ENSG00000140057

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000267584 ENSG00000140057 HEK293_OSMI2_2hA HEK293_TMG_2hB AK7 protein_coding protein_coding 1.538137 2.019714 1.579746 0.4235734 0.4035417 -0.3524799 0.30725093 0.12910142 0.5459428 0.03418963 0.01318523 1.9987993 0.21280000 0.07836667 0.4101333 0.33176667 2.649351e-02 6.709571e-05 FALSE TRUE
ENST00000554313 ENSG00000140057 HEK293_OSMI2_2hA HEK293_TMG_2hB AK7 protein_coding processed_transcript 1.538137 2.019714 1.579746 0.4235734 0.4035417 -0.3524799 0.05586402 0.03910452 0.2617960 0.03910452 0.18133959 2.4685963 0.03223333 0.01600000 0.1476667 0.13166667 4.833162e-01 6.709571e-05 FALSE TRUE
ENST00000554706 ENSG00000140057 HEK293_OSMI2_2hA HEK293_TMG_2hB AK7 protein_coding protein_coding 1.538137 2.019714 1.579746 0.4235734 0.4035417 -0.3524799 0.10359670 0.12094211 0.1915554 0.06583219 0.05026008 0.6222473 0.06579583 0.04953333 0.1202000 0.07066667 3.501324e-01 6.709571e-05 FALSE TRUE
ENST00000555570 ENSG00000140057 HEK293_OSMI2_2hA HEK293_TMG_2hB AK7 protein_coding protein_coding 1.538137 2.019714 1.579746 0.4235734 0.4035417 -0.3524799 0.80340135 1.40743125 0.3682883 0.21714683 0.13412585 -1.9057208 0.53203750 0.72383333 0.2267000 -0.49713333 6.709571e-05 6.709571e-05 FALSE TRUE
ENST00000556643 ENSG00000140057 HEK293_OSMI2_2hA HEK293_TMG_2hB AK7 protein_coding retained_intron 1.538137 2.019714 1.579746 0.4235734 0.4035417 -0.3524799 0.26802414 0.32313455 0.2121638 0.17077205 0.21216380 -0.5844812 0.15714167 0.13226667 0.0953000 -0.03696667 7.069176e-01 6.709571e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000140057 E001 1.1750080 0.011871312 6.197573e-01 7.370860e-01 14 96392128 96392132 5 + 0.271 0.392 0.756
ENSG00000140057 E002 2.5337835 0.007763008 3.431914e-01 4.872597e-01 14 96392133 96392143 11 + 0.437 0.633 0.927
ENSG00000140057 E003 10.1248297 0.001912133 3.873381e-02 8.868751e-02 14 96392144 96392259 116 + 0.900 1.163 0.965
ENSG00000140057 E004 13.7584438 0.001397707 1.372790e-02 3.760369e-02 14 96398075 96398197 123 + 1.023 1.294 0.968
ENSG00000140057 E005 10.6520112 0.001883482 1.732361e-02 4.565622e-02 14 96398198 96398263 66 + 0.915 1.204 1.053
ENSG00000140057 E006 25.7855242 0.057247896 1.639651e-08 1.942390e-07 14 96398264 96399292 1029 + 0.946 1.662 2.519
ENSG00000140057 E007 5.7925682 0.003777120 1.661077e-01 2.831464e-01 14 96404757 96404865 109 + 0.900 0.787 -0.439
ENSG00000140057 E008 1.7380048 0.021040839 3.120807e-01 4.546050e-01 14 96404866 96405052 187 + 0.334 0.551 1.142
ENSG00000140057 E009 2.3520817 0.006493884 2.593523e-01 3.967276e-01 14 96408847 96408941 95 + 0.590 0.452 -0.659
ENSG00000140057 E010 1.9802670 0.018459008 7.491281e-02 1.513927e-01 14 96420822 96420932 111 + 0.590 0.322 -1.397
ENSG00000140057 E011 0.1515154 0.043479384 5.432971e-01   14 96421417 96421566 150 + 0.110 0.000 -8.695
ENSG00000140057 E012 1.7660818 0.084332731 1.346538e-01 2.406194e-01 14 96437835 96437915 81 + 0.556 0.319 -1.262
ENSG00000140057 E013 3.4333031 0.004752588 2.232736e-03 7.944726e-03 14 96442730 96442818 89 + 0.813 0.392 -1.908
ENSG00000140057 E014 3.2235984 0.005170967 1.183913e-03 4.586590e-03 14 96446517 96446607 91 + 0.793 0.322 -2.244
ENSG00000140057 E015 2.4379207 0.007060516 6.261493e-02 1.310488e-01 14 96449802 96449879 78 + 0.650 0.392 -1.245
ENSG00000140057 E016 3.3739679 0.005046908 3.753467e-03 1.244937e-02 14 96451421 96451570 150 + 0.793 0.392 -1.830
ENSG00000140057 E017 3.7351735 0.004592360 2.173877e-02 5.513549e-02 14 96456347 96456475 129 + 0.793 0.505 -1.244
ENSG00000140057 E018 3.4206031 0.008878747 1.696710e-02 4.486394e-02 14 96458083 96458212 130 + 0.772 0.452 -1.424
ENSG00000140057 E019 3.0948839 0.056207452 7.764008e-02 1.556754e-01 14 96471478 96471606 129 + 0.727 0.451 -1.245
ENSG00000140057 E020 2.5925566 0.006744794 1.238053e-01 2.253836e-01 14 96472687 96472755 69 + 0.650 0.452 -0.924
ENSG00000140057 E021 4.1050282 0.003864369 1.443004e-03 5.449799e-03 14 96478465 96478662 198 + 0.867 0.452 -1.797
ENSG00000140057 E022 0.0000000       14 96482982 96482998 17 +      
ENSG00000140057 E023 3.6288112 0.004745333 9.932283e-03 2.859333e-02 14 96482999 96483219 221 + 0.793 0.452 -1.507
ENSG00000140057 E024 3.2987381 0.022212646 3.333073e-02 7.844667e-02 14 96486898 96487056 159 + 0.751 0.452 -1.337
ENSG00000140057 E025 1.2189160 0.010709970 5.573171e-01 6.857491e-01 14 96487958 96488275 318 + 0.388 0.322 -0.398
ENSG00000140057 E026 6.3611147 0.065909183 2.795751e-02 6.793204e-02 14 96488305 96489427 1123 + 0.986 0.673 -1.228