSG00000140092 E018 20.0782505 0.0010405190 3.695326e-01 0.5139348868 14 91937011 91937052 42 - 1.347 1.278 -0.240
ENSG00000140092 E019 23.8520005 0.0334923247 6.833533e-02 0.1406233129 14 91937053 91937201 149 - 1.493 1.306 -0.649
ENSG00000140092 E020 0.0000000       14 91938330 91938452 123 -      
ENSG00000140092 E021 0.6245948 0.0906310376 2.096770e-01 0.3381719054 14 91939850 91939950 101 - 0.000 0.245 11.303
ENSG00000140092 E022 11.4744402 0.0133531430 1.867242e-02 0.0486124867 14 91940565 91940616 52 - 1.234 0.985 -0.897
ENSG00000140092 E023 0.3332198 0.0295543023 7.002039e-01   14 91942037 91942174 138 - 0.154 0.097 -0.766
ENSG00000140092 E024 0.0000000       14 91942175 91942180 6 -      
ENSG00000140092 E025 12.7729119 0.0016019586 2.610134e-03 0.0090949277 14 91942907 91942961 55 - 1.284 1.010 -0.984
ENSG00000140092 E026 0.2965864 0.1645947945 4.364169e-01   14 91946711 91947212 502 - 0.000 0.173 10.485
ENSG00000140092 E027 25.3695391 0.0009413250 4.280425e-04 0.0018821687 14 91947213 91947450 238 - 1.538 1.300 -0.822
ENSG00000140092 E028 17.1228721 0.0021356170 2.581784e-03 0.0090095651 14 91947451 91947694 244 - 1.379 1.130 -0.876
ENSG00000140092 E029 0.1472490 0.0457708864 2.936082e-01   14 91947910 91947934 25 - 0.154 0.000 -11.907
ENSG00000140092 E030 0.2987644 0.0277443544 9.281182e-02   14 91947935 91947987 53 - 0.267 0.000 -13.011