ENSG00000139880

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000397359 ENSG00000139880 HEK293_OSMI2_2hA HEK293_TMG_2hB CDH24 protein_coding protein_coding 5.343157 7.044791 4.30656 0.9307877 0.3701471 -0.7087213 0.4401825 0.3998346 0.8574669 0.06951624 0.1624960 1.0817667 0.09186667 0.05693333 0.2006667 0.14373333 8.259584e-04 4.449647e-05 TRUE TRUE
ENST00000485922 ENSG00000139880 HEK293_OSMI2_2hA HEK293_TMG_2hB CDH24 protein_coding processed_transcript 5.343157 7.044791 4.30656 0.9307877 0.3701471 -0.7087213 1.1191146 1.4131263 0.9458689 0.38843551 0.2848309 -0.5741789 0.20127500 0.19506667 0.2123000 0.01723333 9.643957e-01 4.449647e-05 TRUE TRUE
ENST00000487137 ENSG00000139880 HEK293_OSMI2_2hA HEK293_TMG_2hB CDH24 protein_coding protein_coding 5.343157 7.044791 4.30656 0.9307877 0.3701471 -0.7087213 2.3771597 3.7996470 1.0353195 0.28623270 0.1744643 -1.8657134 0.42598750 0.54930000 0.2483667 -0.30093333 8.486938e-03 4.449647e-05 TRUE TRUE
MSTRG.9212.7 ENSG00000139880 HEK293_OSMI2_2hA HEK293_TMG_2hB CDH24 protein_coding   5.343157 7.044791 4.30656 0.9307877 0.3701471 -0.7087213 1.1710568 0.9407090 1.3512253 0.18161248 0.1823327 0.5178302 0.23966250 0.13130000 0.3119333 0.18063333 4.449647e-05 4.449647e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000139880 E001 0.000000       14 23047062 23047066 5 -      
ENSG00000139880 E002 1.026715 0.0350596738 3.897283e-01 0.5337868851 14 23047067 23047127 61 - 0.382 0.225 -1.056
ENSG00000139880 E003 70.000353 0.0009411983 4.581203e-02 0.1016866060 14 23047128 23047374 247 - 1.733 1.827 0.315
ENSG00000139880 E004 87.637483 0.0089891164 1.309069e-01 0.2354162480 14 23047461 23047659 199 - 1.834 1.927 0.312
ENSG00000139880 E005 74.358768 0.0022203420 6.506276e-01 0.7616459158 14 23047660 23048163 504 - 1.813 1.834 0.073
ENSG00000139880 E006 45.710885 0.0005404193 3.583472e-01 0.5027460435 14 23048164 23048479 316 - 1.651 1.600 -0.173
ENSG00000139880 E007 56.853006 0.0005020410 1.923186e-02 0.0498367988 14 23049027 23049275 249 - 1.617 1.738 0.409
ENSG00000139880 E008 40.002168 0.0014325103 8.544723e-04 0.0034536016 14 23049627 23049738 112 - 1.389 1.608 0.750
ENSG00000139880 E009 40.795634 0.0005880199 5.988252e-04 0.0025291072 14 23049822 23049943 122 - 1.406 1.621 0.739
ENSG00000139880 E010 14.172401 0.0306419352 8.749722e-02 0.1713378998 14 23049944 23050139 196 - 1.265 1.062 -0.724
ENSG00000139880 E011 15.510134 0.0100595526 2.655483e-05 0.0001599801 14 23051222 23051439 218 - 1.414 1.012 -1.427
ENSG00000139880 E012 7.174597 0.0057075247 1.352373e-03 0.0051506377 14 23051970 23051999 30 - 1.106 0.723 -1.457
ENSG00000139880 E013 8.719447 0.0019118814 6.411255e-05 0.0003515770 14 23052000 23052083 84 - 1.205 0.775 -1.602
ENSG00000139880 E014 43.204981 0.0017988751 2.592444e-02 0.0637931617 14 23052473 23052609 137 - 1.499 1.635 0.464
ENSG00000139880 E015 69.606115 0.0013487933 3.983125e-02 0.0907156728 14 23053496 23053749 254 - 1.726 1.824 0.333
ENSG00000139880 E016 56.791652 0.0016514742 4.210003e-01 0.5641592160 14 23054141 23054328 188 - 1.741 1.699 -0.142
ENSG00000139880 E017 52.766778 0.0006844504 9.133630e-03 0.0266173221 14 23054506 23054673 168 - 1.766 1.635 -0.443
ENSG00000139880 E018 47.515307 0.0095776615 3.564584e-02 0.0828975161 14 23054747 23054866 120 - 1.730 1.590 -0.474
ENSG00000139880 E019 49.143190 0.0005239007 4.828311e-04 0.0020945458 14 23055059 23055239 181 - 1.770 1.592 -0.602
ENSG00000139880 E020 29.488219 0.0006861534 2.464216e-01 0.3817625376 14 23055240 23055353 114 - 1.486 1.408 -0.269
ENSG00000139880 E021 37.924598 0.0010991129 8.949564e-01 0.9368757551 14 23055533 23055857 325 - 1.548 1.539 -0.031
ENSG00000139880 E022 10.803683 0.0634116433 4.743696e-01 0.6132066582 14 23057403 23057538 136 - 0.931 1.056 0.465