ENSG00000139910

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000344429 ENSG00000139910 HEK293_OSMI2_2hA HEK293_TMG_2hB NOVA1 protein_coding protein_coding 4.79708 3.815385 5.171012 0.3146746 0.1493864 0.4376291 0.8256422 1.3754942 0.7902212 0.06678709 0.03261183 -0.7919298 0.1962417 0.36863333 0.1527333 -0.21590000 0.0009040446 0.0009040446 FALSE TRUE
ENST00000449198 ENSG00000139910 HEK293_OSMI2_2hA HEK293_TMG_2hB NOVA1 protein_coding protein_coding 4.79708 3.815385 5.171012 0.3146746 0.1493864 0.4376291 0.6907035 0.4471901 0.7603750 0.25617110 0.53046319 0.7527668 0.1362292 0.11063333 0.1414667 0.03083333 1.0000000000 0.0009040446 FALSE FALSE
ENST00000465357 ENSG00000139910 HEK293_OSMI2_2hA HEK293_TMG_2hB NOVA1 protein_coding protein_coding 4.79708 3.815385 5.171012 0.3146746 0.1493864 0.4376291 1.6708071 1.3341880 1.7374281 0.03037475 0.08627309 0.3784981 0.3576042 0.35613333 0.3357333 -0.02040000 0.8929139002 0.0009040446 FALSE TRUE
ENST00000549146 ENSG00000139910 HEK293_OSMI2_2hA HEK293_TMG_2hB NOVA1 protein_coding protein_coding 4.79708 3.815385 5.171012 0.3146746 0.1493864 0.4376291 1.0558274 0.3983694 1.0762152 0.39836942 0.57337297 1.4113631 0.1954625 0.09263333 0.2148333 0.12220000 0.5953301456 0.0009040446   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000139910 E001 0.0000000       14 26443090 26443092 3 -      
ENSG00000139910 E002 11.7695684 0.0046821445 2.068075e-01 3.347256e-01 14 26443093 26445887 2795 - 1.170 1.046 -0.445
ENSG00000139910 E003 151.8276944 0.0006053923 8.026988e-01 8.743409e-01 14 26445888 26448527 2640 - 2.189 2.182 -0.024
ENSG00000139910 E004 15.7790407 0.0098131055 2.975099e-02 7.146960e-02 14 26448528 26448717 190 - 1.317 1.110 -0.733
ENSG00000139910 E005 6.9094501 0.0293569669 2.288331e-02 5.749872e-02 14 26448718 26448733 16 - 1.030 0.707 -1.249
ENSG00000139910 E006 14.9700979 0.0013508828 1.499581e-02 4.047861e-02 14 26448734 26448827 94 - 1.297 1.085 -0.752
ENSG00000139910 E007 9.6377492 0.0019245710 2.641509e-01 4.020983e-01 14 26448828 26448851 24 - 1.078 0.960 -0.434
ENSG00000139910 E008 18.5845558 0.0104027086 3.691982e-01 5.136332e-01 14 26448852 26448963 112 - 1.330 1.246 -0.293
ENSG00000139910 E009 20.9799182 0.0009226110 4.581632e-06 3.290282e-05 14 26470118 26470490 373 - 1.121 1.468 1.217
ENSG00000139910 E010 2.1359325 0.0068891751 8.958901e-01 9.374669e-01 14 26471951 26472319 369 - 0.504 0.481 -0.112
ENSG00000139910 E011 34.7060544 0.0039518858 2.208612e-02 5.585568e-02 14 26472320 26472391 72 - 1.465 1.606 0.481
ENSG00000139910 E012 0.5138669 0.0214343566 6.157584e-01 7.339472e-01 14 26479017 26479976 960 - 0.211 0.127 -0.888
ENSG00000139910 E013 41.7321896 0.0005600773 2.377073e-01 3.714884e-01 14 26479977 26480143 167 - 1.597 1.656 0.201
ENSG00000139910 E014 0.3030308 0.2801445082 2.959535e-01   14 26519199 26519554 356 - 0.212 0.000 -10.901
ENSG00000139910 E015 0.1472490 0.0463020749 5.260915e-01   14 26549351 26549679 329 - 0.118 0.000 -10.636
ENSG00000139910 E016 2.8901751 0.0085473527 1.516886e-01 2.639589e-01 14 26549680 26549781 102 - 0.705 0.481 -1.009
ENSG00000139910 E017 1.4802038 0.0113473121 1.161055e-01 2.143990e-01 14 26568420 26568465 46 - 0.504 0.225 -1.695
ENSG00000139910 E018 0.0000000       14 26588400 26588479 80 -      
ENSG00000139910 E019 23.5820148 0.0009413705 7.558466e-01 8.410692e-01 14 26595410 26595553 144 - 1.384 1.404 0.069
ENSG00000139910 E020 0.0000000       14 26595554 26595626 73 -      
ENSG00000139910 E021 0.0000000       14 26595936 26596075 140 -      
ENSG00000139910 E022 1.5491040 0.0144229634 1.108494e-02 3.137011e-02 14 26596573 26597300 728 - 0.582 0.127 -3.059
ENSG00000139910 E023 32.9604041 0.0077262894 2.932976e-01 4.343347e-01 14 26597301 26598033 733 - 1.492 1.565 0.250