ENSG00000139915

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000357362 ENSG00000139915 HEK293_OSMI2_2hA HEK293_TMG_2hB MDGA2 protein_coding protein_coding 0.6449548 0.3167563 1.152185 0.04795191 0.1280419 1.830553 0.11742681 0.00000000 0.35561124 0.00000000 0.05958088 5.1922385 0.11790833 0.0000000 0.30523333 0.3052333 0.001551641 0.001551641 FALSE TRUE
ENST00000399232 ENSG00000139915 HEK293_OSMI2_2hA HEK293_TMG_2hB MDGA2 protein_coding protein_coding 0.6449548 0.3167563 1.152185 0.04795191 0.1280419 1.830553 0.26626502 0.21536033 0.48743756 0.03730301 0.03699884 1.1422819 0.47423750 0.7174333 0.43586667 -0.2815667 0.447513484 0.001551641 FALSE TRUE
ENST00000426342 ENSG00000139915 HEK293_OSMI2_2hA HEK293_TMG_2hB MDGA2 protein_coding protein_coding 0.6449548 0.3167563 1.152185 0.04795191 0.1280419 1.830553 0.19029692 0.05153414 0.25182122 0.05153414 0.05216651 2.0891231 0.27417917 0.1257000 0.21390000 0.0882000 0.734983498 0.001551641 FALSE TRUE
ENST00000472499 ENSG00000139915 HEK293_OSMI2_2hA HEK293_TMG_2hB MDGA2 protein_coding processed_transcript 0.6449548 0.3167563 1.152185 0.04795191 0.1280419 1.830553 0.04957508 0.04689017 0.03010852 0.02431741 0.03010852 -0.5042706 0.08615417 0.1449667 0.02163333 -0.1233333 0.147176924 0.001551641   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000139915 E001 2.7023446 0.005756972 4.919585e-02 1.077258e-01 14 46839629 46840091 463 - 0.598 0.206 -2.285
ENSG00000139915 E002 20.3040025 0.003516600 2.704194e-06 2.044952e-05 14 46840092 46841784 1693 - 1.148 1.505 1.247
ENSG00000139915 E003 7.6023949 0.006238609 6.703544e-01 7.768255e-01 14 46841785 46842019 235 - 0.862 0.919 0.219
ENSG00000139915 E004 3.7918793 0.045284198 7.597997e-01 8.440675e-01 14 46845766 46845871 106 - 0.617 0.668 0.218
ENSG00000139915 E005 3.8338128 0.030237625 2.145085e-01 3.438711e-01 14 46855024 46855154 131 - 0.685 0.451 -1.073
ENSG00000139915 E006 0.1451727 0.043277912 1.000000e+00   14 46870938 46871960 1023 - 0.070 0.000 -8.589
ENSG00000139915 E007 0.0000000       14 46873334 46873432 99 -      
ENSG00000139915 E008 5.1779257 0.004017170 4.478562e-01 5.892096e-01 14 46873433 46873591 159 - 0.700 0.811 0.451
ENSG00000139915 E009 0.0000000       14 46873919 46874044 126 -      
ENSG00000139915 E010 5.4024940 0.003282105 8.742807e-01 9.231661e-01 14 46874045 46874200 156 - 0.743 0.768 0.103
ENSG00000139915 E011 2.7128494 0.051260809 2.534349e-01 3.899522e-01 14 46877489 46877509 21 - 0.465 0.667 0.925
ENSG00000139915 E012 6.0979385 0.003130375 5.693358e-01 6.959137e-01 14 46882044 46882221 178 - 0.769 0.850 0.319
ENSG00000139915 E013 0.0000000       14 46882222 46882222 1 -      
ENSG00000139915 E014 4.7157796 0.005989909 9.070825e-01 9.450053e-01 14 46920012 46920160 149 - 0.700 0.721 0.088
ENSG00000139915 E015 0.0000000       14 46920161 46920174 14 -      
ENSG00000139915 E016 8.2503460 0.003404199 6.586092e-01 7.676776e-01 14 46957374 46957643 270 - 0.892 0.950 0.219
ENSG00000139915 E017 9.1769289 0.002083945 7.511529e-01 8.376772e-01 14 47035011 47035188 178 - 0.938 0.978 0.152
ENSG00000139915 E018 6.5680282 0.002877877 5.922789e-01 7.148438e-01 14 47035189 47035278 90 - 0.840 0.768 -0.284
ENSG00000139915 E019 4.6877928 0.004092988 5.812250e-01 7.057876e-01 14 47035279 47035304 26 - 0.684 0.768 0.343
ENSG00000139915 E020 0.1451727 0.043277912 1.000000e+00   14 47058600 47058996 397 - 0.070 0.000 -8.589
ENSG00000139915 E021 0.0000000       14 47059195 47059380 186 -      
ENSG00000139915 E022 10.1988297 0.001649600 3.887321e-01 5.328153e-01 14 47061249 47061578 330 - 1.017 0.919 -0.367
ENSG00000139915 E023 5.9529838 0.003038917 1.437447e-01 2.531137e-01 14 47096854 47097039 186 - 0.829 0.607 -0.918
ENSG00000139915 E024 4.2662104 0.004127546 2.896075e-02 6.993128e-02 14 47097040 47097123 84 - 0.743 0.346 -1.897
ENSG00000139915 E025 3.5870958 0.004597880 2.527028e-01 3.891007e-01 14 47131714 47131846 133 - 0.652 0.451 -0.933
ENSG00000139915 E026 3.6871285 0.008992134 4.889219e-01 6.264272e-01 14 47144078 47144274 197 - 0.652 0.536 -0.519
ENSG00000139915 E027 4.4149414 0.011704928 2.474417e-01 3.829446e-01 14 47218021 47218054 34 - 0.729 0.536 -0.840
ENSG00000139915 E028 7.0399668 0.002617938 1.018613e-01 1.933327e-01 14 47218055 47218190 136 - 0.901 0.667 -0.934
ENSG00000139915 E029 2.4284455 0.008176750 7.886600e-02 1.576995e-01 14 47218191 47218195 5 - 0.558 0.206 -2.103
ENSG00000139915 E030 0.8115105 0.025354991 7.064835e-03 2.139373e-02 14 47299347 47299539 193 - 0.070 0.535 3.799
ENSG00000139915 E031 7.9749833 0.002410563 3.469287e-02 8.106105e-02 14 47301411 47301550 140 - 0.963 0.667 -1.167
ENSG00000139915 E032 0.0000000       14 47301551 47301560 10 -      
ENSG00000139915 E033 0.0000000       14 47305231 47305323 93 -      
ENSG00000139915 E034 0.0000000       14 47306077 47306142 66 -      
ENSG00000139915 E035 0.0000000       14 47342942 47343097 156 -      
ENSG00000139915 E036 0.0000000       14 47343098 47343234 137 -      
ENSG00000139915 E037 0.0000000       14 47626339 47626525 187 -      
ENSG00000139915 E038 10.6143369 0.010017528 8.961092e-01 9.376133e-01 14 47674517 47675605 1089 - 1.017 1.005 -0.048