ENSG00000139835

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000375430 ENSG00000139835 HEK293_OSMI2_2hA HEK293_TMG_2hB GRTP1 protein_coding protein_coding 6.831552 8.645809 7.214474 0.1095093 0.1655677 -0.2607761 1.6169429 1.982472 1.447433 0.1920715 0.1562779 -0.451130018 0.23768333 0.22973333 0.2018333 -0.027900000 8.108296e-01 3.556883e-05 FALSE  
ENST00000375431 ENSG00000139835 HEK293_OSMI2_2hA HEK293_TMG_2hB GRTP1 protein_coding protein_coding 6.831552 8.645809 7.214474 0.1095093 0.1655677 -0.2607761 2.0129099 2.271014 2.149362 0.8308983 0.5598373 -0.079070418 0.29563333 0.26080000 0.2957333 0.034933333 9.017414e-01 3.556883e-05 FALSE  
ENST00000476439 ENSG00000139835 HEK293_OSMI2_2hA HEK293_TMG_2hB GRTP1 protein_coding processed_transcript 6.831552 8.645809 7.214474 0.1095093 0.1655677 -0.2607761 1.4817362 1.818693 1.808231 0.1970842 0.1168664 -0.008277292 0.21706250 0.20990000 0.2504000 0.040500000 6.091163e-01 3.556883e-05    
ENST00000620217 ENSG00000139835 HEK293_OSMI2_2hA HEK293_TMG_2hB GRTP1 protein_coding protein_coding 6.831552 8.645809 7.214474 0.1095093 0.1655677 -0.2607761 0.2048706 0.473672 0.000000 0.1438193 0.0000000 -5.595957194 0.03052917 0.05516667 0.0000000 -0.055166667 3.556883e-05 3.556883e-05 FALSE  
MSTRG.9099.3 ENSG00000139835 HEK293_OSMI2_2hA HEK293_TMG_2hB GRTP1 protein_coding   6.831552 8.645809 7.214474 0.1095093 0.1655677 -0.2607761 1.4928386 2.099957 1.809448 0.6083950 0.3259516 -0.213712947 0.21546250 0.24440000 0.2520333 0.007633333 9.620397e-01 3.556883e-05 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000139835 E001 0.00000       13 113324163 113324163 1 -      
ENSG00000139835 E002 0.00000       13 113324164 113324165 2 -      
ENSG00000139835 E003 58.01457 0.0045733295 0.048385458 0.10630244 13 113324166 113324577 412 - 1.688 1.796 0.366
ENSG00000139835 E004 13.93204 0.0629729563 0.704424707 0.80297829 13 113324845 113325061 217 - 1.182 1.141 -0.147
ENSG00000139835 E005 36.50713 0.0007758406 0.005497314 0.01728002 13 113325062 113325660 599 - 1.446 1.612 0.569
ENSG00000139835 E006 57.71859 0.0004122670 0.685947939 0.78855064 13 113325661 113325846 186 - 1.763 1.747 -0.055
ENSG00000139835 E007 44.48318 0.0005727064 0.537194369 0.66881582 13 113325919 113326091 173 - 1.659 1.629 -0.101
ENSG00000139835 E008 35.76280 0.0006060002 0.474904818 0.61369758 13 113344863 113344959 97 - 1.574 1.536 -0.133
ENSG00000139835 E009 38.52386 0.0006505814 0.100856409 0.19176748 13 113350849 113350973 125 - 1.637 1.549 -0.298
ENSG00000139835 E010 33.47451 0.0085893256 0.854070270 0.90971528 13 113355323 113355481 159 - 1.532 1.521 -0.041
ENSG00000139835 E011 38.59336 0.0007375609 0.147550508 0.25836238 13 113359617 113360284 668 - 1.633 1.556 -0.262
ENSG00000139835 E012 53.04799 0.0004820383 0.925775358 0.95727576 13 113363762 113363910 149 - 1.714 1.720 0.020
ENSG00000139835 E013 29.86623 0.0010525294 0.665184749 0.77287966 13 113364020 113364071 52 - 1.486 1.460 -0.090
ENSG00000139835 E014 22.39285 0.0009186941 0.699696964 0.79933602 13 113364072 113364148 77 - 1.338 1.367 0.103