ENSG00000139793

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000343600 ENSG00000139793 HEK293_OSMI2_2hA HEK293_TMG_2hB MBNL2 protein_coding protein_coding 1.378223 0.4667655 1.731051 0.08796193 0.1946836 1.868606 0.309431417 0.03447057 0.3800025 0.03447057 0.1289407 3.132561 0.17209167 0.06216667 0.2386000 0.17643333 4.088447e-01 8.166507e-10 FALSE TRUE
ENST00000449284 ENSG00000139793 HEK293_OSMI2_2hA HEK293_TMG_2hB MBNL2 protein_coding protein_coding 1.378223 0.4667655 1.731051 0.08796193 0.1946836 1.868606 0.114791584 0.31971016 0.0000000 0.10177992 0.0000000 -5.043126 0.24825833 0.64143333 0.0000000 -0.64143333 8.166507e-10 8.166507e-10 FALSE FALSE
ENST00000679496 ENSG00000139793 HEK293_OSMI2_2hA HEK293_TMG_2hB MBNL2 protein_coding protein_coding 1.378223 0.4667655 1.731051 0.08796193 0.1946836 1.868606 0.006926648 0.05541319 0.0000000 0.05541319 0.0000000 -2.709582 0.01247917 0.09983333 0.0000000 -0.09983333 3.981381e-01 8.166507e-10 FALSE TRUE
ENST00000685165 ENSG00000139793 HEK293_OSMI2_2hA HEK293_TMG_2hB MBNL2 protein_coding protein_coding 1.378223 0.4667655 1.731051 0.08796193 0.1946836 1.868606 0.025976851 0.00000000 0.2078148 0.00000000 0.2078148 4.445030 0.01225000 0.00000000 0.0980000 0.09800000 1.000000e+00 8.166507e-10   FALSE
MSTRG.8970.4 ENSG00000139793 HEK293_OSMI2_2hA HEK293_TMG_2hB MBNL2 protein_coding   1.378223 0.4667655 1.731051 0.08796193 0.1946836 1.868606 0.543410214 0.00000000 0.4748392 0.00000000 0.3414841 5.599434 0.26812917 0.00000000 0.2916667 0.29166667 5.363375e-01 8.166507e-10 FALSE TRUE
MSTRG.8970.7 ENSG00000139793 HEK293_OSMI2_2hA HEK293_TMG_2hB MBNL2 protein_coding   1.378223 0.4667655 1.731051 0.08796193 0.1946836 1.868606 0.355994859 0.05717159 0.6683941 0.05717159 0.3359918 3.336201 0.25239167 0.19656667 0.3717333 0.17516667 6.733760e-01 8.166507e-10 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000139793 E001 0.0000000       13 97221434 97221559 126 +      
ENSG00000139793 E002 0.0000000       13 97222324 97222324 1 +      
ENSG00000139793 E003 0.0000000       13 97222325 97222332 8 +      
ENSG00000139793 E004 0.1451727 0.0442840396 1.000000e+00   13 97222333 97222336 4 + 0.055 0.001 -6.609
ENSG00000139793 E005 3.1001851 0.0051176390 6.962535e-02 1.427369e-01 13 97222337 97222354 18 + 0.566 0.253 -1.761
ENSG00000139793 E006 8.2526433 0.0063088133 1.518959e-01 2.642444e-01 13 97222355 97222531 177 + 0.879 0.759 -0.469
ENSG00000139793 E007 21.0005872 0.0009718919 5.309870e-06 3.756587e-05 13 97275632 97276203 572 + 1.275 0.865 -1.495
ENSG00000139793 E008 10.2598945 0.0026002690 2.999176e-02 7.194221e-02 13 97276204 97276409 206 + 0.969 0.759 -0.809
ENSG00000139793 E009 7.4891022 0.0023912563 2.424591e-01 3.770482e-01 13 97334276 97334440 165 + 0.838 0.759 -0.314
ENSG00000139793 E010 8.4738610 0.0027281847 2.614521e-01 3.990921e-01 13 97343016 97343216 201 + 0.879 0.815 -0.246
ENSG00000139793 E011 0.0000000       13 97343217 97343219 3 +      
ENSG00000139793 E012 5.0364198 0.0134675569 4.284052e-02 9.624905e-02 13 97346804 97347003 200 + 0.723 0.412 -1.439
ENSG00000139793 E013 2.2017017 0.0375663718 2.249270e-01 3.563362e-01 13 97347004 97347040 37 + 0.458 0.253 -1.248
ENSG00000139793 E014 2.3615224 0.0266379031 1.816908e-01 3.033550e-01 13 97347041 97347067 27 + 0.478 0.253 -1.348
ENSG00000139793 E015 1.4736481 0.1120042593 5.407676e-01 6.718572e-01 13 97356796 97356849 54 + 0.343 0.252 -0.617
ENSG00000139793 E016 6.2474990 0.0026695764 1.306259e-03 4.997512e-03 13 97357482 97357635 154 + 0.812 0.253 -2.797
ENSG00000139793 E017 0.0000000       13 97365136 97365171 36 +      
ENSG00000139793 E018 4.2137841 0.0045173711 9.797536e-02 1.874257e-01 13 97366459 97366553 95 + 0.652 0.412 -1.139
ENSG00000139793 E019 62.1117101 0.0156839897 6.937649e-13 1.747297e-11 13 97391322 97394120 2799 + 1.569 1.998 1.449