ENSG00000139926

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000344768 ENSG00000139926 HEK293_OSMI2_2hA HEK293_TMG_2hB FRMD6 protein_coding protein_coding 3.903546 1.00182 7.01893 0.1265406 0.5922638 2.796353 1.5101997 0.2664491 3.45799155 0.09370422 0.25320687 3.649015 0.2949583 0.2531667 0.505766667 0.25260000 1.764188e-01 9.771013e-10 FALSE TRUE
ENST00000395718 ENSG00000139926 HEK293_OSMI2_2hA HEK293_TMG_2hB FRMD6 protein_coding protein_coding 3.903546 1.00182 7.01893 0.1265406 0.5922638 2.796353 1.5793703 0.2341302 2.29751265 0.07883909 0.46200266 3.240616 0.4362583 0.2562667 0.323933333 0.06766667 7.336571e-01 9.771013e-10 FALSE TRUE
ENST00000553556 ENSG00000139926 HEK293_OSMI2_2hA HEK293_TMG_2hB FRMD6 protein_coding protein_coding 3.903546 1.00182 7.01893 0.1265406 0.5922638 2.796353 0.1342880 0.5012406 0.04100052 0.10418863 0.04100052 -3.325419 0.1430750 0.4905667 0.005433333 -0.48513333 9.771013e-10 9.771013e-10 FALSE TRUE
ENST00000554778 ENSG00000139926 HEK293_OSMI2_2hA HEK293_TMG_2hB FRMD6 protein_coding protein_coding 3.903546 1.00182 7.01893 0.1265406 0.5922638 2.796353 0.3459351 0.0000000 0.81869389 0.00000000 0.41143401 6.372767 0.0454125 0.0000000 0.107533333 0.10753333 4.737556e-01 9.771013e-10   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000139926 E001 0.0000000       14 51489100 51489136 37 +      
ENSG00000139926 E002 0.0000000       14 51489137 51489420 284 +      
ENSG00000139926 E003 0.0000000       14 51491411 51491534 124 +      
ENSG00000139926 E004 0.0000000       14 51554660 51554668 9 +      
ENSG00000139926 E005 0.0000000       14 51554669 51554682 14 +      
ENSG00000139926 E006 0.0000000       14 51554683 51554805 123 +      
ENSG00000139926 E007 0.0000000       14 51565227 51565440 214 +      
ENSG00000139926 E008 0.0000000       14 51570348 51570410 63 +      
ENSG00000139926 E009 0.0000000       14 51575647 51575756 110 +      
ENSG00000139926 E010 0.0000000       14 51575757 51576205 449 +      
ENSG00000139926 E011 0.0000000       14 51578972 51579297 326 +      
ENSG00000139926 E012 0.0000000       14 51643452 51643738 287 +      
ENSG00000139926 E013 2.2111634 0.0086323295 3.375805e-01 4.814624e-01 14 51651858 51651909 52 + 0.369 0.558 0.963
ENSG00000139926 E014 11.6026498 0.0015168542 8.079928e-01 8.779822e-01 14 51651910 51651979 70 + 0.956 0.987 0.114
ENSG00000139926 E015 12.0726127 0.0014217168 5.292093e-01 6.620293e-01 14 51651980 51651996 17 + 0.990 0.901 -0.334
ENSG00000139926 E016 3.3959428 0.0480725579 3.838443e-02 8.807488e-02 14 51651997 51652217 221 + 0.580 0.000 -13.177
ENSG00000139926 E017 37.7068186 0.0005711929 2.565057e-02 6.321777e-02 14 51689691 51689935 245 + 1.464 1.265 -0.694
ENSG00000139926 E018 0.0000000       14 51697988 51698112 125 +      
ENSG00000139926 E019 0.2966881 0.0269882258 1.000000e+00   14 51698113 51698141 29 + 0.095 0.000 -10.230
ENSG00000139926 E020 20.1932362 0.0008862372 2.220960e-01 3.529076e-01 14 51698142 51698232 91 + 1.200 1.058 -0.510
ENSG00000139926 E021 19.7483686 0.0009312211 1.551212e-01 2.685607e-01 14 51701056 51701135 80 + 1.194 1.024 -0.611
ENSG00000139926 E022 8.5253569 0.0020960466 7.238323e-01 8.175657e-01 14 51701136 51701159 24 + 0.851 0.794 -0.222
ENSG00000139926 E023 18.0352938 0.0011879670 1.669261e-02 4.426045e-02 14 51702512 51702547 36 + 1.173 0.850 -1.190
ENSG00000139926 E024 15.6265299 0.0015906998 8.579541e-03 2.523746e-02 14 51702548 51702588 41 + 1.120 0.728 -1.486
ENSG00000139926 E025 0.0000000       14 51704618 51704638 21 +      
ENSG00000139926 E026 0.0000000       14 51704639 51704719 81 +      
ENSG00000139926 E027 0.0000000       14 51704720 51704748 29 +      
ENSG00000139926 E028 28.5048145 0.0044654658 3.584545e-03 1.196746e-02 14 51704749 51704935 187 + 1.360 1.024 -1.196
ENSG00000139926 E029 23.6531163 0.0008960681 1.817257e-01 3.033996e-01 14 51708078 51708233 156 + 1.265 1.120 -0.516
ENSG00000139926 E030 0.0000000       14 51708234 51708344 111 +      
ENSG00000139926 E031 18.4090816 0.0009613360 4.009259e-01 5.445995e-01 14 51711531 51711596 66 + 1.158 1.058 -0.360
ENSG00000139926 E032 12.6432119 0.0013909389 9.244467e-01 9.564036e-01 14 51712483 51712512 30 + 1.001 0.986 -0.052
ENSG00000139926 E033 14.2236377 0.0026237293 8.772149e-01 9.251428e-01 14 51712513 51712551 39 + 1.046 1.024 -0.080
ENSG00000139926 E034 0.1515154 0.0435864004 7.653930e-01   14 51713647 51715324 1678 + 0.050 0.000 -9.151
ENSG00000139926 E035 27.7832764 0.0007631511 2.745490e-01 4.137201e-01 14 51715325 51715499 175 + 1.329 1.221 -0.378
ENSG00000139926 E036 0.2903454 0.3187035217 1.000000e+00   14 51717255 51717348 94 + 0.094 0.000 -9.480
ENSG00000139926 E037 45.7173296 0.0048602930 1.027240e-02 2.943693e-02 14 51720055 51720390 336 + 1.548 1.322 -0.782
ENSG00000139926 E038 0.1515154 0.0435864004 7.653930e-01   14 51720391 51720525 135 + 0.050 0.000 -9.151
ENSG00000139926 E039 14.2258533 0.0047961988 4.213582e-01 5.645056e-01 14 51721949 51721954 6 + 1.055 0.946 -0.404
ENSG00000139926 E040 28.5098344 0.0007240290 5.284732e-02 1.142166e-01 14 51721955 51722080 126 + 1.346 1.148 -0.700
ENSG00000139926 E041 24.1741347 0.0008615241 9.105408e-02 1.767935e-01 14 51725779 51725870 92 + 1.277 1.090 -0.663
ENSG00000139926 E042 253.8640174 0.0002638286 1.363013e-19 8.305522e-18 14 51727745 51730727 2983 + 2.222 2.419 0.659